Matrix-dependent perturbation of TGFβ signaling and disease

FEBS Letters

Volumn 586, Issue 14, 2012, Pages 2003-2015

  Doyle, Jefferson J ^a,b   Gerber, Elizabeth E ^a,b   Dietz, Harry C ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Extracellular matrix; Fibrillin; Integrin; Marfan syndrome; Stiff skin syndrome; Transforming growth factor beta

Indexed keywords

ADAMST LIKE PROTEIN 2; ADAMTS1 PROTEIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; CELL MEMBRANE PROTEIN; CHEMOKINE RECEPTOR CCR2; ENALAPRIL; FIBRILLIN; FIBRILLIN 1; FIBULIN; FIBULIN 4; FIBULIN 5; GELATINASE A; GELATINASE B; INTEGRIN; LOSARTAN; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; PERINDOPRIL; PLACEBO; RECEPTOR REGULATED SMAD PROTEIN; SIMVASTATIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; ACTIVIN RECEPTOR LIKE KINASE 1 GENE; ADAMTSL2 GENE; ANEURYSM; AORTA ANEURYSM; AORTA DISSECTION; AUTOSOMAL DOMINANT DISORDER; CELL INTERACTION; DYSPLASIA; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBRILLIN 1 GENE; FILAMIN A GENE; GENE; GENETIC ASSOCIATION; GENETIC DISORDER; GEOPHYSIC DYSPLASIA; HUMAN; INTRACELLULAR SIGNALING; LEOPARD SYNDROME; LOEYS DIETZ SYNDROME; MARFAN SYNDROME; MISSENSE MUTATION; NONHUMAN; PERIVENTRICULAR HETEROTOPIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RENDU OSLER WEBER DISEASE; REVIEW; SMOOTH MUSCLE MYOSIN HEAVY CHAIN 1 GENE; STIFF SKIN SYNDROME; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1 GENE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2 GENE;

ANIMALS; CELL MEMBRANE; CYTOKINES; EXTRACELLULAR MATRIX; HOMEOSTASIS; HUMANS; INTEGRINS; MARFAN SYNDROME; MICE; MICROFILAMENT PROTEINS; MUTATION; PHENOTYPE; SIGNAL TRANSDUCTION; SYNDROME; TRANSFORMING GROWTH FACTOR BETA;

EID: 84862763855     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.05.027     Document Type: Review

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