Melanocortins as potential therapeutic agents in severe hypoxic conditions

Frontiers in Neuroendocrinology

Volumn 33, Issue 2, 2012, Pages 179-193

  Giuliani, Daniela ^a   Minutoli, Letteria ^b   Ottani, Alessandra ^a   Spaccapelo, Luca ^a   Bitto, Alessandra ^b   Galantucci, Maria ^a   Altavilla, Domenica ^b   Squadrito, Francesco ^b   Guarini, Salvatore ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Functional recovery; Ischemic diseases; Melanocortins; Neurogenesis; Protective effects; Resuscitation; Vagus nerve

Indexed keywords

ADENOHYPOPHYSIS HORMONE; ALPHA INTERMEDIN; ALPHA INTERMEDIN DERIVATIVE; AP 214; APROTININ; BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; CORTICOTROPIN; CORTICOTROPIN[1-16]; CORTICOTROPIN[1-18]; CORTICOTROPIN[1-24]; CORTICOTROPIN[1-39]; CORTICOTROPIN[4-10]; HP 228; HS 024; INTERMEDIN; ME 10501; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 2 RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 4 RECEPTOR ANATGONIST; METHYLPREDNISOLONE; NORADRENALIN; PG 911; PG 931; RECEPTOR BLOCKING AGENT; RO 27 3225; RY 767; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BRAIN ISCHEMIA; CARDIOGENIC SHOCK; CELL DIFFERENTIATION; CELL PROLIFERATION; EXPERIMENTAL MODEL; FUNCTIONAL STATUS; HEART MUSCLE ISCHEMIA; HEART TRANSPLANTATION; HEMORRHAGIC SHOCK; HUMAN; HYPOVOLEMIC SHOCK; HYPOXIA; INTESTINE ISCHEMIA; ISCHEMIA; KIDNEY ISCHEMIA; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; PROTECTION; REPERFUSION INJURY; RESPIRATORY ARREST; REVIEW; SEPTIC SHOCK; SHOCK; SIGNAL TRANSDUCTION; TESTIS ISCHEMIA; TRAUMATIC BRAIN INJURY;

ANIMALS; ANOXIA; CARDIOTONIC AGENTS; DRUGS, INVESTIGATIONAL; HUMANS; MELANOCORTINS; MODELS, BIOLOGICAL; NEUROPROTECTIVE AGENTS; RECEPTORS, MELANOCORTIN; SEVERITY OF ILLNESS INDEX; SHOCK;

EID: 84862333712     PISSN: 00913022     EISSN: 10956808     Source Type: Journal    
DOI: 10.1016/j.yfrne.2012.04.001     Document Type: Review

References (205)

1. Abou-Mohamed G., Papapetropoulos A., Ulrich D., Catravas I., Tuttle R.R., Caldwell R.W. HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro. J. Pharmacol. Exp. Ther. 1995, 275:584-591.
2. Adams H.P., Del Zoppo G., Alberts M.J., Bhatt D.L., Brass L., Furlan A., Grubb R.L., Higashida R., Jauch E.C., Kidwell C., Lyden P.D., Morgenstern L.B., Qureshi A.I., Rosenwasser R.H., Scott P.A., Wijdicks E.F. Guidelines for the early management of adults with ischemic stroke. Stroke 2007, 38:1655-1711.
3. Altavilla D., Cainazzo M.M., Squadrito F., Guarini S., Bertolini A., Bazzani C. Tumour necrosis factor-α as a target of melanocortins in haemorrhagic shock, in the anaesthetized rat. Br. J. Pharmacol. 1998, 124:1587-1590.
4. Altavilla D., Guarini S., Bitto A., Mioni C., Giuliani D., Bigiani A., Squadrito F., Minutoli L., Venuti F.S., Messineo F., De Meo V., Bazzani C., Squadrito F. Activation of the cholinergic anti-inflammatory pathway reduces NF-kB activation, blunts TNF-α production, and protects againts splanchic artery occlusion shock. Shock 2006, 25:500-506.
5. Ay I., Lu J., Ay H., Gregory Sorensen A. Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia. Neurosci. Lett. 2009, 459:147-151.
6. Banks W.A., Kastin A.J. Permeability of the blood-brain barrier to melanocortins. Peptides 1995, 16:1157-1161.
7. Baue A.E. MOF, MODS, and SIRS: what is in a name or an acronym?. Shock 2006, 26:438-449.
8. Bazzani C., Balugani A., Bertolini A., Guarini S. Comparison of the effects of ACTH-(1-24), methylprednisolone, aprotinin, and norepinephrine in a model of hemorrhagic shock in rats. Resuscitation 1993, 25:219-226.
9. Bazzani C., Bini A., Cainazzo M.M., Meletti E., Tomasi A., Bertolini A., Guarini S. High blood levels of nitric oxide in rats subjected to prolonged respiratory arrest and their modulation during adrenocorticotropin-induced resuscitation. Naunyn-Schmiedeberg's Arch. Pharmacol. 1999, 359:53-59.
10. Bazzani C., Guarini S., Botticelli A.R., Zaffe D., Tomasi A., Bini A., Cainazzo M.M., Ferrazza G., Mioni C., Bertolini A. Protective effect of melanocortin peptides in rat myocardial ischemia. J. Pharmacol. Exp. Ther. 2001, 297:1082-1087.
11. Bazzani C., Mioni C., Ferrazza G., Cainazzo M.M., Bertolini A., Guarini S. Involvement of the central nervous system in the protective effect of melanocortins in myocardial ischaemia/reperfusion injury. Resuscitation 2002, 52:109-115.
12. Bazzani C., Tagliavini S., Bertolini E., Bertolini A., Guarini S. Influence of ACTH-(1-24) on metabolic acidosis and hypoxemia induced by massive hemorrhage in rats. Resuscitation 1992, 23:113-120.
