Assembly of fibronectin extracellular matrix

Annual Review of Cell and Developmental Biology

Volumn 26, Issue , 2010, Pages 397-419

  Singh, Purva ^a   Carraher, Cara ^a   Schwarzbauer, Jean E ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

conformational change; fibrillar; insolubility; integrins; microfibrils; type I collagen

Indexed keywords

CELL SURFACE RECEPTOR; FIBRONECTIN; GLYCOPROTEIN; INTEGRIN;

AMINO TERMINAL SEQUENCE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CYTOSKELETON; EXTRACELLULAR MATRIX; FIBER; HUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; REVIEW; ANIMAL; CHEMISTRY; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; EXTRACELLULAR MATRIX; FIBRONECTINS; HUMANS; SIGNAL TRANSDUCTION;

EID: 78049427279     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev-cellbio-100109-104020     Document Type: Review

References (148)

1. Aguirre KM, McCormick RJ, Schwarzbauer JE. 1994. Fibronectin self-association is mediated by complementary sites within the amino-terminal one-third of the molecule. J. Biol. Chem. 269:27863-68
2. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. 2008. Molecular Biology of the Cell. New York: Garland Science. 1268 pp.
3. Anliker B, Chun J. 2004. Cell surface receptors in lysophospholipid signaling. Semin. Cell Dev. Biol. 15:457-65
4. Aota S, Nomizu M, Yamada K. 1994. The short amino acid sequence Pro-His-Ser-Arg-Asn in human fi-bronectin enhances cell adhesive function. J. Biol. Chem. 269:24756-61
5. Astrof S, Crowley D, Hynes RO. 2007. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev. Biol. 311:11-24
6. Aszódi A, Legate KR, Nakchbandi I, Fässler R. 2006. What mouse mutants teach us about extracellular matrix function. Annu. Rev. Cell Dev. Biol. 22:591-621
7. Bae E, Sakai T, Mosher DF. 2004. Assembly of exogenous fibronectin by fibronectin-null cells is dependent on the adhesive substrate. J. Biol. Chem. 279:35749-59
8. Baneyx G, Baugh L, Vogel V. 2001. Coexisting conformations of fibronectin in cell culture imaged using fluorescence resonance energy transfer. Proc. Natl. Acad. Sci. USA 98:14464-68
9. Banos CC, Thomas AH, Kuo CK. 2008. Collagen fibrillogenesis in tendon development: current models and regulation of fibril assembly. Birth Def. Res. C 84:228-44
10. Bass MD, Humphries MJ. 2002. Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. Biochem. J. 368:1-15
11. Bershadsky AD, Balaban NQ, Geiger B. 2003. Adhesion-dependent cell mechanosensitivity. Annu. Rev. Cell Dev. Biol. 19:677-95
12. Birk DE, Trelstad RL. 1984. Extracellular compartments in matrix morphogenesis: collagen fibril, bundle, and lamellar formation by corneal fibroblasts. J. Cell Biol. 99:2024-33
13. Birk DE, Trelstad RL. 1986. Extracellular compartments in tendon morphogenesis: collagen fibril, bundle, and macroaggregate formation. J. Cell Biol. 103:231-40
14. Bourdoulous S, Orend G, MacKenna DA, Pasqualini R, Ruoslahti E. 1998. Fibronectin matrix regulatesactivation of RHO and CDC42 GTPases and cell cycle progression. J. Cell Biol. 143:267-76
15. Brenner KA, Corbett SA, Schwarzbauer JE. 2000. Regulation of fibronectin matrix assembly by activated Rasin transformed cells. Oncogene 19:3156-63
