Chemoattractants and their receptors in homeostasis and inflammation

Current Opinion in Immunology

Volumn 16, Issue 6, 2004, Pages 724-731

  Sallusto, Federica ^a   MacKay, Charles R ^b  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; CHEMOATTRACTANT; CHEMOKINE RECEPTOR CCR7; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; FINGOLIMOD; G PROTEIN COUPLED RECEPTOR; HOMING RECEPTOR; LEUKOTRIENE B4 RECEPTOR; RECEPTOR BLOCKING AGENT; SPHINGOSINE 1 PHOSPHATE;

ALLERGY; B LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MOTION; DOWN REGULATION; EOSINOPHIL; HOMEOSTASIS; IMMUNE RESPONSE; INFLAMMATION; INFLAMMATORY DISEASE; LEUKOCYTE MIGRATION; LYMPH NODE; LYMPHOCYTE; LYMPHOID TISSUE; MAST CELL; NONHUMAN; PHOSPHORYLATION; REVIEW; T LYMPHOCYTE;

ANIMALS; CELL MOVEMENT; CHEMOTACTIC FACTORS; HOMEOSTASIS; HUMANS; INFLAMMATION; LYMPHOCYTES; LYMPHOID TISSUE; MEMBRANE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, CHEMOKINE; RECEPTORS, COMPLEMENT; RECEPTORS, LEUKOTRIENE B4; RECEPTORS, LYSOSPHINGOLIPID;

EID: 7044233625     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.09.012     Document Type: Review

References (78)

