The benzene metabolite para-benzoquinone is genotoxic in human, phorbol-12-acetate-13-myristate induced, peripheral blood mononuclear cells at low concentrations

Archives of Toxicology

Volumn 83, Issue 7, 2009, Pages 721-729

  Westphal, Götz Alexander ^a   Bünger, Jürgen ^a   Lichey, Nadine ^b   Taeger, Dirk ^a   Mönnich, Angelika ^b   Hallier, Ernst ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Benzene; Para Benzoquinone; Phorbol 12 acetate 13 myristate

Indexed keywords

1,4 BENZOQUINONE; BENZENE DERIVATIVE; CARCINOGEN; CATECHOL DERIVATIVE; HYDROQUINONE; MYELOPEROXIDASE; PHORBOL 12 ACETATE 13 MYRISTATE;

ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; CYTOKINESIS; ENZYME ACTIVITY; GENOTOXICITY; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; LIVER; METABOLITE; MICRONUCLEUS TEST; PERIPHERAL BLOOD MONONUCLEAR CELL; POLLUTANT; PRIORITY JOURNAL;

ADULT; BENZENE; BENZOQUINONES; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CYTOCHALASIN B; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MICRONUCLEUS TESTS; MIDDLE AGED; MUTAGENICITY TESTS; PHYTOHEMAGGLUTININS; TETRADECANOYLPHORBOL ACETATE;

EID: 67650739990     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-009-0402-6     Document Type: Article

References (50)

