CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: A critical role for P-selectin glycoprotein ligand-1

Blood

Volumn 101, Issue 12, 2003, Pages 4775-4782

  Battistini, Luca ^b   Piccio, Laura ^b   Rossi, Barbara ^b   Bach, Simona ^b   Galgani, Simona ^b   Gasperini, Claudio ^b   Ottoboni, Linda ^b   Ciabini, Donatella ^b   Caramia, Maria D ^b   Bernardi, Giorgio ^b   Laudanna, Carlo ^b   Scarpini, Elio ^b   McEver, Rodger P ^b   Butcher, Eugene C ^b   Borsellino, Giovanna ^b   Constantin, Gabriela ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GLYCOPROTEIN; LIGAND; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; BRAIN BLOOD VESSEL; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; IN VITRO STUDY; INFLAMMATION; LYMPHOCYTE; MALE; MEMORY; MULTIPLE SCLEROSIS; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; VENULE;

EID: 10744233874     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-10-3309     Document Type: Article

References (46)

1. Noseworthy JH. Progress in determining the causes and treatment of multiple sclerosis. Nature. 1999;399:A40-A47.
2. Steinman L. Myelin-specific CD8 T cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis. J Exp Med. 2001;194: F27-F30.
3. Traugott U, Reinherz E, Raine CS. Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science. 1983;219:308-310.
4. Hauser SL. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis. Ann Neurol. 1986;19:578-587.
5. Sriram S, Solomon D, Rouse RV, Steinman L. Identification of T cell subsets and B lymphocytes in mouse brain EAE lesions. J Immunol. 1982;129:1649-1654.
6. Sun D, Whitaker JN, Huang Z, et al. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol. 2001;166:7579-7587.
7. Huseby ES, Liggitt D, Brabb T, Schnabel B, Ohlen C, Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med. 2001;194:669-676.
8. Babbe H, Roers A, Waisman A, et al. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med. 2000;192:393-404.
9. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell. 1991;67:1033-1036.
10. Springer TA, Traffic signals for lymphoid recirculation and leukocyte emigration: the multi-step paradigm. Cell. 1994;76:301-314.
11. Butcher EC, Williams M, Youngman K, Rott L, Briskin M. Lymphocyte trafficking and regional immunity. Adv Immnol. 1999;72:209-253.
12. Piccio L, Rossi B, Scarpini E, Laudanna C, et al. Molecular mechanisms involved in lymphocyte recruitment in brain microcirculation: critical roles for PSGL-1 and trimeric Gαi linked receptors. J Immunol. 2002;168:1940-1949.
13. Huo Y, Hafezi-Moghadam A, Ley K. Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions. Circ Res. 2000;87:153-159.
14. Ramos CL, Huo Y, Jung U, et al. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res. 1999;84:1237-1244.
15. Norman KE, Katopodis AG, Thoma G, et al. P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo. Blood. 2000;96:3585-3591.
16. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol, 1983;13:227-231.
17. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50:121-127.
18. Moore KL, Patel KD, Bruehl RE, et al. P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. J Cell Biol. 1995;128:661-671.
19. Constantin G, Majeed M, Giagulli C, et al. Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity. 2000;16:759-769.
20. Comi G, Filippi M, Barkhof F, et al. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet. 2001;357:1576-1582.
21. Paty DW, Arnold DL. The lesions of multiple sclerosis. N Engl J Med. 2002;346:199-200.
22. Okada Y, Copeland BR, Mori E, Tung MM, Thomas WS, del Zoppo GJ. P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke. 1994;25:202-211.
23. Carvalho Tavares J, Hickey MJ, Hutchison J, Michaud J, Sutcliffe IT, Kubes P. A role for platelets and endothelial selectins in tumor necrosis fador-α-induced leukocyte recruitment in the brain microvasculature. Circ Res. 2000;87:1141-1148.
24. Stanimirovic DB, Wong J, Shapiro A, Durkin JP, Increase in surface expression of ICAM-1, VCAM-1 and E-selectin in human cerebromicrovascular endothelial cells subjected to ischemia-like insults. Acta Neurochir Suppl. 1997;70:12-16.
25. Love S, Barbe R. Expression of P-selectin and intercellular adhesion molecule-1 in brain after focal infarction or cardiac arrest. Neuropathol Appl Neurobiol. 2001;27:465-473.
26. Carrithers MD, Visintin I, Kang SK, Janeway CA Jr. Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment. Brain. 2000;123:1092-1101.
27. Lee SJ, Benveniste EN. Adhesion molecule expression and regulation on cells of the central nervous system. J Neuroimmunol. 1999;98:77-92.
28. Johnston B, Walter UM, Issekutz AC, Issekutz TB, Anderson DC, Kubes P. Differential roles of selectins and the α4-integrin in acute, subacute, and chronic leukocyte recruitment in vivo. J Immunol. 1997;159:4514-4527.
29. Grabovsky V, Feigelson S, Chen C, et al. Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions. J Exp Med. 2000;192:495-505.
30. Bradley LM, Duncan DD, Tonkonogy S, Swain SL, Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB-helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma. J Exp Med. 1991;174:547-559.
31. Bradley LM, Atkins GG, Swain SL. Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor. J Immunol. 1992;148:324-331.
32. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712.
33. Weninger W, Crowley MA, Manjunath N, von Andrian UH. Migratory properties of naive, effector, and memory CD8(+) T cells. J Exp Med. 2001;194:953-966.
34. Moore KL, Thompson LF. P-selectin (CD62) binds to subpopulations of human memory T lymphocytes and natural killer cells. Biochem Biophys Res Comm. 1992;186:173-181.
35. Vachino G, Chang XJ, Veldman GM, et al. P-selectin glycoprotein ligand-1 is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells. J Biol Chem. 1995;270:21966-21974.
36. McEver RP, Cummings RD. Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest. 1997;100:485-491.
37. Kerfoot SM, Kubes P. Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis. J Immunol. 2002;169:1000-1006.
38. Borges E, Eytner R, Moll T, et al. The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum. Blood. 1997;90:1934-1942.
39. Borges E, Eytner R, Moll T, et al. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J Exp Med. 1997;185:573-578.
40. Kumar A, Villani MP, Patel UK, Keith JC Jr, Schaub RG. Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model. Circulation. 1999;9:1363-1369.
41. Scalia R, Armstead VE, Minchenko AG, Lefer AM. Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion. J Exp Med. 1999;89:931-938.
42. Vizler C, Bercovici N, Comet A, Cambouns A, Liblau RS. Role of autoreactive CD8+ T cells in organ-specific autoimmune diseases: insight from transgenic mouse models. Immunol Rev. 1999;169:81-92.
43. Hauser SL. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann Neurol. 1986;19:578-587.
44. Grenier Y, Ruijs TC, Robitaille Y, Olivier A, Antel JP. Immunohistochemical studies of adult human glial cells. J Neuroimmunol. 1989;21:103-115.
45. Jurewicz A, Biddison WE, Antel JP. MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes. J Immunol. 1998;160:3056-3059.
46. Soldan SS, Jacobson S. Viruses in etiology and pathogenesis of multiple sclerosis. In: Buchmeier M, Campbell IL, eds. Advances in Virus Research (Neurovirology). San Diego, CA: Academic Press; 2001:517-557.