16. Bultmann H, Santas AJ, Pesciotta Peters DM. 1998. Fibronectin fibrillogenesis involves the heparin II bindingdomain of fibronectin. J. Biol. Chem. 273:2601-9
17. Castelletti F, Donadelli R, Banteria F, Hildebrandt F, Zipfel PF, et al. 2008. Mutations in FN1 cause glomeru-lopathy with fibronectin deposits. Proc. Natl. Acad. Sci. USA 105:2538-43
18. Chen H, Mosher DF. 1996. Formation of sodium dodecyl sulfate-stable fibronectin multimers. J. Biol. Chem.271:9084-89
19. Chen LB, Murray A, Segal RA, Bushnell A, Walsh ML. 1978. Studies on intercellular LETS glycoproteinmatrices. Cell 14:377-91
20. Chernousov MA, Faerman AI, Frid MG, Printseva OY, Koteliansky VE. 1987. Monoclonal antibody tofibronectin which inhibits extracellular matrix assembly. FEBS Lett. 217:124-28
21. Chernousov MA, Fogerty FJ, Koteliansky VE, Mosher DF. 1991. Role of the I-9 and III-1 modules offibronectin in the formation of an extracellular fibronectin matrix. J. Biol. Chem. 266:10851-58
22. Christopher RA, Kowalczyk AP, McKeown-Longo PJ. 1997. Localization of fibronectin matrix assembly siteson fibroblasts and endothelial cells. J. Cell Sci. 110:569-81
23. Chung CY, Erickson HP. 1997. Glycosaminoglycans modulate fibronectin matrix assembly and are essentialfor matrix incorporation of tenascin-C. J. Cell Sci. 110:1413-19
24. Colombi M, Zoppi N, De Petro G, Marchina E, Gardella R, et al. 2003. Matrix assembly induction and cellmigration and invasion inhibition by a 13-amino acid fibronectin peptide. J. Biol. Chem. 278:14346-55
25. Czirok A, Zach J, Kozel BA, Mecham RP, Davis EC, Rongish BJ. 2006. Elastic fiber macro-assembly is ahierarchical, cell motion-mediated process. J. Cell Physiol. 207:97-106
26. Dallas SL, Sivakumar P, Jones CJ, Chen Q, Peters DM, et al. 2005. Fibronectin regulates latent transforminggrowth factor-β (TGFβ) by controlling matrix assembly of latent TGFβ-binding protein-1. J. Biol. Chem. 280:18871-80
27. Danen EH, Aota S, van Kraats AA, Yamada KM, Ruiter DJ, van Muijen GN. 1995. Requirement for thesynergy site for cell adhesion to fibronectin depends on the activation state of integrin α5β1. J. Biol. Chem. 270:21612-18
28. Dzamba BJ, Jakab KR, Marsden M, Schwartz MA, DeSimone DW. 2009. Cadherin adhesion, tissue tension,and noncanonical Wnt signaling regulate fibronectin matrix organization. Dev. Cell 16:421-32
29. Dzamba BJ, Peters DM. 1991. Arrangement of cellular fibronectin in noncollagenous fibrils in human fibro-blast cultures. J. Cell Sci. 100:605-12
30. Dzamba BJ, Wu H, Jaenisch R, Peters DM. 1993. Fibronectin binding site in type I collagen regulate fi-bronectin fibril formation. J. Cell Biol. 121:1165-72
31. Engel J, Odermatt E, Engel A, Madri JA, Furthmayr H, et al. 1981. Shapes, domain organizations andflexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix. J. Mol. Biol.150:97-120
32. Engler AJ, Chan M, Boettiger D, Schwarzbauer JE. 2009. A novel mode of cell detachment from fibrillarfibronectin matrix under shear. J. Cell Sci. 122:1647-53
33. Erickson HP. 1994. Reversible unfolding of fibronectin type III and immunoglobulin domains provides thestructural basis for stretch and elasticity of titin and fibronectin. Proc. Natl. Acad. Sci. USA 91:10114-18