13. Beckmann A.M., Wilce P.A. Egr transcription factors in the nervous system. Neurochem. Int. 1997, 31:447-510.
14. Benoit S.C., Schwartz M.W., Lachey J.L., Hagan M.M., Rushing P.A., Blake K.A., Yagaloff K.A., Kurylko G., Franco L., Danhoo W., Seeley R.J. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J. Neurosci. 2000, 20:3442-3448.
15. Bertolini A., Guarini S., Ferrari W. Adrenal-independent, anti-shock effect of ACTH-(1-24) in rats. Eur. J. Pharmacol. 1986, 122:387-388.
16. Bertolini A., Guarini S., Ferrari W., Rompianesi E. Adrenocorticotropin reversal of experimental hemorrhagic shock is antagonized by morphine. Life Sci. 1986, 39:1271-1280.
17. Bertolini A., Guarini S., Ferrari W., Noera G., Massini C., Di Tizio S. ACTH-(1-24) restores blood pressure in acute hypovolaemia and haemorrhagic shock in humans. Eur. J. Clin. Pharmacol. 1987, 32:537-538.
18. Bertolini A., Guarini S., Rompianesi E., Ferrari W. α-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock. Eur. J. Pharmacol. 1986, 130:19-26.
19. Bertolini A., Poggioli R., Vergoni A.V., Castelli M., Guarini S. Evidence that melanocortins are physiological antagonist of opioids. Central Actions of ACTH and Related Peptides 1986, 207-222. Springer-Verlag, Berlin-Heidelberg. D. De Wied, W. Ferrari (Eds.).
20. Bertolini A., Vergoni W., Gessa G.L., Ferrari W. Induction of sexual excitement by the action of adrenocorticotrophic hormone in brain. Nature 1969, 221:667-669.
21. Bertuglia S., Giusti A. Influence of ACTH-(1-24) and plasma hyperviscosity on free radical production and capillary perfusion after hemorrhagic shock. Microcirculation 2004, 11:227-238.
22. Bitto A., Polito F., Irrera N., Calò M., Spaccapelo L., Marini H.R., Giuliani D., Ottani A., Rinaldi M., Minutoli L., Guarini S., Squadrito F., Altavilla D. Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury. Crit. Care Med. 2012, 40:945-951.
23. Bohus B., De Wied D. Inhibitory and facilitatory effect of two related peptides on extinction of avoidance behaviour. Science 1966, 153:318-320.
24. Bolli R., Marban E. Molecular and cellular mechanisms of myocardial stunning. Physiol. Rev. 1999, 79:609-634.
25. Borovikova L.V., Ivanova S., Zhang M., Yang H., Botchkina G.I., Watkins L.R., Wang H., Abumrad N., Eaton J.W., Tracey K.J. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000, 405:458-462.
26. Bruder E.D., Taylor J.K., Kamer K.J., Raff H. Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 295:R1195-R1203.
27. Brzoska T., Luger T.A., Maaser C., Abels C., Böhm M. α-Melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr. Rev. 2008, 29:581-602.
28. Busl K.M., Greer D.M. Hypoxic-ischemic brain injury: pathophysiology, neuropathology and mechanisms. NeuroRehabilitation 2010, 26:5-13.
29. Catania A. The melanocortin system in leukocyte biology. J. Leukoc. Biol. 2007, 81:383-392.
30. Catania A. Neuroprotective action of melanocortins: a therapeutic opportunity. Trends Neurosci. 2008, 31:353-360.
31. Catania A., Colombo G., Rossi C., Carlin A., Sordi A., Lonati C., Turcatti F., Leonardi P., Grieco P., Gatti S. Antimicrobial properties of α-MSH and related synthetic melanocortins. Sci. World J. 2006, 6:1241-1246.
32. Catania A., Gatti S., Colombo G., Lipton J.M. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol. Rev. 2004, 56:1-29.
33. Catania A., Lonati C., Sordi A., Gatti S. Detrimental consequences of brain injury on peripheral cells. Brain Behav. Immun. 2009, 23:877-884.
34. Catania A., Lonati C., Sordi A., Leonardi P., Carlin A., Gatti S. The peptide NDP-MSH induces phenotype changes in the heart that resemble ischemic preconditioning. Peptides 2010, 31:116-122.
35. Chen G., Frøkiær J., Pedersen M., Nielsen S., Si Z., Pang Q., Stødkilde-Jørgensen H. Reduction of ischemic stroke in rat brain by alpha melanocyte stimulating hormone. Neuropeptides 2008, 42:331-338.
36. Chiao H., Kohda Y., McLeroy P., Craig L., Housini I., Star R.A. α-Melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J. Clin. Invest. 1997, 99:1165-1172.
37. Chitravanshi V.C., Bhatt S., Sapru H.N. Microinjections of α-melanocyte stimulating hormone into the nucleus ambiguus of the rat elicit vagally mediated bradycardia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 296:R1402-R1411.
38. Colombo G., Sordi A., Lonati C., Carlin A., Turcatti F., Leonardi P., Gatti S., Catania A. Treatment with α-melanocyte stimulating hormone preserves calcium regulatory proteins in rat heart allografts. Brain Behav. Immun. 2008, 22:817-823.
39. Colombo G., Gatti S., Turcatti F., Sordi A., Fassati L.R., Bonino F., Lipton J.M., Catania A. Gene expression profiling reveals multiple protective influences of the peptide α-melanocyte-stimulating hormone in experimental heart transplantation. J. Immunol. 2005, 175:3391-3401.
40. Corander M.P., Fenech M., Coll A.P. Science of self-preservation: how melanocortin action in the brain modulates body weight, blood pressure and ischemic damage. Circulation 2009, 120:2260-2268.
41. De Wied D. Effect of peptide hormones on behaviour. Frontiers in Neuroendocrinology 1969, 97-140. Oxford University Press, London/New York. W.F. Ganon, L. Martini (Eds.).