1. F. Sallusto, C.R. Mackay, and A. Lanzavecchia The role of chemokine receptors in primary, effector, and memory immune responses Annu Rev Immunol 18 2000 593 620
2. A. Rot, and U.H. von Andrian Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells Annu Rev Immunol 22 2004 891 928
3. J.G. Cyster Lymphoid organ development and cell migration Immunol Rev 195 2003 5 14
4. K. Chiba, Y. Yanagawa, Y. Masubuchi, H. Kataoka, T. Kawaguchi, M. Ohtsuki, and Y. Hoshino FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing J Immunol 160 1998 5037 5044
5. S. Mandala, R. Hajdu, J. Bergstrom, E. Quackenbush, J. Xie, J. Milligan, R. Thornton, G.J. Shei, D. Card, and C. Keohane Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists Science 296 2002 346 349
6. V. Brinkmann, M.D. Davis, C.E. Heise, R. Albert, S. Cottens, R. Hof, C. Bruns, E. Prieschl, T. Baumruker, and P. Hiestand The immune modulator FTY720 targets sphingosine 1-phosphate receptors J Biol Chem 277 2002 21453 21457
7. M.L. Allende, J.L. Dreier, S. Mandala, and R.L. Proia Expression of the sphingosine-1-phosphate receptor, S1P1, on T-cells controls thymic emigration J Biol Chem 2004
8. M. Matloubian, C.G. Lo, G. Cinamon, M.J. Lesneski, Y. Xu, V. Brinkmann, M.L. Allende, R.L. Proia, and J.G. Cyster Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 Nature 427 2004 355 360 Using mice whose haematopoietic cells lack a particular S1P receptor (S1P1) the authors demonstrate that S1P1 is essential for lymphocyte recirculation, and that it regulates egress from both thymus and peripheral lymphoid organs. Importantly, S1P1-dependent chemotactic responsiveness is strongly upregulated in T cell development before exit from the thymus, whereas S1P1 is downregulated during peripheral lymphocyte activation, and this is associated with retention in lymphoid organs.
9. M.G. Sanna, J. Liao, E. Jo, C. Alfonso, M.Y. Ahn, M.S. Peterson, B. Webb, S. Lefebvre, J. Chun, and N. Gray Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate J Biol Chem 279 2004 13839 13848 This paper describes a selective S1P1 agonist. This agonist established that the effect of S1P on lymphocyte recirculation occurs through S1P1 and not S1P3. An undesired effect of broad S1P receptor agonists is bradycardia, and this was shown to be abolished in S1P3-deficient mice. S1P1 appears to be an attractive target that could be used to interfere with lymphocyte trafficking.
10. G. Cinamon, M. Matloubian, M.J. Lesneski, Y. Xu, C. Low, T. Lu, R.L. Proia, and J.G. Cyster Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone Nat Immunol 5 2004 713 720 By demonstrating the migration and localization of S1P1-deficient marginal zone B cells, this study reveals an interplay between S1P effects and the chemokine system.
11. E.J. Goetzl, and M.H. Graler Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T Lymphocytes J Leukoc Biol 76 2004 30 35
12. E. Sawicka, C. Zuany-Amorim, C. Manlius, A. Trifilieff, V. Brinkmann, D.M. Kemeny, and C. Walker Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720 J Immunol 171 2003 6206 6214
13. R. Forster, A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs Cell 99 1999 23 33
14. F. Sallusto, D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 401 1999 708 712
15. M.L. Scimone, T.W. Felbinger, I.B. Mazo, J.V. Stein, U.H. Von Andrian, and W. Weninger CXCL12 Mediates CCR7-independent Homing of Central Memory Cells, But Not Naive T Cells, in Peripheral Lymph Nodes J Exp Med 199 2004 1113 1120
16. Rivino L, Messi M, Jarrossay D, Lanzavecchia A, Sallusto F, Geginat J: Chemokine receptor expression identifies pre-Th1, pre-Th2 and non-polarized cells among CD4+ central memory T cells. J Exp Med 2004, in press.
17. M. Vitale, M. Della Chiesa, S. Carlomagno, C. Romagnani, A. Thiel, L. Moretta, and A. Moretta The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells Eur J Immunol 34 2004 1715 1722
18. B. Johnston, C.H. Kim, D. Soler, M. Emoto, and E.C. Butcher Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets J Immunol 171 2003 2960 2969
19. F. Dieli, F. Poccia, M. Lipp, G. Sireci, N. Caccamo, C. Di Sano, and A. Salerno Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites J Exp Med 198 2003 391 397
20. M. Brandes, K. Willimann, A.B. Lang, K.H. Nam, C. Jin, M.B. Brenner, C.T. Morita, and B. Moser Flexible migration program regulates gamma delta T-cell involvement in humoral immunity Blood 102 2003 3693 3701
21. H.M. Serra, Y. Eberhard, A.P. Martin, N. Gallino, J. Gagliardi, C.E. Baena-Cagnani, A.R. Lascano, S. Ortiz, A.L. Mariani, and M. Uguccioni Secondary lymphoid tissue chemokine (CCL21) is upregulated in allergic contact dermatitis Int Arch Allergy Immunol 133 2004 64 71
22. A. Martin-Fontecha, S. Sebastiani, U.E. Hopken, M. Uguccioni, M. Lipp, A. Lanzavecchia, and F. Sallusto Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming J Exp Med 198 2003 615 621 This study shows that DC migration from inflamed peripheral tissues to draining lymph nodes is under the control of several co-operative events.
