Benzene and human health: A historical review and appraisal of associations with various diseases

Critical Reviews in Toxicology

Volumn 40, Issue SUPPL. 2, 2010, Pages 1-46

  Galbraith, David ^a   Gross, Sherilyn A ^a   Paustenbach, Dennis ^a  

^a CARDNO CHEMRISK   (United States)

Author keywords

Acute myelogenous leukemia; benzene; epidemiology; myelodysplastic syndrome; toxicology

Indexed keywords

BENZENE;

ACUTE GRANULOCYTIC LEUKEMIA; ANEMIA; APLASTIC ANEMIA; AUTOPSY; BLOOD TOXICITY; CONFUSION; DIZZINESS; DYSPNEA; ERYTHROCYTE COUNT; FATALITY; HAZARD; HEADACHE; HUMAN; LASSITUDE; LEUKOPENIA; LONG TERM EXPOSURE; LYMPHOCYTOPENIA; LYMPHOMA; MORBIDITY; MUCOSA; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NEUTROPHIL COUNT; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; OCCUPATIONAL HEALTH; PANCYTOPENIA; REVIEW; SYMPOSIUM; THROMBOCYTOPENIA; WORKPLACE; FEMALE; HISTORY; MALE; NONHODGKIN LYMPHOMA; OCCUPATIONAL DISEASE; STANDARD;

ANIMALIA;

BENZENE; FEMALE; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; LEUKEMIA, MYELOID, ACUTE; LYMPHOMA, NON-HODGKIN; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROMES; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; WORKPLACE;

EID: 77957953377     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2010.508162     Document Type: Review

References (338)

1. ACGIH (American Conference of Governmental Industrial Hygienists). (1976). TLVs-Treshold Limit Values for Chemical Substances in Workroom Air Adopted by ACGIH for 1976. Cincinnati, OH: ACGIH, 10-11; 36-37.
2. ACGIH (American Conference of Governmental Industrial Hygienists). 2001 Documentation of TLV for Benzene. Cincinnati, OH: ACGIH.
3. Aksoy M. (1978). Benzene and leukemia. Lancet 1:441.
4. Aksoy M. (1980a.). Malignancies due to occupational exposure to benzene. Haematologica 65:370-373.
5. Aksoy M. (1980b). Diferent types of malignancies due to occupational exposure to benzene: A review of recent observations in Turkey. Environ Res 23:181-190.
6. Aksoy M. (1985). Malignancies due to occupational exposure to benzene. Am J Ind Med 7:395-402.
7. Aksoy M, Dincol K, Erdem S, Dincol, G. (1972). Acute leukemia due to chronic exposure to benzene. Am J Med 52:160-166.
8. Aksoy M, Erdem S, Dincol G. (1974). Leukemia in shoe-workers exposed chronically to benzene. Blood 44:837-841.
9. Aksoy M, Erdem S. (1978). Follow-up study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic exposure to benzene. Blood 52:285-292.
10. Aksoy M, Erdem S, Dincol G, Kutlar A, Bakioglu I, Hepyuksel T. (1984). Clinical observations showing the role of some factors in the etiology of multiple myeloma. A study in 7 patients. Acta Haematol 71:116-20.
11. Alexander DD, Mink PJ, Adami HO, Change ET, Cole P, Mandel JS, Trichopoulos D. (2007). Te non-Hodgkin lymphomas: A review of the epidemiologic literature. Int J Cancer 120:1-39. (Pubitemid 46732571)
12. American Cancer Society (ACS). (2008a). Cancer Reference Information: Detailed Guide to Acute Myeloid Leukemia. Available at: http://docu-ments. cancer.org/6892.00/6892.00.pdf [Accessed June 1, 2010]
13. American Cancer Society (ACS). (2008b). Cancer Reference Information: Detailed Guide to Chronic Lymphocytic Leukemia. Available at: http://documents.cancer.org/6893.00/6893.00.pdf
14. American Cancer Society (ACS). (2008c). Cancer Reference Information: Detailed Guide to Non-Hodgkin Lymphoma. Available at: http://docu-ments.cancer. org/178.00/178.00.pdf
15. American Cancer Society (ACS). (2009). Cancer Reference Information: Detailed Guide to Multiple Myeloma. Available at: http://documents.cancer.org/ 175.00/175.00.pdf
16. Ames BN, Gold LS. (2000). Paracelsus to parascience: Te environmental cancer distraction. Mutat Res 447:3-13.
17. Andersen ME, MacNaughton MG, Clewell HJ, Paustenbach DJ. (1987). Adjusting exposure limits for long and short exposure periods using a physiological pharmacokinetic model. Am Ind Hyg Assoc J 48:335-343.
18. API (American Petroleum Institute). (1948). API Toxicological Review on Benzene. New York: API Department of Safety.
19. API (American Petroleum Institute). (1960). API Toxicological Review on Benzene. 2nd ed. New York: API.
20. ATSDR (Agency for Toxic Substances and Disease Registry). (2000). Case Studies in Environmental Medicine (CSEM): Benzene Toxicity\-Who is at Risk. Revised June 30, 2000. Available at: http://www.ATSDR.cdc.gov/csem/ benzene/whosat-risk.html
21. ATSDR (Agency for Toxic Substances and Disease Registry) (2007) Toxicological Profle for Benzene. Atlanta, GA: Department of Health and Human Services. Available at: http://www.atsdr.cdc.gov/toxprofles/tp3.html.
22. Aul C, Bowen DT, Yoshida Y. (1998). Recent advances in myelodysplastic syndromes. Haematology 83:71-86.
23. Austin H, Cole P, McCraw DS. (1986). A case-control study of leukemia at an oil refnery. J Occup Med 28:1169-1173.
24. Austin H, Delzell E, Cole P. (1988). Benzene and leukemia: A review of the literature and a risk assessment. Am J Epidemiol 127:419-439.
25. Bao L, Gross SA, Ryder J, Wang X, Ji M, Chen Y, Yang Y, Zhu S, Irons RD. (2009). Adult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases. Int J Hematol 89:431-437.
26. Bennett JM. (2005). A comparative review of classifcation systems in myelod-ysplastic syndromes (MDS). Semin Oncol 32:S3-10.
27. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C. (1976). Proposals for the classifcation of the acute leukaemias. Br J Haematol 33:4561-458.
28. Bennett JM, Catovsky D, Daniel MT. (1982). Proposal for the classifcation of myelodysplastic syndromes. Br J Haematol 51:189-100.
29. Bennett JM, Komrokji RS. (2005). Te myelodysplastic syndromes: Diagnosis, molecular biology and risk assessment. Hematolog 10:258-269.
30. Bergsagel DE, Wong O, Bergsagel P, Alexanian R, Anderson K, Kyle RA, Raabe GK. (1999). Benzene and multiple myeloma: Appraisal of the sci-entifc evidence. Blood 94:1174-1182.
31. Bergsagel L, Kuehl WM. (2005). Molecular pathogenesis and a consequent clas-sifcation of multiple myeloma. J Clin Oncol 23:6333-6338.
32. Bernard SM, Cartwright RA, Bird CC, Richards ID, Lauder I, Roberts BE. (1984). Aetiologic factors in lymphoid malignancies: A case-control epidemio-logical study. Leuk Res 8:681-689.
33. Bezabeh S, Engel A, Morris CB, Lamm SH. (1996). Does benzene cause multiple myeloma? An analysis of the published case-control literature. Environ Health Perspect Suppl 104:1393-1398.
34. Binner R, Sommerfeld G, Krumrey V. (2007). Reports on food safety, 2005. Bundesamt für Verbraucherschutz und Lebensmittelsicherheit (Federal Ofce of Consumer Protection and Food Safety), Berlin, Germany. Available at: http://www.bvl.bund.de
35. Bird MG, Greim H, Kaden DA, Rice JM, Snyder R. (2010). Benzene 2009: Health efects and mechanisms of bone marrow toxicity: Implications for t-AML and the mode of action framework. Chem Biol Interact 184:3-6.
36. Bjork J, Johansson B, Broberg K, Albin M. (2009). Smoking as a risk factor for myelodysplastic syndromes and acute myeloid leukemia and its relation to cytogenetic fndings: A case-control study. Leukemia Res 33:788-791.
37. Blair A, Linos A, Stewart PA, Burmeister LF, Gibson R, Everett G, Shuman L, Cantor KP. (1993). Evaluation of risks for non-Hodgkin's lymphoma by occupation and industry exposures from a case-control study. Am J Ind Med 23:301-312.
38. Block M, Jacobson LO, Bethard WR. (1953). Preleukemic acute human leukemia JAMA 152:1018-1028.
39. Bloemen LJ, Youk A, Bradley TD, Bodner KM, Marsh G. (2004). Lymphohaematopoietic cancer risk among chemical workers exposed to benzene. Occup Environ Med 61:270-274.