42. Debus E.S., Müller-Hülsbeck S., Kölbel T., Larena-Avellaneda A. Intestinal ischemia. Int. J. Colorectal Dis. 2011, 26:1087-1097.
43. Deng J., Hu X., Yuen P.S., Star R.A. α-Melanocyte-stimulating hormone inhibits lung injury after renal ischemia/reperfusion. Am. J. Respir. Crit. Care Med. 2004, 169:749-756.
44. Diener H-C, Lees K.R., Lyden P., Grotta J., Davalos A., Davis S.M., Shuaib A., Ashwood T., Wasiewski W., Alderfer V., Hårdemark H.G., Rodichok L. SAINT I and II investigators, NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II trials. Stroke 2008, 39:1751-1758.
45. Dmitrieva V.G., Povarova O.V., Skvortsova V.I., Limborska S.A., Myasoedov N.F., Dergunova L.V. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell. Mol. Neurobiol. 2010, 30:71-79.
46. Doi K., Ishizu T., Fujita T., Noiri E. Lung injury following acute kidney injury: kidney-lung crosstalk. Clin. Exp. Nephrol. 2011, 15:464-470.
47. Donaldson M.D.J., Vesey C.J., Wilks M., Watson J.D., Hinds C.J. Lack of effect of ACTH in porcine Escherichia coli septic shock. Circ. Shock 1991, 35:152-158.
48. Duan X., Kang E., Liu C.Y., Ming G.L., Song H. Development of neural stem cell in the adult brain. Curr. Opin. Neurobiol. 2008, 18:108-115.
49. Eberle A.N. The Melanotropins: Chemistry, Physiology and Mechanisms of Action 1988, Karger, Basel.
50. Eefting F., Rensing B., Wigman J., Pannekoek W.J., Liu W.M., Cramer M.J., Lips D.J., Doevendans P.A. Role of apoptosis in reperfusion injury. Cardiovasc. Res. 2004, 61:414-426.
51. Ehrenreich H., Weissenborn K., Prange H., Schneider D., Weimar C., Wartenberg K., Schellinger P.D., Bohn M., Becker H., Wegrzyn M., Jähnig P., Herrmann M., Knauth M., Bähr M., Heide W., Wagner A., Schwab S., Reichmann H., Schwendemann G., Dengler R., Kastrup A., Bartels C. for the EPO Stroke Trial Group, Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke 2009, 40:e647-e656.
52. Emsley H.C.A., Smith C.J., Gavin C.M., Georgiou R.F., Vail A., Barberan E.M., Hallenbeck J.M., del Zoppo G.J., Rothwell N.J., Tyrrell P.J., Hopkins S.J. An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J. Neuroimmunol. 2003, 139:93-101.
53. Ferrari W. Behavioural changes in animals after intracisternal injection with adrenocorticotrophic hormone and melanocyte-stimulating hormone. Nature 1958, 181:925-926.
54. Ferrari W., Floris E., Paulesu F. Eosinopenic effect of ACTH injected into the cisterna magna. Boll. Soc. Ital. Biol. Sper. 1955, 31:859-862.
55. Ferrari W., Gessa G.L., Vargiu L. Behavioral effects induced by intracisternally injected ACTH and MSH. Ann. NY Acad. Sci. 1963, 104:330-345.
56. Florio P., Abella R., Marinoni E., Di Iorio R., Li Volti G., Galvano F., Pongiglione G., Frigiola A., Pinzauti S., Petraglia F., Gazzolo D. Biochemical markers of perinatal brain damage. Front. Biosci. (Schol Ed) 2010, 2:47-72.
57. Forslin Aronsson å., Spulber S., Oprica M., Winblad B., Post C., Schultzberg M. α-MSH rescues neurons from excitotoxic cell death. J. Mol. Neurosci. 2007, 33:239-251.
58. Forslin Aronsson å., Spulber S., Popescu L.M., Winblad B., Post C., Oprica M., Schultzberg M. α-Melanocyte-stimulating hormone is neuroprotective in rat global cerebral ischemia. Neuropeptides 2006, 40:65-75.
59. Frangogiannis N.G., Smith C.W., Entman M.L. The inflammatory response in myocardial infarction. Cardiovasc. Res. 2002, 53:31-47.
60. Fretz P.C., Sandlow J.I. Varicocele: current concepts in pathophysiology, diagnosis, and treatment. Urol. Clin. North Am. 2002, 29:921-937.
61. Gatti S., Colombo G., Buffa R., Turcatti F., Garofalo L., Carboni N., Ferla L., Fassati L.R., Lipton J.M., Catania A. α-Melanocyte-stimulating hormone protects the allograft in experimental heart transplantation. Transplantation 2002, 74:1678-1684.
62. Gatti S., Lonati C., Acerbi F., Sordi A., Leonardi P., Carlin A., Gaini S.M., Catania A. Protective action of NDP-MSH in experimental subarachnoid hemorrhage. Exp. Neurol. 2012, 234:230-238.
63. Gendron A., Teitelbaum J., Cossette C., Nuara S., Dumont M., Geadah D., du Souich P., Kouassi E. Temporal effects of left versus right middle cerebral artery occlusion on spleen lymphocyte subsets and mitogenic response in wistar rats. Brain Res. 2002, 955:85-97.
64. Getting S.J. Targeting melanocortin receptors as potential novel therapeutics. Pharmacol. Ther. 2006, 111:1-15.
65. Getting S.J., Di Filippo C., Christian H.C., Lam C.W., Rossi F., D'Amico M., Perretti M. MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. J. Leukoc. Biol. 2004, 76:845-853.
66. Getting S.J., Di Filippo C., D'Amico M., Perretti M. The melanocortin peptide HP228 displays protective effects in acute models of inflammation and organ damage. Eur. J. Pharmacol. 2006, 532:138-144.
67. 7]α-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils. Eur. J. Pharmacol. 2006, 538:48-56.
