메뉴 건너뛰기




Volumn 6, Issue 1, 2011, Pages

Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells

Author keywords

[No Author keywords available]

Indexed keywords

BLOOM SYNDROME HELICASE; PROTEIN P53; RAD51 PROTEIN; RECQ HELICASE; RETINOBLASTOMA PROTEIN; SHORT HAIRPIN RNA; EXODEOXYRIBONUCLEASE; WRN PROTEIN, HUMAN;

EID: 79251580717     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014546     Document Type: Article
Times cited : (9)

References (71)
  • 1
    • 0033771208 scopus 로고    scopus 로고
    • The Werner syndrome protein: An update
    • Oshima J (2000) The Werner syndrome protein: an update. Bioessays 22: 894-901.
    • (2000) Bioessays , vol.22 , pp. 894-901
    • Oshima, J.1
  • 2
    • 0034001767 scopus 로고    scopus 로고
    • RecQ family helicases: Roles in cancer and aging
    • Karow JK, Wu L, Hickson ID (2000) RecQ family helicases: roles in cancer and aging. Curr Opin Genet Dev 10: 32-38.
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 32-38
    • Karow, J.K.1    Wu, L.2    Hickson, I.D.3
  • 3
    • 24044441918 scopus 로고    scopus 로고
    • Deficient DNA repair in the human progeroid disorder, Werner syndrome
    • Bohr VA (2005) Deficient DNA repair in the human progeroid disorder, Werner syndrome. Mutat Res 577: 252-259.
    • (2005) Mutat Res , vol.577 , pp. 252-259
    • Bohr, V.A.1
  • 4
    • 45449110194 scopus 로고    scopus 로고
    • Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases
    • Ouyang KJ, Woo LL, Ellis NA (2008) Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. Mech Ageing Dev 129: 425-440.
    • (2008) Mech Ageing Dev , vol.129 , pp. 425-440
    • Ouyang, K.J.1    Woo, L.L.2    Ellis, N.A.3
  • 5
    • 53149151798 scopus 로고    scopus 로고
    • Roles of the Werner syndrome RecQ helicase in DNA replication
    • Sidorova JM (2008) Roles of the Werner syndrome RecQ helicase in DNA replication. DNA Repair (Amst) 7: 1776-1786.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1776-1786
    • Sidorova, J.M.1
  • 6
    • 76749168005 scopus 로고    scopus 로고
    • Roles of Werner syndrome protein in protection of genome integrity
    • Rossi ML, Ghosh AK, Bohr VA (2010) Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) 9: 331-344.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 331-344
    • Rossi, M.L.1    Ghosh, A.K.2    Bohr, V.A.3
  • 8
    • 0035034884 scopus 로고    scopus 로고
    • Premature aging and predisposition to cancers caused by mutations in RecQ family helicases
    • Furuichi Y (2001) Premature aging and predisposition to cancers caused by mutations in RecQ family helicases. Ann N Y Acad Sci 928: 121-131.
    • (2001) Ann N Y Acad Sci , vol.928 , pp. 121-131
    • Furuichi, Y.1
  • 9
    • 29144478593 scopus 로고    scopus 로고
    • Polymorphisms of the TP53 codon 72 and WRN codon 1367 in individuals from Northern Brazil with gastric adenocarcinoma
    • Khayat AS, Lobo Gatti L, Moura Lima E, de Assumpcao PP, Nascimento Motta FJ, et al. (2005) Polymorphisms of the TP53 codon 72 and WRN codon 1367 in individuals from Northern Brazil with gastric adenocarcinoma. Clin Exp Med 5: 161-168.
    • (2005) Clin Exp Med , vol.5 , pp. 161-168
    • Khayat, A.S.1    Lobo Gatti, L.2    Moura Lima, E.3    de Assumpcao, P.P.4    Nascimento Motta, F.J.5
  • 10
    • 70349910088 scopus 로고    scopus 로고
    • A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women
    • Wang Z, Xu Y, Tang J, Ma H, Qin J, et al. (2009) A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women. Breast Cancer Res Treat.
