Molecular changes induced in rat liver by hemorrhage and effects of melanocortin treatment

Anesthesiology

Volumn 116, Issue 3, 2012, Pages 692-700

  Lonati, Caterina ^a   Sordi, Andrea ^a   Giuliani, Daniela ^b   Spaccapelo, Luca ^b   Leonardi, Patrizia ^c   Carlin, Andrea ^c   Ottani, Alessandra ^b   Galantucci, Maria ^b   Grieco, Paolo ^d   Catania, Anna ^a   Guarini, Salvatore ^b  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ALPHA 2 MACROGLOBULIN; BUTYL HISTIDYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLSARCOSINAMIDE; EARLY GROWTH RESPONSE FACTOR 1; ERYTHROPOIETIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN HSPA1A; HEME OXYGENASE 1; INTERLEUKIN 6; LACTIC ACID; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; NUCLEAR RECEPTOR NUR77; PROTEIN C JUN; PROTEIN ZO1; RO 273225; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; GAS ANALYSIS; GENE EXPRESSION PROFILING; LACTATE BLOOD LEVEL; LIVER; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; MELANOCORTINS; PEPTIDES; RATS; RATS, WISTAR; RECEPTOR, MELANOCORTIN, TYPE 1; RECEPTOR, MELANOCORTIN, TYPE 4; SHOCK, HEMORRHAGIC; TREATMENT OUTCOME;

EID: 84859109157     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318246ea68     Document Type: Article

References (45)

