Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 649, Issue 1-2, 2008, Pages 54-61

  Galván, Noé ^a   Lim, Sophia ^a   Zmugg, Stephan ^a   Smith, Martyn T ^a   Zhang, Luoping ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

H2AX; DNA repair; Leukemia; Lymphoma; p53; RNA interference; siRNA; Strand breaks

Indexed keywords

DOUBLE STRANDED DNA; HISTONE H2AX; HYDROQUINONE; SMALL INTERFERING RNA; WERNER SYNDROME PROTEIN;

APOPTOSIS; ARTICLE; BLOOD TOXICITY; CANCER RISK; CELL CULTURE; CELL PROLIFERATION; CELL PROTECTION; COMET ASSAY; CYTOTOXICITY; DNA DAMAGE; DRUG EXPOSURE; GENE MUTATION; GENE SILENCING; GENETIC SUSCEPTIBILITY; HELA CELL; HUMAN; HUMAN CELL; NECROSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; RNA INTERFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; WERNER SYNDROME;

APOPTOSIS; BENZENE; BLOTTING, WESTERN; CELL PROLIFERATION; COMET ASSAY; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; EXODEOXYRIBONUCLEASES; FLOW CYTOMETRY; HELA CELLS; HISTONES; HUMANS; HYDROQUINONES; RECQ HELICASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 36849041045     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.07.011     Document Type: Article

References (28)

1. Comai L., and Li B. The Werner syndrome protein at the crossroads of DNA repair and apoptosis. Mech. Ageing Dev. 125 (2004) 521-528
2. Epstein C.J., Martin G.M., Schultz A.L., and Motulsky A.G. Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) 45 (1966) 177-221
3. Szekely A.M., Bleichert F., Numann A., Van Komen S., Manasanch E., Ben Nasr A., Canaan A., and Weissman S.M. Werner protein protects non-proliferating cells from oxidative DNA damage. Mol. Cell Biol. 25 (2005) 10492-10506
4. Lan L., Nakajima S., Komatsu K., Nussenzweig A., Shimamoto A., Oshima J., and Yasui A. Accumulation of Werner protein at DNA double-strand breaks in human cells. J. Cell Sci. 118 (2005) 4153-4162
5. Shen M., Zheng T., Lan Q., Zhang Y., Zahm S.H., Wang S.S., Holford T.R., Leaderer B., Yeager M., Welch R., Kang D., Boyle P., Zhang B., Zou K., Zhu Y., Chanock S., and Rothman N. Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. Hum. Genet. 119 (2006) 659-668
6. Wirtenberger M., Frank B., Hemminki K., Klaes R., Schmutzler R.K., Wappenschmidt B., Meindl A., Kiechle M., Arnold N., Weber B.H., Niederacher D., Bartram C.R., and Burwinkel B. Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer. Carcinogenesis 27 (2006) 1655-1660
7. Shen M., Lan Q., Zhang L., Chanock S., Li G., Vermeulen R., Rappaport S.M., Guo W., Hayes R.B., Linet M., Yin S., Yeager M., Welch R., Forrest M.S., Rothman N., and Smith M.T. Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. Carcinogenesis 27 (2006) 2083-2089
8. Lan Q., Zhang L., Li G., Vermeulen R., Weinberg R.S., Dosemeci M., Rappaport S.M., Shen M., Alter B.P., Wu Y., Kopp W., Waidyanatha S., Rabkin C., Guo W., Chanock S., Hayes R.B., Linet M., Kim S., Yin S., Rothman N., and Smith M.T. Hematotoxicity in workers exposed to low levels of benzene. Science 306 (2004) 1774-1776
9. Kolachana P., Subrahmanyam V.V., Meyer K.B., Zhang L., and Smith M.T. Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo. Cancer Res. 53 (1993) 1023-1026
10. Winn L.M. Homologous recombination initiated by benzene metabolites: a potential role of oxidative stress. Toxicol. Sci. 72 (2003) 143-149
11. Gowans I.D., Lorimore S.A., McIlrath J.M., and Wright E.G. Genotype-dependent induction of transmissible chromosomal instability by gamma-radiation and the benzene metabolite hydroquinone. Cancer Res. 65 (2005) 3527-3530
12. Pilch D.R., Sedelnikova O.A., Redon C., Celeste A., Nussenzweig A., and Bonner W.M. Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem. Cell Biol. 81 (2003) 123-129
13. Sakaguchi K., Herrera J.E., Saito S., Miki T., Bustin M., Vassilev A., Anderson C.W., and Appella E. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12 (1998) 2831-2841
14. Fernandez-Capetillo O., Lee A., Nussenzweig M., and Nussenzweig A. H2AX: the histone guardian of the genome. DNA Repair (Amst) 3 (2004) 959-967
15. Singh N.P., and Stephens R.E. X-ray induced DNA double-strand breaks in human sperm. Mutagenesis 13 (1998) 75-79
16. Bode A.M., and Dong Z. Post-translational modification of p53 in tumorigenesis. Nat. Rev. Cancer 4 (2004) 793-805
17. Roy S., Packman K., Jeffrey R., and Tenniswood M. Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells. Cell Death Differ. 12 (2005) 482-491
18. Ito A., Lai C.H., Zhao X., Saito S., Hamilton M.H., Appella E., and Yao T.P. p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. Embo. J. 20 (2001) 1331-1340
19. Jackson S.P. Sensing and repairing DNA double-strand breaks. Carcinogenesis 23 (2002) 687-696
20. Whysner J., Reddy M.V., Ross P.M., Mohan M., and Lax E.A. Genotoxicity of benzene and its metabolites. Mutat. Res. 566 (2004) 99-130
21. Grandori C., Wu K.J., Fernandez P., Ngouenet C., Grim J., Clurman B.E., Moser M.J., Oshima J., Russell D.W., Swisshelm K., Frank S., Amati B., Dalla-Favera R., and Monnat Jr. R.J. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev. 17 (2003) 1569-1574
22. Cheng W.H., Sakamoto S., Fox J.T., Komatsu K., Carney J., and Bohr V.A. Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1. FEBS Lett. 579 (2005) 1350-1356
23. Spillare E.A., Wang X.W., von Kobbe C., Bohr V.A., Hickson I.D., and Harris C.C. Redundancy of DNA helicases in p53-mediated apoptosis. Oncogene 25 (2006) 2119-2123
24. Brosh Jr. R.M., and Bohr V.A. Roles of the Werner syndrome protein in pathways required for maintenance of genome stability. Exp. Gerontol. 37 (2002) 491-506
25. Brosh Jr. R.M., Karmakar P., Sommers J.A., Yang Q., Wang X.W., Spillare E.A., Harris C.C., and Bohr V.A. p53 Modulates the exonuclease activity of Werner syndrome protein. J. Biol. Chem. 276 (2001) 35093-35102
26. Blander G., Kipnis J., Leal J.F., Yu C.E., Schellenberg G.D., and Oren M. Physical and functional interaction between p53 and the Werner's syndrome protein. J. Biol. Chem. 274 (1999) 29463-29469
27. Prives C., and Manley J.L. Why is p53 acetylated?. Cell 107 (2001) 815-818
28. Amin R.P., and Witz G. DNA-protein crosslink and DNA strand break formation in HL-60 cells treated with trans,trans-muconaldehyde, hydroquinone and their mixtures. Int. J. Toxicol. 20 (2001) 69-80