    • (2009) Breast Cancer Res Treat
    • Wang, Z.1    Xu, Y.2    Tang, J.3    Ma, H.4    Qin, J.5
  • 11
    • 38949208772 scopus 로고    scopus 로고
    • Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan
    • Nakayama R, Sato Y, Masutani M, Ogino H, Nakatani F, et al. (2008) Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan. Cancer Sci 99: 333-339.
    • (2008) Cancer Sci , vol.99 , pp. 333-339
    • Nakayama, R.1    Sato, Y.2    Masutani, M.3    Ogino, H.4    Nakatani, F.5
  • 12
    • 33847763165 scopus 로고    scopus 로고
    • Genetic variation in the premature aging gene WRN: A case-control study on breast cancer susceptibility
    • Ding SL, Yu JC, Chen ST, Hsu GC, Shen CY (2007) Genetic variation in the premature aging gene WRN: a case-control study on breast cancer susceptibility. Cancer Epidemiol Biomarkers Prev 16: 263-269.
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 263-269
    • Ding, S.L.1    Yu, J.C.2    Chen, S.T.3    Hsu, G.C.4    Shen, C.Y.5
  • 13
    • 33745056414 scopus 로고    scopus 로고
    • Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
    • Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, et al. (2006) Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A 103: 8822-8827.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 8822-8827
    • Agrelo, R.1    Cheng, W.H.2    Setien, F.3    Ropero, S.4    Espada, J.5
  • 14
    • 69249209608 scopus 로고    scopus 로고
    • RecQ helicases: Multifunctional genome caretakers
    • Chu WK, Hickson ID (2009) RecQ helicases: multifunctional genome caretakers. Nat Rev Cancer.
    • (2009) Nat Rev Cancer
    • Chu, W.K.1    Hickson, I.D.2
  • 16
    • 0026702210 scopus 로고
    • Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines
    • Poot M, Hoehn H, Runger TM, Martin GM (1992) Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res 202: 267-273.
    • (1992) Exp Cell Res , vol.202 , pp. 267-273
    • Poot, M.1    Hoehn, H.2    Runger, T.M.3    Martin, G.M.4
  • 17
    • 27944477757 scopus 로고    scopus 로고
    • Werner protein protects nonproliferating cells from oxidative DNA damage
    • Szekely AM, Bleichert F, Numann A, Van Komen S, Manasanch E, et al. (2005) Werner protein protects nonproliferating cells from oxidative DNA damage. Mol Cell Biol 25: 10492-10506.
    • (2005) Mol Cell Biol , vol.25 , pp. 10492-10506
    • Szekely, A.M.1    Bleichert, F.2    Numann, A.3    Van Komen, S.4    Manasanch, E.5
  • 18
    • 34547670683 scopus 로고    scopus 로고
    • Role for the Werner syndrome protein in the promotion of tumor cell growth
    • Opresko PL, Calvo JP, von Kobbe C (2007) Role for the Werner syndrome protein in the promotion of tumor cell growth. Mech Ageing Dev 128: 423-436.
    • (2007) Mech Ageing Dev , vol.128 , pp. 423-436
    • Opresko, P.L.1    Calvo, J.P.2    von Kobbe, C.3
  • 19
    • 59349116567 scopus 로고    scopus 로고
    • Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone
    • Ren X, Lim S, Smith MT, Zhang L (2009) Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone. Toxicol Sci 107: 367-375.
    • (2009) Toxicol Sci , vol.107 , pp. 367-375
    • Ren, X.1    Lim, S.2    Smith, M.T.3    Zhang, L.4
  • 20
    • 0035266463 scopus 로고    scopus 로고
    • Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase
    • Lebel M, Cardiff RD, Leder P (2001) Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res 61: 1816-1819.
