MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct

Journal of Leukocyte Biology

Volumn 76, Issue 4, 2004, Pages 845-853

  Getting, Stephen J ^a,b   Di Filippo, Clara ^b   Christian, Helen C ^c   Lam, Connie W ^a   Rossi, Francesco ^b   D'Amico, Michele ^b   Perretti, Mauro ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HEART MUSCLE EXTRACT; HS 024; INTERLEUKIN 1; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 3 RECEPTOR AGONIST; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 4 RECEPTOR AGONIST; MELANOTAN II; MESSENGER RNA; MYELOPEROXIDASE; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; PROTEIN; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; FIBROBLAST; GENE MUTATION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IMMUNOGOLD LABELING; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REPERFUSION INJURY;

ACUTE DISEASE; ALPHA-MSH; ANIMALS; FIBROBLASTS; INTERLEUKIN-1; MACROPHAGES; MELANOCYTE-STIMULATING HORMONES; MICE; MUTATION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; PEPTIDES, CYCLIC; PEROXIDASE; RATS; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTORS, CORTICOTROPIN;

ANIMALIA;

EID: 4744373167     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0306175     Document Type: Article

References (52)

1. Poon, B. Y., Ward, C. A., Cooper, C. B., Giles, W. R., Burns, A. R., Kubes, P. (2001) alpha(4)-Integrin mediates neutrophil-induced free radical injury to cardiac myocytes. J. Cell Biol. 152, 857-866.
2. Lefer, D. J. (2002) Do neutrophils contribute to myocardial reperfusion injury? Basic Res. Cardiol. 97, 263-267.
3. Lefer, D. J., Granger, D. N. (2000) Oxidative stress and cardiac disease. Am. J. Med. 109, 315-323.
4. Frangogiannis, N. G., Smith, C. W., Entman, M. L. (2002) The inflammatory response in myocardial infarction. Cardiovasc. Res. 53, 31-47.
5. La, M., Tailor, A., D'Amico, M., Flower, R. J., Perrelli, M. (2001) Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment. Eur. J. Pharmacol. 429, 263-278.
6. Latini, R., Bianchi, M., Correale, E., Dinarello, C. A., Fantuzzi, G., Fresco, C., Maggioni, A. P., Mengozzi, M., Romano, S., Shapiro, L., et al. (1994) Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist. J. Cardiovasc. Pharmacol. 23, 1-6.
7. Blum, A. (1906) Interleukin-1 in acute myocardial infarction. Lancet 347, 56.
8. Maulik, N., Engelman, R. M., Wei, Z., Lu, D., Rouson, J. A., Das, D. K. (1993) Interleukin-1 alpha preconditioning reduces myocardial ischemia reperfusion injury. Circulation 88, 11387-11394.
9. Pannitteri, G., Marino, B., Campa, P. P., Martucci, R., Testa, U., Peschle, C. (1997) Interleukins 6 and 8 as mediators of acute phase response in acute myocardial infarction. Am. J. Cardiol. 80, 622-625.
10. Abe, Y., Kawakami, M., Kuroki, M., Yamamoto, T., Fujii, M., Kobayashi, H., Yaginuma, T., Kashii, A., Saito, M., Matsushima, K. (1993) Transient rise in serum interleukin-8 concentration during acute myocardial infarction. Br. Heart J. 70, 132-134.
11. Anguera, I., Miranda-Guardiola, F., Bosch, X., Filella, X., Sitges, M., Marin, J. L., Betriu, A., Sanz, G. (2002) Elevation of serum levels of the anti-inflammatory (cytokine interleukin-10 and decreased risk of coronary events in patients with unstable angina. Am. Heart J. 144, 811-817.
12. de Lemos, J. A., Morrow, D. A., Sabatine, M. S., Murphy, S. A., Gibson, C. M., Antman, E. M., McCabe, C. H., Cannon, C. P., Braunwald, E. (2003) Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes. Circulation 107, 690-695.
13. Mallat, Z., Henry, P., Fressonnet, R., Alouani, S., Scoazec, A., Beaufils, P., Chvatchko, Y., Tedgui, A. (2002) Increased plasma concentrations of interleukin-18 in acute coronary syndromes. Heart 88, 467-469.
14. D'Amico, M., Di Filippo, C., La, M., Solito, E., McLean, P. G., Flower, R. J., Oliani, S. M., Perretti, M. (2000) Lipocortin 1 reduces myocardial ischaemia-reperfusion injury by affecting local leukocyte recruitment. FASEB J. 14, 1867-1869.
