Disruption of the gene encoding the latent transforming growth factor-β binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

Genes and Development

Volumn 16, Issue 17, 2002, Pages 2264-2273

  Sterner Kock, Anja ^a   Thorey, Irmgard S ^a   Koli, Katri ^b   Wempe, Frank ^a   Otte, Jürgen ^a   Bangsow, Thorsten ^a   Kuhlmeier, Katharina ^a   Kirchner, Thomas ^c   Jin, Shenchu ^a   Keski Oja, Jorma ^b   Von Melchner, Harald ^a  

^a GOETHE UNIVERSITY   (Germany)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Cardiomyopathy; Colorectal cancer; Extracellular matrix; LTBP; Pulmonary emphysema; TGF

Indexed keywords

BINDING PROTEIN; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 4; MYC PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; COLORECTAL CANCER; CONTROLLED STUDY; ELASTIC FIBER; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENE DISRUPTION; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG EMPHYSEMA; MOUSE; NONHUMAN; NUCLEIC ACID HYBRIDIZATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARDIOMYOPATHIES; CARRIER PROTEINS; COLORECTAL NEOPLASMS; ELASTIC TISSUE; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; HUMANS; INTRONS; LATENT TGF-BETA BINDING PROTEINS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PHENOTYPE; PULMONARY EMPHYSEMA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0036713792     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.229102     Document Type: Article

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