메뉴 건너뛰기




Volumn 1, Issue 2, 2010, Pages 79-93

T cell migration into the central nervous system during health and disease: Different molecular keys allow access to different central nervous system compartments

Author keywords

Adhesion molecules; Blood brain barriers; EAE; T cell trafficking

Indexed keywords

ALPHA4 INTEGRIN; BETA2 INTEGRIN; CD27 ANTIGEN; CD4 ANTIGEN; CD99 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR4; GELATINASE A; GELATINASE B; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; INTERLEUKIN 12; L SELECTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; SECONDARY LYMPHOID TISSUE CHEMOKINE; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

EID: 78751706537     PISSN: None     EISSN: 17591961     Source Type: Journal    
DOI: 10.1111/j.1759-1961.2010.009.x     Document Type: Review
Times cited : (70)

References (103)
  • 1
    • 0017734968 scopus 로고
    • Immunologically priviledged sites
    • Barker CF, Billingham RE. Immunologically priviledged sites. Adv Immunol. 1977; 25: 1-54.
    • (1977) Adv Immunol , vol.25 , pp. 1-54
    • Barker, C.F.1    Billingham, R.E.2
  • 2
    • 78651010946 scopus 로고
    • Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue and to anterior chamber of the eye
    • Medawar PB. Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue and to anterior chamber of the eye. Br J Exp Pathol. 1948; 29: 58-69.
    • (1948) Br J Exp Pathol , vol.29 , pp. 58-69
    • Medawar, P.B.1
  • 3
    • 23744475685 scopus 로고    scopus 로고
    • The ins and outs of T-lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms
    • DOI 10.1016/j.it.2005.07.004, PII S1471490605001833
    • Engelhardt B, Ransohoff RM. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol. 2005; 26: 485-95. (Pubitemid 41139258)
    • (2005) Trends in Immunology , vol.26 , Issue.9 , pp. 485-495
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 5
    • 33845784758 scopus 로고    scopus 로고
    • Blood-brain barrier delivery
    • DOI 10.1016/j.drudis.2006.10.013, PII S1359644606004363
    • Pardridge WM. Blood-brain barrier delivery. Drug Discov Today. 2007; 12: 54-61. (Pubitemid 46014479)
    • (2007) Drug Discovery Today , vol.12 , Issue.1-2 , pp. 54-61
    • Pardridge, W.M.1
  • 6
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • DOI 10.1126/science.277.5323.242
    • Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science. 1997; 277: 242-5. (Pubitemid 27446080)
    • (1997) Science , vol.277 , Issue.5323 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 7
    • 0035947768 scopus 로고    scopus 로고
    • Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis
    • Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol. 2001; 153: 933-46.
    • (2001) J Cell Biol , vol.153 , pp. 933-946
    • Sixt, M.1    Engelhardt, B.2    Pausch, F.3    Hallmann, R.4    Wendler, O.5    Sorokin, L.M.6
  • 8
    • 1842688920 scopus 로고    scopus 로고
    • Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae
    • DOI 10.1007/s00401-003-0812-0
    • Warth A, Kroger S, Wolburg H. Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta Neuropathol (Berl). 2004; 107: 311-8. (Pubitemid 38477357)
    • (2004) Acta Neuropathologica , vol.107 , Issue.4 , pp. 311-318
    • Warth, A.1    Kroger, S.2    Wolburg, H.3
  • 9
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • DOI 10.1038/nrn1824
    • Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006; 7: 41-53. (Pubitemid 41828930)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 10
    • 58149402415 scopus 로고    scopus 로고
    • Perivascular spaces and the two steps to neuroinflammation
    • Owens T, Bechmann I, Engelhardt B. Perivascular spaces and the two steps to neuroinflammation. J Neuropathol Exp Neurol. 2008; 67: 1113-21.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 1113-1121
    • Owens, T.1    Bechmann, I.2    Engelhardt, B.3
  • 11
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey WF, Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science. 1988; 239: 290-2. (Pubitemid 18061496)
    • (1988) Science , vol.239 , Issue.4837 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 13
    • 40149099870 scopus 로고    scopus 로고
    • Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: Significance for cerebral amyloid angiopathy and neuroimmunology
    • DOI 10.1111/j.1365-2990.2007.00926.x
    • Carare RO, Bernardes-Silva M, Newman TA, Page AM, Nicoll JA, Perry VH, et al. Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol Appl Neurobiol. 2008; 34: 131-44. (Pubitemid 351327967)
    • (2008) Neuropathology and Applied Neurobiology , vol.34 , Issue.2 , pp. 131-144
    • Carare, R.O.1    Bernardes-Silva, M.2    Newman, T.A.3    Page, A.M.4    Nicoll, J.A.R.5    Perry, V.H.6    Weller, R.O.7
  • 14
    • 0030848142 scopus 로고    scopus 로고
    • Is the pial microvessel a good model for blood-brain barrier studies?
