Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase IIα: 1,4-Hydroquinone is a topoisomerase II poison

Chemical Research in Toxicology

Volumn 18, Issue 4, 2005, Pages 761-770

  Lindsey Jr , R Hunter ^a,b   Bender, Ryan P ^a   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNITED STATES MILITARY ACADEMY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 BENZENETRIOL; 1,4 BENZOQUINONE; 1,4 HYDROQUINONE; 2,2' BIPHENYLDIOL; 4,4' DIHYDROXYBIPHENYL; BENZENE; CATECHOL; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IIALPHA; HYDROQUINONE DERIVATIVE; PHENOL DERIVATIVE; POISON; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CHROMOSOME DAMAGE; DNA CLEAVAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; METABOLITE; OXIDATION REDUCTION REACTION; REACTION ANALYSIS;

ANTIGENS, NEOPLASM; BENZENE; CELLS, CULTURED; DNA; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; HUMANS; HYDROQUINONES; LEUKEMIA;

EID: 17644390211     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049659z     Document Type: Article

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