Early effects of low benzene exposure on blood cell counts in Bulgarian petrochemical workers

Medicina del Lavoro

Volumn 100, Issue 2, 2009, Pages 83-90

  Pesatori, Angela Cecilia ^a,b   Garte, S ^c   Popov, T ^d   Georgieva, Tzveta ^d   Panev, T ^d   Bonzini, M ^b,e   Consonni, D ^b   Carugno, M ^a   Goldstein, B D ^b   Taioli, Emanuela ^c   Fontana, V ^f   Stagi, Elena ^f   Bertazzi, P A ^a,b   Merlo, D E ^f  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^e UNIVERSITY OF PARMA MEDICAL SCHOOL   (Italy)

^f UNIVERSITY OF GENOA   (Italy)

Author keywords

Benzene; Genetic polymorphisms; Hematological effects; Petrochemicals

Indexed keywords

BENZENE; PETROLEUM;

ADULT; ARTICLE; BLOOD CELL COUNT; BULGARIA; CHEMICAL INDUSTRY; FEMALE; HUMAN; MALE; OCCUPATIONAL EXPOSURE; TIME;

ADULT; BENZENE; BLOOD CELL COUNT; BULGARIA; CHEMICAL INDUSTRY; FEMALE; HUMANS; MALE; OCCUPATIONAL EXPOSURE; PETROLEUM; TIME FACTORS;

EID: 63149105969     PISSN: 00257818     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. BROWN RD: Environmental use of diffusive samples: evaluation of reliable diffusive uptake rates for benzene, toluene and xylene. J Environ Monit 1999; 1:115-116
2. BURATTI M, FUSTINONI S, COLOMBI A: Fast liquid chromatographic determination of urinary trans,trans-muconic acid. J Chromatogr B Analyt Technol Biomed Life Sci 1996; 677:257-263
3. COLONS JJ, BELINDA K, EASTERDAY PA, et al: Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection. Journal Occup Environ Med 1997; 39:232-237
4. COLLINS JJ, CONNER PC, FRIEDLANDER BR, et al: A study of the hematological effects of chronic low-level exposure to benzene. Journal Occup Med 1991; 33: 619-626.
5. GARTE S, GASPARI L, ALEXANDRIE AK, et al: Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev 2001; 10: 1239-1248
6. GARTE S, POPOV T, GEORGIEVA T, et al: Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene. Chemico-Biological Interactions 2005; 153-4:247-251
7. GOLDSTEIN BD: Benzene toxicity. Occup Med 1988; 3:541-554
8. HORNUNG RW, REED LD: Estimation of average concentration in the presence of non-detectable values. Appl Occup Environ Hyg 1990; 5:48-51
9. IRONS RD, MOORE BJ: Effect of short term benzene administration on circulating lymphocyte subpopulations in the rabbit: evidence of a selective b-lymphocyte sensitivity. Res Commun Chem pathol Pharmacol 1980;27:147-155
10. LAMM SH, GRUNWALD HW: Benzene exposure and hematotoxicity. Science 2006; 312: 998-999
11. LAN Q, VERMEULEN R, ZHANG L, et al: Benzene exposure and hematotoxicity. Science 2006; 312: 998-999.
12. LAN Q, ZHANG L, LI G, et al: Hematotoxicity in workers exposed to low levels of benzene. Science 2004; 306:1774-1776
13. NORDLINDER R: Exposure to benzene at different work places. In Imbriani M, Ghittori S, Pezzagno G, Capodaglio E (eds): Update on benzene. Advances in occupational medicine and rehabilitation. Vol. 1. Pavia: Fondazione Salvátore Maugeri Edizioni PI-ME Press, 1995:1-8
14. QU Q, SHORE R, LI G, et al. Hematological changes among Chinese workers with a broad range of benzene exposures. Am J Ind Med 2002; 42:275-285.
15. ROSS D: Functions and distributions of NQO1 in human bone marrow: potential clues to benzene toxicity. Chemico-Biological Interactions 2005; 153-4:137-146
16. ROTHMAN N, SMITH MT, HAYES RB, et al: Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C→T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res 1997; 57:2839-2842
17. SNYDER R, HEDLI CC: An overview of benzene metabolism. Environ Health Perspect 1996; 104: s1165-s1171
18. STATACORP: Stata Statistical Software: Release 9. College Station, TX: StataCorp LP, 2005
19. TSAI SP, FOX EE, RANDSELL JD, et al: A hematology surveillance study of petrochemical workers exposed to benzene. Regul Toxicol Pharmacol 2004; 40: 67-73
20. TSAI SP, WEN CP, WEISS NS, et al: Retrospective mortality and medical surveillance studies of workers in benzene areas of refineries. Journal Occup Med 1983; 25: 685-692
21. WALLACE L: Environmental Exposure to benzene: An update. Environ Health Perspect 1996; 104: 1129-1136
22. WAN J, SHI J, HUI L, et al: Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 gene with benzene poisoning. Environ Health Perspect 2002; 110: 1213-1218