1. F Aucherè C Capeillère-Blandin 1999 NADPH as a co-substrate for studies of the chlorinating activity of myeloperoxidase Biochem J 343 603 613 (Pubitemid 29537372)
2. DF Bainton JL Ullyotm MG Farquhar 1971 The development of neutrophilic polymorphonuclear leukocytes in human bone marrow J Exp Med 134 907 934
3. WE Bechtold JK Willis JD Sun WC Griffith TV Reddy 1992 Biological markers of exposure to benzene: S-phenylcysteine in albumin Carcinogenesis 13 1217 1220
4. EL Cavalieri KM Li N Balu M Saeed P Devanesan S Higginbotham J Zhao ML Gross EG Rogan 2002 Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases Carcinogenesis 23 1071 1077 (Pubitemid 34752965)
5. R Corvi S Albertini T Hartung S Hoffmann D Maurici S Pfuhler J van Benthem P Vanparys 2008 ECVAM retrospective validation of in vitro micronucleus test (MNT) Mutagenesis 23 271 283 (Pubitemid 351918959)
6. LM Coussens Z Werb 2002 Inflammation and cancer Nature 420 860 867 (Pubitemid 36019639)
7. 14C]-Benzene in B6C3F1 mice Carcinogenesis 18 2421 2427
8. P Crosignani A Tittarelli A Borgini T Codazzi A Rovelli E Porro P Contiero N Bianchi G Tagliabue R Fissi F Rossitto F Berrino 2004 Childhood leukemia and road traffic: a population-based case-control study Int J Cancer 108 596 599 (Pubitemid 38036662)
9. RT Dzarlieva-Petrusevska NE Füsenig 1985 Tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced chromosome aberrations in mouse keratinocyte cell lines: a possible genetic mechanism of tumor promotion Carcinogenesis 6 1447 1456 (Pubitemid 16238938)
10. DA Eastmond JD Tucker 1989 Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody Environ Mol Mutagen 13 34 43 (Pubitemid 19252654)
11. DA Eastmond MT Smith 1990 Xenobiotic activation by stimulated human polymorphonuclear leukocytes and myeloperoxidase Methods Enzymol 186 579 585 (Pubitemid 20280001)
12. DA Eastmond MT Smith LO Ruzo D Ross 1986 Metabolic activation of phenol by human myeloperoxidase and horseradish peroxidase Mol Pharmacol 30 674 679 (Pubitemid 17228916)
13. Environmental Protection Agency USA (1998) Carcinogenic effects of benzene: an update. EPA document 600/P-97/001. National Center for Environmental Assessment, Washington Office, Office of Research and Development, US Environmental Protection Agency
14. M Fenech 1993 The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations Mutat Res 285 35 44 (Pubitemid 23029552)
15. A Forni 1971 Chromosome studies in workers exposed to benzene or toluene or both Arch Environ Health 22 373 378
16. RB Hayes SN Yin M Dosemeci GL Li S Wacholder LB Travis CY Li N Rothman RN Hoover MS Linet 1997 Benzene and the dose-related incidence of hematologic neoplasms in China J Natl Cancer Inst 89 1065 1071 (Pubitemid 27327872)
17. D Kirkland S Pfuhler D Tweats M Aardema R Corvi F Darroudi A Elhajouji H Glatt P Hastwell M Hayashi P Kasper S Kirchner A Lynch D Marzin D Maurici JR Meunier L Muller G Nohynek J Parry E Parry V Thybaud R Tice J van Benthem P Vanparys P White 2007 How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: report of an ECVAM Workshop Mutat Res 628 31 55 (Pubitemid 46316835)
18. E Krewet C Verkoyen G Müller C Schell W Popp K Norpoth 1993 Studies on guanine adducts excreted in rat urine after benzene exposure Carcinogenesis 14 245 250 (Pubitemid 23143401)
19. SH Lamm A Engel DM Byrd 2005 Non-Hodgkin lymphoma and benzene exposure: a systematic literature review Chem Biol Interact 153-154 231 237 (Pubitemid 40797814)
20. Q Lan L Zhang G Li R Vermeulen RS Weinberg M Dosemeci SM Rappaport M Shen BP Alter Y Wu W Kopp S Waidyanatha C Rabkin W Guo S Chanock RB Hayes M Linet S Kim S Yin N Rothman MT Smith 2004 Hematotoxicity in workers exposed to low levels of benzene Science 306 1774 1776 (Pubitemid 39601394)
21. G Lévay WJ Bodell 1992 Potentiation of DNA adduct formation in HL-60 cells by combinations of benzene metabolites Proc Natl Acad Sci USA 89 7105 7109
22. G Ludewig S Dogra H Glatt 1989 Genotoxicity of 1, 4-benzoquinone and 1, 4-naphthoquinone in relation to effects on glutathione and NAD(P)H levels in V79 cells Environ Health Perspect 82 223 228 (Pubitemid 19231553)
23. C Maltoni B Conti G Cotti F Belpoggi 1985 Experimental studies on benzene carcinogenicity at the Bologna Institute of Oncology: current results and ongoing research Am J Ind Med 7 415 446 (Pubitemid 15066367)
24. 13C6]benzene Cancer Res 54 4907 4914
25. MA Mehlman 2004 Benzene: a haematopoietic and multi-organ carcinogen at any level above zero Eur J Oncol 9 15 36 (Pubitemid 38679186)
26. B Miller F Pötter-Locher A Seelbach H Stopper D Utesch S Madle 1998 Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft für Umwelt-Mutations-forschung Mutat Res 410 81 116 (Pubitemid 28201941)
27. 1 Mice (Gavage Studies), NTP Technical Report 289, NIH Publ. No. 86-2545, Research Triangle Park, NC