15. 2,-receptor activation inhibits neutrophil-mediated injury to coronary endothelium. Am. J. Physiol. 271, H1456-H1464.
16. Di Filippo, C., Rossi, F., Rossi, S., D'Amico, M. (2004) Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN. J. Leukoc. Biol. 75, 453-459.
17. Wikberg, J. E., Muceniece, R., Mandrika, I., Prusis P., Lindblom, J., Post, C., Skottner, A. (2000) New aspects on the melanocortins and their receptors. Pharmacol. Res. 42, 393-420.
18. Delgado, R., Carlin, A., Airaghi, L., Demitri, M. T., Meda, L., Galimberti, D., Baron, P., Lipton, J. M., Catania, A. (1998) Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia. J. Leukoc. Biol. 63, 740-745.
19. Altavilla, D., Cainazzo, M. M., Squadrito, F., Guarini, S., Bertolini, A., Bazzani, C. (1998) Tumour necrosis factor-alpha as a target of melanocortins in haemorrhagic shock, in the anaesthetized rat. Br. J. Pharmacol. 124, 1587-1590.
20. Squadrito, F., Guarini, S., Altavilla, D., Squadrito, G., Campo, G. M., Arlotta, M., Quartarone, C., Saitta, A., Cucinotta, D., Bazzani, C., et al. (1999) Adrenocorticotropin reverses vascular dysfunction and protects against splanchnic artery occlusion shock. Br. J. Pharmacol. 128, 816-822.
21. Getting, S. J., Gibbs, L., Clark, A. J., Flower, R. J., Perretti, M. (1999) POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. J. Immunol. 162, 7446-7453.
22. Getting, S. J., Christian, H. C., Flower, R. J., Perretti, M. (2002) Activation of melanocortin type 3 receptor as a molecular mechanism for adronocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum. 46, 2765-2775.
23. 1. PAF and rIL-8. Cytokine 4, 320-328.
24. Lipton, J. M., Catania, A. (1997) Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunol. Today 18, 140-145.
25. Gautz, I., Fong, T. M. (2003) The melanocortin system. Am. J. Physiol. Endocrinol. Metab. 284, E468-E474.
26. Getting, S. J. (2002) Melanocortin peptides and their receptors: new targets for anti-inflammatory therapy. Trends Pharmacol. Sci. 23, 447-449.
27. Getting, S. J., Christian, H. C., Lam, C. W., Gavins, K. N., Flower, R. J., Schioth, H. B., Perretti, M. (2003) Redundancy of a Functional Melanocortin 1 Receptor in the Anti-inflammatory Actions of Melanocortin Peptides: Studies in the Recessive Yellow (e/e) Mouse Suggest an Important Role for Melanocortin 3 Receptor. J. Immunol. 170, 3323-3330.
28. Gautz, I., Konda, Y., Tashiro, T., Shimoto, Y., Miwa, H., Muuzert, G., Watson, S. J., Del Valle, J., Yamada, T. (1993) Molecular cloning of a novel melanocortin receptor. J. Biol. Chem. 268, 8246-8250.
29. Guarini, S., Schioth, H. B., Mioni, C., Cainazzo, M., Ferrazza, C., Ginliani, D., Wikberg, J. E., Bertolini, A., Bazzani, C. (2002) MC(3) receptors are involved in the protective effect of melanocortins in myocardial ischemia/reperfusion-induced arrhythmias. Naunyn Schmiedergras Arch Pharmacol 366, 177-182.
30. Mioni, C., Giuliani, D., Cainazzo, M. M., Leone, S., Iannone, C., Bazzani, C., Grieco, P., Novellino, E., Tomasi, A., Bertolini, A., et al. (2003) Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC(3) receptors. Eur. J. Pharmacol. 477, 227-234.
31. Michael, L. H., Entman, M. L., Hartley, C. J., Youker, K. A., Zhu, J., Hall, S. R., Hawkins, H. K., Berens, K., Ballantyne, C. M. (1995) Myocardial ischemia and reperfusion: a murine model. Am. J. Physiol. 269, H2147-H2154.
32. Al-Obeidi, F., Castrucci, A. M., Hadley, M. E., Hruby, V. J. (1989) Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics. J. Med. Chem. 32, 2555-2561.
33. Hruby, V. J., Lu, D., Sharma, S. D., Castrucci, A. L., Kesterson, R. A., al-Obeidi, F. A., Hadley, M. E., Cone, R. D. (1995) Cyclic lactam alpha-melanotropin analogues of Ar-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH12 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38, 3454-3461.
