p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice

Journal of Biological Chemistry

Volumn 284, Issue 9, 2009, Pages 5630-5636

  Carta, Luca ^a   Smaldone, Silvia ^a   Zilberberg, Lior ^c   Loch, David ^b   Dietz, Harry C ^b   Rifkin, Daniel B ^c   Ramirez, Francesco ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AORTIC ANEURYSMS; AORTIC WALLS; CELLULAR PHENOTYPES; CONNECTIVE TISSUES; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX PROTEIN; FIBRILLIN-1; IN-VIVO ANALYSIS; KINASE ACTIVITY; MARFAN SYNDROME; MOUSE MODELS; MUTANT MICE; P38 MAPK; PRIMARY CULTURE; REACTIVE OXYGEN SPECIES; THORACIC AORTA; TRANSFORMING GROWTH FACTORS; VASCULAR SMOOTH MUSCLE CELLS;

BLOOD VESSEL PROSTHESES; BLOOD VESSELS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE ENCODING; MUSCULOSKELETAL SYSTEM; OXYGEN; SIGNALING;

CELL CULTURE;

ACTIVATING TRANSCRIPTION FACTOR 2; FIBRILLIN 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PLACEBO; REACTIVE OXYGEN METABOLITE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; ACTIN BINDING PROTEIN; FIBRILLIN; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN SERINE THREONINE KINASE; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; ARTICLE; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; GENE ACTIVATION; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; MARFAN SYNDROME; MOUSE; MUSCLE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THORACIC AORTA; VASCULAR SMOOTH MUSCLE; ANIMAL; CYTOLOGY; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PHYSIOLOGY;

MUS;

ANIMALS; AORTA, THORACIC; CELLS, CULTURED; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOBLOTTING; IMMUNOENZYME TECHNIQUES; MAP KINASE KINASE KINASES; MICE; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MUSCLE, SMOOTH, VASCULAR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN;

EID: 65549088034     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806962200     Document Type: Article

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