28. RT Petrusevska G Fürstenberger F Marks NE Füsenig 1988 Cytogenetic effects caused by phorbol ester tumor promoters in primary mouse keratinocyte cultures: correlation with the convertogenic activity of TPA in multistage skin carcinogenesis Carcinogenesis 9 1207 1215 (Pubitemid 18172053)
29. D Picciano 1979 Cytogenetic study of workers exposed to benzene Environ Res 19 33 38 (Pubitemid 9191590)
30. W Popp C Vahrenholz S Yaman C Müller W Schmieding K Norpoth R Fahnert 1992 Investigations of the frequency of DNA strand breakage and cross-linking and of sister chromatid exchange frequency in the lymphocytes of female workers exposed to benzene and toluene Carcinogenesis 13 57 61
31. N Rothman R Haas RB Hayes GL Li J Wiemels S Campleman PJ Quintana LJ Xi M Dosemeci N Titenko-Holland KB Meyer W Lu LP Zhang W Bechtold YZ Wang P Kolachana SN Yin W Blot MT Smith 1995 Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans Proc Natl Acad Sci USA 92 4069 4073
32. N Rothman GL Li M Dosemeci WE Bechtold GE Marti YZ Wang M Linet LJ Xi W Lu MT Smith N Titenko-Holland LP Zhang W Blot SN Yin RB Hayes 1996 Hematotoxicity among Chinese workers heavily exposed to benzene Am J Ind Med 29 236 246 (Pubitemid 26080773)
33. R Ruiz-Ramos ME Cebrian E Garrido 2005 Benzoquinone activates the ERK/MAPK signaling pathway via ROS production in HL-60 cells Toxicology 209 279 287 (Pubitemid 40439221)
34. A Seidler M Möhner J Berger B Mester E Deeg G Elsner A Nieters N Becker 2007 Solvent exposure and malignant lymphoma: a population-based case-control study in Germany J Occup Med Toxicol 2 2
35. MT Smith L Zhang Y Wang RB Hayes G Li J Wiemels M Dosemeci N Titenko-Holland L Xi P Kolachana S Yin N Rothman 1998 Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene Cancer Res 58 2176 2181 (Pubitemid 28232905)
36. MT Smith RM Jones AH Smith 2007 Benzene exposure and risk of non-Hodgkin lymphoma Cancer Epidemiol Biomarkers Prev 16 385 391 (Pubitemid 46548637)
37. R Snyder 2007 Benzene's toxicity: a consolidated short review of human and animal studies by HA Khan Hum Exp Toxicol 26 687 696 Comment on: Khan et al. (2007) Hum Exp Toxicol 26:677-685 (Pubitemid 350157337)
38. C Steffen MF Auclerc A Auvrignon A Baruchel K Kebaili A Lambiliotte G Leverger D Sommelet E Vilmer D Hémon J Clavel 2004 Acute childhood leukemia and environmental exposure to potential sources of benzene and other hydrocarbons; a case-control study Occup Environ Med 61 773 778 (Pubitemid 39185851)
39. VV Subrahmanyam D Ross DA Eastmond MT Smith 1991 Potential role of free radicals in benzene-induced myelotoxicity and leukemia Free Radic Biol Med 11 495 515 (Pubitemid 121003256)
40. A Tompa J Major MG Jakab 1994 Monitoring of benzene-exposed workers for genotoxic effects of benzene: improved-working-condition-related decrease in the frequencies of chromosomal aberrations in peripheral blood lymphocytes Mutat Res 304 159 165 (Pubitemid 24033324)
41. IM Tough PG Smith WM Court Brown DG Hamden 1970 Chromosome studies on workers exposed to atmospheric benzene. The possible influence of age Eur J Cancer 6 49 55
42. MA Trush 1984 Activation of bleomycin A2 to a DNA-damaging intermediate by phorbolester-stimulated human polymorphonuclear leukocytes Toxicol Lett 20 297 302 (Pubitemid 14163030)
43. J Tuo S Loft HE Poulsen 1999 Enhanced benzene-induced DNA damage in PMA-stimulated cells in vitro and in LPS-treated animals Free Radic Biol Med 26 801 808 (Pubitemid 29198351)
44. DJ Tweats D Blakey RH Heflich A Jacobs SD Jacobsen T Morita T Nohmi MR O'Donovan YF Sasaki T Sofuni R Tice 2007 IWGT Working Group. Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test Mutat Res 627 92 105 (Pubitemid 46098932)
45. S Walrand S Valeix C Rodriguez P Ligot J Chassagne MP Vasson 2003 Flow cytometry study of polymorphonuclear neutrophil oxidative burst: a comparison of three fluorescent probes Clin Chim Acta 331 103 110 (Pubitemid 36412031)
46. CC Winterbourn 2002 Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid Toxicology 181-182 223 227 (Pubitemid 36015703)
47. JW Yager DA Eastmond ML Robertson WM Paradisin MT Smith 1990 Characterization of micronuclei induced in human lymphocytes by benzene metabolites Cancer Res 50 393 399 (Pubitemid 20041247)
48. F Zarani P Papazafiri A Kappas 1999 Induction of micronuclei in human lymphocytes by organic solvents in vitro J Environ Pathol Toxicol Oncol 18 21 28 (Pubitemid 29056274)
49. L Zhang Y Wang N Shang MT Smith 1998 Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes Leuk Res 22 105 113 (Pubitemid 28185342)
50. L Zhang W Yang AE Hubbard MT Smith 2005 Nonrandom aneuploidy of chromosomes 1, 5, 6, 7, 8, 9, 11, 12, and 21 induced by the benzene metabolites hydroquinone and benzenetriol Environ Mol Mutagen 45 388 396 (Pubitemid 40647134)