    • Allt G, Lawrenson JG. Is the pial microvessel a good model for blood-brain barrier studies? Brain Res Brain Res Rev. 1997; 24: 67-76.
    • (1997) Brain Res Brain Res Rev , vol.24 , pp. 67-76
    • Allt, G.1    Lawrenson, J.G.2
  • 15
    • 0029988267 scopus 로고    scopus 로고
    • Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion
    • Barkalow FJ, Goodman MJ, Gerritsen ME, Mayadas TN. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Blood. 1996; 88: 4585-93. (Pubitemid 26419141)
    • (1996) Blood , vol.88 , Issue.12 , pp. 4585-4593
    • Barkalow, F.J.1    Goodman, M.J.2    Gerritsen, M.E.3    Mayadas, T.N.4
  • 16
    • 0344110498 scopus 로고    scopus 로고
    • Nicotine induces leukocyte rolling and adhesion in the cerebral microcirculation of the mouse
    • DOI 10.1016/S0165-5728(97)00151-3, PII S0165572897001513
    • Yong T, Zheng MQ, Linthicum DS. Nicotine induces leukocyte rolling and adhesion in the cerebral microcirculation of the mouse. J Neuroimmunol. 1997; 80: 158-64. (Pubitemid 28015336)
    • (1997) Journal of Neuroimmunology , vol.80 , Issue.1-2 , pp. 158-164
    • Yong, T.1    Zheng, M.Q.2    Linthicum, D.S.3
  • 17
    • 0018847124 scopus 로고
    • The vascular system of the cerebral cortex
    • Bär T. The vascular system of the cerebral cortex. Adv Anat Embryol Cell Biol. 1980; 59: 1-62.
    • (1980) Adv Anat Embryol Cell Biol , vol.59 , pp. 1-62
    • Bär, T.1
  • 18
    • 0035153262 scopus 로고    scopus 로고
    • Involvement of the Choroid Plexus in Central Nervous System Inflammation
    • DOI 10.1002/1097-0029(20010101)52:1<112::AID-JEMT13>3.0.CO;2-5
    • Engelhardt B, Wolburg-Buchholz K, Wolburg H. Involvement of the choroid plexus in central nervous system inflammation. Microsc Res Tech. 2001; 52: 112-29. (Pubitemid 32065034)
    • (2001) Microscopy Research and Technique , vol.52 , Issue.1 , pp. 112-129
    • Engelhardt, B.1    Wolburg-Buchholz, K.2    Wolburg, H.3
  • 20
    • 65249175159 scopus 로고    scopus 로고
    • C-C chemokine receptor 6- regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    • Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, et al. C-C chemokine receptor 6- regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009; 10: 514-23.
    • (2009) Nat Immunol , vol.10 , pp. 514-523
    • Reboldi, A.1    Coisne, C.2    Baumjohann, D.3    Benvenuto, F.4    Bottinelli, D.5    Lira, S.6
  • 23
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: The leukocyte adhesion cascade updated
    • DOI 10.1038/nri2156, PII NRI2156
    • Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007; 7: 678-89. (Pubitemid 47327397)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.9 , pp. 678-689
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 24
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol. 2005; 23: 683-747. (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 25
    • 70249125817 scopus 로고    scopus 로고
    • Multiple sclerosis: Human model for EAE?
    • Hohlfeld R. Multiple sclerosis: human model for EAE? Eur J Immunol. 2009; 39: 2036-9.
    • (2009) Eur J Immunol , vol.39 , pp. 2036-2039
    • Hohlfeld, R.1
  • 26
    • 0033978459 scopus 로고    scopus 로고
    • Animal models for autoimmune demyelinating disorders of the nervous system
    • DOI 10.1016/S1357-4310(99)01639-1, PII S1357431099016391
    • Gold R, Hartung HP, Toyka KV. Animal models for autoimmune demyelinating disorders of the nervous system. Mol Med Today. 2000; 6: 88-91. (Pubitemid 30070671)
    • (2000) Molecular Medicine Today , vol.6 , Issue.2 , pp. 88-91
    • Gold, R.1    Hartung, H.-P.2    Toyka, K.V.3
  • 27
    • 0019465142 scopus 로고
    • The rapid isolation of clonable antigen-specific T cell lines capable of mediating autoimmune encephalomyelitis
    • Ben-Nun A, Wekerle H, Cohen I. The rapid isolation of clonable antigen-specific T cell lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol. 1981; 11: 195.
    • (1981) Eur J Immunol , vol.11 , pp. 195
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.3
  • 28
    • 0025717402 scopus 로고
    • Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation
    • Hickey WF. Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation. Brain Pathol. 1991; 1: 97-105.