68. Giuliani D., Mioni C., Altavilla D., Leone S., Bazzani C., Minutoli L., Bitto A., Cainazzo M.M., Marini H., Zaffe D., Botticelli A.R., Pizzala R., Savio M., Necchi D., Schiöth H.B., Bertolini A., Squadrito F., Guarini S. Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia. Endocrinology 2006, 147:1126-1135.
69. 4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br. J. Pharmacol. 2007, 150:595-603.
70. Giuliani D., Ottani A., Altavilla D., Bazzani C., Squadrito F., Guarini S. Melanocortins and the cholinergic anti-inflammatory pathway. Adv. Exp. Med. Biol. 2010, 681:71-87.
71. Giuliani D., Ottani A., Minutoli L., Di Stefano V., Galantucci M., Bitto A., Zaffe D., Altavilla D., Botticelli A.R., Squadrito F., Guarini S. Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268. Brain Behav. Immun. 2009, 23:844-850.
72. Giuliani D., Ottani A., Mioni C., Bazzani C., Galantucci M., Minutoli L., Bitto A., Zaffe D., Botticelli A.R., Squadrito F., Guarini S. Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins. Eur. J. Pharmacol. 2007, 570:57-65.
73. 4 receptor agonists induces marked neurogenesis and long-lasting functional recovery. Acta Neuropathol. 2011, 122:443-453.
74. Gladstone D.J., Black S.E., Hakim A.M. Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 2002, 33:2123-2136.
75. Gonindard C., Goigoux C., Hollande E., D'Hinterland L.D. The administration of an α-MSH analogue reduces the serum release of IL-1α and TNF-α induced by the injection of a sublethal dose of lipopolysaccharides in the BALB/c mouse. Pigm. Cell Res. 1996, 9:148-153.
76. Granfeldt A., Lefer D.J., Vinten-Johansen J. Protective ischaemia in patients: preconditioning and postconditioning. Cardiovasc. Res. 2009, 83:234-246.
77. Guarini S., Altavilla D., Cainazzo M.M., Giuliani D., Bigiani A., Marini H., Squadrito G., Minutoli L., Bertolini A., Marini R., Adamo E.B., Venuti F.S., Squadrito F. Efferent vagal fibre stimulation blunts nuclear factor-kB activation and protects against hypovolemic hemorrhagic shock. Circulation 2003, 107:1189-1199.
78. Guarini S., Bazzani C., Bertolini A. Resuscitating effect of melanocortin peptides after prolonged respiratory arrest. Br. J. Pharmacol. 1997, 121:1454-1460.
79. Guarini S., Bazzani C., Bini A., Cainazzo M.M., Tomasi A., Bertolini A. Adrenocorticotropin counteracts the increase in free radical blood levels, detected by electron spin resonance spectrometry, in rats subjected to prolonged asphyxia. Life Sci. 1998, 63:97-104.
80. Guarini S., Bazzani C., Cainazzo M.M., Mioni C., Ferrazza G., Vergoni A.V., Schiöth H.B., Wikberg J.E., Bertolini A. Evidence that melanocortin 4 receptor mediates hemorrhagic shock reversal caused by melanocortin peptides. J. Pharmacol. Exp. Ther. 1999, 291:1023-1027.
81. Guarini S., Bazzani C., Mattera Ricigliano G., Bini A., Tomasi A., Bertolini A. Influence of ACTH-(1-24) on free radical levels in the blood of haemorrhage-shocked rats: direct ex vivo detection by electron spin resonance spectrometry. Br. J. Pharmacol. 1996, 119:29-34.
82. Guarini S., Bazzani C., Tagliavini S., Bertolini A., Ferrari W. Reversal of experimental hemorrhagic shock by dimethylphenylpiperazinium (DMPP). Experientia 1992, 48:663-667.
83. Guarini S., Bini A., Bazzani C., Mattera Ricigliano G., Cainazzo M.M., Tomasi A., Bertolini A. Adrenocorticotropin normalizes the blood levels of nitric oxide in haemorrhage-shocked rats. Eur. J. Pharmacol. 1997, 336:15-21.
84. Guarini S., Cainazzo M.M., Giuliani D., Mioni C., Altavilla D., Marini H., Bigiani A., Ghiaroni V., Passaniti M., Leone S., Bazzani C., Caputi A.P., Squadrito F., Bertolini A. Adrenocorticotropin reverses hemorrhagic shock in anesthetized rats through the rapid activation of a vagal anti inflammatory pathway. Cardiovasc. Res. 2004, 63:357-365.
85. Guarini S., Ferrari W., Bertolini A. Anti-shock effect of ACTH-(1-24): influence of subtotal hepatectomy. Pharmacol. Res. Commun. 1988, 20:395-403.
86. Guarini S., Ferrari W., Mottillo G., Bertolini A. Anti-shock effect of ACTH: haematological changes and influence of splenectomy. Arch. Int. Pharmacodyn. 1987, 289:311-318.
87. Guarini S., Rompianesi E., Ferrari W., Bertolini A. Influence of vagotomy and of atropine on the anti-shock effect of adrenocorticotropin. Neuropeptides 1986, 8:19-24.
88. 3 receptors are involved in the protective effect of melanocortins in myocardial ischaemia/reperfusion-induced arrhythmias. Naunyn-Schmiedeberg's Arch. Pharmacol. 2002, 366:177-182.
89. Guarini S., Tagliavini S., Bazzani C., Benelli A., Bertolini A., Ferrari W. Effect of ACTH-(1-24) on the volume of circulating blood and on regional blood flow in rats bled to hypovolemic shock. Resuscitation 1989, 18:133-134.
90. Guarini S., Tagliavini S., Bazzani C., Bertolini A., Ferrari W. Nicotine reverses hemorrhagic shock in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 1991, 343:427-430.
91. Guarini S., Tagliavini S., Bazzani C., Ferrante F., Bertolini A. Intracerebroventricular injection of hemicolinium-3 prevents the ACTH-induced, but not the physostigmine-induced, reversal of hemorrhagic shock in rats. Pharmacology 1990, 40:85-89.