34. Erickson HP. 2002. Stretching fibronectin. J. Musc. Res. Cell Motil. 23:575-80
35. Erickson HP, Carrell NA. 1983. Fibronectin in extended and compact conformations. Electron microscopyand sedimentation analysis. J. Biol. Chem. 258:14539-44
36. Essner JJ, Chen E, Ekker SC. 2006. Syndecan-2. Int. J. Biochem. Cell Biol. 38:152-56
37. Fogelgren B, Polgár N, Szauter KM, Ujfaludi Z, Laczkó R, et al. 2005. Cellular fibronectin binds to lysyloxidase with high affinity and is critical for its proteolytic activation. J. Biol. Chem. 280:24690-97
38. Fogerty FJ, Akiyama SK, Yamada KM, Mosher DF. 1990. Inhibition of binding of fibronectin to matrixassembly sites by anti-integrin (α5β1) antibodies. J. Cell Biol. 111:699-708
39. Friedland JC, Lee MH, Boettiger D. 2009. Mechanically activated integrin switch controls α5β1 function. Science 323:642-44
40. Fukuda T, Yoshida N, Kataoka Y, Manabe R, Mizuno-Horikawa Y, et al. 2002. Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Cancer Res. 62:5603-10
41. Galante LL, Schwarzbauer JE. 2007. Requirements for sulfate transport and the diastrophic dysplasia sulfate transporter in fibronectin matrix assembly. J. Cell Biol. 179:999-1009
42. Gee EP, Ingber DE, Stultz CM. 2008. Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. PLoS One 3:e2373
43. Geiger B, Bershadsky A, Pankov R, Yamada KM. 2001. Transmembrane extracellular matrix-cytoskeleton crosstalk. Nat. Rev. Mol. Cell Biol. 2:793-805
44. George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, Hynes RO. 1993. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119:1079-91
45. Green JA, Berrier AL, Pankov R, Yamada KM. 2009. β1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1. J. Biol. Chem. 284:8148-59
46. Guan J-L, Hynes RO. 1990. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1. Cell 60:53-61
47. Guan J-L, Trevithick JE, Hynes RO. 1990. Retroviral expression of alternatively spliced forms of rat fi-bronectin. J. Cell Biol. 110:833-47
48. Hall A. 2005. Rho GTPases and the control of cell behaviour. Biochem. Soc. Trans. 33:891-95
49. Halliday NL, Tomasek JJ. 1995. Mechanical properties of the extracellular matrix influence fibronectin fibril assembly in vitro. Exp. Cell Res. 217:109-17
50. Hocking DC, Smith RK, McKeown-Longo PJ. 1996. A novel role for the integrin-binding III-10 module in fibronectin matrix assembly. J. Cell Biol. 133:431-44
51. Hocking DC, Sottile J, McKeown-Longo PJ. 1994. Fibronectin's III-1 module contains a conformation-dependent binding site for the amino-terminal region of fibronectin. J. Biol. Chem. 269:19183-91
52. Hocking DC, Sottile J, McKeown-Longo PJ. 1998. Activation of distinct α5β1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domains. J. Cell Biol. 141:241-53
53. Hocking DC, Sottile J, Reho T, Fassler R, McKeown-Longo PJ. 1999. Inhibition of fibronectin matrix assembly by the heparin-binding domain of vitronectin. J. Biol. Chem. 274:27257-64
54. Huveneers S, Danen EH. 2009. Adhesion signaling-crosstalk between integrins, Src and Rho. J. Cell Sci. 122:1059-69
55. Huveneers S, Truong H, Fässler R, Sonnenberg A, Danen EH. 2008. Binding of soluble fibronectin to integrin α5β1-link to focal adhesion redistribution and contractile shape. J. Cell Sci. 121:2452-62