34. Kask, A., Mutulis, F., Muceniece, R., Palikla, R., Mutule, I., Wikberg, J. E., Rago, L., Schioth, H. B. (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139, 5006-5014.
35. Getting, S. J., Allcock, G. H., Flower, R., Perretti, M. (2001) Natural and synthetic agonists of the melanocortin receptor type 3 possess antiinflammatory properties. J. Leukoc. Biol. 69, 98-104.
36. Harris, J. C., Flower, R. J., Perrelli, M. (1995) Endogenous corticosteroids mediate neutrophilia caused by platelet-activating factor in the mouse. Eur. J. Pharmacol. 283, 9-18.
37. Mullane, K. M., Kraemer, R., Smith, B. (1985) Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischaemic myocardium. J. Pharmacol. Methods 14, 157-163.
38. Lim, Y. C., Garcia-Cardena, G., Allport, J. R., Zervoglos, M., Connolly, A. J., Gimbrone, M. A., Jr., Luscinskas, F. W. (2003) Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am. J. Pathol. 162, 1591-1601.
39. Yamashita, N., Nishida, M., Hoshida, S., Kuznya, T., Hori, M., Taniguchi, N., Kamada T., Tada, M. (1994) Induction of manganese superoxide dismutase in rat cardiac myocytes increases tolerance to hypoxia 24 hours after preconditioning. J. Clin. Invest. 94, 2193-2199.
40. La, M., D'Amico, M., Bandiera, S., Di Filippo, C., Oliani, S. M., Gavins, F. N., Flower, R. J., Perretti, M. (2001) Annexin 1 peptides protect against experimental myocardial ischemia- reperfusion: analysis of their mechanism of action. FASEB J. 15, 2247-2256.
41. Mason, M. J., Van Epps, D. (1989) Modulation of IL-1, tumor necrosis factor, and C5a-mediated murine neutrophil migration by α-melanocyte- stimulating hormone. J. Immunol. 142, 1646-1651.
42. Getting, S. J., Flower, R. J., Perretti, M. (1999) Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx. Inflamm. Res. 48, Suppl 2, S140-S141.
43. Bazzani, C., Guarini, S., Botlicelli, A. R., Xaffe, D., Tomasi, A., Bini, A., Cainazzo, M. M., Ferrazza, G., Mioni, C., Bertolini, A. (2001) Protective effect of melanocortin peptides in rat myocardial ischemia. J. Pharmacol. Exp. Ther. 297, 1082-1087.
44. Fan, W., Boston, B. A., Kesterson, R. A., Hruhy, V. J., Cone, R. D. (1997) Role of melanocortinergic neorones in feeding and the agouti obesity syndrome. Nature 385, 165-108.
45. Roselli-Rehfuss, L., Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., Low, M. J., Tatro, J. R., Entwistle, M. L., Simerly, R. B., Cone, R. D. (1993) Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc. Natl. Acad. Sci. USA 90, 8856-8860.
46. Li, S. J., Varga, K., Archer, P., Hruby, V. J., Sharma, S. D., Kesterson, R. A., Cone, R. D., Kunos, G. (1996) Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte- stimulating hormones. J. Neurosci. 16, 5182-5188.
47. Robbins, L. S., Nadeau, J. H., Johnson, K. R., Kelly, M. A., Roselli-Rehfuss, L., Baack, E., Mountjoy, K. G., Cone, K. D. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72, 827-834.
48. Catania, A., Gatti, S., Colombo, G., Lipton, J. M. (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol. Rev. 56, 1-29.
49. Catania, A., Rajora, N., Capsoni, F., Minonzio, F., Star, R. A., Lipton, J. M. (1996) The neuropeptide alpha-MSH has specific receptors on neutrophils and reduces chemolaxis in vitro. Peptides 17, 675-679.
50. Adachi, S., Nakano, T., Vliagoftis, H., Metcalfe, D. D. (1999) Receptor-mediated modulalion of murine mast cell function by alpha-melanocyte stimulating hormone. J. Immunol. 163, 3363-3368.
51. Hasko, G., Kuhel, D. G., Chen, J. F., Schwarzschild, M. A., Deitch, E. A., Mabley, J. G., Marton, A., Szaho, C. (2000) Adenosine inhibits IL-12 and TNF-α production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J. 14, 2065-2074.
52. Gersch, C., Dewald, O., Zoerlein, M., Michael, L. H., Entman, M. L., Frangogiannis. N. G. (2002) Mast cells and macrophages in normal C57/BL/6 mice. Histochem. Cell Biol. 118, 41-49.