    • (1991) Brain Pathol , vol.1 , pp. 97-105
    • Hickey, W.F.1
  • 30
    • 0032908722 scopus 로고    scopus 로고
    • Leukocyte traffic in the central nervous system: The participants and their roles
    • DOI 10.1006/smim.1999.0168
    • Hickey WF. Leukocyte traffic in the central nervous system: the participants and their roles. Semin Immunol. 1999; 11: 125-37. (Pubitemid 29201818)
    • (1999) Seminars in Immunology , vol.11 , Issue.2 , pp. 125-137
    • Hickey, W.F.1
  • 31
    • 85047682713 scopus 로고    scopus 로고
    • Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
    • DOI 10.1172/JCI200112440
    • Vajkoczy P, Laschinger M, Engelhardt B. Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest. 2001; 108: 557-65. (Pubitemid 32777735)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.4 , pp. 557-565
    • Vajkoczy, P.1    Laschinger, M.2    Engelhardt, B.3
  • 32
    • 0036914616 scopus 로고    scopus 로고
    • Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo
    • DOI 10.1002/1521-4141(200212)32:12<3598::AID-IMMU3598>3.0.CO;2-6
    • Laschinger M, Vajkoczy P, Engelhardt B. Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo. Eur J Immunol. 2002; 32: 3598-606. (Pubitemid 36024396)
    • (2002) European Journal of Immunology , vol.32 , Issue.12 , pp. 3598-3606
    • Laschinger, M.1    Vjakoczy, P.2    Engelhardt, B.3
  • 33
    • 0242476427 scopus 로고    scopus 로고
    • Requirements for passage of T lymphocytes across non-inflamed retinal microvessels
    • DOI 10.1016/S0165-5728(03)00258-3, PII S0165572803002583
    • Xu H, Manivannan A, Liversidge J, Sharp PF, Forrester JV, Crane IJ. Requirements for passage of T lymphocytes across non-inflamed retinal microvessels. J Neuroimmunol. 2003; 142: 47-57. (Pubitemid 38368587)
    • (2003) Journal of Neuroimmunology , vol.142 , Issue.1-2 , pp. 47-57
    • Xu, H.1    Manivannan, A.2    Liversidge, J.3    Sharp, P.F.4    Forrester, J.V.5    Crane, I.J.6
  • 34
    • 0034123924 scopus 로고    scopus 로고
    • Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment
    • Carrithers MD, Visintin I, Kang SJ, Janeway CA Jr. Differential adhesion molecule requirements for immune surveillance and inflammatory recruiment. Brain. 2000; 123: 1092-101. (Pubitemid 30312102)
    • (2000) Brain , vol.123 , Issue.6 , pp. 1092-1101
    • Carrithers, M.D.1    Visintin, I.2    Kang, S.J.3    Janeway Jr., C.A.4
  • 35
    • 0027209421 scopus 로고
    • Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
    • Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 1993; 74: 541-54. (Pubitemid 23244619)
    • (1993) Cell , vol.74 , Issue.3 , pp. 541-554
    • Mayadas, T.N.1    Johnson, R.C.2    Rayburn, H.3    Hynes, R.O.4    Wagner, D.D.5
  • 36
    • 40049095589 scopus 로고    scopus 로고
    • E- and P-Selectin Are Not Required for the Development of Experimental Autoimmune Encephalomyelitis in C57BL/6 and SJL Mice
    • Doring A, Wild M, Vestweber D, Deutsch U, Engelhardt B. E- and P-Selectin Are Not Required for the Development of Experimental Autoimmune Encephalomyelitis in C57BL/6 and SJL Mice. J Immunol. 2007; 179: 8470-9.
    • (2007) J Immunol , vol.179 , pp. 8470-8479
    • Doring, A.1    Wild, M.2    Vestweber, D.3    Deutsch, U.4    Engelhardt, B.5
  • 37
    • 0030726193 scopus 로고    scopus 로고
    • E- And P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis
    • Engelhardt B, Vestweber D, Hallmann R, Schulz M. E- and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis. Blood. 1997; 90: 4459-72. (Pubitemid 27508451)
    • (1997) Blood , vol.90 , Issue.11 , pp. 4459-4472
    • Engelhardt, B.1    Vestweber, D.2    Hallmann, R.3    Schulz, M.4
  • 38
    • 33646468932 scopus 로고    scopus 로고
    • Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis
    • Kerfoot SM, Norman MU, Lapointe BM, Bonder CS, Zbytnuik L, Kubes P. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J Immunol. 2006; 176: 6225-34.
    • (2006) J Immunol , vol.176 , pp. 6225-6234
    • Kerfoot, S.M.1    Norman, M.U.2    Lapointe, B.M.3    Bonder, C.S.4    Zbytnuik, L.5    Kubes, P.6
  • 39
    • 70449106029 scopus 로고    scopus 로고
    • Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
    • Bartholomaus I, Kawakami N, Odoardi F, Schlager C, Miljkovic D, Ellwart JW, et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature. 2009; 462: 94-8.
    • (2009) Nature , vol.462 , pp. 94-98
    • Bartholomaus, I.1    Kawakami, N.2    Odoardi, F.3    Schlager, C.4    Miljkovic, D.5    Ellwart, J.W.6
  • 40
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • DOI 10.1038/nri1130
    • Ransohoff RM, Kivisakk P, Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol. 2003; 3: 569-81. (Pubitemid 37328676)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.7 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 41
    • 0029952623 scopus 로고    scopus 로고
    • ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro
    • Steffen BJ, Breier G, Butcher EC, Schulz M, Engelhardt B. ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am J Pathol. 1996; 148: 1819-38.