23. R.T. Palframan, S. Jung, G. Cheng, W. Weninger, Y. Luo, M. Dorf, D.R. Littman, B.J. Rollins, H. Zweerink, and A. Rot Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues J Exp Med 194 2001 1361 1373
24. H. Yoneyama, K. Matsuno, Y. Zhang, T. Nishiwaki, M. Kitabatake, S. Ueha, S. Narumi, S. Morikawa, T. Ezaki, and B. Lu Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules Int Immunol 16 2004 915 928
25. F. Sallusto, J. Geginat, and A. Lanzavecchia Central memory and effector memory T cell subsets: function, generation, and maintenance Annu Rev Immunol 22 2004 745 763
26. H. Yoneyama, S. Narumi, Y. Zhang, M. Murai, M. Baggiolini, A. Lanzavecchia, T. Ichida, H. Asakura, and K. Matsushima Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes J Exp Med 195 2002 1257 1266
27. V.N. Ngo, H.L. Tang, and J.G. Cyster Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells J Exp Med 188 1998 181 191
28. P. Perrier, F.O. Martinez, M. Locati, G. Bianchi, M. Nebuloni, G. Vago, F. Bazzoni, S. Sozzani, P. Allavena, and A. Mantovani Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13 J Immunol 172 2004 7031 7042
29. E.J. Kunkel, and E.C. Butcher Plasma-cell homing Nat Rev Immunol 3 2003 822 829
30. A.E. Hauser, G.F. Debes, S. Arce, G. Cassese, A. Hamann, A. Radbruch, and R.A. Manz Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response J Immunol 169 2002 1277 1282
31. G. Cassese, S. Arce, A.E. Hauser, K. Lehnert, B. Moewes, M. Mostarac, G. Muehlinghaus, M. Szyska, A. Radbruch, and R.A. Manz Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals J Immunol 171 2003 1684 1690
32. L. Colantonio, H. Recalde, F. Sinigaglia, and D. D'Ambrosio Modulation of chemokine receptor expression and chemotactic responsiveness during differentiation of human naive T cells into Th1 or Th2 cells Eur J Immunol 32 2002 1264 1273
33. A. Langenkamp, K. Nagata, K. Murphy, L. Wu, A. Lanzavecchia, and F. Sallusto Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells Eur J Immunol 33 2003 474 482
34. C.H. Kim, K. Nagata, and E.C. Butcher Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation J Immunol 171 2003 152 158
35. •].
36. + T cells.
37. I.C. Ho, and L.H. Glimcher Transcription: tantalizing times for T cells Cell 109 Suppl 2002 S109 S120
38. M. Messi, I. Giacchetto, K. Nagata, A. Lanzavecchia, G. Natoli, and F. Sallusto Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes Nat Immunol 4 2003 78 86
39. M.S. Sundrud, S.M. Grill, D. Ni, K. Nagata, S.S. Alkan, A. Subramaniam, and D. Unutmaz Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation J Immunol 171 2003 3542 3549
40. G. Lametschwandtner, T. Biedermann, C. Schwarzler, C. Gunther, J. Kund, S. Fassl, S. Hinteregger, N. Carballido-Perrig, S.J. Szabo, and L.H. Glimcher Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities J Allergy Clin Immunol 113 2004 987 994
41. F. Sallusto, A. Lanzavecchia, and C.R. Mackay Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses Immunol Today 19 1998 568 574
42. K. Nagata, and H. Hirai The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes Prostaglandins Leukot Essent Fatty Acids 69 2003 169 177
43. K. Takeshita, T. Yamasaki, K. Nagao, H. Sugimoto, M. Shichijo, F. Gantner, and K.B. Bacon CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation Int Immunol 16 2004 947 959
44. •].
45. •], this paper establishes that some monocytes are predisposed to migrate to inflamed tissues, and that these cells express the fractalkine receptor CX3CR1.
46. J.A. Gonzalo, C.M. Lloyd, D. Wen, J.P. Albar, T.N. Wells, A. Proudfoot, A.C. Martinez, M. Dorf, T. Bjerke, and A.J. Coyle The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness J Exp Med 188 1998 157 167
47. B. Ma, Z. Zhu, R.J. Homer, C. Gerard, R. Strieter, and J.A. Elias The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling J Immunol 172 2004 1872 1881
48. A.A. Humbles, B. Lu, D.S. Friend, S. Okinaga, J. Lora, A. Al-Garawi, T.R. Martin, N.P. Gerard, and C. Gerard The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness Proc Natl Acad Sci USA 99 2002 1479 1484
49. W. Ma, P.J. Bryce, A.A. Humbles, D. Laouini, A. Yalcindag, H. Alenius, D.S. Friend, H.C. Oettgen, C. Gerard, and R.S. Geha CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation J Clin Invest 109 2002 621 628
50. S.W. Chensue, N.W. Lukacs, T.Y. Yang, X. Shang, K.A. Frait, S.L. Kunkel, T. Kung, M.T. Wiekowski, J.A. Hedrick, and D.N. Cook Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice J Exp Med 193 2001 573 584
51. I. Goya, R. Villares, A. Zaballos, J. Gutierrez, L. Kremer, J.A. Gonzalo, R. Varona, L. Carramolino, A. Serrano, and P. Pallares Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease J Immunol 170 2003 2138 2146
52. C.D. Chung, F. Kuo, J. Kumer, A.S. Motani, C.E. Lawrence, W.R. Henderson Jr., and C. Venkataraman CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease J Immunol 170 2003 581 587
