Cytochromes P450 involved with benzene metabolism in hepatic and pulmonary microsomes

Journal of Biochemical and Molecular Toxicology

Volumn 14, Issue 6, 2000, Pages 303-309

  Powley, Mark W ^a   Carlson, Gary P ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Benzene Metabolism; CYP2B; CYP2E1; CYP2F; Human; Liver; Lung; Microsomes; Mouse; Rat

Indexed keywords

ALPHA METHYLBENZYLAMINOBENZOTRIAZOLE; ALPHA-METHYLBENZYLAMINOBENZOTRIAZOLE; BENZENE; CYTOCHROME P450 2B1; CYTOCHROME P450 2E1; DIETHYLDITHIOCARBAMIC ACID; TRIAZOLE DERIVATIVE;

ADOLESCENT; AGED; ANIMAL; ARTICLE; BIOTRANSFORMATION; CAUCASIAN; DRUG EFFECT; ENZYMOLOGY; FEMALE; HUMAN; LIVER MICROSOME; LUNG; MALE; METABOLISM; MICROSOME; MIDDLE AGED; MOUSE; RAT; SPRAGUE DAWLEY RAT; UNITED STATES;

ADOLESCENT; AGED; ANIMALS; BENZENE; BIOTRANSFORMATION; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP2E1; DITIOCARB; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; LUNG; MALE; MICE; MICROSOMES; MICROSOMES, LIVER; MIDDLE AGED; RATS; RATS, SPRAGUE-DAWLEY; TRIAZOLES; UNITED STATES;

EID: 0034567095     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0461(2000)14:6<303::AID-JBT2>3.0.CO;2-8     Document Type: Article

References (12)

1. Infante PF, Rinsky RA, Wagoner JK, Young RJ. Leukeamia in benzene workers. Lancet 1977;19:407-421.
2. Askoy M. Different types of malignancies due to occupational exposure to benzene: a review of recent observations in Turkey. Environ Res 1980;23:181-190.
3. Askoy M. Problems with benzene in Turkey. Reg Toxicol Pharmacol 1981;1:147-155.
4. Askoy M. Benzene as a leukemogenic and carcinogenic agent. Am J Ind Med 1985;8:9-20.
5. National Toxicology Program. Toxicology and carcinogenesis studies of benzene in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program Technical Report Series 1986, nr 289.
6. Snyder CA, Sellakumar AR, James DJ, Albert RE. The carcinogenicity of discontinuous inhaled benzene exposure in CD-1 and C57B1/6 mice. Arch Toxicol 1988;62: 331-335.
7. Maltoni C, Ciliberti A, Cotti G, Conti B, Belpoggi F. Benzene, an experimental multipotential carcinogen: results of the long-term bioassays performed at the Bologna Institute of Oncology. Environ Health Perspec 1989;82:109-124.
8. Farris GM, Everitt JI, Irons RD, Popp JA. Carcinogenicity of inhaled benzene in CBA mice. Fundam Appl Toxicol 1993;20:503-507.
9. Jerina A, Daly J, Witkop B, Zaltzman-Nirenberg P, Udenfriend S. Role of the arene oxide-oxepin system in the metabolism of aromatic substances: in-vitro conversion of benzene oxide to a premercapturic acid and dihydrodiol. Arch Biochem Biophys 1968;128:176-193.
10. Busby WF, Wand J-S, Stevens KS, Padykula RE, Aleksejczyk RA, Berchtold GA. Lung tumorigenicity of benzene oxide, benzene dihydrodiols and benzene diolepoxides in the BLU:Ha newborn mouse assay. Carcinogenesis 1990;11:1473-1478.
11. Lindstrom AB, Yeowell-O'Connell K, Waidyanatha S, Golding BT, Tornero-Valez R, Rappaport SM. Measurement of benzene oxide in the blood of rats following administration of benzene. Carcinogenesis 1997;18:1637-1641.
12. Lovern MR, Turner MJ, Meyer M, Kedderis GL, Bechtold WE, Schlosser PM. Identification of benzene oxide as a product of benzene metabolism by mouse, rat, and human liver microsomes. Carcinogenesis 1997;18:1695-1700.