    • (1996) Am J Pathol , vol.148 , pp. 1819-1838
    • Steffen, B.J.1    Breier, G.2    Butcher, E.C.3    Schulz, M.4    Engelhardt, B.5
  • 42
    • 0037867698 scopus 로고    scopus 로고
    • Ultrastructural localization of adhesion molecules in the healthy and inflamed choroid plexus of the mouse
    • DOI 10.1007/s004410051287
    • Wolburg K, Gerhardt H, Schulz M, Wolburg H, Engelhardt B. Ultrastructural localization of adhesion molecules in the healthy and inflamed choroid plexus of the mouse. Cell Tissue Res. 1999; 296: 259-69. (Pubitemid 29219178)
    • (1999) Cell and Tissue Research , vol.296 , Issue.2 , pp. 259-269
    • Wolburg, K.1    Gerhardt, H.2    Schulz, M.3    Wolburg, H.4    Engelhardt, B.5
  • 43
    • 67649525179 scopus 로고    scopus 로고
    • CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues
    • Villares R, Cadenas V, Lozano M, Almonacid L, Zaballos A, Martinez AC, et al. CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues. Eur J Immunol. 2009; 39: 1671-81.
    • (2009) Eur J Immunol , vol.39 , pp. 1671-1681
    • Villares, R.1    Cadenas, V.2    Lozano, M.3    Almonacid, L.4    Zaballos, A.5    Martinez, A.C.6
  • 44
    • 64849093508 scopus 로고    scopus 로고
    • Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response
    • Liston A, Kohler RE, Townley S, Haylock-Jacobs S, Comerford I, Caon AC, et al. Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response. J Immunol. 2009; 182: 3121-30.
    • (2009) J Immunol , vol.182 , pp. 3121-3130
    • Liston, A.1    Kohler, R.E.2    Townley, S.3    Haylock-Jacobs, S.4    Comerford, I.5    Caon, A.C.6
  • 45
    • 68049115475 scopus 로고    scopus 로고
    • Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis
    • Elhofy A, Depaolo RW, Lira SA, Lukacs NW, Karpus WJ. Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis. J Neuroimmunol. 2009; 213: 91-9.
    • (2009) J Neuroimmunol , vol.213 , pp. 91-99
    • Elhofy, A.1    Depaolo, R.W.2    Lira, S.A.3    Lukacs, N.W.4    Karpus, W.J.5
  • 46
    • 0035005143 scopus 로고    scopus 로고
    • Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
    • DOI 10.1016/S1074-7613(01)00143-1
    • Flugel A, Berkowicz T, Ritter T, Labeur M, Jenne DE, Li Z, et al. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis. Immunity. 2001; 14: 547-60. (Pubitemid 32520866)
    • (2001) Immunity , vol.14 , Issue.5 , pp. 547-560
    • Flugel, A.1    Berkowicz, T.2    Ritter, T.3    Labeur, M.4    Jenne, D.E.5    Li, Z.6    Ellwart, J.W.7    Willem, M.8    Lassmann, H.9    Wekerle, H.10
  • 48
    • 0037100456 scopus 로고    scopus 로고
    • 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis
    • Kerfoot S, Kubes P. Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis. J Immunol. 2002; 169: 1000-6. (Pubitemid 34753459)
    • (2002) Journal of Immunology , vol.169 , Issue.2 , pp. 1000-1006
    • Kerfoot, S.M.1    Kubes, P.2
  • 50
    • 23044481655 scopus 로고    scopus 로고
    • PSGL-1 is not required for development of experimental autoimmune encephalomyelitis
    • DOI 10.1016/j.jneuroim.2005.06.001, PII S0165572805002158
    • Osmers I, Bullard DC, Barnum SR. PSGL-1 is not required for development of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005; 166: 193-6. (Pubitemid 41074669)
    • (2005) Journal of Neuroimmunology , vol.166 , Issue.1-2 , pp. 193-196
    • Osmers, I.1    Bullard, D.C.2    Barnum, S.R.3
  • 51
    • 23244449103 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice
    • Engelhardt B, Kempe B, Merfeld-Clauss S, Laschinger M, Furie B, Wild MK, et al. P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice. J Immunol. 2005; 175: 1267-75. (Pubitemid 41095016)
    • (2005) Journal of Immunology , vol.175 , Issue.2 , pp. 1267-1275
    • Engelhardt, B.1    Kempe, B.2    Merfeld-Clauss, S.3    Laschinger, M.4    Furie, B.5    Wild, M.K.6    Vestweber, D.7
  • 52
    • 33644956900 scopus 로고    scopus 로고
    • IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination
    • Deshpande P, King IL, Segal BM. IL-12 driven upregulation of P-selectin ligand on myelin-specific T cells is a critical step in an animal model of autoimmune demyelination. J Neuroimmunol. 2006; 173: 35-44.
