Targeting the melanocortin receptor system for anti-stroke therapy

Trends in Pharmacological Sciences

Volumn 32, Issue 2, 2011, Pages 90-98

  Holloway, Paul M ^a   Smith, Helen K ^a   Renshaw, Derek ^c   Flower, Roderick J ^b   Getting, Stephen J ^c   Gavins, Felicity N E ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF WESTMINSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AFAMELANOTIDE; AGOUTI PROTEIN; AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; BETA INTERMEDIN; BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; BMS 470539; CORTICOTROPIN; GAMMA INTERMEDIN; HORMONE RECEPTOR AFFECTING AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MELANOCORTIN RECEPTOR; MELANOTAN II; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE; THIQ; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN INFARCTION; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CYTOKINE RELEASE; ERECTILE DYSFUNCTION; ERYTHROPOIETIC PROTOPORPHYRIA; HEMORRHAGIC SHOCK; HUMAN; LEUKOCYTE ADHERENCE; LIPID METABOLISM; NERVOUS SYSTEM INFLAMMATION; NEUROPATHY; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PHOTODERMATOSIS; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; RISK FACTOR; TRAUMATIC SHOCK;

ANIMALS; HUMANS; MOLECULAR TARGETED THERAPY; RECEPTORS, MELANOCORTIN; SIGNAL TRANSDUCTION; STROKE;

EID: 79651472010     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2010.11.010     Document Type: Review

References (64)