56. Hynes RO. 1990. Fibronectins. New York: Springer-Verlag. 544 pp.
57. Ichihara-Tanaka K, Maeda T, Titani K, Sekiguchi K. 1992. Matrix assembly of recombinant fibronectin polypeptide consisting of amino-terminal 70 kDa and carboxyl-terminal 37 kDa regions. FEBS Lett. 299:155-58
58. Ilic D, Kovacic B, Johkura K, Schlaepfer DD, Tomasevic N, et al. 2004. FAK promotes organization of fibronectin matrix and fibrillar adhesions. J. Cell Sci. 117:177-87
59. Ingham KC, Brew SA, Erickson HP. 2004. Localization of a cryptic binding site for tenascin on fibronectin. J. Biol. Chem. 279:28132-35
60. Ingham KC, Brew SA, Huff S, Litvinovich SV. 1997. Cryptic self-association sites in type III modules of fibronectin. J. Biol. Chem. 272:1718-24
61. Johnson KJ, Sage H, Briscoe G, Erickson HP. 1999. The compact conformation of fibronectin is determined by intramolecular ionic interactions. J. Biol. Chem. 274:15473-79
62. Kadler KE, HillA, Canty-Laird EG. 2008. Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators. Curr. Opin. Cell Biol. 20:495-501
63. Karuri NW, Lin Z, Rye HS, Schwarzbauer JE. 2009. Probing the conformation of the fibronectin III1-2 domain by fluorescence resonance energy transfer. J. Biol. Chem. 284:3445-52
64. Kinsey R, Williamson MR, Chaudhry S, Mellody KT, McGovern A, et al. 2008. Fibrillin-1 microfibril deposition is dependent on fibronectin assembly. J. Cell Sci. 121:2696-704
65. Klass CM, Couchman JR, Woods A. 2000. Control of extracellular matrix assembly by syndecan-2 proteo-glycan. J. Cell Sci. 113:493-506
66. Klein RM, Zheng M, Ambesi A, Van De Water L, McKeown-Longo PJ. 2003. Stimulation of extracellular matrix remodeling by the first type III repeat in fibronectin. J. Cell Sci. 116:4663-74
67. Kozel BA, Rongish BJ, Czirok A, Zach J, Little CD, et al. 2006. Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. J. Cell Physiol. 207:87-96
68. Krammer A, Lu H, Isralewitz B, Schulten K, Vogel V. 1999. Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch. Proc. Natl. Acad. Sci. USA 96:1351-56
69. Langenbach KJ, Sottile J. 1999. Identification of protein-disulfide isomerase activity in fibronectin. J. Biol. Chem. 274:7032-38
70. Leahy DJ, Aukhil I, Erickson HP. 1996. 2.0 A? crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell 84:155-64
71. Ledger PW, Uchida N, Tanzer ML. 1980. Immunocytochemical localization of procollagen and fibronectin in human fibroblasts: effects of the monovalent ionophore, monensin. J. Cell Biol. 87:663-71
72. Litvinovich SV, Brew SA, AotaS, Akiyama SK, Haudenschild C, Ingham KC. 1998. Formation of amyloid-like fibrils by self-association of a partially unfolded fibronectin type III module. J. Mol. Biol. 280:245-58
73. Mao Y, Schwarzbauer JE. 2005a. Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. Matrix Biol. 24:389-99
74. Mao Y, Schwarzbauer JE. 2005b. Stimulatory effects of a three-dimensional microenvironment on cell-mediated fibronectin fibrillogenesis. J. Cell Sci. 118:4427-36
75. Mao Y, Schwarzbauer JE. 2006. Accessibility to the fibronectin synergy site in a 3D matrix regulates engagement of α5β1 versus αvβ3 integrin receptors. Cell Commun. Adhes. 13(5-6):267-77
76. Maqueda A, Moyano JV, Hernández Del CerroM,Peters DM, Garcia-PardoA.2007. The heparin III-binding domain offibronectin (III4-5 repeats) binds tofibronectin and inhibits fibronectin matrix assembly. Matrix Biol. 26:642-51
77. McDonald JA. 1988. Extracellular matrix assembly. Annu. Rev. Cell Biol. 4:183-207