    • (2006) J Neuroimmunol , vol.173 , pp. 35-44
    • Deshpande, P.1    King, I.L.2    Segal, B.M.3
  • 53
    • 70350721913 scopus 로고    scopus 로고
    • Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line
    • Bahbouhi B, Berthelot L, Pettre S, Michel L, Wiertlewski S, Weksler B, et al. Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line. J Leukoc Biol. 2009; 86: 1049-63.
    • (2009) J Leukoc Biol , vol.86 , pp. 1049-1063
    • Bahbouhi, B.1    Berthelot, L.2    Pettre, S.3    Michel, L.4    Wiertlewski, S.5    Weksler, B.6
  • 54
    • 70350718157 scopus 로고    scopus 로고
    • Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis
    • Coisne C, Mao W, Engelhardt B. Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. J Immunol. 2009; 182: 5909-13.
    • (2009) J Immunol , vol.182 , pp. 5909-5913
    • Coisne, C.1    Mao, W.2    Engelhardt, B.3
  • 55
    • 60549086393 scopus 로고    scopus 로고
    • {beta}1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
    • Bauer M, Brakebusch C, Coisne C, Sixt M, Wekerle H, Engelhardt B, et al. {beta}1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A. 2009; 106: 1920-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1920-1925
    • Bauer, M.1    Brakebusch, C.2    Coisne, C.3    Sixt, M.4    Wekerle, H.5    Engelhardt, B.6
  • 56
    • 37149030961 scopus 로고    scopus 로고
    • 4-integrins in multiple sclerosis
    • DOI 10.1159/000109933
    • Engelhardt B, Kappos L. Natalizumab: targeting alpha4-integrins in multiple sclerosis. Neurodegener Dis. 2008; 5: 16-22. (Pubitemid 350261811)
    • (2008) Neurodegenerative Diseases , vol.5 , Issue.1 , pp. 16-22
    • Engelhardt, B.1    Kappos, L.2
  • 57
    • 30344437881 scopus 로고    scopus 로고
    • The expression and function of chemokines involved in CNS inflammation
    • DOI 10.1016/j.tips.2005.11.002, PII S0165614705003044
    • Ubogu EE, Cossoy MB, Ransohoff RM. The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol Sci. 2006; 27: 48-55. (Pubitemid 43063124)
    • (2006) Trends in Pharmacological Sciences , vol.27 , Issue.1 , pp. 48-55
    • Ubogu, E.E.1    Cossoy, M.B.2    Ransohoff, R.M.3
  • 58
    • 34547281274 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors: Multipurpose players in neuroinflammation
    • Ransohoff RM, Liu L, Cardona AE. Chemokines and chemokine receptors: multipurpose players in neuroinflammation. Int Rev Neurobiol. 2007; 82: 187-204.
    • (2007) Int Rev Neurobiol , vol.82 , pp. 187-204
    • Ransohoff, R.M.1    Liu, L.2    Cardona, A.E.3
  • 59
    • 0036687120 scopus 로고    scopus 로고
    • Functional expression of the lymphoid chemokines CCL19 (ECL) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis
    • DOI 10.1002/1521-4141(200208)32:8<2133::AID-IMMU2133>3.0.CO;2-W
    • Alt C, Laschinger M, Engelhardt B. Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur J Immunol. 2002; 32: 2133-44. (Pubitemid 34965876)
    • (2002) European Journal of Immunology , vol.32 , Issue.8 , pp. 2133-2144
    • Alt, C.1    Laschinger, M.2    Engelhardt, B.3
  • 60
    • 0037248807 scopus 로고    scopus 로고
    • Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: Implications for the maintenance of chronic neuroinflammation
    • Columba-Cabezas S, Serafini B, Ambrosini E, Aloisi F. Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: implications for the maintenance of chronic neuroinflammation. Brain Pathol. 2003; 13: 38-51. (Pubitemid 36133791)
    • (2003) Brain Pathology , vol.13 , Issue.1 , pp. 38-51
    • Columba-Cabezas, S.1    Serafini, B.2    Ambrosini, E.3    Aloisi, F.4
  • 63
    • 33751557620 scopus 로고    scopus 로고
    • CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis
    • McCandless EE, Wang Q, Woerner BM, Harper JM, Klein RS. CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis. J Immunol. 2006; 177: 8053-64. (Pubitemid 44846323)
    • (2006) Journal of Immunology , vol.177 , Issue.11 , pp. 8053-8064
    • McCandless, E.E.1    Wang, Q.2    Mark, W.B.3    Harper, J.M.4    Klein, R.S.5
  • 64
    • 0035576282 scopus 로고    scopus 로고
    • The chemokine receptor CCR2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels
    • Dzenko KA, Andjelkovic AV, Kuziel WA, Pachter JS. The chemokine receptor CCR2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels. J Neurosci. 2001; 21: 9214-23. (Pubitemid 33096865)
    • (2001) Journal of Neuroscience , vol.21 , Issue.23 , pp. 9214-9223
    • Dzenko, K.A.1    Andjelkovic, A.V.2    Kuziel, W.A.3    Pachter, J.S.4
  • 65
    • 39749175539 scopus 로고    scopus 로고
    • Transcellular transport of CCL2 across brain microvascular endothelial cells
    • DOI 10.1111/j.1471-4159.2007.05056.x
    • Ge S, Song L, Serwanski DR, Kuziel WA, Pachter JS. Transcellular transport of CCL2 across brain microvascular endothelial cells. J Neurochem. 2008; 104: 1219-32. (Pubitemid 351293336)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.5 , pp. 1219-1232
    • Ge, S.1    Song, L.2    Serwanski, D.R.3    Kuziel, W.A.4    Pachter, J.S.5
  • 66
    • 0034596949 scopus 로고    scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    • Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med. 2000; 192: 1075-80.
