Increased gene expression in human promyeloid leukemia cells exposed to trans,trans-muconaldehyde, a hematotoxic benzene metabolite

Carcinogenesis

Volumn 18, Issue 4, 1997, Pages 739-744

  Ho, Teh Yuan ^a   Witz, Gisela ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MUCONALDEHYDE; NUCLEAR PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BLOOD TOXICITY; BONE MARROW CELL; CELL CULTURE; CELL STRAIN HL 60; CONSENSUS SEQUENCE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DNA BINDING;

ALDEHYDES; ANIMALS; BENZENE; BONE MARROW; DNA; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, FOS; GENES, JUN; HL-60 CELLS; HUMANS; MICE; NF-KAPPA B; PROTEIN BINDING; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 0031417429     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.4.739     Document Type: Article

References (33)

1. Goldstein, B. (1977) Hematotoxicity in humans. J. Toxicol. Environ. Hlth, 2 (suppl.), 69-105.
2. Huff, J.E., Haseman, J.K., DeMarini, D.M., Eustis, S., Maronpot, R.P., Peters, A.C., Persing, R.L., Chrisp, C.E. and Jacobs, A.C. (1989) Multiple-site carcinogenicity of benzene in Fisher 344 rats and B6C3F1 mice. Environ. Hlth Perspect., 82, 125-163.
3. Snyder, R. and Kalf, G.F. (1994) A perspective on benzene leukemogenesis. Crit. Rev. Toxicol., 24, 177-209.
4. Snyder, R., Witz, G. and Goldstein, B.D. (1993) The toxicology of benzene. Environ. Hlth Perspect., 100, 293-306.
5. Subrahmanyam, V., Ross, D., Eastmond, D. and Smith, M. (1991) Potential role of free radicals in benzene-induced myelotoxicity and leukemia. Free Radical Biol. Med., 11, 495-515.
6. Kolachana, P., Subrahmanyam, V., Meyer, K., Zhang, L. and Smith, M. (1993) Benzene and its phenolic metabolites produce oxidative DNA damage in HL-60 cells in vitro and in the bone marrow in vivo. Cancer Res., 53, 1023-1026.
7. Eastmond, D.A., Smith, M.T. and Irons, R.D. (1987) An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure. Toxicol. Appl. Pharmacol., 91, 85-95.
8. Weitzman, S.A. and Gordon, L.I. (1990) Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood, 76, 655-663.
9. Epe, B., Heggler, J. and Wild, D. (1990) Singlet oxygen as an ultimately reactive species in Salmonella typhimurium DNA damage induced by methylene blue-visible light. Carcinogenesis, 10, 2019-2024.
10. Remacle, J., Raes, M., Toussaint, O., Renard, P. and Rao, G. (1995) Low levels of reactive oxygen species as modulators of cell function. Mutat. Res., 316, 103-122.
11. Cerutti, P.A. and Trump, B.F. (1991) Inflammation and oxidative stress in carcinogenesis. Cancer Cells, 3, 1-7.
12. Schreck, R., Albermann, K. and Baeuerle, P.A. (1992) Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells. Free Radical Res. Commun., 17, 221-237.
13. Siebenlist, U., Franzoso, G. and Brown, K. (1994) Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol., 10, 405-455.
14. Witz, G., Rao, G.S. and Goldstein, B.D. (1985) Short term toxicity of trans, trans-muconaldehyde. Toxicol. Appl. Pharmacol., 80, 511-516.
15. Latriano, L., Goldstein, B.D. and Witz, G. (1986) Formation of muconaldehyde, an open-ring metabolite of benzene in mouse liver microsomes: a novel pathway for toxic metabolites. Proc. Natl Acad. Sci. USA, 83, 8356-8360.
16. Schatz-Kornbrust, E., Goldstein, B.D. and Witz, G. (1991) The binding of trans, trans-muconaldehyde to deoxyguanosine and calf thymus DNA. Toxicologist, 11, 253.
17. Udupi, V., Goldstein, B.D. and Witz, G. (1991) Interaction of trans,trans-muconaldehyde with bovine serum albumin. Arch. Biochem. Biophys., 310, 385-391.
18. Kline, S.A., Xiang, Q., Goldstein, B.D. and Witz, G. (1993) Reaction of (E,E)-muconaldehyde and its aldehydic metabolites, (E,E)-6-oxo-hexadienoic acid and (E,E)-6-hydroxy-hexa-2,4-dienal, with glutathione. Chem. Res. Toxicol., 6, 578-583.
19. Witz, G., Zhang, Z. and Goldstein, B.D. (1996) Reactive ring-opened aldehyde metabolites in benzene hematotoxicity. Environ. Hlth Perspect., 104, 1195-1199.
20. Feinberg, A.P. and Vogelstein, B.A. (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 132, 6-13.
21. Andrews, N.C. and Faller, D.V. (1991) A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acid Res., 19, 2499.
22. Bradford, M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
23. Chomczynski, P. and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
24. Sambrook, J., Fritsch, E.F. and Maniatas, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
25. Abate, C., Patel, L., Rauscher, F.J. and Curran, T. (1990) Redox regulation of fos and jun DNA binding activity in vitro. Science, 249, 1157-1161.
26. Xanthoudakis, S., Miao, G., Wang, F., Pan, Y. and Curran, T. (1992) Redox activation of fos-jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J., 11, 3323-3335.
27. Schreck, R., Rieber, P. and Baeuerle, P.A. (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV I. EMBO J., 10, 2247-2258.
28. Goldstein, B.D. (1989) Occam's razor is dull. Environ. Hlth Perspect., 82, 3-6.
29. Bergelson, S., Pinkus, R. and Daniel, V. (1994) Intracellular glutathione levels regulate fos/jun induction and activation of glutathione S-transferase gene expression. Cancer Res., 54, 36-40.
30. Mihm, S., Galter, D. and Droge, W. (1995) Modulation of transcription factor NF-κB activity by intracellular glutathione levels and by variations of the extracellular cysteine supply. FASEB J., 9, 247-252.
31. Kaul, N. and Forman, H.J. (1996) Activation of NF-κB by the respiratory burst of macrophages. Free Radical Biol. Med., 21, 401-405.
32. Witz, G., Lawrie, N.J., Amoruso, M.A. and Goldstein, B.D. (1987) Inhibition by reactive aldehydes of superoxide anion radical production from stimulated polymorphonuclear leukocytes and pulmonary alveolar macrophages: effects on cellular sulfhydryl groups and NADPH oxidase activity. Biochem. Pharmacol., 36, 721-726.
33. Angel, P. and Karin, M. (1991) The role of jun, fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta, 1072, 129-157.