92. Guarini S., Tagliavini S., Bazzani C., Ferrari W., Bertolini A. Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective. Crit. Care Med. 1990, 18:862-865.
93. Guarini S., Vergoni A.V., Bertolini A. Anti-shock effect of ACTH-(1-24): comparison between intracerebroventricular and intravenous route of administration. Pharmacol. Res. Commun. 1987, 19:255-260.
94. Hassoun H.T., Zou L., Moore F.A., Kozar R.A., Weisbrodt N.W., Kone B.C. α-Melanocyte stimulating hormone protects against mesenteric ischemia-reperfusion injury. Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 282:G1059-G1068.
95. Hausenloy D.J., Yellon D.M. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc. Res. 2004, 61:448-460.
96. Holloway P.M., Smith H.K., Renshaw D., Flower R.J., Getting S.J., Gavins F.N.E. Targeting the melanocortin receptor system for anti-stroke therapy. Trends Pharmacol. Sci. 2011, 32:90-98.
97. Huang Q., Tatro J.B. α-Melanocyte stimulating hormone suppresses intracerebral tumor necrosis factor-α and interleukin-1β gene expression following transient cerebral ischemia in mice. Neurosci. Lett. 2002, 334:186-190.
98. Huh S.K., Lipton J.M., Batjer H.H. The protective effects of α-melanocyte stimulating hormone on canine brain ischemia. Neurosurgery 1997, 40:132-140.
99. Inestrosa N.C., Arenas E. Emerging roles of Wnts in the adult nervous system. Nat. Rev. Neurosci. 2010, 11:77-86.
100. Jarrar D., Chaudry I.H., Wang P. Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches. Int. J. Mol. Med. 1999, 4:575-583.
101. Jo S.K., Yun S.Y., Chang K.H., Cha D.R., Cho W.Y., Kim H.K., Won N.H. α-MSH decreases apoptosis in ischaemic acute renal failure in rats: possible mechanism of this beneficial effect. Nephrol. Dial. Transplant. 2001, 16:1583-1591.
102. Jochem J. Involvement of proopiomelanocortin-derived peptides in endogenous central istamine-induced reversal of critical haemorrhagic hypotension in rats. J. Physiol. Pharmacol. 2004, 55:57-71.
103. Juhasz B., Der P., Szodoray P., Gesztelyi R., Lekli I., Bak I., Antal M., Maulik N., Tosaki A., Vecsernyes M. Adrenocorticotrope hormone fragment (4-10) attenuates the ischemia/reperfusion-induced cardiac injury in isolated rat hearts. Antioxid. Redox Signal. 2007, 9:1851-1861.
104. Kawada T., Yamazaki T., Akiyama T., Kitagawa H., Shimizu S., Mizuno M., Li M., Sugimachi M. Vagal stimulation suppresses ischemia-induced myocardial interstitial myoglobin release. Life Sci. 2008, 83:490-495.
105. Kazanis I. The subependymal zone neurogenic niche: a beating heart in the centre of the brain. Brain 2009, 132:2909-2921.
106. Kernie S.G., Parent J.M. Forebrain neurogenesis after focal ischemic and traumatic brain injury. Neurobiol. Dis. 2010, 37:267-274.
107. Kishi T., Aschkenasi C.J., Lee C.E., Mountjoy K.G., Saper C.B., Elmquist J.K. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J. Comp. Neurol. 2003, 457:213-235.
108. Kloner R.A., Schwartz Longacre L. State of the science of cardioprotection: challenges and opportunities - proceedings of the NHLBI workshop on cardioprotection. J. Cardiovasc. Pharmacol. Ther. 2010, 16(2011):223-232.
109. Kokaia Z., Darsalia V. Neural stem cell-based therapy for ischemic stroke. Transl. Stroke Res. 2011, 2:272-278.
110. Kourbeti I.S., Vakis A.F., Papadakis J.A., Karabetsos D., Bertsias G., Filippou M., Ioannou A., Neophytou C., Anastasaki M., Samonis G. Infections in traumatic brain injury patients. Clin. Microbiol. Infect. 2012, 18:359-364.
111. Krishnamurthy P., Rajasingh J., Lambers E., Qin G., Losordo D.W., Kishore R. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ. Res. 2009, 104:E9-E18.
112. Krizbai I.A., Lenzser G., Szatmari E., Farkas A.E., Wilhelm I., Fekete Z., Erdos B., Bauer H., Bauer H-C, Sandor P., Komjati K. Blood-brain barrier changes during compensated and decompensated hemorrhagic shock. Shock 2005, 24:428-433.
113. Kutsogiannis D.J., Bagshaw S.M., Laing B., Brindley P.G. Predictors of survival after cardiac or respiratory arrest in critical care units. CMAJ 2011, 183:1589-1595.
114. Kuwabara T., Hsieh J., Muotri A., Yeo G., Warashina M., Lie D.C., Moore L., Nakashima K., Asashima M., Gage F.H. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat. Neurosci. 2009, 12:1097-1105.
115. Kwon T.H., Frøkiaer J., Fernández-Llama P., Knepper M.A., Nielsen S. Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by α-MSH. Am. J. Physiol. 1999, 277:F413-F427.
116. Landmesser U., Wollert K.C., Drexler H. Potential novel pharmacological therapies for myocardial remodelling. Cardiovasc. Res. 2009, 81:519-527.
117. Lasaga M., Debeljuk L., Durand D., Scimonelli T.N., Caruso C. Role of alpha-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation. Peptides 2008, 29:1825-1835.
118. Laskowitz D.T., Kolls B.J. Neuroprotection in subarachnoid hemorrhage. Stroke 2010, 41:S79-S84.
119. Le Tulzo Y., Shenkar R., Kaneko D., Moine P., Fantuzzi G., Dinarello C.A., Abraham E. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: involvement of catecholamines in nuclear factor-kB regulation and cytokine expression. J. Clin. Invest. 1997, 99:1516-1524.