    • (2000) J Exp Med , vol.192 , pp. 1075-1080
    • Izikson, L.1    Klein, R.S.2    Charo, I.F.3    Weiner, H.L.4    Luster, A.D.5
  • 67
    • 0033807680 scopus 로고    scopus 로고
    • CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
    • Fife BT, Huffnagle GB, Kuziel WA, Karpus WJ. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J Exp Med. 2000; 192: 899-905.
    • (2000) J Exp Med , vol.192 , pp. 899-905
    • Fife, B.T.1    Huffnagle, G.B.2    Kuziel, W.A.3    Karpus, W.J.4
  • 68
    • 0025127157 scopus 로고
    • Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis
    • Cross AH, Cannella B, Brosnan CF, Raine CS. Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab Invest. 1990; 63: 162-70.
    • (1990) Lab Invest , vol.63 , pp. 162-170
    • Cross, A.H.1    Cannella, B.2    Brosnan, C.F.3    Raine, C.S.4
  • 69
    • 0028283232 scopus 로고
    • Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    • Steffen BJ, Butcher EC, Engelhardt B. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am J Pathol. 1994; 145: 189-201. (Pubitemid 24217497)
    • (1994) American Journal of Pathology , vol.145 , Issue.1 , pp. 189-201
    • Steffen, B.J.1    Butcher, E.C.2    Engelhardt, B.3
  • 70
    • 0027529932 scopus 로고
    • Surface expression of alpha4 integrin by CD4 T cells is required for their entry into brain parenchyma
    • DOI 10.1084/jem.177.1.57
    • Baron JL, Madri JA, Ruddle NH, Hashim G, Janeway CA Jr. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med. 1993; 177: 57-68. (Pubitemid 23008085)
    • (1993) Journal of Experimental Medicine , vol.177 , Issue.1 , pp. 57-68
    • Baron, J.L.1    Madri, J.A.2    Ruddle, N.H.3    Hashim, G.4    Janeway Jr., C.A.5
  • 71
    • 84942872259 scopus 로고    scopus 로고
    • Molecular mechanisms involved in lymphocyte interaction with blood-spinal cord barrier endothelium in vivo
    • Sharma HS, Westman J, eds. London: Academic Press
    • Engelhardt B, Laschinger M, Vajkoczy P. Molecular mechanisms involved in lymphocyte interaction with blood-spinal cord barrier endothelium in vivo. In The Blood-Spinal Cord and Brain Barriers in Health and Disease. Sharma HS, Westman J, eds. London: Academic Press; 2004: 19-31.
    • (2004) The Blood-Spinal Cord and Brain Barriers in Health and Disease , pp. 19-31
    • Engelhardt, B.1    Laschinger, M.2    Vajkoczy, P.3
  • 72
    • 0032535368 scopus 로고    scopus 로고
    • The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin
    • Engelhardt B, Laschinger M, Schulz M, Samulowitz U, Vestweber D, Hoch G. The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin. J Clin Invest. 1998; 102: 2096-105. (Pubitemid 29018816)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.12 , pp. 2096-2105
    • Engelhardt, B.1    Laschinger, M.2    Schulz, M.3    Samulowitz, U.4    Vestweber, D.5    Hoch, G.6
  • 74
    • 0025301596 scopus 로고
    • Intercellular Adheison Molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system
    • Sobel RA, Mitchell ME, Fondren G. Intercellular Adheison Molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol. 1990; 136: 1309-16.
    • (1990) Am J Pathol , vol.136 , pp. 1309-1316
    • Sobel, R.A.1    Mitchell, M.E.2    Fondren, G.3
  • 76
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • Cannella B, Raine CS. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol. 1995; 37: 424-35.