53. P. Schaerli, L. Ebert, K. Willimann, A. Blaser, R.S. Roos, P. Loetscher, and B. Moser A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells J Exp Med 199 2004 1265 1275 For the first time, these findings define a chemokine system for homeostatic T cell traffic in normal human skin.
54. B.F. Chong, J.E. Murphy, T.S. Kupper, and R.C. Fuhlbrigge E-selectin, thymus- and activation-regulated chemokine/CCL17, and intercellular adhesion molecule-1 are constitutively coexpressed in dermal microvessels: a foundation for a cutaneous immunosurveillance system J Immunol 172 2004 1575 1581
55. Y. Reiss, A.E. Proudfoot, C.A. Power, J.J. Campbell, and E.C. Butcher CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin J Exp Med 194 2001 1541 1547
56. T. Biedermann, C. Schwarzler, G. Lametschwandtner, G. Thoma, N. Carballido-Perrig, J. Kund, J.E. de Vries, A. Rot, and J.M. Carballido Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo Eur J Immunol 32 2002 3171 3180
57. B. Homey, H. Alenius, A. Muller, H. Soto, E.P. Bowman, W. Yuan, L. McEvoy, A.I. Lauerma, T. Assmann, and E. Bunemann CCL27-CCR10 interactions regulate T cell-mediated skin inflammation Nat Med 8 2002 157 165
58. •], this paper provides evidence for yet another level of regulation in Th1/Th2 mediated responses.
59. P.C. Fulkerson, N. Zimmermann, E.B. Brandt, E.E. Muntel, M.P. Doepker, J.L. Kavanaugh, A. Mishra, D.P. Witte, H. Zhang, and J.M. Farber Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9) Proc Natl Acad Sci USA 101 2004 1987 1992 In this study the authors found that the CXCR3 ligand CXCL9 (Mig), which is normally associated with Th1-type responses, is expressed in allergen-challenged airways and that CXCL9 is a negative regulator of eosinophil recruitment, through antagonism of CCR3.
60. E. Lippert, D.L. Yowe, J.A. Gonzalo, J.P. Justice, J.M. Webster, E.R. Fedyk, M. Hodge, C. Miller, J.C. Gutierrez-Ramos, and F. Borrego Role of regulator of G protein signaling 16 in inflammation- induced T lymphocyte migration and activation J Immunol 171 2003 1542 1555
61. S.P. Schoenberger BLT for speed Nat Immunol 4 2003 937 939
62. 4 that mediates chemotaxis Nature 387 1997 620 624
63. W.W. Huang, E.A. Garcia-Zepeda, A. Sauty, H.C. Oettgen, M.E. Rothenberg, and A.D. Luster Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils J Exp Med 188 1998 1063 1074
64. B. Haribabu, M.W. Verghese, D.A. Steeber, D.D. Sellars, C.B. Bock, and R. Snyderman Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis J Exp Med 192 2000 433 438
65. A.M. Tager, J.H. Dufour, K. Goodarzi, S.D. Bercury, U.H. von Andrian, and A.D. Luster BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis J Exp Med 192 2000 439 446
66. •].
67. •] the paper shows that besides chemokines, leukotriene B4 is intimately involved in effector T cell migration to inflamed tissues.
68. V.L. Ott, J.C. Cambier, J. Kappler, P. Marrack, and B.J. Swanson Mast cell-dependent migration of effector CD8(+) T cells through production of leukotriene B(4) Nat Immunol 4 2003 974 981 In this paper it is shown that activated mast cells, through production of leukotriene B4, induce chemotaxis of effector but not central memory CD8+ T cells. This indicates that leukotriene B4 production by activated peripheral leukocytes could be important for effector T cell recruitment to sites of inflammation.
69. A.A. Humbles, B. Lu, C.A. Nilsson, C. Lilly, E. Israel, Y. Fujiwara, N.P. Gerard, and C. Gerard A role for the C3a anaphylatoxin receptor in the effector phase of asthma Nature 406 2000 998 1001
70. C.L. Karp, A. Grupe, E. Schadt, S.L. Ewart, M. Keane-Moore, P.J. Cuomo, J. Kohl, L. Wahl, D. Kuperman, and S. Germer Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma Nat Immunol 1 2000 221 226
71. C.R. Mackay Chemokines: immunology's high impact factors Nat Immunol 2 2001 95 101
72. A. Alcami Viral mimicry of cytokines, chemokines and their receptors Nat Rev Immunol 3 2003 36 50
73. D.H. Miller, O.A. Khan, W.A. Sheremata, L.D. Blumhardt, G. Rice, M.A. Libonati, A. Wilmer-Hulme, C. Dalton, K. Miszkiel, and P. O'Connor A controlled trial of Natalizumab for relapsing multiple sclerosis N Engl J Med 348 2003 15 23
74. U.H. von Andrian, and B. Engelhardt Alpha4 integrins as therapeutic targets in autoimmune disease N Engl J Med 348 2003 68 72
75. S.G. Ward Do phosphoinositide 3-kinases direct lymphocyte navigation? Trends Immunol 25 2004 67 74
76. E. Hirsch, V.L. Katanaev, C. Garlanda, O. Azzolino, L. Pirola, L. Silengo, S. Sozzani, A. Mantovani, F. Altruda, and M.P. Wymann Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation Science 287 2000 1049 1053
77. Z. Li, H. Jiang, W. Xie, Z. Zhang, A.V. Smrcka, and D. Wu Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction Science 287 2000 1046 1049
78. M. Laffargue, R. Calvez, P. Finan, A. Trifilieff, M. Barbier, F. Altruda, E. Hirsch, and M.P. Wymann Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function Immunity 16 2002 441 451