1. G.A. Donnan Stroke Lancet 371 2008 1612 1623 (Pubitemid 351626845)
2. Office for National Statistics (2008) Deaths: underlying cause, sex and age-group, 2008. Chapter IX. Diseases of the circulatory system. In Mortality Statistics: Deaths Registered in 2008, National Statistics
3. N.R. Sims, and H. Muyderman Mitochondria, oxidative metabolism and cell death in stroke Biochim. Biophys. Acta 1802 2010 80 91
4. X. Li Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia J. Neurochem. 113 2010 1012 1022
5. F. Gavins, G. Yilmaz, and D.N. Granger The evolving paradigm for blood cell-endothelial cell interactions in the cerebral microcirculation Microcirculation 14 2007 667 681 (Pubitemid 47434284)
6. 4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion Brain Res. 1323 2010 174 183
7. F.N. Gavins Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation FASEB J. 21 2007 1751 1758 (Pubitemid 46855621)
8. J. Zhang Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury J. Neurosci. Res. 86 2008 1501 1510 (Pubitemid 351642443)
9. K. Arai, and E.H. Lo Experimental models for analysis of oligodendrocyte pathophysiology in stroke Exp. Transl. Stroke Med. 1 2009 6
10. D.J. Gladstone, S.E. Black, and A.M. Hakim Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions Stroke 33 2002 2123 2136 (Pubitemid 34840080)
11. A. Catania Targeting melanocortin receptors as a novel strategy to control inflammation Pharmacol. Rev. 56 2004 1 29 (Pubitemid 38314578)
12. T. Brzoska alpha-Melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases Endocr. Rev. 29 2008 581 602
13. A. Catania The melanocortin system in leukocyte biology J. Leukoc. Biol. 81 2007 383 392 (Pubitemid 46198388)
14. S.J. Getting Targeting melanocortin receptors as potential novel therapeutics Pharmacol. Ther. 111 2006 1 15 (Pubitemid 43765537)
15. J.M. Lipton Mechanisms of anti-inflammatory action of alpha-MSH peptides. In vivo and in vitro evidence Ann. N. Y. Acad. Sci. 885 1999 173 182
16. G. Leoni Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion FASEB J. 22 2008 4228 4238
17. A. Bertolini, R. Tacchi, and A.V. Vergoni Brain effects of melanocortins Pharmacol. Res. 59 2009 13 47
18. J.D. Spencer, and K.U. Schallreuter Regulation of pigmentation in human epidermal melanocytes by functional high-affinity beta-melanocyte-stimulating hormone/melanocortin-4 receptor signaling Endocrinology 150 2009 1250 1258
19. D.J. Lee, D.J. Biros, and A.W. Taylor Injection of an alpha-melanocyte stimulating hormone expression plasmid is effective in suppressing experimental autoimmune uveitis Int. Immunopharmacol. 9 2009 1079 1086
20. D. Giuliani Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia Endocrinology 147 2006 1126 1135 (Pubitemid 43244343)
21. S.K. Manna, and B.B. Aggarwal alpha-Melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappaB activation induced by various inflammatory agents J. Immunol. 161 1998 2873 2880 (Pubitemid 28425709)
22. B.W. McColl, S.M. Allan, and N.J. Rothwell Systemic inflammation and stroke: aetiology, pathology and targets for therapy Biochem. Soc. Trans. 35 2007 1163 1165 (Pubitemid 350206451)
23. S.K. Manna, A. Sarkar, and Y. Sreenivasan alpha-Melanocyte-stimulating hormone down-regulates CXC receptors through activation of neutrophil elastase Eur. J. Immunol. 36 2006 754 769
24. A. Ottani Vagus nerve mediates the protective effects of melanocortins against cerebral and systemic damage after ischemic stroke J. Cereb. Blood Flow Metab. 29 2008 512 523
25. S. Lakhan, A. Kirchgessner, and M. Hofer Inflammatory mechanisms in ischemic stroke: therapeutic approaches J. Transl. Med. 7 2009 97
26. Q. Huang, and J.B. Tatro alpha-Melanocyte stimulating hormone suppresses intracerebral tumor necrosis factor-alpha and interleukin-1beta gene expression following transient cerebral ischemia in mice Neurosci. Lett. 334 2002 186 190 (Pubitemid 35350857)
27. D. Giuliani Functional recovery after delayed treatment of ischemic stroke with melanocortins is associated with overexpression of the activity-dependent gene Zif268 Brain Behav. Immun. 23 2009 844 850
28. E.I. Minder Afamelanotide. Melanocortin MC1 receptor agonist, photoprotective agent Drugs Future 35 2010 365 372
29. H. Shinyama Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization Endocrinology 144 2003 1301 1314 (Pubitemid 36428472)
30. A.A. da Silva Does obesity induce resistance to the long-term cardiovascular and metabolic actions of melanocortin 3/4 receptor activation? Hypertension 47 2006 259 264 (Pubitemid 43189772)
31. R. Muceniece Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation Basic Clin. Pharmacol. Toxicol. 101 2007 416 420 (Pubitemid 350135344)