    • (1995) Ann Neurol , vol.37 , pp. 424-435
    • Cannella, B.1    Raine, C.S.2
  • 78
    • 67349218765 scopus 로고    scopus 로고
    • Alpha4 Integrin? FN-CS1 mediated leukocyte adhesion to brain microvascular endothelial cells under flow conditions
    • Man S, Tucky B, Bagheri N, Li X, Kochar R, Ransohoff RM. Alpha4 Integrin ? FN-CS1 mediated leukocyte adhesion to brain microvascular endothelial cells under flow conditions. J Neuroimmunol. 2009; 210: 92-9.
    • (2009) J Neuroimmunol , vol.210 , pp. 92-99
    • Man, S.1    Tucky, B.2    Bagheri, N.3    Li, X.4    Kochar, R.5    Ransohoff, R.M.6
  • 79
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature. 1992; 356: 63-6.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5    Karin, N.6
  • 80
    • 0033622322 scopus 로고    scopus 로고
    • Interaction of alpha4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro
    • Laschinger M, Engelhardt B. Interaction of alpha4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro. J Neuroimmunol. 2000; 102: 32-43.
    • (2000) J Neuroimmunol , vol.102 , pp. 32-43
    • Laschinger, M.1    Engelhardt, B.2
  • 82
    • 0028791506 scopus 로고
    • Lymphocyte adhesion and transendothelial migration in the central nervous system: The role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off
    • Greenwood J, Wang Y, Calder VL. Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off. Immunology. 1995; 86: 408-15.
    • (1995) Immunology , vol.86 , pp. 408-415
    • Greenwood, J.1    Wang, Y.2    Calder, V.L.3
  • 84
    • 0028987311 scopus 로고
    • A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis
    • Kent SJ, Karlik SJ, Cannon C, Hines DK, Yednock TA, Fritz LC, et al. A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis. J Neuroimmunol. 1995; 58: 1-10.
    • (1995) J Neuroimmunol , vol.58 , pp. 1-10
    • Kent, S.J.1    Karlik, S.J.2    Cannon, C.3    Hines, D.K.4    Yednock, T.A.5    Fritz, L.C.6
  • 85
    • 0029834867 scopus 로고    scopus 로고
    • Evidence for a prolonged role of a4 integrin throughout active experimental allergic encephalomyelitis
    • Keszthelyi E, Karlik S, Hyduk S, Rice GPA, Gordon G, Yednock T, et al. Evidence for a prolonged role of a4 integrin throughout active experimental allergic encephalomyelitis. Neurology. 1996; 47: 1053-9.
    • (1996) Neurology , vol.47 , pp. 1053-1059
    • Keszthelyi, E.1    Karlik, S.2    Hyduk, S.3    Rice, G.P.A.4    Gordon, G.5    Yednock, T.6
  • 86
    • 0026574125 scopus 로고
    • Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering
    • Ruegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ. Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol. 1992; 117: 179-89.
    • (1992) J Cell Biol , vol.117 , pp. 179-189
    • Ruegg, C.1    Postigo, A.A.2    Sikorski, E.E.3    Butcher, E.C.4    Pytela, R.5    Erle, D.J.6
  • 88
    • 33846253253 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis
    • Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis. J Immunol. 2007; 178: 851-7. (Pubitemid 46095157)
    • (2007) Journal of Immunology , vol.178 , Issue.2 , pp. 851-857
    • Bullard, D.C.1    Hu, X.2    Schoeb, T.R.3    Collins, R.G.4    Beaudet, A.L.5    Barnum, S.R.6
  • 89
    • 0027448726 scopus 로고
    • Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis
    • Cannella B, Cross AH, Raine CS. Anti-adhesion molecule therapy in experimental autoimmune encephalomyelitis. J Neuroimmunol. 1993; 46: 43-55.
    • (1993) J Neuroimmunol , vol.46 , pp. 43-55
    • Cannella, B.1    Cross, A.H.2    Raine, C.S.3
  • 90
    • 30044447736 scopus 로고    scopus 로고
    • Immune cell migration in inflammation: Present and future therapeutic targets
    • DOI 10.1038/ni1275, PII N1275
    • Luster AD, Alon R, von Andrian UH. Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol. 2005; 6: 1182-90. (Pubitemid 43045626)
    • (2005) Nature Immunology , vol.6 , Issue.12 , pp. 1182-1190
    • Luster, A.D.1    Alon, R.2    Von, A.U.H.3
  • 91
    • 61949089067 scopus 로고    scopus 로고
    • Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin
    • Shulman Z, Shinder V, Klein E, Grabovsky V, Yeger O, Geron E, et al. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity. 2009; 30: 384-96.
    • (2009) Immunity , vol.30 , pp. 384-396
    • Shulman, Z.1    Shinder, V.2    Klein, E.3    Grabovsky, V.4    Yeger, O.5    Geron, E.6
  • 92
    • 38049063929 scopus 로고    scopus 로고
    • Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell
    • Stanley P, Smith A, McDowall A, Nicol A, Zicha D, Hogg N. Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell. EMBO J. 2008; 27: 62-75.