120. Lee Y.S., Park J.J., Chung K.Y. Change of melanocortin receptor expression in rat kidney ischemia-reperfusion injury. Transplant. Proc. 2008, 40:2142-2144.
121. Leker R.R., Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res. Rev. 2002, 39:55-73.
122. Li C., Browder W., Kao R.L. Early activation of transcription factor NF-kB during ischemia in perfused rat heart. Am. J. Physiol. Heart Circ. Physiol. 1999, 276:H543-H552.
123. Li S.J., Varga K., Archer P., Hruby V.J., Sharma S.D., Kesterson R.A., Cone R.D., Kunos G. Melanocortin antagonists define two distinct pathways of cardiovascular control by α- and γ-melanocyte-stimulating hormones. J. Neurosci. 1996, 16:5182-5188.
124. Lichtenwalner R.J., Parent J.M. Adult neurogenesis and the ischemic forebrain. J. Cereb. Blood Flow Metab. 2006, 26:1-20.
125. Lim S.Y., Hausenloy D.J. Remote ischemic conditioning: from bench to bedside. Front. Physiol. 2012, 3:27.
126. Lipton J.M., Ceriani G., Macaluso A., McCoy D., Carnes K., Biltz J., Catania A. Antiinflammatory effects of the neuropeptide α-MSH in acute, chronic, and systemic inflammation. Ann. NY Acad. Sci. 1994, 741:137-148.
127. Liu Y.P., Lang B.T., Baskaya M.K., Dempsey R.J., Vemuganti R. The potential of neural stem cells to repair stroke-induced brain damage. Acta Neuropathol. 2009, 117:469-480.
128. Loane D.J., Faden A.I. Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol. Sci. 2010, 31:596-604.
129. Lonati C., Sordi A., Giuliani D., Spaccapelo L., Leonardi P., Carlin A., Ottani A., Galantucci M., Grieco P., Catania A., Guarini S. Molecular changes induced in rat liver by hemorrhage and effects of melanocortin treatment. Anesthesiology 2012, 116:692-700.
130. Ludbrook J., Ventura S. ACTH-(1-24) blocks the decompensatory phase of the haemodynamic response to acute hypovolaemia in conscious rabbits. Eur. J. Pharmacol. 1995, 275:267-275.
131. Maathuis M.H., Leuvenink H.G., Ploeg R.J. Perspectives in organ preservation. Transplantation 2007, 83:1289-1298.
132. Magnoni S., Stocchetti N., Colombo G., Carlin A., Colombo A., Lipton J.M., Catania A. α-Melanocyte stimulating hormone is decreased in plasma of patients with acute brain injury. J. Neurotrauma 2003, 20:251-260.
133. Maybhate A., Hu C., Bazley F.A., Yu Q., Thakor N.V., Kerr C.L., All A.H. Potential long-term benefits of acute hypothermia after spinal cord injury: assessments with somatosensory-evoked potentials. Crit. Care Med. 2012, 40:573-579.
134. Michalski D., Grosche J., Pelz J., Schneider D., Weise C., Bauer U., Kacza J., Gärtner U., Hobohm C., Härtig W. A novel quantification of blood-brain barrier damage and histochemical typing after embolic stroke in rats. Brain Res. 2010, 1359:186-200.
135. Minutoli L., Bitto A., Squadrito F., Irrera N., Rinaldi M., Nicotina P.A., Arena S., Magno C., Marini H., Spaccapelo L., Ottani A., Giuliani D., Romeo C., Guarini S., Antonuccio P., Altavilla D. Melanocortin 4 receptor activation protects against testicular ischemia-reperfusion injury by triggering the cholinergic antinflammatory pathway. Endocrinology 2011, 152:3852-3861.
136. Mioni C., Bazzani C., Giuliani D., Altavilla D., Leone S., Ferrari A., Minutoli L., Bitto A., Marini H., Zaffe D., Botticelli A.R., Iannone A., Tomasi A., Bigiani A., Bertolini A., Squadrito F., Guarini S. Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats. Crit. Care Med. 2005, 33:2621-2628.
137. 3 receptors. Eur. J. Pharmacol. 2003, 477:227-234.
138. Monassier J.P. Reperfusion injury in acute myocardial infarction: from bench to cath lab. Part II: clinical issues and therapeutic options. Arch. Cardiovasc. Dis. 2008, 101:565-575.
139. Moore E.M., Nichol A.D., Bernard S.A., Bellomo R. Therapeutic hypothermia: benefits, mechanisms and potential clinical applications in neurological, cardiac and kidney injury. Injury 2011, 42:843-854.
140. Morita Y., Takizawa S., Kamiguchi H., Uesugi T., Kawada H., Takagi S. Administration of hematopoietic cytokines increases the expression of anti-inflammatory cytokine (IL-10) mRNA in the subacute phase after stroke. Neurosci. Res. 2007, 58:356-360.
141. Moskowitz M.A., Lo E.H., Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron 2010, 67:181-198.
142. Moukarbel G.V., Ayoub C.M., Abchee A.B. Pharmacological therapy for myocardial reperfusion injury. Curr. Opin. Pharmacol. 2004, 4:147-153.
143. Mountjoy K. Distribution and function of melanocortin receptors within the brain. Adv. Exp. Med. Biol. 2010, 681:29-48.
144. Mountjoy K.G., Robbins L.S., Mortrud M.T., Cone R.D. The cloning of a family of genes that encode the melanocortin receptors. Science 1992, 257:1248-1251.
145. Murphy T.H., Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat. Rev. Neurosci. 2009, 10:861-872.
146. Myers D.A., Bell P.A., Hyatt K., Mlynarczyk M., Ducsay C.A. Long-term hypoxia enhances proopiomelanocortin processing in the near-term ovine fetus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R1178-R1184.