    • (2001) Cancer Res , vol.61 , pp. 1816-1819
    • Lebel, M.1    Cardiff, R.D.2    Leder, P.3
  • 21
    • 0032573157 scopus 로고    scopus 로고
    • A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
    • Lebel M, Leder P (1998) A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A 95: 13097-13102.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13097-13102
    • Lebel, M.1    Leder, P.2
  • 22
    • 17544402913 scopus 로고    scopus 로고
    • Mutations in the WRN gene in mice accelerate mortality in a p53-null background
    • Lombard DB, Beard C, Johnson B, Marciniak RA, Dausman J, et al. (2000) Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol 20: 3286-3291.
    • (2000) Mol Cell Biol , vol.20 , pp. 3286-3291
    • Lombard, D.B.1    Beard, C.2    Johnson, B.3    Marciniak, R.A.4    Dausman, J.5
  • 23
    • 3543043128 scopus 로고    scopus 로고
    • Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    • Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, et al. (2004) Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36: 877-882.
    • (2004) Nat Genet , vol.36 , pp. 877-882
    • Chang, S.1    Multani, A.S.2    Cabrera, N.G.3    Naylor, M.L.4    Laud, P.5
  • 24
    • 33748047128 scopus 로고    scopus 로고
    • RB and cell cycle progression
    • Giacinti C, Giordano A (2006) RB and cell cycle progression. Oncogene 25: 5220-5227.
    • (2006) Oncogene , vol.25 , pp. 5220-5227
    • Giacinti, C.1    Giordano, A.2
  • 25
    • 0040436076 scopus 로고    scopus 로고
    • Functional and physical interaction between WRN helicase and human replication protein A
    • Brosh RM, Jr., Orren DK, Nehlin JO, Ravn PH, Kenny MK, et al. (1999) Functional and physical interaction between WRN helicase and human replication protein A. J Biol Chem 274: 18341-18350.
    • (1999) J Biol Chem , vol.274 , pp. 18341-18350
    • Brosh Jr., R.M.1    Orren, D.K.2    Nehlin, J.O.3    Ravn, P.H.4    Kenny, M.K.5
  • 26
    • 13944255048 scopus 로고    scopus 로고
    • Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery
    • Franchitto A, Pichierri P (2004) Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery. Cell Cycle 3: 1331-1339.
    • (2004) Cell Cycle , vol.3 , pp. 1331-1339
    • Franchitto, A.1    Pichierri, P.2
  • 28
    • 0141740425 scopus 로고    scopus 로고
    • WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair
    • Chen L, Huang S, Lee L, Davalos A, Schiestl RH, et al. (2003) WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell 2: 191-199.
    • (2003) Aging Cell , vol.2 , pp. 191-199
    • Chen, L.1    Huang, S.2    Lee, L.3    Davalos, A.4    Schiestl, R.H.5
  • 29
    • 18144431719 scopus 로고    scopus 로고
    • Genotypedependent induction of transmissible chromosomal instability by gammaradiation and the benzene metabolite hydroquinone
    • Gowans ID, Lorimore SA, McIlrath JM, Wright EG (2005) Genotypedependent induction of transmissible chromosomal instability by gammaradiation and the benzene metabolite hydroquinone. Cancer Res 65: 3527-3530.
    • (2005) Cancer Res , vol.65 , pp. 3527-3530
    • Gowans, I.D.1    Lorimore, S.A.2    McIlrath, J.M.3    Wright, E.G.4
  • 30
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 31
    • 0035169035 scopus 로고    scopus 로고
    • Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle
    • Pichierri P, Franchitto A, Mosesso P, Palitti F (2001) Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle. Mol Biol Cell 12: 2412-2421.
    • (2001) Mol Biol Cell , vol.12 , pp. 2412-2421
    • Pichierri, P.1    Franchitto, A.2    Mosesso, P.3    Palitti, F.4
  • 32
    • 0033119701 scopus 로고    scopus 로고
    • Defending genome integrity during DNA replication: A proposed role for RecQ family helicases
    • Chakraverty RK, Hickson ID (1999) Defending genome integrity during DNA replication: a proposed role for RecQ family helicases. Bioessays 21: 286-294.
