Inhibition of transforming growth factor-β signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 2, 2010, Pages

  Lucas, Jason A ^a   Zhang, Yun ^a   Li, Peng ^a   Gong, Kaizheng ^a   Miller, Andrew P ^a   Hassan, Erum ^a   Hage, Fadi ^a   Xing, Dongqi ^a   Wells, Bryan ^a   Oparil, Suzanne ^a   Chen, Yiu Fai ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Cardiac hypertrophy; Extracellular matrix; Myofibroblast; Smad protein

Indexed keywords

COLLAGEN; KI 67 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; CELL PROLIFERATION; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; GENE EXPRESSION; HEART DILATATION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC DIAMETER; HEART LEFT VENTRICLE FAILURE; MALE; MOUSE; NONHUMAN; PRESSURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STAINING; TRANSGENIC MOUSE;

ANIMALS; CARDIOMYOPATHY, DILATED; CELL PROLIFERATION; COLLAGEN; DISEASE MODELS, ANIMAL; FIBROBLASTS; HEART; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; VASODILATION; VENTRICULAR DYSFUNCTION, LEFT; ZINC SULFATE;

EID: 74949131203     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00529.2009     Document Type: Article

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