Benzene metabolites induce apoptosis in lymphocytes

Experimental and Toxicologic Pathology

Volumn 58, Issue 1, 2006, Pages 65-70

  Martinez Velazquez M ^a   Maldonado, V ^a   Ortega, A ^b   Melendez Zajgla J ^a,c   Albores, A ^b  

^a INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c HOSPITAL JUÁREZ DE MÉXICO   (Mexico)

Author keywords

Apoptosis; Benzene; Detoxification; Hepatocyte; Hepatoma cell line; In vitro biotransformation; Muconic acid

Indexed keywords

BENZENE DERIVATIVE; DNA FRAGMENT; HYDROCARBON; MUCONIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOTRANSFORMATION; BLOOD TOXICITY; CELL ISOLATION; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DNA DAMAGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CELL CULTURE; LYMPHOCYTE CULTURE; MALE; METABOLITE; NICK END LABELING; NONHUMAN; RAT; SUPERNATANT; TOXICITY TESTING; TOXICOKINETICS;

EID: 33746378327     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2006.03.010     Document Type: Article

References (29)

1. Abernethy D.J., Kleymenova E.V., Rose J., et al. Human CD34+ hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone. Toxicol Sci 79 (2004) 82-89
2. Anderson D. Factors contributing to biomarker responses in exposed workers. Mutat Res 428 (1999) 197-202
3. Bartczak A., Kline S.A., Yu R., et al. Evaluation of assays for the identification and quantitation of muconic acid, a benzene metabolite in human urine. J Toxicol Environ Health 42 (1994) 245-258
4. Bechtold W.E., and Henderson R.F. Biomarkers of human exposure to benzene. J Toxicol Environ Health 40 (1993) 377-386
5. Brief R.S., Lynch J., Bernath T., et al. Benzene in the workplace. Am Ind Hyg Assoc J 41 (1980) 616-623
6. de Paula F.C., Silveira J.N., Junqueira R.G., et al. Assessment of urinary trans, trans-muconic acid as a biomarker of exposure to benzene. Rev Saude Publica 37 (2003) 780-785
7. Dees C., Askari M., and Henley D. Carcinogenic potential of benzene and toluene when evaluated using cyclin-dependent kinase activation and p53-DNA binding. Environ Health Perspect 104 Suppl 6 (1996) 1289-1292
8. Farris G.M., Robinson S.N., Gaido K.W., et al. Benzene-induced hematotoxicity and bone marrow compensation in B6C3F1 mice. Fundam Appl Toxicol 36 (1997) 119-129
9. Farris G.M., Robinson S.N., Wong B.A., et al. Effects of benzene on splenic, thymic, and femoral lymphocytes in mice. Toxicology 118 (1997) 137-148
10. Glass D.C., Gray C.N., Jolley D.J., et al. Leukemia risk associated with low-level benzene exposure. Epidemiology 14 (2003) 569-577
11. Hirabayashi Y., Yoon B.I., Li G.X., et al. Mechanism of benzene-induced hematotoxicity and leukemogenicity: current review with implication of microarray analyses. Toxicol Pathol 32 Suppl 2 (2004) 12-16
12. Inayat-Hussain S.H., Winski S.L., and Ross D. Differential involvement of caspases in hydroquinone-induced apoptosis in human leukemic hl-60 and jurkat cells. Toxicol Appl Pharmacol 175 (2001) 95-103
13. Kolachana P., Subrahmanyam V.V., Meyer K.B., et al. Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo. Cancer Res 53 (1993) 1023-1026
14. Levay G., and Bodell W.J. Potentiation of DNA adduct formation in HL-60 cells by combinations of benzene metabolites. Proc Natl Acad Sci USA 89 (1992) 7105-7109
15. Lynge E., Andersen A., Nilsson R., et al. Risk of cancer and exposure to gasoline vapors. Am J Epidemiol 145 (1997) 449-458
16. Maldonado V., Melendez-Zajgla J., and Ortega A. Modulation of NF-kappa B, and Bcl-2 in apoptosis induced by cisplatin in HeLa cells. Mutat Res 381 (1997) 67-75
17. Maldonado V., Melendez J., Gonzalez H., et al. Internucleosomal DNA cleavage in HeLa cells exposed to cisplatin. Biochem Mol Biol Int 37 (1995) 691-696
18. Mehlman M.A. Carcinogenic effects of benzene: Cesare Maltoni's contributions. Ann N Y Acad Sci 982 (2002) 137-148
19. Pemex. Anuario Estadistico, 1994.
20. Rao N.R., and Snyder R. Oxidative modifications produced in HL-60 cells on exposure to benzene metabolites. J Appl Toxicol 15 (1995) 403-409
21. Rappaport S.M., Tornero-Velez R., Golding B.T., et al. Measurement of benzene oxide in the blood of rats following administration of benzene. Carcinogenesis 18 (1997) 1637-1641
22. Registry A.F.TS.A.D. Toxicological profile for benzene (1996), U.S. Department of Health and Human Services
23. Rinsky R.A., Young R.J., and Smith A.B. Leukemia in benzene workers. Am J Ind Med 2 (1981) 217-245
24. Robinson S.N., Shah R., Wong B.A., et al. Immunotoxicological effects of benzene inhalation in male Sprague-Dawley rats. Toxicology 119 (1997) 227-237
25. Rossman R.G., Klein C.B., and Snyder C.A. Mutagenic metabolites of benzene detected in the Microscreen assay. Environ Health Perspect 81 (1989) 77-79
26. Schrenk D., Orzechowski A., Schwarz L.R., et al. Phase II metabolism of benzene. Environ Health Perspect 104 Suppl 6 (1996) 1183-1188
27. Snyder R. Xenobiotic metabolism and the mechanism(s) of benzene toxicity. Drug Metab Rev 36 (2004) 531-547
28. Turteltaub K.W., and Mani C. Benzene metabolism in rodents at doses relevant to human exposure from urban air. Res Rep Health Eff Inst (2003) 1-26 (discussion 27-35)
29. World Health Organization. Benzene. International Programme on Chemical Safety, Environmental Health Criteria, 1993.