A Distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal

Cell Stem Cell

Volumn 7, Issue 2, 2010, Pages 186-197

  Milyavsky, Michael ^a,b   Gan, Olga I ^a,b   Trottier, Magan ^b,e   Komosa, Martin ^e   Tabach, Ofer ^f   Notta, Faiyaz ^a,b   Lechman, Eric ^a,b   Hermans, Karin G ^a,b   Eppert, Kolja ^a,b   Konovalova, Zhanna ^a,b   Ornatsky, Olga ^c   Domany, Eytan ^f   Meyn, M Stephen ^b,d,e   Dick, John E ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^f WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H2AX; PROTEIN BCL 2; PROTEIN P53;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL PROTECTION; CELL RENEWAL; CELL SUBPOPULATION; CELLULAR STRESS RESPONSE; DORMANCY; DOUBLE STRANDED DNA BREAK; GAMMA RADIATION; GENE INACTIVATION; GENE OVEREXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IONIZING RADIATION; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; CYTOPROTECTION; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; HELA CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; MYELOPOIESIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION, IONIZING; RECOMBINATION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77956233247     PISSN: 19345909     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stem.2010.05.016     Document Type: Article

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