147. Noera G., Angiello L., Biagi B., Pensa P. Haemorrhagic shock in cardiac surgery. Pharmacological treatment with ACTH (1-24). Resuscitation 1991, 22:123-127.
148. Noera G., Lamarra M., Guarini S., Bertolini A. Survival rate after early treatment for acute type-A aortic dissection with ACTH-(1-24). Lancet 2001, 358:469-470.
149. Noera G., Pensa P., Guelfi P., Biagi B., Curcio C., Bentini B. ACTH-(1-24) and hemorrhagic shock: preliminary clinical results. Resuscitation 1989, 18:145-147.
150. O'Collins V.E., Macleod M.R., Donnan G.A., Horky L.L., van der Worp B.H., Howells D.W. 1026 experimental treatments in acute stroke. Ann. Neurol. 2006, 59:467-477.
151. O'Donohue T.I., Dorsa D.M. The opiomelanotropinergic neuronal and endocrine systems. Peptides 1982, 3:353-395.
152. O'Neill C.A., Fu L.W., Halliwell B., Longhurst J.C. Hydroxyl radical production during myocardial ischemia and reperfusion in cats. Am. J. Physiol. Heart Circ. Physiol. 1996, 271:H660-H667.
153. Offner H., Subramanian S., Parker S.M., Afentoulis M.E., Vandenbark A.A., Hurn P.D. Experimental stroke induces massive, rapid activation of the peripheral immune system. J. Cereb. Blood Flow Metab. 2006, 26:654-665.
154. Oi S. Classification of hydrocephalus: critical analysis of classification categories and advantages of " Multi-categorical Hydrocephalus Classification" (Mc HC). Childs Nerv. Syst. 2011, 27:1523-1533.
155. Ottani A., Giuliani D., Galantucci M., Spaccapelo L., Novellino E., Grieco P., Jochem J., Guarini S. Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism. Eur. J. Pharmacol. 2010, 637:124-130.
156. Ottani A., Giuliani D., Mioni C., Galantucci M., Minutoli L., Bitto A., Altavilla D., Zaffe D., Botticelli A.R., Squadrito F., Guarini S. Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke. J. Cereb. Blood Flow Metab. 2009, 29:512-523.
157. Patel H.B., Leoni G., Melendez T.M., Sampaio A.L., Perretti M. Melanocortin control of cell trafficking in vascular inflammation. Adv. Exp. Med. Biol. 2010, 681:88-106.
158. Pavlov V.A., Ochani M., Gallowitsch-Puerta M., Ochani K., Huston J.M., Czura C.J., Al-Abed Y., Tracey K.J. Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc. Natl. Acad. Sci. USA 2006, 103:5219-5223.
159. Pinelli G., Chesi G., Di Donato C., Reverzani A., Marani L. Preliminary data on the use of ACTH-(1-24) in human shock conditions. Resuscitation 1989, 18:149-150.
160. Prass K., Meisel C., Hoflich C., Braun J., Halle E., Wolf T., Ruscher K., Victorov I.V., Priller J., Dirnagl U., Volk H.D., Meisel A. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by post-stroke T helper cell type 1-like immunostimulation. J. Exp. Med. 2003, 198:725-736.
161. Raff H., Goldmann R.W., Kindwall E.P. Adrenocortical function after acute carbon monoxide exposure in humans. Arch. Environ. Health 1985, 40:88-90.
162. Ramasamy R., Hwang Y.C., Liu Y., Son N.H., Ma N., Parkinson J., Sciacca R., Albala A., Edwards N., Szalbolcs M.Z., Cannon P.J. Metabolic and functional protection by selective inhibition of nitric oxide synthase 2 during ischemia-reperfusion in isolated perfused hearts. Circulation 2004, 109:1668-1673.
163. Regan C., Shepherd C., Strack A., Weinberg D., Nargund R., Ye Z., Polard P., Fong T., Renolds I., Lynch J. Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model. Pharmacology 2009, 83:38-44.
164. Ringdahl E., Teague L. Testicular torsion. Am. Fam. Phys. 2006, 74:1739-1743.
165. Rogalewski A., Schneider A., Ringelstein E.B., Schäbitz W.R. Toward a multimodal neuroprotective treatment of stroke. Stroke 2006, 37:1129-1136.
166. Rosas-Ballina M., Olofsson P.S., Ochani M., Valdés-Ferrer S.I., Levine Y.A., Reardon C., Tusche M.W., Pavlov V.A., Andersson U., Chavan S., Mak T.W., Tracey K.J. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science 2011, 334:98-101.
167. Savos A.V., Gee J.M., Zierath D., Becker K.J. α-MSH: a potential neuroprotective and immunomodulatory agent for the treatment of stroke. J. Cereb. Blood Flow Metab. 2011, 31:606-613.
168. Schiöth H.B. The physiological role of melanocortin receptors. Vitam. Horm. 2001, 63:195-232.
169. Schiöth H.B., Haitina T., Ling M.K., Ringholm A., Fredriksson R., Cerdá-Reverter J.M., Klovins J. Evolutionary conservation of the structural, pharmacological, and genomic characteristics of the melanocortin receptor subtypes. Peptides 2005, 26:1886-1900.
170. Schneider C.P., Schwacha M.G., Chaudry I.H. The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage. Biochim. Biophys. Acta 2004, 1689:22-32.
171. Sharma H.S., Skottner A., Lundstedt T., Flärdh M., Wiklund L. Neuroprotective effects of melanocortins in experimental spinal cord injury. An experimental study in the rat using topical application of compounds with varying affinity to melanocortin receptors. J. Neural Transm. 2006, 113:463-476.
172. Shimizu N., Yoshiyama M., Omura T., Hanatani A., Kim S., Takeuchi K., Iwao H., Yoshikawa J. Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats. Cardiovasc. Res. 1998, 38:116-124.