    • (2008) EMBO J , vol.27 , pp. 62-75
    • Stanley, P.1    Smith, A.2    McDowall, A.3    Nicol, A.4    Zicha, D.5    Hogg, N.6
  • 93
    • 0031684385 scopus 로고    scopus 로고
    • T cell interaction with ICAM-1-deficient endothelium in vitro: Essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells
    • DOI 10.1002/(SICI)1521-4141(199810)28:10<3086::AID-IMMU3086>3.0. CO;2-Z
    • Reiss Y, Hoch G, Deutsch U, Engelhardt B. T cell interaction with ICAM-1-deficient endothelium in vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells. Eur J Immunol. 1998; 28: 3086-99. (Pubitemid 28470254)
    • (1998) European Journal of Immunology , vol.28 , Issue.10 , pp. 3086-3099
    • Reiss, Y.1    Hoch, G.2    Deutsch, U.3    Engelhardt, B.4
  • 94
    • 0242494863 scopus 로고    scopus 로고
    • T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: The cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells
    • DOI 10.1182/blood-2003-02-0358
    • Lyck R, Reiss Y, Gerwin N, Greenwood J, Adamson P, Engelhardt B. T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. Blood. 2003; 102: 3675-83. (Pubitemid 37409388)
    • (2003) Blood , vol.102 , Issue.10 , pp. 3675-3683
    • Lyck, R.1    Reiss, Y.2    Gerwin, N.3    Greenwood, J.4    Adamson, P.5    Engelhardt, B.6
  • 95
    • 0043136667 scopus 로고    scopus 로고
    • Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration
    • Greenwood J, Amos CL, Walters CE, Couraud PO, Lyck R, Engelhardt B, et al. Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. J Immunol. 2003; 171: 2099-108. (Pubitemid 36966494)
    • (2003) Journal of Immunology , vol.171 , Issue.4 , pp. 2099-2108
    • Greenwood, J.1    Amos, C.L.2    Walters, C.E.3    Couraud, P.-O.4    Lyck, R.5    Engelhardt, B.6    Adamson, P.7
  • 96
    • 50849131655 scopus 로고    scopus 로고
    • Trans-cellular migration: Cellcell contacts get intimate
    • Carman CV, Springer TA. Trans-cellular migration: cellcell contacts get intimate. Curr Opin Cell Biol. 2008; 20: 533-40.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 533-540
    • Carman, C.V.1    Springer, T.A.2
  • 97
    • 38349176343 scopus 로고    scopus 로고
    • Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system
    • Cayrol R, Wosik K, Berard JL, Dodelet-Devillers A, Ifergan I, Kebir H, et al. Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nat Immunol. 2008; 9: 137-45.
    • (2008) Nat Immunol , vol.9 , pp. 137-145
    • Cayrol, R.1    Wosik, K.2    Berard, J.L.3    Dodelet-Devillers, A.4    Ifergan, I.5    Kebir, H.6
  • 98
    • 0026345883 scopus 로고
    • Central nervous system endothelial cell-polymorphonuclear cell interactions during autoimmune demyelination
    • Cross AH, Raine CS. Central nervous system endothelial cell-polymorphonuclear cell interactions during autoimmune demyelination. Am J Pathol. 1991; 139: 1401-9.
    • (1991) Am J Pathol , vol.139 , pp. 1401-1409
    • Cross, A.H.1    Raine, C.S.2
  • 99
    • 9244250315 scopus 로고    scopus 로고
    • Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?
    • Engelhardt B, Wolburg H. Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house? Eur J Immunol. 2004; 34: 2955-63.
    • (2004) Eur J Immunol , vol.34 , pp. 2955-2963
    • Engelhardt, B.1    Wolburg, H.2
  • 100
    • 16344368162 scopus 로고    scopus 로고
    • Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact
    • DOI 10.1007/s00401-004-0928-x
    • Wolburg H, Wolburg-Buchholz K, Engelhardt B. Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta Neuropathol (Berl). 2005; 109: 181-90. (Pubitemid 40468387)
    • (2005) Acta Neuropathologica , vol.109 , Issue.2 , pp. 181-190
    • Wolburg, H.1    Wolburg-Buchholz, K.2    Engelhardt, B.3
  • 102
    • 67349162632 scopus 로고    scopus 로고
    • Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain
    • Wu C, Ivars F, Anderson P, Hallmann R, Vestweber D, Nilsson P, et al. Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med. 2009; 15: 519-27.
    • (2009) Nat Med , vol.15 , pp. 519-527
    • Wu, C.1    Ivars, F.2    Anderson, P.3    Hallmann, R.4    Vestweber, D.5    Nilsson, P.6
  • 103
    • 33645869560 scopus 로고    scopus 로고
    • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
    • Agrawal S, Anderson P, Durbeej M, van Rooijen N, Ivars F, Opdenakker G, et al. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J Exp Med. 2006; 203: 1007-19.
    • (2006) J Exp Med , vol.203 , pp. 1007-1019
    • Agrawal, S.1    Anderson, P.2    Durbeej, M.3    Van Rooijen, N.4    Ivars, F.5    Opdenakker, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.