    • (1999) Bioessays , vol.21 , pp. 286-294
    • Chakraverty, R.K.1    Hickson, I.D.2
  • 34
    • 42249115685 scopus 로고    scopus 로고
    • The consequences of Rad51 overexpression for normal and tumor cells
    • Klein HL (2008) The consequences of Rad51 overexpression for normal and tumor cells. DNA Repair (Amst) 7: 686-693.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 686-693
    • Klein, H.L.1
  • 35
    • 0242268056 scopus 로고    scopus 로고
    • Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance
    • Henning W, Sturzbecher HW (2003) Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance. Toxicology 193: 91-109.
    • (2003) Toxicology , vol.193 , pp. 91-109
    • Henning, W.1    Sturzbecher, H.W.2
  • 36
    • 0023712434 scopus 로고
    • Spontaneous and induced chromosomal instability in Werner syndrome
    • Gebhart E, Bauer R, Raub U, Schinzel M, Ruprecht KW, et al. (1988) Spontaneous and induced chromosomal instability in Werner syndrome. Hum Genet 80: 135-139.
    • (1988) Hum Genet , vol.80 , pp. 135-139
    • Gebhart, E.1    Bauer, R.2    Raub, U.3    Schinzel, M.4    Ruprecht, K.W.5
  • 37
    • 0020460340 scopus 로고
    • Clonal structural chromosomal rearrangements in primary fibroblast cultures and in lymphocytes of patients with Werner's Syndrome
    • Scappaticci S, Cerimele D, Fraccaro M (1982) Clonal structural chromosomal rearrangements in primary fibroblast cultures and in lymphocytes of patients with Werner's Syndrome. Hum Genet 62: 16-24.
    • (1982) Hum Genet , vol.62 , pp. 16-24
    • Scappaticci, S.1    Cerimele, D.2    Fraccaro, M.3
  • 38
    • 0019440557 scopus 로고
    • Cytogenetics of Werner's syndrome cultured skin fibroblasts: Variegated translocation mosaicism
    • Salk D, Au K, Hoehn H, Martin GM (1981) Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet 30: 92-107.
    • (1981) Cytogenet Cell Genet , vol.30 , pp. 92-107
    • Salk, D.1    Au, K.2    Hoehn, H.3    Martin, G.M.4
  • 39
    • 34247164462 scopus 로고    scopus 로고
    • Involvement of homologous recombination in carcinogenesis
    • Reliene R, Bishop AJ, Schiestl RH (2007) Involvement of homologous recombination in carcinogenesis. Adv Genet 58: 67-87.
    • (2007) Adv Genet , vol.58 , pp. 67-87
    • Reliene, R.1    Bishop, A.J.2    Schiestl, R.H.3
  • 40
    • 0033753844 scopus 로고    scopus 로고
    • Homologous recombination as a mechanism for genome rearrangements: Environmental and genetic effects
    • Bishop AJ, Schiestl RH (2000) Homologous recombination as a mechanism for genome rearrangements: environmental and genetic effects. Hum Mol Genet 9: 2427-2334.
    • (2000) Hum Mol Genet , vol.9 , pp. 2427-2334
    • Bishop, A.J.1    Schiestl, R.H.2
  • 41
    • 56549122306 scopus 로고    scopus 로고
    • Brca2/ Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)- methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs
    • Roos WP, Nikolova T, Quiros S, Naumann SC, Kiedron O, et al. (2009) Brca2/ Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)- methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs. DNA Repair (Amst) 8: 72-86.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 72-86
    • Roos, W.P.1    Nikolova, T.2    Quiros, S.3    Naumann, S.C.4    Kiedron, O.5
  • 42
    • 0032999346 scopus 로고    scopus 로고
    • Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
    • Sonoda E, Sasaki MS, Morrison C, Yamaguchi-Iwai Y, Takata M, et al. (1999) Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol Cell Biol 19: 5166-5169.