173. Simmons M.N., Subramanian Crouzet V., Haber G-P., Colombo J.R., Ukimura O., Nielsen S., Gill I.S. α-Melanocyte stimulating hormone analogue AP214 protects against ischemia induced acute kidney injury in a porcine surgical model. J. Urol. 2010, 183:1625-1629.
174. 4 receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia. Eur. J. Pharmacol. 2011, 670:479-486.
175. J Spencer S., Mouihate A., Pittman Q.J. Peripheral inflammation exacerbates damage after global ischemia independently of temperature and acute brain inflammation. Stroke 2007, 38:1570-1577.
176. Spulber S., Moldovan M., Oprica M., Aronsson A.F., Post C., Winblad B., Schultzberg M. α-MSH decreases core and brain temperature during global cerebral ischemia in rats. Neuroreport 2005, 16:69-72.
177. Squadrito F., Guarini S., Altavilla D., Squadrito G., Campo G.M., Arlotta M., Quartarone C., Saitta A., Cucinotta D., Bazzani C., Cainazzo M.M., Mioni C., Bertolini A., Caputi A.P. Adrenocorticotropin reverses vascular dysfunction and protects against splanchnic artery occlusion shock. Br. J. Pharmacol. 1999, 128:816-822.
178. Starowicz K., Przewlocka B. The role of melanocortins and their receptors in inflammatory processes, nerve regeneration and nociception. Life Sci. 2003, 73:823-847.
179. Stavchansky V.V., Yuzhakov V.V., Botsina A.Y., Skvortsova V.I., Bondurko L.N., Tsyganova M.G., Limborska S.A., Myasoedov N.F., Dergunova L.V. The effect of semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study. J. Mol. Neurosci. 2011, 45:177-185.
180. Stefanutti G., Pierro A., Parkinson E.J., Smith V.V., Eaton S. Moderate hypothermia as a rescue therapy against intestinal ischemia and reperfusion injury in the rat. Crit. Care Med. 2008, 36:1564-1572.
181. Suh H., Deng W., Gage F.H. Signaling in adult neurogenesis. Annu. Rev. Cell Dev. Biol. 2009, 25:253-275.
182. Tatro J.B. Melanotropin receptors in the brain are differentially distributed and recognize both corticotrophin and alpha-melanocyte stimulating hormone. Brain Res. 1990, 536:124-132.
183. Tatro J.B. Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides. Neuroimmunomodulation 1996, 3:259-284.
184. Tatro J.B. Melanocortins defend their territory: multifaceted neuroprotection in cerebral ischemia. Endocrinology 2006, 147:1122-1125.
185. Tatro J.B., Entwistle M.L. Distribution of melanocortin receptors in the lower brainstem of the rat. Ann. NY Acad. Sci. 1994, 739:311-314.
186. Tatro J.B., Sinha P.S. The central melanocortin system and fever. Ann. NY Acad. Sci. 2003, 994:246-257.
187. Tracey K.J. The inflammatory reflex. Nature 2002, 420:853-859.
188. Tracey K.J. Physiology and immunology of the cholinergic antiinflammatory pathway. J. Clin. Invest. 2007, 117:289-296.
189. Van der Zanden E.P., Boeckxstaens G.E., de Jonge W.J. The vagus nerve as a modulator of intestinal inflammation. Neurogastroenterol. Motil. 2009, 21:6-17.
190. Van Westerloo D. The vagal immune reflex: a blessing from above. Wien Med. Wochenschr. 2010, 160:112-117.
191. Vecsernyes M., Juhasz B., Der P., Kocsan R., Feher P., Bacskay I., Kovacs P., Tosaki A. The administration of α-melanocyte-stimulating hormone protects the ischemic/reperfused myocardium. Eur. J. Pharmacol. 2003, 470:177-183.
192. Versteeg D.H.G., Van Bergen P., Adan R.A.H., De Wildt D.J. Melanocortins and cardiovascular regulation. Eur. J. Pharmacol. 1998, 360:1-14.
193. Vila N., Castillo J., Dávalos A., Esteve A., Planas A.M., Chamorro A. Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke. Stroke 2003, 34:671-675.
194. Vinten-Johansen J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc. Res. 2004, 61:481-497.
195. Westendorp W.F., Nederkoorn P.J., Vermeij J.D., Dijkgraaf M.G., van de Beek D. Post-stroke infection: a systematic review and meta-analysis. BMC Neurol. 2011, 11:110.
196. Wikberg J.E., Mutulis F. Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction. Nat. Rev. Drug Discov. 2008, 7:307-323.
197. Wikberg J.E.S., Muceniece R., Mandrika I., Prusis P., Lindblom J., Post C., Skottner A. New aspects on the melanocortins and their receptors. Pharmacol. Res. 2000, 42:393-420.
198. Xi G., Keep R.F., Hoff J.T. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006, 5:53-63.
199. Yassin M.M.I., Harkin D.W., Barros D'Sa A.A.B., Halliday M.I., Rowlands B.J. Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction. World J. Surg. 2002, 26:115-121.
200. Yepes M., Roussel B.D., Ali C. Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic. Trends Neurosci. 2009, 32:48-55.
201. Young J.A. Pharmacotherapy for traumatic brain injury: focus on sympathomimetics. Pharmacol. Ther. 2012, 134:1-7.
202. Zhang G., Zhang L., Logan R., Jung B.P., Yuen D., Ching Hsu J., Eubanks J.H. Decreased expression and impaired function of muscarinic acetylcholine receptors in the rat hippocampus following transient forebrain ischemia. Neurobiol. Dis. 2005, 20:805-813.
203. Zhang Z.G., Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol. 2009, 8:491-500.
204. Zorowitz R., Brainin M. Advances in brain recovery and rehabilitation. Stroke 2010, 42(2011):294-297.
205. Zou L., Sato N., Attuwaybi B.O., Kone B.C. Delayed administration of α-melanocyte-stimulating hormone or combined therapy with BAY 11-7085 protects against gut ischemia-reperfusion injury. Shock 2003, 20:469-475.