Fibulin-4 deficiency results in ascending aortic aneurysms: A potential link between abnormal smooth muscle cell phenotype and aneurysm progression

Circulation Research

Volumn 106, Issue 3, 2010, Pages 583-592

  Huang, Jianbin ^a   Davis, Elaine C ^c   Chapman, Shelby L ^a   Budatha, Madhusudhan ^a   Marmorstein, Lihua Y ^d   Word, R Ann ^b   Yanagisawa, Hiromi ^a  

^a Department of Molecular Biology ^*  (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

Aneurysms; ECM; Elastic fibers; Mouse; Smooth muscle cells

Indexed keywords

CONTRACTILE PROTEIN; ELASTIN; FIBULIN 4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN HEAVY CHAIN; UNCLASSIFIED DRUG;

ANEURYSM RUPTURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; AORTA MEDIA; ARTERY WALL; ARTICLE; ASCENDING AORTA; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ELASTIC FIBER; EMBRYO DEVELOPMENT; GENE DELETION; GENE EXPRESSION; GERM LINE; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; THORACIC AORTA; TISSUE DIFFERENTIATION; UPREGULATION;

ANIMALS; AORTA; AORTIC ANEURYSM; CELL DIFFERENTIATION; CROSSES, GENETIC; ELASTIC TISSUE; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GERM-LINE MUTATION; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; ORGAN SPECIFICITY; TUNICA MEDIA;

EID: 77649165897     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.207852     Document Type: Article

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