    • (1999) Mol Cell Biol , vol.19 , pp. 5166-5169
    • Sonoda, E.1    Sasaki, M.S.2    Morrison, C.3    Yamaguchi-Iwai, Y.4    Takata, M.5
  • 43
    • 26644456369 scopus 로고    scopus 로고
    • A case of Werner syndrome with three primary lesions of malignant melanoma
    • Shibuya H, Kato A, Kai N, Fujiwara S, Goto M (2005) A case of Werner syndrome with three primary lesions of malignant melanoma. J Dermatol 32: 737-744.
    • (2005) J Dermatol , vol.32 , pp. 737-744
    • Shibuya, H.1    Kato, A.2    Kai, N.3    Fujiwara, S.4    Goto, M.5
  • 44
    • 0020455613 scopus 로고
    • Werner's syndrome: A review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations
    • Salk D (1982) Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations. Hum Genet 62: 1-5.
    • (1982) Hum Genet , vol.62 , pp. 1-5
    • Salk, D.1
  • 45
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274: 1664-1672.
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 46
    • 61449249141 scopus 로고    scopus 로고
    • Balancing the decision of cell proliferation and cell fate
    • Hallstrom TC, Nevins JR (2009) Balancing the decision of cell proliferation and cell fate. Cell Cycle 8: 532-535.
    • (2009) Cell Cycle , vol.8 , pp. 532-535
    • Hallstrom, T.C.1    Nevins, J.R.2
  • 47
    • 33748275681 scopus 로고    scopus 로고
    • The p53 tumor suppressor participates in multiple cell cycle checkpoints
    • Giono LE, Manfredi JJ (2006) The p53 tumor suppressor participates in multiple cell cycle checkpoints. J Cell Physiol 209: 13-20.
    • (2006) J Cell Physiol , vol.209 , pp. 13-20
    • Giono, L.E.1    Manfredi, J.J.2
  • 48
    • 0030561571 scopus 로고    scopus 로고
    • The retinoblastoma protein pathway and the restriction point
    • Bartek J, Bartkova J, Lukas J (1996) The retinoblastoma protein pathway and the restriction point. Curr Opin Cell Biol 8: 805-814.
    • (1996) Curr Opin Cell Biol , vol.8 , pp. 805-814
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 49
    • 0032832195 scopus 로고    scopus 로고
    • Physical and functional interaction between p53 and the Werner's syndrome protein
    • Blander G, Kipnis J, Leal JF, Yu CE, Schellenberg GD, et al. (1999) Physical and functional interaction between p53 and the Werner's syndrome protein. J Biol Chem 274: 29463-29469.
    • (1999) J Biol Chem , vol.274 , pp. 29463-29469
    • Blander, G.1    Kipnis, J.2    Leal, J.F.3    Yu, C.E.4    Schellenberg, G.D.5
  • 50
    • 13944277101 scopus 로고    scopus 로고
    • p53 modulates RPA-dependent and RPA-independent WRN helicase activity
    • Sommers JA, Sharma S, Doherty KM, Karmakar P, Yang Q, et al. (2005) p53 modulates RPA-dependent and RPA-independent WRN helicase activity. Cancer Res 65: 1223-1233.
    • (2005) Cancer Res , vol.65 , pp. 1223-1233
    • Sommers, J.A.1    Sharma, S.2    Doherty, K.M.3    Karmakar, P.4    Yang, Q.5
  • 51
    • 0034231844 scopus 로고    scopus 로고
    • Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
    • Constantinou A, Tarsounas M, Karow JK, Brosh RM, Bohr VA, et al. (2000) Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO Rep 1: 80-84.
    • (2000) EMBO Rep , vol.1 , pp. 80-84
    • Constantinou, A.1    Tarsounas, M.2    Karow, J.K.3    Brosh, R.M.4    Bohr, V.A.5
  • 52
    • 0036161562 scopus 로고    scopus 로고
    • Roles of the Werner syndrome protein in pathways required for maintenance of genome stability
    • Brosh RM, Jr., Bohr VA (2002) Roles of the Werner syndrome protein in pathways required for maintenance of genome stability. Exp Gerontol 37: 491-506.
