Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton

Cancer Cell

Volumn 9, Issue 4, 2006, Pages 261-272

  Wicki, Andreas ^a   Lehembre, François ^a   Wick, Nikolaus ^b   Hantusch, Brigitte ^b   Kerjaschki, Dontscho ^b   Christofori, Gerhard ^a  

^a Center for Biomedicine   (Switzerland)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

CELLBIO

Indexed keywords

ACTIN; BIOLOGICAL MARKER; PODOPLANIN; RHO GUANOSINE TRIPHOSPHATASE; TUMOR MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER INVASION; CARCINOGENESIS; CELL MIGRATION; CELL REGENERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; FILOPODIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MESENCHYME CELL; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PANCREAS CARCINOMA; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR BIOPSY;

ANIMALIA;

EID: 33645758275     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2006.03.010     Document Type: Article

References (39)

1. Breiteneder-Geleff S., Soleiman A., Kowalski H., Horvat R., Amann G., Kriehuber E., Diem K., Weninger W., Tschachler E., Alitalo K., and Kerjaschki D. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am. J. Pathol. 154 (1999) 385-394
2. Cavallaro U., and Christofori G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat. Rev. Cancer 4 (2004) 118-132
3. Cavallaro U., Schaffhauser B., and Christofori G. Cadherins and the tumour progression: is it all in a switch?. Cancer Lett. 176 (2002) 123-128
4. Christofori G., Naik P., and Hanahan D. A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature 369 (1994) 414-418
5. Farr A.G., Berry M.L., Kim A., Nelson A.J., Welch M.P., and Aruffo A. Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J. Exp. Med. 176 (1992) 1477-1482
6. Folkman J., Watson K., Ingber D., and Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339 (1989) 58-61
7. Friedl P., and Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3 (2003) 362-374
8. Friedl P., Hegerfeldt Y., and Tusch M. Collective cell migration in morphogenesis and cancer. Int. J. Dev. Biol. 48 (2004) 441-449
9. Fukata M., Nakagawa M., and Kaibuchi K. Roles of Rho-family GTPases in cell polarisation and directional migration. Curr. Opin. Cell Biol. 15 (2003) 590-597
10. Gadea G., Lapasset L., Gauthier-Rouviere C., and Roux P. Regulation of Cdc42-mediated morphological effects: a novel function for p53. EMBO J. 21 (2002) 2373-2382
11. Gonzalez R.F., and Dobbs L.G. Purification and analysis of RTI40, a type I alveolar epithelial cell apical membrane protein. Biochim. Biophys. Acta 1429 (1998) 208-216
12. Grunert S., Jechlinger M., and Beug H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat. Rev. Mol. Cell Biol. 4 (2003) 657-665
13. Hanahan D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315 (1985) 115-122
14. Hsu M.Y., Wheelock M.J., Johnson K.R., and Herlyn M. Shifts in cadherin profiles between human normal melanocytes and melanomas. J. Investig. Dermatol. Symp. Proc. 1 (1996) 188-194
15. Hunter K.W. Ezrin, a key component in tumor metastasis. Trends Mol. Med. 10 (2004) 201-204
16. Ivetic A., and Ridley A.J. Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes. Immunology 112 (2004) 165-176
17. Izawa I., Amano M., Chihara K., Yamamoto T., and Kaibuchi K. Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation. Oncogene 17 (1998) 2863-2871
18. Kato Y., Kaneko M., Sata M., Fujita N., Tsuruo T., and Osawa M. Enhanced Expression of Aggrus (T1alpha/Podoplanin), a Platelet-Aggregation-Inducing Factor in Lung Squamous Cell Carcinoma. Tumour Biol. 26 (2005) 195-200
19. Kimura N., and Kimura I. Podoplanin as a marker for mesothelioma. Pathol. Int. 55 (2005) 83-86
20. Labosky P.A., Barlow D.P., and Hogan B.L. Embryonic germ cell lines and their derivation from mouse primordial germ cells. Ciba Found. Symp. 182 (1994) 157-168
21. Martin-Villar E., Scholl F.G., Gamallo C., Yurrita M.M., Munoz-Guerra M., Cruces J., and Quintanilla M. Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int. J. Cancer 113 (2005) 899-910
22. Matsui T., Maeda M., Doi Y., Yonemura S., Amano M., Kaibuchi K., and Tsukita S. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J. Cell Biol. 140 (1998) 647-657
23. McClatchey A.I. Merlin and ERM proteins: unappreciated roles in cancer development?. Nat. Rev. Cancer 3 (2003) 877-883
24. Mohr U., Capen C.C., Dungworth D.L., Greaves P., Hardisty J.F., Hayashi Y., Ito N., Long P.H., and Krinke G. International Classification of Rodent Tumors: Part II, The Mouse (2001), Springer, Berlin
25. Noren N.K., Liu B.P., Burridge K., and Kreft B. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J. Cell Biol. 150 (2000) 567-580
26. Nose K., Saito H., and Kuroki T. Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. Cell Growth Differ. 1 (1990) 511-518
27. Perl A.K., Wilgenbus P., Dahl U., Semb H., and Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392 (1998) 190-193
28. Price L.S., Leng J., Schwartz M.A., and Bokoch G.M. Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol. Biol. Cell 9 (1998) 1863-1871
29. Rishi A.K., Joyce-Brady M., Fisher J., Dobbs L.G., Floros J., VanderSpek J., Brody J.S., and Williams M.C. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives. Dev. Biol. 167 (1995) 294-306
30. Sahai E., and Marshall C.J. RHO-GTPases and cancer. Nat. Rev. Cancer 2 (2002) 133-142
31. Sander E.E., ten Klooster J.P., van Delft S., van der Kammen R.A., and Collard J.G. Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol. 147 (1999) 1009-1022
32. Schacht V., Ramirez M.I., Hong Y.K., Hirakawa S., Feng D., Harvey N., Williams M., Dvorak A.M., Dvorak H.F., Oliver G., and Detmar M. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 22 (2003) 3546-3556
33. Schacht V., Dadras S.S., Johnson L.A., Jackson D.G., Hong Y.K., and Detmar M. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am. J. Pathol. 166 (2005) 913-921
34. Shen Z.Y., Xu L.Y., Chen M.H., Li E.M., Li J.T., Wu X.Y., and Zeng Y. Upregulated expression of Ezrin and invasive phenotype in malignantly transformed esophageal epithelial cells. World J. Gastroenterol. 9 (2003) 1182-1186
35. Siegel P.M., and Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat. Rev. Cancer 3 (2003) 807-821
36. Smalley K.S., Brafford P., Haass N.K., Brandner J.M., Brown E., and Herlyn M. Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. Am. J. Pathol. 166 (2005) 1541-1554
37. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2 (2002) 442-454
38. Zimmer G., Lottspeich F., Maisner A., Klenk H.D., and Herrler G. Molecular characterization of gp40, a mucin-type glycoprotein from the apical plasma membrane of Madin-Darby canine kidney cells (type I). Biochem. J. 326 (1997) 99-108
39. Zimmer G., Oeffner F., Von Messling V., Tschernig T., Groness H.J., Klenk H.D., and Herrler G. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem. J. 341 (1999) 277-284