40. Bloomfeld CD. (1951). Studies of health hazards in industry: Chemical hazards: Benzol vapor. Ind Health Month 11:62-64.
41. Bofetta P, de Vocht F. (2007). Occupation and the risk of non-Hodgkin lym-phoma. Cancer Epidemiol Biomarkers Prev 16:369-372.
42. Bois FY, Paxman DG. (1992). An analysis of exposure rate efects for benzene using a physiologically based pharmacokinetic model. Reg Tox Pharm 15(2 Pt 1):122-136.
43. Bollati V, Baccarelli A, Hou L, Bonzini M, Fustinoni S, Cavallo D, Byun HM, Jiang J, Marinelli B, Pesatori AC, Bertazzi PA, Yang AS. (2007). Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res 67:876-880.
44. Bond GG, McLaren EA, Baldwin CL, Cook RR. (1986). An update of mortality among chemical workers exposed to benzene. Br J Ind Med 43:685-691.
45. Bosetti C, Levi F, Ferlay J, Lucchini F, Negri E, La Vecchia C. (2008). Incidence and mortality from non-Hodgkin lymphoma in Europe: Te end of an epidemic? Int J Cancer 123:1917-1923.
46. Brandt L. (1992). Exposure to organic solvents and risk of hematologic malignancies. Leuk Res 16:67-70.
47. Brief RS, Lynch J, Bernath T, Scala RA. (1980). Benzene in the workplace. Am Ind Hyg Assoc J 41:616-623.
48. Brown EA, Shelley ML, Fisher JW. (1998). A pharmacokinetic study of occupational and environmental benzene exposure with regard to gender. Risk Anal 18:205-213.
49. Browning E. (1937). Report 80: Toxicity of Industrial Organic Solvents: Summaries of Published Work. London: Committee on the Toxicity of Industrial Solvents, Medical Research Council, Industrial Health Research Board.
50. Brucken V. (1923). Uber chronischer Benzolvergiftung. Deutsche med Wchnschr 49:1120-1121.
51. Bufer PA, Kwan ML. (2005). Environmental and genetic risk factors for childhood leukemia: Appraising the evidence. Cancer Invest 1:60-75.
52. Calabrese EJ, Stanek EJ, Nascarella MA, Hofmann GR. (2008). Hormesis predicts low-dose responses better than threshold models. Int J Toxicol 27:369-378.
53. Capleton AC, Levy LS. (2005). An overview of occupational benzene exposures and occupational exposure limits in Europe and North America. Chem-Bio Interact 153-154:43-53.
54. Catenacci DVT, Schiller GJ. (2005). Myelodysplastic syndromes: A comprehensive review. Blood Rev 19:301-319.
55. Checkoway H, Wilcosky T, Wolf P, Tyroler H. (1984). An evaluation of the associations of leukemia and rubber industry solvent exposures. Am J Ind Med 5:239-249.
56. Clare MG, Yardley-Jones A, Maclean AC, Dean BJ. (1984). Chromosome analysis from peripheral blood lymphocytes of workers after an acute exposure to benzene. Br J Ind Med 41:249-253.
57. Clinton, M. (1994). Video deposition of Marshall Clinton, M.D., taken in the matter of: Bessie Mae Duhon et al. v. Mobil Oil Corp.; Catherine Ann Spruill et al. v. Mobil Oil Corp., and Anita Selman et al. v. Mobil Oil Corp. Civil Action Nos. 1:93CV489, 1:93CV542, and 1:93CV469. United States District Court for the Eastern District of Texas, Beaumont Division. April 19, 1994.
58. Cody RP, Strawderman WW, Kipen HM. (1993). Hematologic efects of benzene: Job-specifc trends during the frst year of employment among a cohort of benzene-exposed rubber workers. J Occup Med 35:776-782.
59. Collins JJ, Conner P, Friedlander BR, Easterday PA, Nair RS, Braun J. (1991). A study of the hematologic efects of chronic low-level exposure to benzene. J Occup Med 33:619-626.
60. Collins JJ, Ireland B, Buckley CF, Shepperly D. (2003). Lymphohaematopoeitic cancer mortality among workers with benzene exposure. Occup Environ Med 60:676-679.
61. Constantini AS, Benvenuti A, Vineis P, Kriebel D, Tumino R, Ramazzotti V, Rodella S, Stagnaro E, Crosignani P, Amadori D, Mirabelli D, Sommani L, Belletti I, Troschel L, Romeo L, Mceli G, Tozzi GA, Mendico I, Maltoni SA, Miliqi L. (2008). Risk of leukemia and multiple myeloma associated with exposure to benzene and other organic solvents: Evidence from the Italian multicenter case-control study. Am J Ind Med 51: 803-811.
62. Costantini S, Quinn M, Consonni D, Zappa M. (2003). Exposure to benzene and risk of leukemia among shoe factory workers. Scand J Work Environ Health 29:51-59.
63. Cronkite EP. (1961). Evidence for radiation and chemicals as leukemogenic agents. Arch Environ Health 3:297-303.
64. Cronkite EP, Bullis JE, Inoue T, Drew RT. (1984). Benzene inhalation produces leukemia in mice. Toxicol Appl Pharmacol 75:358-361.
65. Cronkite EP, Drew RT, Inoue T, Bullis JE. (1985). Benzene hematotoxicity and leukemogenesis. Am J Ind Med 7:447-456.
66. Crosignani P, Tittarelli A, Borgini A, Codazzi T, Rovelli A, Porro E, Contiero P, Bianchi N, Tagliabue G, Fissi R, Rossitto F, Berrino F. (2004). Childhood leukemia and road trafc: A population-based case-control study. Intl J Cancer 108:596-599.
67. Crump K, Allen B. (1984). Quantitative estimates of risk of leukemia from occupational exposure to benzene. OSHA.docket H-059b, Exhibit 152 (appendix B). Washington, DC: OSHA.
68. Cuneo A, Fagioli F, Pazzi I, Tallarico A, Previati R, Piva N, Carli MG, Balboni M, Castoldi G. (1992). Morphologic, immunologic, and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solvents. Leuk Res 16:789-796.
69. De Gowin RL. (1963). Benzene exposure and aplastic anemia and leukemia 15 years later. JAMA 185:748-751.
70. DeCoufe P, Blattner WA, Blair A. (1983). Mortality among chemical workers exposed to benzene and other agents. Environ Res 30: 16-25.
71. DeLore P, Borgomano C. (1928). Leukaemia aigue au cours de l'intoxication benzenique, sur l'origine toxique de certains leukemies aigues et leur relations avec les anemies graves. J Med Lyons 9:227-233.
72. Descatha A, Jenabian A, Conso F, Ameille J. (2005). Occupational exposures and haematological malignancies: Overview on human recent data. Cancer Causes Control 16:939-953.
73. Divine BJ, Barron V. (1986). Texaco mortality study: II. Patterns of mortality among white males by specifc job groups. Am J Ind Med 10: 371-81.
74. Dodsworth H, Dean A, Broom G. (1981). Efects of smoking and the pill on the blood count. Br J Haematol 49:484-488.
75. Dores GM, Anderson WF, Curtis RE, Landgren O, Ostroumova E, Bluhm EC, Rabkin CS, Devesa SS, Linet MS. (2007). Chronic lymphocytic leukaemia and small lymphocytic lymphoma: Overview of the descriptive epidemiology. Br J Haematol 2007;139:809-819.
76. Dougherty D, Garte S, Barchowsky A, Zmuda J, Taioli E. (2008). NQO1, MPO, Cyp2E1, GSTT1 and GSTM1 polymorphisms and biological efects of benzene exposure\-A literature review. Toxicol Lett 182:7-17.
77. Dreiher J, Kordysh E. (2006). Non-Hodgkin lymphoma and pesticide exposure: 25 years of research. Acta Haematol 116:153-164.
78. Dreyfus B. (1976). Preleukemic states. Blood Cells 2:33-35.
79. Duarte-Davidson R, Courage C, Rushton L, Levy L. (2001). Benzene in the environment: An assessment of the potential risks to the health of the population. Occup Environ Med 58:2-13.
80. ECB (European Chemicals Bureau). (2007). Benzene: Summary Risk Assessment Report: Final Approved Version. Prepared in the context of Council Regulation (EEC) No. 793/93 on the evaluation and control of the risks of existing substances. Available at: http://ecb.jrc.ec.europa. eu/documents/Existing- Chemicals/RISK-ASSESSMENT/SUMMARY/ benzenesum063.pdf
81. Edwards SW, Preston RJ. (2008). Systems biology and mode of action based risk assessment. Toxicol Sci 106:312-318.
82. EFSA (European Food Safety Authority) (2005) EFSA/WHO International Conference with Support of ILSI Europe on Risk Assessment of Compounds That Are Both Genotoxic and Carcinogenic. Brussels, Belgium. Available at http://www.efsa.europa.eu/cs/BlobServer/Scientifc-Document/ EFSA-Gentox.pdf? ssbinary=true.