78. McDonald JA, Quade BJ, Broekelman TJ, LaChance R, Forsman K, et al. 1987. Fibronectin's cell-adhesive domain and an amino-terminal matrix assembly domain participate in its assembly into fibroblast peri-cellular matrix. J. Biol. Chem. 262:2957-67
79. McKeown-Longo PJ, Mosher DF. 1983. Binding of plasma fibronectin to cell layers of human skin fibroblasts. J. Cell Biol. 97:466-72
80. McKeown-Longo PJ, Mosher DF. 1985. Interaction of the 70,000-mol. wt. amino terminal fragment of fibronectin with matrix-assembly receptor of fibroblasts. J. Cell Biol. 100:364-74
81. Mitra S, Schlaepfer DD. 2006. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18:516-23
82. Morla A, Ruoslahti E. 1992. A fibronectin self-assembly site involved in fibronectin matrix assembly: reconstruction in a synthetic peptide. J. Cell Biol. 118:421-29
83. Morla A, Zhang Z, Ruoslahtl E. 1994. Superfibronectin is a functionally distinct form of fibronectin. Nature 367:193-96
84. Muro AF, Chauhan AK, Gajovic S, Iaconcig A, Porro F, et al. 2003. Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J. Cell Biol. 162:149-60
85. Oberhauser AF, Badilla-Fernandez C, Carrion-Vazquez M, Fernandez JM. 2002. The mechanical hierarchies of fibronectin observed with single-molecule AFM. J. Mol. Biol. 319:433-47
86. Ohashi T, Augustus AM, Erickson HP. 2009. Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin. Biochemistry 48:4189-97
87. Ohashi T, Erickson HP. 2005. Domain unfolding plays a role in superfibronectin formation. J. Biol. Chem. 280:39143-51
88. Ohashi T, Erickson HP. 2009. Revisiting the mystery of fibronectin multimers: the fibronectin matrix is composed of fibronectin dimers cross-linked by non-covalent bonds. Matrix Biol. 28:170-75
89. Ohashi T, Kiehart DP, Erickson HP. 1999. Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein. Proc. Natl. Acad. Sci. USA 96:2153-58
90. Ohashi T, Kiehart DP, Erickson HP. 2002. Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. J. Cell Sci. 115:1221-29
91. Olorundare OE, Peyruchaud O, Albrecht RM, Mosher DF. 2001. Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists. Blood 98:117-24
92. 1 integrins promotes early fibronectin fibrillogenesis. J. Cell Biol. 148:1075-90
93. Plato. 1965. Timaeus (English translation). Baltimore: Penguin Books. 121 pp.
94. Potts JR, Campbell ID. 1994. Fibronectin structure and assembly. Curr. Opin. Cell Biol. 6:648-55
95. Pozzi A, Voziyan PA, Hudson BG, Zent R. 2009. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr. Pharm. Des. 15:1318-33
96. Ramirez F, Sakai LY. 2010. Biogenesis and function of fibrillin assemblies. Cell Tissue Res. 339:71-82
97. Rossi A, Kaitila I, Wilcox WR, Rimoin DL, Steinmann B, et al. 1998. Proteoglycan sulfation in cartilage and cell cultures from patients with sulfate transporter chondrodysplasias: relationship to clinical severity and indications on the role of intracellular sulfate production. Matrix Biol. 17:361-69
98. Ruoslahti E, Obrink B. 1996. Common principles in cell adhesion. Exp. Cell Res. 227:1-11
99. Sabatier L, Chen D, Fagotto-Kaufmann C, Hubmacher D, McKee MD, et al. 2009. Fibrillin assembly requires fibronectin. Mol. Biol. Cell 20:846-58
100. Schwartz MA, Schaller MD, Ginsberg MH. 1995. Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11:549-99
101. Schwarzbauer JE. 1991a. Fibronectin: from gene to protein. Curr. Opin. Cell Biol. 3:786-91
102. Schwarzbauer JE. 1991b. Identification of the fibronectin sequences required for assembly of a fibrillar matrix. J. Cell Biol. 113:1463-73
103. Schwarzbauer JE, Spencer CS, Wilson CL. 1989. Selective secretion of alternatively spliced fibronectin variants. J. Cell Biol. 109:3445-53