    • (2002) Exp Gerontol , vol.37 , pp. 491-506
    • Brosh Jr., R.M.1    Bohr, V.A.2
  • 53
    • 33846141125 scopus 로고    scopus 로고
    • Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest
    • Otterlei M, Bruheim P, Ahn B, Bussen W, Karmakar P, et al. (2006) Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci 119: 5137-5146.
    • (2006) J Cell Sci , vol.119 , pp. 5137-5146
    • Otterlei, M.1    Bruheim, P.2    Ahn, B.3    Bussen, W.4    Karmakar, P.5
  • 54
    • 0037077223 scopus 로고    scopus 로고
    • Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins
    • von Kobbe C, Karmakar P, Dawut L, Opresko P, Zeng X, et al. (2002) Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem 277: 22035-22044.
    • (2002) J Biol Chem , vol.277 , pp. 22035-22044
    • von Kobbe, C.1    Karmakar, P.2    Dawut, L.3    Opresko, P.4    Zeng, X.5
  • 55
    • 0029965507 scopus 로고    scopus 로고
    • Cell cycledependent expression of the mouse Rad51 gene in proliferating cells
    • Yamamoto A, Taki T, Yagi H, Habu T, Yoshida K, et al. (1996) Cell cycledependent expression of the mouse Rad51 gene in proliferating cells. Mol Gen Genet 251: 1-12.
    • (1996) Mol Gen Genet , vol.251 , pp. 1-12
    • Yamamoto, A.1    Taki, T.2    Yagi, H.3    Habu, T.4    Yoshida, K.5
  • 56
    • 0032526320 scopus 로고    scopus 로고
    • Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation
    • Vispe S, Cazaux C, Lesca C, Defais M (1998) Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation. Nucleic Acids Res 26: 2859-2864.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2859-2864
    • Vispe, S.1    Cazaux, C.2    Lesca, C.3    Defais, M.4
  • 57
    • 0842287698 scopus 로고    scopus 로고
    • DNA double-strand break repair by homologous recombination
    • Dudas A, Chovanec M (2004) DNA double-strand break repair by homologous recombination. Mutat Res 566: 131-167.
    • (2004) Mutat Res , vol.566 , pp. 131-167
    • Dudas, A.1    Chovanec, M.2
  • 58
    • 34249993770 scopus 로고    scopus 로고
    • Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells
    • Ariyoshi K, Suzuki K, Goto M, Watanabe M, Kodama S (2007) Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells. J Radiat Res (Tokyo) 48: 219-231.
    • (2007) J Radiat Res (Tokyo) , vol.48 , pp. 219-231
    • Ariyoshi, K.1    Suzuki, K.2    Goto, M.3    Watanabe, M.4    Kodama, S.5
  • 59
    • 11844250625 scopus 로고    scopus 로고
    • Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1
    • Lavoie J, Carter R, Drouin R, Lebel M (2005) Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1. Cancer Genet Cytogenet 156: 134-143.
    • (2005) Cancer Genet Cytogenet , vol.156 , pp. 134-143
    • Lavoie, J.1    Carter, R.2    Drouin, R.3    Lebel, M.4
  • 60
    • 0037469359 scopus 로고    scopus 로고
    • Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system
    • Lu X, Lozano G, Donehower LA (2003) Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system. Mutat Res 522: 69-83.
    • (2003) Mutat Res , vol.522 , pp. 69-83
    • Lu, X.1    Lozano, G.2    Donehower, L.A.3
  • 61
    • 0033578066 scopus 로고    scopus 로고
    • Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint
    • Saintigny Y, Rouillard D, Chaput B, Soussi T, Lopez BS (1999) Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint. Oncogene 18: 3553-3563.