83. Enterline PE. (1979). Lymphomas and benzene. Lancet 11:1021.
84. EPA. (1998). Carcinogenic Efects of Benzene: An Update. Washington, DC: US Environmental Protection Agency.
85. Erf LA, Rhoads CP. (1939). Te hematological efects of benzene (benzol) poisoning. J Ind Hyg Toxicol 21:421-435.
86. Evans LS, Hancock BW. (2003). Non-Hodgkin lymphoma. Lancet 362:139-146.
87. Fabbro-Peray P, Daures JP, Rossi JF. (2001). Environmental risk factors for non-Hodgkin's lymphoma: A population-based case-control study in Languedoc-Roussillon, France. Cancer Causes Control 12: 201-212.
88. Fagioli F, Cuneo A, Piva N, Carli MG, Previati R, Balboni M, Tomasi P, Cariani D, Scapoli G, Castoldi G. (1992). Distinct cytogenetic and cliniopathological features in acute myeloid leukemia after occupational exposure to pesticides and organic solvents. Cancer 70:77-85.
89. Farris GM, Everitt JI, Irons RD, Popp JA. (1993). Carcinogenicity of inhaled benzene in CBA mice. Fundam Appl Toxicol 20:503-507.
90. Farris GM, Robinson SN, Wong BA, Wong VA, Hahn WP, Shah R. (1997). Efects of benzene on splenic, thymic, and femoral lymphocytes in mice. Toxicology 118:137-148.
91. Finkelstein MM. (2000). Leukemia after exposure to benzene: Temporal trends and implications for standards. Am J Ind Med 38:1-7.
92. Fisch IR, Freedman SH. (1975). Smoking, oral contraceptives, and obesity: Efects on white blood cell count. JAMA 234:500-506.
93. Fishbeck WA, Townsend JC, Swank MG. (1978). Efects of chronic occupational exposure to measured concentrations of benzene. J Occup Med 20:539-542.
94. Flury F. (1928). II. Toxicities in modern industry. IIa. Pharmacological-toxicological aspects of intoxicants in modern industry. Arch Exp Pathol Pharmakol 138:65-82. (German)
95. Franceschi S, Serraino D, Bidoli E, Talamini R, Tirelli U, Carbone A, La Vecchia C. (1989). Te epidemiology of non-Hodgkin's lymphoma in the northeast of Italy: A hospital-based case-control study. Leuk Res 13:465-472. (Pubitemid 19206829)
96. French JE, Saulnier M. (2000). Benzene leukemogenesis: An Environmental Carcinogen-induced tissue-specifc model of neoplasia using genetically altered mice. J Tox Environ Health 61:377-379.
97. Fritschi L, Benke G, Hughes AM, Kricker A, Vajdic CM, Grulich A, Turner J, Milliken S, Kaldor J, Armstrong BK. (2005). Risk of non-Hodgkin lym-phoma associated with occupational exposure to solvents, metals, organic dusts and PCBs (Australia). Cancer Causes Control 16:599-607.
98. Fu H, Demers PA, Costantini AS, Winter P, Colin D, Kogevinas M, Bofetta P. (1996). Cancer mortality among shoe manufacturing workers: An analysis of two cohorts. Occup Environ Med 53:394-398.
99. Gafafer WM. (1943). Manual of Industrial Hygiene. United States Public Health Service, National Institutes of Health. Phildadelphia, PA: WB Saunders.
100. Gafney SH, Panko JM, Unice KM, Burns AM, Kreider ML, Gelatt RH, Booher LE, Paustenbach DJ. (2009). Occupational exposure to benzene at the ExxonMobil Refnery in Baytown, TX (1978-2006). J Expos Sci Environ Epidemiol Advance online publication October 28, 2009; doi:10.1038/ jes.2009.53.
101. Garrand R, Gardias J, Bizet M, Bremond JL, Accard F, Callat MP, de Bouchony ET, Goasguen JE. (1992). Heterogeneity of acquired idiopathic sideroblastic anaemia (Aisa). Leuk Res 16:463-468.
102. Gerarde HW. (1963). Te aromatic hydrocarbons. In: Patty FA, ed. Industrial Hygiene and Toxicology. Vol. 2. New York: John Wiley and Sons, 555.
103. Girard R, Revol L. (1970). La frequence d'une exposition benzenique au cours des hemopathies graves. Nouv Rev Fr Hematol 10:477-484.
104. Glass DC, Gray CN, Jolley DJ, Gibbons C, Sim MR, Fritschi L. (2003). Leukemia risk associated with low-level benzene exposure. Epidemiology 14:569-577.
105. Glass DC, Sim MR, Fritschi L, Gray CN, Jolley DJ, Gibbons C. (2004). Leukemia risk and relevant benzene exposure period\-Re: Follow-up time on risk estimates. Am J Ind Med 45:222-3.
106. Glass DC, Gray CN, Jolley DJ, Gibbons C, Sim MR. (2006). Te Health Watch case-control study of leukemia and benzene: Te story so far. Ann NY Acad Sci 1076:80-89.
107. Goguel A, Cavigneaux A, Bernard J. (1967). Les leucemies benzeniques. Bull Inst Natl Santé Rech Med 22:421-442.
108. Gold LS, De Roos AJ, Brown EE, Lan Q, Milliken K, Davis S, Chancock SJ, Zhang Y, Severson R, Zahm SH, Zheng T, Rothman N, Baris D. (2009). Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma. Cancer Epidemiol 33:276-80.
109. Goldstein BD. (1977). Benzene Toxicity: A critical evaluation. Report for the American Petroleum Institute. Washington, DC: Hemisphere Publishing. Goldstein BD. (1988). Benzene toxicity. Occup Med 3:541-554.
110. Goldstein BD. (1990). Is exposure to benzene a cause of human multiple myeloma? Ann NY Acad Sci 609:225-230.
111. Goldstein BD. (2004). Benzene exposure and leukemia. Epidemiology 15:509-510.
112. Goldstein BD, Cody R. (2000). Assessment of complete blood count variations among workers exposed to low levels of benzene. J Occup Environ Med 42:113-114.
113. Goldwater LJ, Tewksbury MP. (1941). Recovery following exposure to benzene (benzol). J Ind Hyg 23:217-231.
114. Graham JD, Green LC, Roberts MJ. (1991). In Search of Safety: Chemicals and Cancer Risk. Cambridge, MA: Harvard University Press. Greenburg G. (1926). Benzol poisoning as an industrial hazard. Public Health Rep 41:1516-1549.
115. Greenburg L, Mayers MR, Goldwater L, Smith AR. (1939). Benzene (benzol) poisoning in the rotogravure printing industry in New York City. J Ind Hyg Toxicol 21:395-420.
116. Greer N, Mosser G, Logan G, Halaas GW. (2000). A practical approach to evidence grading. J Qual Improve 26:700-712.
117. Greer JP, Rodgers GM, Foerster J, Lukens JN, Paraskevas F, Rodgers GM. (2004). Wintrobe's Clinical Hematology. 11th ed. Philadelphia: Lippincott Williams & Wilkins.
118. Gross SA, Irons RD, Schnatter AR, Ryder J, Wang XQ, Copley GB, Armstrong TW. (2010). A hospital-based case control study of aplastic anemia in Shanghai, China. Chem Biol Interact 184:165-173.
119. Guenel P, Imbernon E, Chevalier A, Crinquand-Calastreng A, Goldberg M. (2002). Leukemia in relation to occupational exposures to benzene and other agents: A case-control study nested in a cohort of gas and electric utility workers. Am J Ind Med 42:87-97.
120. Gun RT, Pilotto L, Ryan P, Roder D, Pratt N, Grifth E, McDermott B. (2000). Health Watch Eleventh Report 2000. Adelaide, Australia: Department of Public Health, Adelaide University.
121. Gun RT, Ryan P, Roder D, Pratt N, Grifth E, McDermott B. (2005). Health Watch Twelfth Report 2005. Adelaide, Austraila: Department of Public Health, Adelaide University.
122. Guzelian PS, Victorof MS, Halmes NC, James RC, Guzelian CP. (2005). Evidence-based toxicology: A comprehensive framework for causation. Hum Exp Toxicol 24:161-201.