32. G. Leoni The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature Br. J. Pharmacol. 160 2010 171 180
33. J. Mann Truths about the NINDS study: setting the record straight West J. Med. 176 2002 192 219
34. C. Brekenfeld Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase J. Neurol. Neurosurg. Psychiatry. 78 2007 280 285 (Pubitemid 46579667)
35. C.S. Kase Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: The PROACT II trial Neurology 57 2001 1603 1610 (Pubitemid 33055477)
36. The Multicenter Acute Stroke Trial - Europe Study Group. (1996) Thrombolytic therapy with streptokinase in acute ischemic stroke. N. Engl. J. Med. 335, 145-150
37. M. Paciaroni, E. Medeiros, and J. Bogousslavsky Desmoteplase Expert Opin. Biol. Ther. 9 2009 773 778
38. K.J. Becker Anti-leukocyte antibodies: LeukArrest (Hu23F2G) and Enlimomab (R6.5) in acute stroke Curr. Med. Res. Opin. 18 2002 18 22
39. M.E. Sughrue Anti-adhesion molecule strategies as potential neuroprotective agents in cerebral ischemia: a critical review of the literature Inflamm. Res. 53 2004 497 508 (Pubitemid 40110114)
40. Y. Lampl Minocycline treatment in acute stroke: an open-label, evaluator-blinded study Neurology 69 2007 1404 1410 (Pubitemid 47511461)
41. E. van Breda PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN 74418480] BMC Cardiovascular Disorders 5 2005 24
42. K. Yamagata Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat Neuroscience 153 2008 428 435
43. L.C. Pettigrew Effect of arundic acid on serum S-100β in ischemic stroke J. Neurol. Sci. 251 2006 57 61 (Pubitemid 44792139)
44. H.C.A. Emsley A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients J. Neurol. Neurosurg. Psychiatry. 76 2005 1366 1372 (Pubitemid 41360973)
45. X. Liu Efficacy and safety of ginsenoside-Rd for acute ischaemic stroke: a randomized, double-blind, placebo-controlled, phase II multicenter trial Eur. J. Neurol. 16 2009 569 575
46. P. Bath Tirilazad mesylate in acute ischemic stroke: a systematic review Stroke 31 2000 2257 2265
47. S.G. Sydserff Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window Br. J. Pharmacol. 135 2002 103 112 (Pubitemid 34102103)
48. M.K. Sinha Edaravone in acute ischemic stroke. An Indian experience Neurol. Asia 14 2009 7 10
49. M. Ishikawa Angiotensin II type 1 receptor signaling contributes to platelet-leukocyte-endothelial cell interactions in the cerebral microvasculature Am. J. Physiol. Heart Circ. Physiol. 292 2007 H2306 H2315
50. U. Fischer Impact of comorbidity on ischemic stroke outcome Acta Neurol. Scand 113 2006 108 113
51. G.N. Neigh Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by minocycline Stroke 40 2009 3601 3607
52. J. Kofler Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia J. Cereb. Blood Flow Metab. 26 2006 135 141 (Pubitemid 41818077)
53. A. Radovsky Regional prevalence and distribution of ischemic neurons in dog brains 96 hours after cardiac arrest of 0 to 20 minutes Stroke 26 1995 2127 2133
54. R. Kumari The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse J. Cereb. Blood Flow Metab. 30 2010 352 360
55. A. Bacher, J.Y. Kwon, and M.H. Zornow Effects of temperature on cerebral tissue oxygen tension, carbon dioxide tension, and pH during transient global ischemia in rabbits Anesthesiology 88 1998 403 409 (Pubitemid 28081201)
56. T. Brott Measurements of acute cerebral infarction: lesion size by computed tomography Stroke 20 1989 871 875 (Pubitemid 19188241)
57. L. Belayev Middle cerebral artery occlusion in the mouse by intraluminal suture coated with poly-L-lysine: neurological and histological validation Brain Res. 833 1999 181 190 (Pubitemid 29333792)
58. J.D. Lozano Characterization of a thromboembolic photochemical model of repeated stroke in mice J. Neurosci. Methods 162 2007 244 254 (Pubitemid 46527933)
59. O. Mayzel-Oreg Microsphere-induced embolic stroke: an MRI study Magn. Reson. Med. 51 2004 1232 1238 (Pubitemid 38797009)
60. W.A. Pulsinelli, and J.B. Brierley A new model of bilateral hemispheric ischemia in the unanesthetized rat Stroke 10 1979 267 272 (Pubitemid 9141527)
61. R. Muceniece The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation model Peptides 27 2006 1443 1450 (Pubitemid 43766982)
62. R. Muceniece beta-MSH inhibits brain inflammation via MC3/4 receptors and impaired NF-kappaB signaling J. Neuroimmunol. 169 2005 13 19 (Pubitemid 41527087)
63. D.M. Dinulescu, and R.D. Cone Agouti and Agouti-related protein: analogies and contrasts J. Biol. Chem. 275 2000 6695 6698 (Pubitemid 30146202)
64. P. Grieco Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors J. Med. Chem. 45 2002 5287 5294 (Pubitemid 35429167)