    • (1999) Oncogene , vol.18 , pp. 3553-3563
    • Saintigny, Y.1    Rouillard, D.2    Chaput, B.3    Soussi, T.4    Lopez, B.S.5
  • 62
    • 2442477786 scopus 로고    scopus 로고
    • p53's double life: Transactivationindependent repression of homologous recombination
    • Bertrand P, Saintigny Y, Lopez BS (2004) p53's double life: transactivationindependent repression of homologous recombination. Trends Genet 20: 235-243.
    • (2004) Trends Genet , vol.20 , pp. 235-243
    • Bertrand, P.1    Saintigny, Y.2    Lopez, B.S.3
  • 63
    • 0034713347 scopus 로고    scopus 로고
    • DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma
    • Maacke H, Jost K, Opitz S, Miska S, Yuan Y, et al. (2000) DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma. Oncogene 19: 2791-2795.
    • (2000) Oncogene , vol.19 , pp. 2791-2795
    • Maacke, H.1    Jost, K.2    Opitz, S.3    Miska, S.4    Yuan, Y.5
  • 64
    • 0034672182 scopus 로고    scopus 로고
    • Overexpression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer
    • Maacke H, Opitz S, Jost K, Hamdorf W, Henning W, et al. (2000) Overexpression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer. Int J Cancer 88: 907-913.
    • (2000) Int J Cancer , vol.88 , pp. 907-913
    • Maacke, H.1    Opitz, S.2    Jost, K.3    Hamdorf, W.4    Henning, W.5
  • 65
    • 1842791545 scopus 로고    scopus 로고
    • Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1
    • Li B, Navarro S, Kasahara N, Comai L (2004) Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem 279: 13659-13667.
    • (2004) J Biol Chem , vol.279 , pp. 13659-13667
    • Li, B.1    Navarro, S.2    Kasahara, N.3    Comai, L.4
  • 66
    • 0034665971 scopus 로고    scopus 로고
    • Functional interaction between Ku and the werner syndrome protein in DNA end processing
    • Li B, Comai L (2000) Functional interaction between Ku and the werner syndrome protein in DNA end processing. J Biol Chem 275: 28349-28352.
    • (2000) J Biol Chem , vol.275 , pp. 28349-28352
    • Li, B.1    Comai, L.2
  • 67
    • 47249106520 scopus 로고    scopus 로고
    • Werner protein cooperates with the XRCC4-DNA ligase IV complex in endprocessing
    • Kusumoto R, Dawut L, Marchetti C, Wan Lee J, Vindigni A, et al. (2008) Werner protein cooperates with the XRCC4-DNA ligase IV complex in endprocessing. Biochemistry 47: 7548-7556.
    • (2008) Biochemistry , vol.47 , pp. 7548-7556
    • Kusumoto, R.1    Dawut, L.2    Marchetti, C.3    Wan Lee, J.4    Vindigni, A.5
  • 68
    • 33749553917 scopus 로고    scopus 로고
    • Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    • Shen M, Lan Q, Zhang L, Chanock S, Li G, et al. (2006) Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. Carcinogenesis 27: 2083-2089.
    • (2006) Carcinogenesis , vol.27 , pp. 2083-2089
    • Shen, M.1    Lan, Q.2    Zhang, L.3    Chanock, S.4    Li, G.5
  • 69
    • 59049095168 scopus 로고    scopus 로고
    • Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity
    • Lan Q, Zhang L, Shen M, Jo WJ, Vermeulen R, et al. (2009) Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis 30: 50-58.
    • (2009) Carcinogenesis , vol.30 , pp. 50-58
    • Lan, Q.1    Zhang, L.2    Shen, M.3    Jo, W.J.4    Vermeulen, R.5
  • 70
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175: 184-191.
    • (1988) Exp Cell Res , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 71
    • 0036043770 scopus 로고    scopus 로고
    • The comet assay. Principles, applications, and limitations
    • Collins AR (2002) The comet assay. Principles, applications, and limitations. Methods Mol Biol 203: 163-177.
    • (2002) Methods Mol Biol , vol.203 , pp. 163-177
    • Collins, A.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.