123. Hamilton A. (1922). Te growing menace of benzene (benzol) poisoning in American industry. JAMA 78:627-630.
124. Hamilton A. (1929). Industrial Poisons in the United States. New York: MacMillan.
125. Hamilton A. (1931). Benzene (benzol) poisoning. Arch Pathol 11:434-601.
126. Hamilton A. (1934). Industrial Toxicology. 3rd ed. New York: Harper and Bros.
127. Hamilton A. (1945). Industrial Toxicology. New York: Oxford University Press.
128. Hamilton A, Hardy HL. (1974). Industrial Toxicology. 3rd ed. Acton, MA: Publishing Sciences Group.
129. Hardell L, Eriksson M, Lenner P, Lundgren E. (1981). Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: A case-control study. Br J Cancer 43:169-176.
130. Hardell L, Eriksson M, Degerman A. (1994). Exposure to phenoxyacetic acids, chlorophenols, or organic solvents in relation to histopathology, stage and anatomical localization of non-Hodgkin's lymphoma. Cancer Res 54:2386-2389.
131. Harrington TF. (1917). Industrial benzol poisoning in Massachusetts. Boston Med Surg J 177:203-206.
132. Harrison RM, Leung PL, Somerville L, Smith R, Gilman E. (1999). Analysis of incidence of childhood cancer in the West Midlands of the United Kingdom in relation to proximity to main roads and petrol stations. Occup Environ Med 56:774-780.
133. Hartwig A. (2010). Te role of DNA repair in benzene-induced carcinogenesis. Chem Biol Interact 184:269-272.
134. Hayes RB, Yin SN, Dosemeci M, Li GL, Wacholder S, Travis LB, Li CY, Rothman N, Hoover RN, Linet MS. (1997). Benzene and the dose-related incidence of hematologic neoplasms in China. J Nat Canc Inst 89:1065-1071.
135. Hayes RB, Yin S, Rothman N, Dosemeci M, Li G, Travis LT, Smith MT, Linet MS. (2000). Benzene and lymphohematopoietic malignancies in China. J Tox Environ Health 61:419-432.
136. Health Canada. (2009). Chrysotile Asbestos Consensus Statement and Summary: Chrysotile Asbestos Expert Panel. Summary of views presented at Health Canada. conference in Montreal, Quebec, November 13-14, 2007.
137. Hefter A. (1915). Ueber die acute Vergiftung durch Benzoldampf. Deutsch med Wchnschr 41:182-185.
138. Hemeon WCL. (1955). Plant and Process Ventilation. New York: Industrial Press.
139. Hemeon WCL. (1963). Plant and Process Ventilation. 2nd ed. New York: Industrial Press.
140. Henderson RF. (1996). Species diferences in the metabolism of benzene. Environ Health Perspect 104:1473-1475.
141. Hollins, DM, Paustenbach, DJ, Clark, K, Mangold CA. (2009). A visual historical review of exposure to asbestos at Puget Sound Naval Shipyard (1962-1972). J Toxicol Environ Health B 12:124-156.
142. Hooker AM, Bhat M, Day TK, Lane JM, Swinburne SJ, Morely AA, Sykes PJ. (2004). Te linear no-threshold model does not hold for low-dose ionizing radiation. Radiat Res 162:447-452.
143. IARC. (1982). Some industrial chemical and dyestufs: Benzene. IARC.Monogr Eval Carcinog Risk Chem to Hum 29:93-148.
144. Infante PF. (2001). Benzene: An historical perspective on the American and European occupational setting. In: Harremoes P, Gee D, MacGarvin M, Stirling A, Keys J, Wynne B, Vaz SG, eds. Late Lessons from Early Warnings: Te Precautionary Principle 1896-2000: Environmental Issue Report No. 22. Copenhagen, Denmark: European Environmental Agency, 38-47.
145. Infante PF. (2006). Benzene exposure and multiple myeloma: A detailed meta-analysis of benzene cohort studies. Ann NY Acad Sci 1076:90-109.
146. Infante PF, Rinsky RA, Wagoner JK, Young RJ. (1977). Leukaemia in benzene workers. Lancet 8028:76-78.
147. International Fuel Quality Center. (2008). International Gasoline Rankings\-Top 100 Benzene. Houston, TX: Hart Energy Publishing. Available at: http://www.ifqc.org/MiscellaneousContent.aspx?ContentId=20 Irons RD. (1983). Benzene: Metabolism and mechanisms. Paper presented at the International Conference on Benzene. Sponsored by Collegium Ramazzini, New York, November 3 and 4, 1983.
148. Irons RD. (2000). Molecular models of benzene leukemogenesis. J Tox Environ Health 61:391-397.
149. Irons RD, Lv L, Gross SA, Ye X, Bao L, Wang XQ, Ryder J, Armstrong TW, Zhou Y, Miao L, Le AT, Kerzic PJ, Ni W, Fu H. (2005). Chronic exposure to benzene results in a unique form of dysplasia. Leuk Res 29:1371-1380.
150. Irons RD, Gross SA, Le A, Wang XQ, Chen Y, Ryder J, Schnatter AR. (2010). Integrating WHO 2001-2008 criteria for the diagnosis of myelodysplastic syndrome (MDS): A case-case analysis of benzene exposure. Chem Biol Interact 184:30-38.
151. Jafe ES, Harris NL, Stein H, Vardiman JW. (2001). Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classifcation of Tumours. Lyon, France: IARC Press.
152. Johnson GT, Harbison SC, McCluskey JD, Harbison RD. (2009). Characterization of cancer risk from airborne benzene exposure. Regul Toxicol Pharmacol 55:361-366.
153. Jones SE, Fuks Z, Bull M, Kadin ME, Dorfman RF, Kaplan HS, Rosenberg SA, Kim H. (1973). Non-Hodgkin's lymphomas IV. Clinicopathologic correlation in 405 cases. Cancer 31:806-823.
154. Joshua DE. (2005). Multiple myeloma: Te present and the future. Med J Aust 183:344.
155. Kalf GF. (2000). Utility of a mouse model for studying the efects of benzene on the myeloid lineage: efects of hydroquinone on a model system. J Tox Environ Health 61:399-411.
156. Kato I, Koenig KL, Watanabe H. (2005). Personal and occupational exposure to organic solvents and risk of non-Hodgkin's lymphoma (NHL) in women (United States). Cancer Causes Control 16:1215-1224.
157. Kawasaki Y, Hirabayashi Y, Kaneko T, Kodama Y, Matsushima Y, Ogawa Y, Saitoh M, Sekita K, Uchida O, Umemura T, Yoon BI, Inoue T. (2009). Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-defcient C57BL/6 and C3H/He mice. Toxicol Sci 110:293-306.
158. Khuder SA, Youngdale MC, Bisesi MS, Schaub EA. (1999). Assessment of complete blood count variations among workers exposed to low levels of benzene. J Occup Environ Med 41:821-826.
159. Kim S, Vermeulen R, Waidyanatha S, Johnson BA, Lan Q, Smith MT, Zhang L, Li G, Shen M, Yin S, Rothman N, Rappaport SM. (2006). Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev 15:2246-2252.
160. Kipen HM, Cody RP, Goldstein BD. (1989). Use of longitudinal analysis of peripheral blood counts to validate historical reconstructions of benzene exposure. Environ Health Perspect 82:199-206.
161. Kirkeleit J, Riise T, Bratveit M, Moen BE. (2008). Increased risk of acute myelogenous leukemia and multiple myeloma in a historical cohort of upstream petroleum workers exposed to crude oil. Cancer Causes Control 19:13-23.
162. Knox EG, Gilman EA. (1997). Hazard proximities of childhood cancers in Great Britain from 1953-80. J Epidemiol Community Health 51: 151-159.
163. Knutsen J, Kuykendall J, Paustenbach DJ. (2008). Comparing equal delivered doses of airborne benzene for 8 hr/day steady exposure vs. peak exposure regimens using a PB-PK model. Presented at the American Industrial Hygiene Conference and Expo (AIHce), May 31-June 5, 2008, Minneapolis, MN. Abstract #14. Related manuscript currently in journal review.
164. Koranyi S. (1912). A leukaemia kezelese benzollal. [Treatment of leukemia with benzene.] Budapest, Hungary: Orvosi Hetilap.
165. Kyle RA, Rajkumar SV. (2004). Multiple myeloma. New Engl J Med 351:1860-1873.
166. Lamm SH, Engel A, Byrd DM. (2005). Non-Hodgkin lymphoma and benzene exposure: A systematic literature review. Chem Biol Interact 153:231-237.
167. Lamm SH, Walters AS, Wilson R, Byrd DM, Grunwald H. (1989). Consistencies and inconsistencies underlying the quantitative assessment of leukemia risk from benzene exposure. Environ Health Perspect 82:289-297.
168. Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Dosemeci M, Rappaport SM, Shen M, Alter BP, Wu Y, Kopp W, Waidyantha S, Rabkin C, Cuo W, Chancok S, Hayes RB, Linet M, Kim S, Yin S, Rothman N, Smith MT. (2004). Hematotoxicity in workers exposed to low levels of benzene. Science 306:1174-1176.
169. Landgren O, Kyle RA, Pfeifer RM, Katzmann JA, Caporaso NE, Hayes RB, Dispenzieri A, Kumar S, Clark RJ, Baris D, Hoover R and Rajkumar V (2009). Monoclonal gammopathy of undetermined signifcance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood 113(22):5412-5417.
170. Langholz B, Ebi KL, Tomas DC, Peters JM, London SJ. (2002). Trafc density and the risk of childhood leukemia in a Los Angeles case-control study. Ann Epidemiol 12:482-487.
171. Larson RA. (2000). Myeloid leukemia after cytotoxic therapy and other hema-totoxins. J Tox Environ Health 61:381-386.
172. Laskin DL, Heck DE, Punjabi CJ, Laskin JD. (2000). Nitric Oxide as a mediator of benzene induced hematosuppression and toxicity. J Tox Environ Health 61:413-417.
173. Legge TM. (1920). Chronic benzol poisoning. J Ind Hyg 1:539-541.
174. Lehmann KB. (1919). Kurzes Lehrbuch der Arbeits-und Gewerbehygiene. Leipzig: S. Hirzel.
175. Lenoir A, Claude J. (1897). On a case of purpura attributed to benzene intoxication. Bull Mem Soc Med Hop Paris 3:1251-1261.
176. Leukemia and Lymphoma Society. (2009a). Disease Information: Chronic Lymphocytic Leukemia. Available at: http://www.leukemia-lymphoma. org/all-page?item-id=7059
177. Leukemia and Lymphoma Society. (2009b). Risk factors for leukemia. Available at: http://www.leukemia-lymphoma.org/all-page?item-id=7026#risk
178. Leukemia and Lymphoma Society. (2009c). Facts 2008-2009. Available at: http://www.leukemia-lymphoma.org/attachments/National/br-1215783647. pdf
179. Lewis RJ, Schnatter AR, Drummond I, Murray N, Tompson FS, Katz AM, Jorgensen G, Nicolich MJ, Dahlman D, Teriault G. (2003). Mortality and cancer morbidity in a cohort of Canadian petroleum workers. Occup Environ Med 60:918-928.
180. Linet MS, Stewart WF, Van Natta ML, McCafrey LD, Szklo M. (1987). Comparison of methods for determining occupational exposure in a case-control interview study of chronic lymphocytic leukemia. J Occup Med 29:136-141.
181. Linet MS, Yin S-N, Travis LB, Li CY, Zhang ZN, Li DG, Rothman N, Li GL, Chow WH, Donaldson J, Dosemeci M, Wacholder S, Blot WJ, Hayes RB. (1996). Clinical features of hematopoietic malignancies and related disorders among benzene-exposed workers in China. Environ Health Perspect 104(Suppl 6):1353-1364.
182. List AF, Sandberg AA, Doll DC. (2004). Myelodysplastic syndromes. In: Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskeyas F, Glader B, eds. Wintrobe's Clinical Hematology. 11th ed. Philadelphia: Lippincott Williams & Wilkins, 2207-2234.
183. Loomis DP, Savitz DA. (1991). Occupation and leukemia mortality among men in 16 states: 1985-1987. Am J Ind Med 19:509-521.
184. Lukes RJ, Collins RD. (1974). Immunologic characterization of human malignant lymphomas. Cancer 34:1488-1503.
185. Lukes RJ, Collins RD. (1975). New approaches to the classifcation of the lym-phomata. Br J Cancer 31(Supp 11):1-28.
186. Lynge E, Andersen A, Nilsson R, Bofetta P, Grandjean P, Heikkila P, Horte LG, Jakobsson R, Lundberg I, Moen B, Partanen T, Riise T. (1997). Risk of cancer and exposure to gasoline vapors. Am J Epidemiol 145:449-458.
187. MacDonald TA, Yeowell K, Rappaport SM. (1994). Comparison of protein
188. Madl AK, Paustenbach DJ. (2002). Airborne concentrations of benzene due to diesel locomotive exhaust in a roundhouse. J Toxicol Environ Health A 65:1945-1964.
189. Mallory TB, Gall EA, Brickley WJ. (1939). Chronic exposure to benzene (benzol). III. Te pathologic results. J Ind Hyg Toxicol 21:355-377.
190. Malone KE, Koepsell TD, Daling JR, Weiss NS, Morris PD, Taylor JW, Swanson GM, Lyon JL. (1989). Chronic lymphocytic leukemia in relation to chemical exposures. Am J Epidemiol 130:1152-1158.
191. Mao Y, Hu J, Ugnat AM, White K. (2000). Non-Hodgkin's lymphoma and occupational exposure to chemicals in Canada. Ann Oncol 11:S69-S73.
192. McCord CP. (1931). Benzene. In: Industrial Hygiene for Engineers and Managers. New York: Harper and Brothers, 62.
193. McCormick DL, Kavet R. (2004). Animal models for the study of childhood leukemia: Considerations for model identifcation and optimization to identify potential risk factors. Int J Toxicol 23:149-61.
194. McCraw DS, Joyner RE, Cole P. (1985). Excess leukemia in a refnery population. J Occup Med 27:220-222.
195. Mc Farland W and Dameshek W. (1958). Biopsy of bone marrow with the vim-silverman needle. JAMA 106 (12):1464-1466.
196. McHale CM, Zhang L, Lan Q, Li G, Hubbard AE, Forrest MS, Vermeulen R, Chen J, Shen M, Rappaport SM, Yin S, Smith MT, Rothman N. (2009). Changes in the peripheral blood transcriptome associated with occupational benzene exposure identifed by cross-comparison on two microarray platforms. Genomics 93:343-349.
197. McMichael AJ, Spirtas R, Kupper LL. (1974). An epidemiologic study of mortality within a cohort of rubber workers, 1964-72. J Occup Med 16:458-464.
198. McMichael AJ, Spirtas R, Kupper LL, Gamble JF. (1975). Solvent exposure and leukemia among rubber workers: An epidemiologic study. J Occup Med 17:234-239.
199. McMichael AJ, Spirtas R, Gamble JF, Tousey PM. (1976). Mortality among rubber workers\-Relationship to specifc jobs. J Occup Med 18:178-185.
200. Meda G. (1922). Il benzolismo professionale. Lavoro 13:264-270.
201. Medinsky MA, Kenyon EM, Schlosser PM. (1995). Benzene: A case study in parent chemical and metabolite interactions. Toxicology 105:225-233.
202. Meek ME, Klaunig JE. (2010). Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment. Chem Biol Interact 184:279-285.
203. Mehlman MA. (2006). Causal relationship between chronic myelogenous leukemia and benzene-containing solvents. Ann NY Acad Sci 1076: 110-119.
204. Midzenski MA, McDiarmid MA, Rothman N, Kolodner K. (1992). Acute high dose exposure to benzene in shipyard workers. Am J Ind Med 22:553-565.
205. Miligi L, Costantini AS, Benvenuti A, Kriebel D, Bolejack V, Tumino R, Ramazzotti V, Rodella S, Stagnaro E, Crosignani P, Amadori D, Mirabelli D, Sommani L, Belletti I, Troshel L, Romeo L Miceli G, Tozzi GA, Mendico I, Vineis P. (2006). Occupational exposure to solvents and the risk of lym-phomas. Epidemiology 17:552-561.
206. Mondrala S, Eastmond DA. (2010). Topoisomerase II inhibition by the bioacti-vated benzene metabolite hydroquinone involves multiple mechanisms. Chem Biol Interact 184:259-268.
207. Najean Y. (1981). Long-term follow-up in patients with aplastic anemia: A study of 137 androgen-treated patients surviving more than two years. Am J Med 1:543-551.
208. Natelson EA. (2007a). Benzene exposure and refractory sideroblastic erythro-poiesis: Is there an association? Am J Med Sci 334:356-360.
209. Natelson EA. (2007b). Benzene-induced acute myeloid leukemia: A clinician's perspective. Am J Hematol 82:826-830.
210. National Research Council. (1981). Indoor Pollutants. Washington, DC: National Academy Press.
211. NCI (National Cancer Institute). (2005). Surveillance Epidemiology and End Results (SEER) database statistics for leukemia. Available at: http://seer. cancer.gov/
212. NCI (National Cancer Institute). (2008). What You Need to Know about Multiple Myeloma. NIH Publication No. 08-1575. Bethesda, MD: US Department of Health and Human Services, National Institutes of Health. Available at: http://www.cancer.gov/cancertopics/wyntk/myeloma.pdf.