104. Sechler JL, Corbett SA, Schwarzbauer JE. 1997. Modulatory roles for integrin activation and the synergy site of fibronectin during matrix assembly. Mol. Biol. Cell 8:2563-73
105. Sechler JL, Cumiskey AM, Gazzola DM, Schwarzbauer JE. 2000. A novel RGD-independent fibronectin assembly pathway initiated by α4β1 integrin binding to the alternatively spliced V region. J. Cell Sci. 113:1491-98
106. Sechler JL, Rao H, Cumiskey AM, Vega-Colon I, Smith MS, et al. 2001. A novel fibronectin binding site required for fibronectin fibril growth during matrix assembly. J. Cell Biol. 154:1081-88
107. Sechler JL, Schwarzbauer JE. 1998. Control of cell cycle progression by fibronectin matrix architecture. J. Biol. Chem. 273:25533-36
108. Sechler JL, Takada Y, Schwarzbauer JE. 1996. Altered rate of fibronectin matrix assembly by deletion of the first type III repeats. J. Cell Biol. 134:573-83
109. Sharma A, Askari JA, Humphries MJ, Jones EY, Stuart DI. 1999. Crystal structure of a heparin- and integrin-binding segment of human fibronectin. EMBO J. 18:1468-79
110. Shi F, Sottile J. 2008. Caveolin-1-dependent β1 integrin endocytosis is a critical regulator of fibronectin turnover. J. Cell Sci. 121:2360-71
111. Singer II. 1979. The fibronexus: a transmembrane association of fibronectin-containing fibers and bundles of 5 nm microfilaments in hamster and human fibroblasts. Cell 16:675-85
112. Smith ML, Gourdon D, Little WC, Kubow KE, Eguiluz RA, et al. 2007. Force-induced unfolding of fi-bronectin in the extracellular matrix of living cells. PLoS Biol. 5:e268
113. Sottile J, Chandler J. 2005. Fibronectin matrix turnover occurs through a caveolin-1-dependent process. Mol. Biol. Cell 16:757-68
114. Sottile J, Hocking DC. 2002. Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol. Biol. Cell 13:3546-59
115. Sottile J, Hocking DC, Langenbach KJ. 2000. Fibronectin polymerization stimulates cell growth by RGD-dependent and -independent mechanisms. J. Cell Sci. 113:4287-99
116. Sottile J, Schwarzbauer JE, Selegue J, Mosher DF. 1991. Five type I modules of fibronectin form a functional unit that binds to fibroblasts and Staphylococcus aureus. J. Biol. Chem. 266:12840-43
117. Sottile J, Wiley S. 1994. Assembly of amino-terminal fibronectin dimers into the extracellular matrix. J. Biol. Chem. 269:17192-98
118. Takahashi S, Leiss M, Moser M, Ohashi T, Kitao T, et al. 2007. The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J. Cell Biol. 178:167-78
119. Tan MH, Sun Z, Opitz SL, Schmidt TE, Peters JH, George EL. 2004. Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood 104:11-18
120. Twal WO, Czirok A, Hegedus B, Knaak C, Chintalapudi MR, et al. 2001. Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility. J. Cell Sci. 114:4587-98
121. Ugarova TP, Ljubimov AV, Deng L, Plow EF. 1996. Proteolysis regulates exposure of the IIICS-1 adhesive sequence in plasma fibronectin. Biochemistry 35:10913-21
122. Ugarova TP, Zamaroon C, Veklich Y, Bowditch RD, Ginsberg MH, et al. 1995. Conformational transitions in the cell binding domain of fibronectin. Biochemistry 34:4457-66
123. Vakonakis I, Staunton D, Rooney LM, Campbell ID. 2007. Interdomain association in fibronectin: insight into cryptic sites and fibrillogenesis. EMBO J. 26:2575-83
124. Valenick LV, Hsia HC, Schwarzbauer JE. 2005. Fibronectin fragmentation promotes α4β1 integrin-mediated contraction of a fibrin-fibronectin provisional matrix. Exp. Cell Res. 309:48-55
125. Ventura E, Sassi F, Parodi A, Balza E, Borsi L, et al. 2010. Alternative splicing of the angiogenesis associated extra-domain B of fibronectin regulates the accessibility of the B-C loop of the type III repeat 8. PLoS One 5:e9145