1. Jastrow KM 3rd, Gonzalez EA, McGuire MF, Suliburk JW, Kozar RA, Iyengar S, Motschall DA, McKinley BA, Moore FA, Mercer DW: Early cytokine production risk stratifies trauma patients for multiple organ failure. J Am Coll Surg 2009; 209:320-31
2. Marik PE, Corwin HL: Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature. Crit Care Med 2008; 36:2667-74
3. Prince JM, Ming MJ, Levy RM, Liu S, Pinsky DJ, Vodovotz Y, Billiar TR: Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock. Shock 2007; 27:157-64 (Pubitemid 46105832)
4. Evgenov OV, Liaudet L: Role of nitrosative stress and activation of poly(ADP-ribose) polymerase-1 in cardiovascular failure associated with septic and hemorrhagic shock. Curr Vasc Pharmacol 2005; 3:293-9 (Pubitemid 40933051)
5. Hierholzer C, Billiar TR: Molecular mechanisms in the early phase of hemorrhagic shock. Langenbecks Arch Surg 2001; 386:302-8 (Pubitemid 32702760)
6. Feinman R, Deitch EA, Aris V, Chu HB, Abungu B, Caputo FJ, Galante A, Xu D, Lu Q, Colorado I, Streck D, Dermody J, Soteropoulos P: Molecular signatures of trauma-hemorrhagic shock-induced lung injury: Hemorrhage-and injury-associated genes. Shock 2007; 28:360-8 (Pubitemid 47282029)
7. Sundar SV, Li YY, Rollwagen FM, Maheshwari RK: Hemorrhagic shock induces differential gene expression and apoptosis in mouse liver. Biochem Biophys Res Commun 2005; 332:688-96 (Pubitemid 40745169)
8. van Meurs M, Wulfert FM, Knol AJ, De Haes A, Houwertjes M, Aarts LP, Molema G: Early organ-specific endothelial activation during hemorrhagic shock and resuscitation. Shock 2008; 29:291-9
9. Peitzman AB, Billiar TR, Harbrecht BG, Kelly E, Udekwu AO, Simmons RL: Hemorrhagic shock. Curr Probl Surg 1995; 32:925-1002
10. Catania A, Gatti S, Colombo G, Lipton JM: Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 2004; 56:1-29 (Pubitemid 38314578)
11. Mountjoy KG: Distribution and function of melanocortin receptors within the brain. Adv Exp Med Biol 2010; 681:29-48
12. Catania A: The melanocortin system in leukocyte biology. J Leukoc Biol 2007; 81:383-92
13. Gatti S, Colombo G, Turcatti F, Lonati C, Sordi A, Bonino F, Lipton JM, Catania A: Reduced expression of the melanocortin- 1 receptor in human liver during brain death. Neuroimmunomodulation 2006; 13:51-5 (Pubitemid 44174861)
14. Giuliani D, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Capolongo S, Sabba A, Galantucci M, Iannone A, Grieco P, Novellino E, Colombo G, Tomasi A, Catania A, Guarini S: Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol 2007; 150:595-603 (Pubitemid 46355552)
15. Guarini S, Altavilla D, Cainazzo MM, Giuliani D, Bigiani A, Marini H, Squadrito G, Minutoli L, Bertolini A, Marini R, Adamo EB, Venuti FS, Squadrito F: Efferent vagal fibre stimulation blunts nuclear factor-κB activation and protects against hypovolemic hemorrhagic shock. Circulation 2003; 107:1189-94 (Pubitemid 36297213)
16. Guarini S, Cainazzo MM, Giuliani D, Mioni C, Altavilla D, Marini H, Bigiani A, Ghiaroni V, Passaniti M, Leone S, Bazzani C, Caputi AP, Squadrito F, Bertolini A: Adrenocorticotropin reverses hemorrhagic shock in anesthetized rats through the rapid activation of a vagal anti-inflammatory pathway. Cardiovasc Res 2004; 63:357-65 (Pubitemid 38900850)
17. Guarini S, Tagliavini S, Bazzani C, Ferrari W, Bertolini A: Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective. Crit Care Med 1990; 18:862-5 (Pubitemid 20233480)
18. Noera G, Lamarra M, Guarini S, Bertolini A: Survival rate after early treatment for acute type-A aortic dissection with ACTH-(1-24). Lancet 2001; 358:469-70 (Pubitemid 32769856)
19. Guarini S, Ferrari W, Mottillo G, Bertolini A: Anti-shock effect of ACTH: Haematological changes and influence of splenectomy. Arch In Pharmacodyn 1987; 289:311-8 (Pubitemid 18053887)
20. Alam HB, Stegalkina S, Rhee P, Koustova E: cDNA array analysis of gene expression following hemorrhagic shock and resuscitation in rats. Resuscitation 2002; 54:195-206 (Pubitemid 34879909)
21. Bazzani C, Tagliavini S, Bertolini E, Bertolini A, Guarini S: Influence of ACTH-(1-24) on metabolic acidosis and hypoxemia induced by massive hemorrhage in rats. Resuscitation 1992; 23:113-20
22. Catania A, Lonati C, Sordi A, Leonardi P, Carlin A, Gatti S: The peptide NDP-MSH induces phenotype changes in the heart that resemble ischemic preconditioning. Peptides 2010; 31:116-22
23. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3:RESEARCH0034
24. Prince JM, Levy RM, Yang R, Mollen KP, Fink MP, Vodovotz Y, Billiar TR: Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg 2006; 202:407-17 (Pubitemid 43356214)
25. Meng ZH, Dyer K, Billiar TR, Tweardy DJ: Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock. Am J Physiol Cell Physiol 2001; 280:C343-51
26. Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T, Le Beaud MM, Adamsone ED: A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 1988; 53:37-43
27. Yan SF, Fujita T, Lu J, Okada K, Shan Zou Y, Mackman N, Pinsky DJ, Stern DM: Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 2000; 6:1355-61 (Pubitemid 32001019)
28. Khachigian LM, Collins T: Inducible expression of Egr-1- dependent genes. A paradigm of transcriptional activation in vascular endothelium. Circ Res 1997; 81:457-61 (Pubitemid 27432731)
29. Khachigian LM, Anderson KR, Halnon NJ, Gimbrone MA Jr, Resnick N, Collins T: Egr-1 isactivated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter. Arterioscler Thromb Vasc Biol 1997; 17:2280-6 (Pubitemid 28057133)
30. Ni XP, Butler AA, Cone RD, Humphreys MH: Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones. J Hypertens 2006; 24:2239-46 (Pubitemid 44611033)
31. Matsumura K, Tsuchihashi T, Abe I, Iida M: Central α-melanocyte- stimulating hormone acts at melanocortin-4 receptor to activate sympathetic nervous system in conscious rabbits. Brain Res 2002; 948:145-8 (Pubitemid 35283772)
32. Bertolini A, Guarini S, Rompianesi E, Ferrari W: α-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock. Eur J Pharmacol 1986; 130:19-26 (Pubitemid 17170848)
33. Maxwell MA, Muscat GE: The NR4A subgroup: immediate early response genes with pleiotropic physiological roles. Nucl Recept Signal 2006; 4:e002
34. Song KH: Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression. Biochem Biophys Res Commun 2010; 392:63-6
35. Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P: NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med 2006; 12:1048-55 (Pubitemid 44353386)
36. Torres Filho IP, Torres LN, Pittman RN: Early physiologic responses to hemorrhagic hypotension. Transl Res 2010; 155:78-88
37. Torres LN, Torres Filho IP, Barbee RW, Tiba MH, Ward KR, Pittman RN: Systemic responses to prolonged hemorrhagic hypotension. Am J Physiol Heart Circ Physiol 2004; 286:H1811-20 (Pubitemid 38525470)
38. Harhaj NS, Antonetti DA: Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol 2004; 36:1206-37 (Pubitemid 38519069)
39. Blum MS, Toninelli E, Anderson JM, Balda MS, Zhou J, O'Donnell L, Pardi R, Bender JR: Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines. Am J Physiol 1997; 273:H286-94
40. Yang R, Han X, Uchiyama T, Watkins SK, Yaguchi A, Delude RL, Fink MP: IL-6 isessential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol Gastrointest Liver Physiol 2003; 285:G621-9 (Pubitemid 37021822)
41. Fink MP, Delude RL: Epithelial barrier dysfunction: A unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin 2005; 21:177-96 (Pubitemid 40386748)
42. Ichiyama T, Sakai T, Catania A, Barsh GS, Furukawa S, Lipton JM: Inhibition of peripheral NF-κB activation by central action of α-melanocyte-stimulating hormone. J Neuroimmunol 1999; 99:211-7 (Pubitemid 29518233)
43. Macaluso A, McCoy D, Ceriani G, Watanabe T, Biltz J, Catania A, Lipton JM: Antiinflammatory influences of α-MSH molecules: Central neurogenic and peripheral actions. J Neurosci 1994; 14:2377-82
44. Giuliani D, Ottani A, Altavilla D, Bazzani C, Squadrito F, Guarini S: Melanocortins and the cholinergic anti-inflammatory pathway. Adv Exp Med Biol 2010; 681:71-87
45. Corander MP, Fenech M, Coll AP: Science of self-preservation: How melanocortin action in the brain modulates body weight, blood pressure, and ischemic damage. Circulation 2009; 120:2260-8