213. NCI (National Cancer Institute). (2007). What You Need to Know about Non-Hodgkin Lymphoma. NIH Publication No. 07-1567. Bethesda, MD: US Department of Health and Human Services, National Institutes of Health. Available at: http://www.cancer.gov/cancertopics/wyntk/non-hodgkin-lymphoma.pdf
214. NIH (National Institutes of Health). (2009a). Information on National Centers for Systems Biology. Available at: http://www.nigms.nih.gov/Initiatives/ SysBio/
215. NIH (National Institutes of Health). (2009b). Medline Plus Medical Encyclopedia: Chronic Lymphocytic Leukemia. Available at: http://www. nlm.NIH.gov/MEDLINEPLUS/ency/article/000532.htm
216. NIOSH (National Institute for Occupational Safety and Health.%Ee. (1979). Revised Recommendation for an Occupational Exposure standard for Benzene. Cincinnati, OH: US Department of Health, Education and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health.
217. Nordlinder R, Jarvholm B. (1997). Environmental exposure to gasoline and leukemia in children and young adults\-An ecology study. Int Arch Occup Environ Health 70:57-60.
218. NTP (National Toxicology Program). (2005). Report on Carcinogens, Eleventh Edition. Research Triangle Park: US Department of Health and Human Services, Public Health Service.
219. Nwosu VC, Kissling GE, Trempus CS, Honeycutt H, French JE. (2004). Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways. Toxicol Appl Pharmacol 196:37-46.
220. Occupational Safety and Health Administration. (1987). Occupational Exposure to Benzene. Final Rule. Federal Register 52:34460-34578. Washington, DC: US Department of Labor.
221. Ott MG, Teta MJ, Greenberg HL. (1989). Lymphatic and hematopoietic tissue cancer in a chemical manufacturing environment. Am J Ind Med 16:631-643.
222. Ott MG, Townsend JC, Fishbeck WA, Langner RA. (1978). Mortality among workers occupationally exposed to benzene. Arch Environ Health 33: 3-10.
223. Panko JM, Gafney SH, Burns AM, Unice KM, Kreider ML, Booher LE, Gelatt RH, Marshall JR, Paustenbach DJ. (2009). Occupational exposure to benzene at the ExxonMobil refnery at Baton Rouge, Louisiana (1977-2005). J Occup Environ Hyg 6:517-529.
224. Parapia LA. (2007). Trepanning or trephines: a history of bone marrow biopsy. Brit J Haematol 139: 14-19.
225. Paustenbach DJ, Price PS, Ollison W, Blank C, Jernigan JD, Bass D, Peterson HD. (1992). Reevaluation of benzene exposure for the plioflm (rubberworker) cohort (1936-1976). J Toxicol Environ Health 36:177-231.
226. Paustenbach DJ. (1995). Acute and chronic exposure to benzene: Efects in humans. In: Imbriani M, Ghittori S, Pezzagno G, Capodaglio E, eds. Advances in Occupational Medicine and Rehabilitation: Update on Benzene. Vol. 1. Pavia, Italy: PI-ME Press, 69-91.
227. Paxman D, Rappaport SM. (1990). Analysis of OSHA's short-term-exposure limit for benzene. Reg Tox Pharm 11:275-87.
228. Paxton MB, Chinchilli VM, Brett SM, Rodricks JV. (1994). Leukemia risk associated with benzene exposure in the Plioflm cohort. II. Risk estimates. Risk Anal 14:155-161.
229. Pearson R, Wachtel H, Ebi K. (2000). Distance-weighted trafc density in proximity to a home is a risk factor for leukemia and other childhood cancers. J Air Waste Manag Assoc. 2000;50:175-180.
230. Pederson-Bjergaard J, Phillip P, Mortensen BT, Ersboll J, Jensen G, Panduro J, Tomsen M. (1981). Acute nonlymphocytic leukemia, preleuke-mia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. Clinical and cytogenetic characteristics and results of in vitro culture of bone marrow and HLA typing. Blood 57: 712-723.
231. Petitti DB, Kipp H. (1986). Te leukocyte count: Associations with intensity of smoking and persistence of efect after quitting. Am J Epidemiol 123:89-95.
232. Picciano D (1979). Cytogenetic study of workers exposed to benzene. Environ Res 19:33-38.
233. Pogoda JM, Preston-Martin S, Nichols PW, Ross RK. (2002). Smoking and risk of acute myeloid leukemia: Results from a Los Angeles County case-control study. Am J Epidemiol 155:546-553.
234. Price B, Ware A. (2004). Mesothelioma trends in the United States: An update based on surveillance, epidemiology, and end results program data for 1973 through 2003. Am J Epidemiology 159:107-112.
235. Pyatt D. (2004). Benzene and hematopoietic malignancies. Clin Occup Environ Med 4:529-555.
236. Pyatt D, Hays S. (2010). A review of the potential association between childhood leukemia and benzene. Chem Bioll Interact 184:151-164.
237. Qu Q, Cohen BS, Shore R, Chen LC, Li G, Jin X, Meliian AA, Yin S, Yan H, Xu B, Li Y, Mu R, Zhang X, Li K. (2003). Benzene exposure measurement in shoe and glue manufacturing: A study to validate biomarkers. Appl Occup Environ Hyg. 18:988-98.
238. Qu Q, Shore R, Li G, Jin X, Chen LC, Cohen B, Melikian AA, Eastmond D, Parraport SM, Yin S, Li H, Waidyantha S, Li Y, Mu R, Zhang X, Li K. (2002). Hematological changes among Chinese workers with a broad range of benzene exposures. Am J Ind Med 42:275-285.
239. Queensland Health. (2007). Investigation of Chronic Lymphoid Leukemia Gladstone\-Calliope, 1996-2004: Full technical report, August 2007.
240. Queensland, Australia: Queensland Government. Available at: http://www.health.qld.gov.au/ph/documents/caphs/fnalgladstone.pdf
241. Raabe GK, Wong O. (1996). Leukemia mortality by cell type in petroleum workers with potential exposure to benzene. Environ Health Perspect 104:1381-1392.
242. Raaschou-Nielsen O, Hertel O, Tomsen BL, Olsen JH. (2001). Air pollution from trafc at the residence of children with cancer. Am J Epidemiol 153:433-443.
243. Rajkumar SV, Kyle R. (2005). Multiple myeloma: Diagnosis and treatment. Mayo Clin Proc 80:1371-1382.
244. Rappaport H. (1966). Tumors of the hematopoietic system. In: Atlas of Tumor Pathology, Section 111, Fasicle 8. Washington, DC: Armed Forces Institute of Pathology, 97-161.
245. Rappaport SM, Kim S, Lan Q, Li G, Vermeulen R, Waidyanatha S, Zhang L, Yin S, Smith MT, Rothman N. (2010). Human benzene metabolism following occupational and environmental exposures. Chem Biol Interact 184:189-195.
246. Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Hertz A, Smith D. (2002). Trafc patterns and childhood cancer incidence rates in California, United States. Cancer Causes Control 13:665-673.
247. Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Hertz A. (2004). Residential exposure to trafc in California and childhood cancer. Epidemiology 15:6-12.
248. Richardson DB. (2008). Temporal variation in the association between benzene and leukemia mortality. Environ Health Perspect 116:370-374.
249. Rigolin GM, Cuneo A, Roberti MG, Bardi A, Bigoni R, Piva N, Minotto C, Agostini P, De Angeli C, Del Senno L, Spanedda R, Castoldi G. (1998). Exposure to myelotoxic agents and myelodysplasia: Case-control study and correlation with clinicobiological fndings. Br J Haematol 103:189-197.
250. Rinsky RA, Young RJ, Smith AB. (1981). Leukemia in benzene workers. Am J Ind Med 2:217-245.
251. Rinsky RA, Smith AB, Hornung R, Filloon TG, Young RJ, Okun AH, Landrigan PJ. (1987). Benzene and leukemia: An epidemiologic risk assessment. New Engl J Med 316:1044-1050.
252. Rinsky RA, Hornung RW, Silver SR, Tseng CY. (2002). Benzene exposure and hematopoiet ic mortality: A long-term epidemiologic risk assessment. Am J Ind Med 42:474-480.
253. Ross D. (2000). Te role of metabolism and specifc metabolites in benzene-induced toxicity: Evidence and issues. J Toxicol Environ Health A 61:357-372.
254. Rothman N, Smith MT, Hayes RB, Li GL, Irons RD, Dosemeci M, Haas R, Stillman WS, Linet M, Xi LQ, Bechtold WE, Wiemeis J, Campleman S, Zhang L, Quintana PJ, Titenko-Holland N, Wang YZ, Lu W, Kolachana P, Meyer KB, Yin S. (1996). An epidemiologic study of early biologic efects of benzene in Chinese workers. Environ Health Perspect 104(Supp 6):1365-1370.