126. Wagenseil JE, Mecham RP. 2007. New insights into elastic fiber assembly. Birth Def. Res. C 81:229-40
127. Wayner EA, Garcia-Pardo A, Humphries MJ, McDonald JA, Carter WG. 1989. Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J. Cell Biol. 109:1321-30
128. Wierzbicka-Patynowski I, Mao Y, Schwarzbauer JE. 2007. Continuous requirement for pp60-Src and phospho-paxillin during fibronectin matrix assembly by transformed cells. J. Cell. Physiol. 210:750-56
129. Wierzbicka-Patynowski I, Schwarzbauer JE. 2002. Regulatory role for Src and phosphatidylinositol 3-kinase in initiation of fibronectin matrix assembly. J. Biol. Chem. 277:19703-8
130. Wierzbicka-Patynowski I, Schwarzbauer JE. 2003. The ins and outs of fibronectin matrix assembly. J. Cell Sci. 116:3269-76
131. Wilcox-Adelman SA, Denhez F, Goetinck PF. 2002. Syndecan-4 modulates focal adhesion kinase phospho-rylation. J. Biol. Chem. 277:32970-77
132. Wolfram D, Tzankov A, Pü lzl P, Piza-Katzer H. 2009. Hypertrophic scars and keloids-a review of their pathophysiology, risk factors, and therapeutic management. Dermatol. Surg. 35:171-81
133. Woods A. 2001. Syndecans: transmembrane modulators of adhesion and matrix assembly. J. Clin. Invest. 107:935-41
134. Woods A, Longley RL, Tumova S, Couchman JR. 2000. Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts. Arch. Biochem. Biophys. 374:66-72
135. 3: initiation of fibronectin matrix assembly. Cell Adhes. Commun. 4:149-58
136. Wu C, Keivenst VM, V O'Toole TE, McDonald JA, Ginsberg MH. 1995. Integrin activation and cytoskeletal interaction are critical steps in the assembly of a fibronectin matrix. Cell 83:715-24
137. Xu J, Bae E, Zhang Q, Annis DS, Erickson HP, Mosher DF. 2009. Display of cell surface sites for fibronectin assembly is modulated by cell adherence to 1F3 and C-terminal modules of fibronectin. PLoS One 4:e4113
138. v integrins. Mol. Biol. Cell 7:1737-48
139. Yoneda A, Ushakov D, Multhaupt HAB, Couchman JR. 2007. Fibronectin matrix assembly requires distinct contributions from Rho kinases I and -II. Mol. Biol. Cell 18:66-75
140. Yurchenco PD, Patton BL. 2009. Developmental and pathogenic mechanisms of basement membrane assembly. Curr. Pharm. Des. 15:1277-94
141. Zaidel-Bar R, Milo R, Kam Z, Geiger B. 2007. A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J. Cell Sci. 120:137-48
142. Zamir E, Katz BZ, Aota S, Yamada KM, Geiger B, Kam Z. 1999. Molecular diversity of cell-matrix adhesions. J. Cell Sci. 112:1655-69
143. Zhang G, Young BB, Ezura Y, Favata M, Soslowsky LJ, et al. 2005. Development of tendon structure and function: regulation of collagen fibrillogenesis. J. Musculoskelet. Neuronal Interact. 5:5-21
144. Zhang Q, Checovich WJ, Peters DM, Albrecht RM, Mosher DF. 1994. Modulation of cell surface fibronectinassembly sites by lysophosphatidic acid. J. Cell Biol. 127:1447-59
145. 2-terminal region of fibronectin to molecules of largeapparent molecular mass. J. Biol. Chem. 271:33284-92
146. Zhang Q, Peyruchaud O, French KJ, Magnusson MK, Mosher DF. 1999. Sphingosine 1-phosphate stimu lates fibronectin matrix assembly through a Rho-dependent signal pathway. Blood 93:2984-90
147. Zhang Z, Morla AO, Vuori K, Bauer JS, Juliano RL, Ruoslahti E. 1993. The αvβ1 integrin functions as afibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin. J. Cell Biol. 122:235-42
148. Zhong C, Chrzanowska-Wodnicka M, Brown J, Shaub A, Belkin AM, Burridge K. 1998. Rho-mediatedcontractility exposes a cryptic site in fibronectin and induces fibronectin matrix assembly. J. Cell Biol.141:539-51