255. Ruchirawat M, Navasumrit P, Settachan D. (2010). Exposure to benzene in various susceptible populations: Co-exposures to 1,3-butadience and PAHs and implications for carcinogenic risk. Chem Biol Interact 184:67-76.
256. Ruiz MA, Augusto LGS, Vassallo J. (1994). Bone marrow morphology in patients with neutropenia due to chronic exposure to organic solvent (benzene): Early lessons. Path Res Pract 190:151-154.
257. Runion HE. (1988). Occupational exposures to potentially hazardous agents in the petroleum industry. Occup Med State Art Rev 3:431-444.
258. Runion HE, Scott LM. (1985). Benzene exposure in the United States 1978-1983: An overview. Am J Ind Med 7:385-393.
259. Rushton L. (1993). A 39 year follow-up of the UK oil refnery and distribution center studies: Results for kidney cancer and leukemia. Environ Health Perspect Suppl 101:77-84.
260. Rushton L, Romaniuk H. (1997). A case-control study to investigate the risk of leukaemia associated with exposure to benzene in petroleum marketing and distribution workers in the United Kingdom. Occup Environ Med 54:152-166.
261. Sandler DP, Shore DL, Anderson JR, Davey FR, Arthur D, Mayer RJ, Silver RT, Weiss RB, Moore JO, Schifer CA, Doris H, Wurster-Hill O, McIntyre R, Bloomfeld CD. (1993). Cigarette smoking and risk of acute leukemia: Associations with morphology and cytogenetic abnormalities in bone marrow. J Natl Cancer Inst 85:1994-2003.
262. Santesson CG. (1897). Uber chronische Vergiftungen mit Steinkohlentheerbenzin. Arch Fur Hyg. 31:336-376.
263. Sathiakumar N, Delzell E, Cole P, Brill I, Frisch J, Spivey G. (1995). A case-control study of leukemia among petroleum workers. J Occup Environ Med 37:1269-1277.
264. Sathiakumar N, Graf J, Maldonado G, Matthews R, Delzell E, Macaluso M. (2005). An updated study of mortality among North American synthetic rubber industry workers. Occup Environ Med 62:822-829.
265. Satin KP, Bailey WJ, Newton KL, Ross AY, Wong O. (2002). Updated epidemio-logical study of workers at two California petroleum refneries, 1950-95. Occup Environ Med 59:248-256.
266. Savilahti M. (1956). More than 100 cases of benzol poisoning in a shoe factory: Observation on hematologic symptoms and the development of the disease during one year. Arch Gewerbepathol Gewerbehyg 15:147-157.
267. Savitz DA, Andrews KW. (1997). Review of epidemiologic evidence on benzene and lymphatic and hematopoietic cancers. Am J Ind Med 31:287-295.
268. Savitz DA, Feingold L. (1989). Association of childhood cancer with residential trafc density. Scand J Work Environ Health 15:360-363.
269. Scherr PA, Hutchison GB, Neiman RS. (1992). Non-Hodgkin's lymphoma and occupational exposure. Cancer Res 52:5503s-5509s.
270. Schnatter AR. (2004). Benzene exposure and leukemia. Epidemiology 15:509.
271. Schnatter AR, Armstrong TW, Tompson LS, Nicolich MJ, Katz AM, Huebner WW, Pearlman ED. (1996). Te relationship between low-level benzene exposure and leukemia in Canadian petroleum distribution workers. Environ Health Perspect 104(Supp 6):1375-1379.
272. Schnatter AR, Nicholich MJ, Bird MG. (1996). Determination of leukemogenic benzene exposure concentrations: Refned analyses of the plioflm cohort. Risk Anal 16:833-840.
273. Schnatter AR, Rosamilia K, Wojcik NC. (2005). Review of the literature on benzene exposure and leukemia subtypes. Chem Biol Interact 153:9-21.
274. Scott BR. (2008). Low-dose radiation risk extrapolation fallacy associated with the linear-no-threshold model. Human Exp Toxicol 27:163-168.
275. Selling L. (1910). A preliminary report of some cases of purpura hemorrhagica due to benzol poisoning. Bull Johns Hopkins Hosp 21:33-37.
276. Sicherman B, Hamilton A. (1984). Alice Hamilton: A Life in Letters. Cambridge, MA: Harvard University Press.
277. Siddique M, Sabapathy K. (2006). Trp53-dependent DNA-repair is afected by the codon 72 polymorphism. Oncogene 25:3489-3500.
278. Skarin AT, Dorfman DM. (1997). Non-Hodgkin's lymphomas: Current classifca-tion and management. CA Cancer J Clin 47:351-372.
279. Smedby KE, Vajdic CM, Falster M, Engels EA, Martinez-Maza O, Turner J, Hjalgrim H, Vineis P, Constantini AS, Holly E, Bracci P, Roman E, Spinelli J, Maso LD, Zheng T, Becker N, De Sanjose S, Chiu BC-H, Cocco P, Maynadie M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan J, Breen EC, Birmann B, Grulich AE, Cozen W. (2008). Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: A pooled analysis within the InterLymph Consortium. Blood 111:4029-4038.
280. Smith MT, Skibola CF, Allan JM, Morgan GJ. (2004). Causal models of leukaemia and lymphoma. In: Bufer P, Rice J, Baan R, Bird M, Bofetta P, eds. Mechanisms of Carcinogenesis: Contributions of Molecular Epidemiology. IARC Scientifc Publications No. 157. Lyon: International Agency for Research on Cancer, 373-392.
281. Smith MT, Jones RM, Smith AH. (2007). Benzene exposure and risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 16:385-391.
282. Snyder R. (2002). Benzene and leukemia. Crit Rev Toxicol 32:155-210.
283. Song Y, Du X, Hoa, F, Gu X, Zhang Z, Zang S, Li C, Li H, Ma J. (2010). Immunosuppressive therapy of Cyclospporing A for severe benzene-induced haematopoietic disorders and a 6-month follow up. Chem-Bio Interact 186:96-102
284. Sorahan T, Kinlen LJ, Doll R. (2005). Cancer risks in a historical UK cohort of benzene exposed workers. Occup Environ Med 62:231-236.
285. Stellman JM, Daum SM. (1973). Work is Dangerous to Your Health. New York: Random House.
286. Stokstad E. (2004). Factory study shows low levels of benzene reduce blood cell counts. Science 306:1665.
287. Strom SS, Gu Y, Gruschkus SK, Pierce SA, Estey EH. (2005). Risk factors of myel-odysplastic syndromes: A case-control study. Leukemia 19:1912-1918.
288. Sunyer J, Munoz A, Peng Y, Margolick J, Chmiel JS, Oishi J, Kingsley L, Samet JM. (1996). Longitudinal relation between smoking and white blood cells. Am J Epidemiol 144:734-741.
289. Sury-Bienz P. (1888). Gerichtlich-Medicinisches aus chemichen Fabriken. Vrtljschr f gerichtl Med 49:138-142. (As referenced in Hamilton, 1929).
290. Swaen GM, Scheffers T, de Cock J, Slangen J, Drooge H. (2005). Leukemia risk in caprolactam workers exposed to benzene. Ann Epidemiol 15:21-28.
291. Swerdlow SH, Campo E, Harris NL, Jafe ES, Pileri SA, Stein H, Tiele J, Vardiman JW. (2008). WHO classifcation of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Geneva, Switzerland: WHO Press.
292. Tomas WA. (1982). Supreme Court review of the OSHA benzene standard. Am Stat 36:264-266.
293. Torpe JJ. (1974). Epidemiologic survey of leukemia in persons potentially exposed to benzene. J Occup Med 16:375-382.
294. Tice RR, Luke CA, Drew RT. (1989). Efect of exposure route, regimen, and duration on benzene-induced genotoxic and cytotoxic bone marrow damage in mice. Environ Health Perspect 82:65-74.
295. Tort K, Olofsson T, Tunek A, Berlin M. (1982). Toxic efects on mouse bone marrow caused by inhalation of benzene. Arch Toxicol 51:295-302.
296. Travis CC, Arms AD. (1987). Te food chain as a source of toxics exposure. In: Lave LB and Upton AC, eds. Toxic Chemicals, Health, and the Environment. New York: Plenum Press, 95-113.
297. Travis LB, Li, C-Y, Zhang Z-N, Li DG, Yin SN, Chow WH, Li GL, Dosemeci M, Blot W, Fraumeni JF, Hayes RB, Linet MS. (1994). Hematopoietic malignancies and related disorders among benzene-exposed workers in China. Leuk Lymphoma 14:91-102.
298. Tsai SP, Wen CP, Weiss NS, Wong O, McClellan WA, Gibson RL. (1983). Retrospective mortality and medical surveillance studies of workers in benzene areas of refneries. J Occup Med 25:685-692.
299. Tsai SP, Fox EE, Ransdell JD, Wendt JK, Waddell LC, Donnelly RP. (2004). A hematology surveillance study of petrochemical workers exposed to benzene. Regul Toxicol Pharmacol 40:67-73.
300. Tsai SP, Ahmed FS, Wendt JK, Foster DE, Donnelly RP, Stawmyer TR. (2007). A 56 year mortality follow-up of Texas petroleum refnery and chemical employees, 1948-2003. J Occup Environ Med 49:557-567.
301. US FDA (United States Food and Drug Administration). (2007). Data on benzene in soft drinks and other beverages. Silver Springs, MD: Center for Food Safety and Applied Nutrition. Available at: http://www.cfsan.fda. gov/~dms/benzdata.html
302. US FDA (United States Food and Drug Administration). (2009). Guidance for Industry: Evidence-based Review System for the Scientifc Evaluation of Health Claims. College Park, MD: Center for Food Safety and Applied Nutrition, Food and Drug Administration. Available at: http://www.cfsan. fda.gov/~dms/hclmgui6.html
303. Vardiman JW. (2010). Te World Health Organization (WHO) classifcation of tumors of the hematopoietic and lymphoid tissues: An overview with emphasis on the myeloid neoplasms. Chem Biol Interact 184:16-20.
304. Vianna NJ, Polan A. (1979). Lymphomas and occupational benzene exposure. Lancet 6:1394-1395.
305. Vigliani EC, Forni A. (1976). Benzene and leukemia. Environ Res 11:122-127.
306. Vigliani EC, Saita G. (1964). Benzene and leukemia. New Engl J Med 271:872-876.
307. Von Oettingen WF. (1940). Benzene. In: Public Health Bulletin No. 225: Toxicity and Potential Dangers of Aliphatic and Aromatic Hydrocarbons\-A Critical Review of the Literature. Washington, DC: US Public Health Service, 66-97.
308. Vose JM, Chiu BC-H, Cheson BD, Dancey J, Wright J. (2002). Update on epidemiology and therapeutics for non-Hodgkin's lymphoma. Hematology 2002:241-262.
309. Waddell WJ. (2006). Critique of dose response in carcinogenesis. Human Exp Toxicol 25:413-436.
310. Wallace LA. (1996a). Te exposure of the general population to benzene. Cell Biol Toxicol 5:297-314.
311. Wallace LA. (1996b). Environmental exposure to benzene: An update. Environ Health Perspect 104(Supp 6):1129-1136.
312. Wang L, Zhou Y, Liang Y, Wong O, Armstrong T, Schnatter AR, Wu Q, Fang J, Ye X, Fu H, Irons RD. (2006). Benzene exposure in the shoemaking industry in China, a literature survey, 1978-2004. Regul Toxicol Pharmacol 46:149-156.
313. Ward E, Hornung R, Morris J, Rinsky R, Wild D, Halperin W, Guthrie W. (1996). Risk of low red or white blood cell count related to estimated benzene exposure in a rubberworker cohort (1940-1975). Am J Ind Med 29:247-257.
314. Weisburger EK. (2001). History and background of the threshold limit value committee of the American Conference of Governmental Industrial Hygienists. Chem Health Safety 8:10-12.
315. Weiss BM, Abadie J, Verma P, Howard RS, and Kuehl WM (2009). A monoclonal gammopathy precedes multiple myeloma in most patients. Blood 113(22):5418-5422.
316. WHO World Health Organization) (1993) Environmental Health Criteria 150: Benzene. Geneva, Switzerland: International Programme on Chemical Safety.
317. Whysner J, Reddy MV, Ross PM, Mohan M, Lax EA. (2004). Genotoxicity of benzene and its metabolites. Mutat Res 566:99-130.
318. Wijngaarden E, Stewart PA. (2003). Critical literature review of determinants and levels of occupational benzene exposure for US community-based case-control studies. Appl Occup Environ Hyg 18:678-693.
319. Wilcosky TC, Checkoway H, Marshall EG, Tyroler HA. (1984). Cancer mortality and solvent exposures in the rubber industry. Am Ind Hyg Assoc J 45:809-811.
320. Williams PR, Paustenbach DJ. (2003). Reconstruction of benzene exposure for the Plioflm cohort (1936-1976) using Monte Carlo techniques. J Toxicol Environ Health A 66:677-781.
321. Williams PR, Paustenbach DJ. (2005). Characterizing historical industrial hygiene data: A case study involving benzene exposures at a chemical manufacturing facility (1976-1987). J Occup Environ Hyg 2:341-350.
322. Williams PR, Knutsen JS, Atkinson C, Madl AK, Paustenbach DJ. (2007). Airborne concentrations of benzene associated with the historical use of some formulations of Liquid Wrench. J Occup Environ Hyg 4:547-561.
323. Williams PR, Panko JM, Unice K, Brown JL, Paustenbach DJ. (2008). Occupational exposures associated with petroleum-derived products containing trace levels of benzene. J Occup Environ Hyg 5:565-574.
324. Wilson R, Crouch EA. (1987). Risk assessments and comparisons: An introduction. Science 236:267-270.
325. Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA. (2004). Environmental and chemical carcinogenesis. Semin Cancer Biol 14:473-486.
326. Wong O. (1987). An industry wide mortality study of chemical workers occu-pationally exposed to benzene: II\-Dose response analyses. Br J Ind Med 44:382-395. (Pubitemid 17079355)
327. Wong O. (1999). A critique of the exposure assessment in the epidemiologic study of benzene-exposed workers in China conducted by the Chinese Academy of Preventive Medicine and the US National Cancer Institute. Regul Toxicol Pharmacol 30:259-267.
328. Wong O, Raabe GK. (1995). Cell-type specifc leukemia analyses in a combined cohort of more than 208,000 petroleum workers in the United States and the United Kingdom, 1937-1989. Regul Toxicol Pharmacol 21:307-321.
329. Wong O, Raabe GK. (2000). Non-Hodgkin's lymphoma and exposure to benzene in a multinational cohort of more than 308,000 petroleum workers, 1937 to 1996. J Occup Environ Med 42:554-568.
330. Wong O, Harris F, Rosamilia K, Raabe GK. (2001). Updated mortality study of workers at a petroleum refnery in Torrance, California, 1959 to 1997. J Occup Environ Med 43:1089-1102.
331. Wong O, Harris F, Armstrong TW, Hua F. (2010a). A hospital-based case-control study of acute myeloid leukemia in Shanghai: Analysis of environmental and occupational risk factors by WHO subtypes. Chem Biol Interact 184:112-128.
332. Wong O, Harris F, Armstrong TW, Hua F. (2010b). A hospital-based case-control study of non-Hodgkin lymphoid neoplasms in Shanghai: Analysis of environmental and occupational risk factors by WHO subtypes. Chem Biol Interact 184:129-146.
333. Yager JW, Eastmond DA, Robertson ML, Paradisin WM, Smith MT. (1990). Characterization of micronuclei induced in human lymphocytes by benzene metabolites. Cancer Res 50:393-399.
334. Yin SN, Hayes RB, Linet MS, Li GL, Dosemeci M, Travis LB, Li CY, Zhang ZN, Li DG, Chow WH, Wacholder S, Wang YZ, Jiang ZL, Dai TR, Zhang WY, Chao XJ, Ye PZ, Kou QR, Zhang XC, Lin XF, Meng JF, Ding CY, Zho JS, Blot WJ. (1996). A cohort study among benzene-exposed workers in China: Overall results. Am J Ind Med 29:227-233.
335. Yin SN, Li Q, Liu Y, Tian F, Du C, Jin C. (1987). Occupational exposure to benzene in China. Br J Ind Med 44:192-195.
336. Zarbl H, Gallo MA, Glick J, Yeung KY, Vouros P. (2010). Te vanishing zero revisited: Tresholds in the age of genomics. Chem Biol Interact 184:273-278.
337. Zeeb H, Blettner M. (1998). Adult leukaemia: What is the role of currently known risk factors? Radiat Environ Biophys 36:217-28.
338. Zhang L, McHale CM, Rothman N, Li G, Ji Z, Vermeulen R, Hubbard AE, Ren X, Shen M, Rappaport SM, North M, Skibola CF, Yin S, Vulpe C, Chanock SJ, Smith MT, Lan Q. (2010). Systems biology of human benzene exposure: Toxicogenomic studies. Chem-Bio Interact 184: 86-93.