메뉴 건너뛰기




Volumn 8, Issue 5, 2009, Pages 491-500

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; SILDENAFIL;

EID: 64349107251     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(09)70061-4     Document Type: Review
Times cited : (521)

References (146)
  • 1
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • NINDS
    • NINDS. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 333 (1995) 1581-1587
    • (1995) N Engl J Med , vol.333 , pp. 1581-1587
  • 2
    • 52649165720 scopus 로고    scopus 로고
    • Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
    • Hacke W., Kaste M., Bluhmki E., et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359 (2008) 1317-1329
    • (2008) N Engl J Med , vol.359 , pp. 1317-1329
    • Hacke, W.1    Kaste, M.2    Bluhmki, E.3
  • 3
    • 0030635616 scopus 로고    scopus 로고
    • The role of polypeptide growth factors in recovery from stroke
    • Freund H.-J., Sabel B.A., and Witte O.W. (Eds), Lippincott-Raven, Philadephia
    • Kawamata T., Speliotes E.K., and Finklestein S.P. The role of polypeptide growth factors in recovery from stroke. In: Freund H.-J., Sabel B.A., and Witte O.W. (Eds). Brain Plasticity (1997), Lippincott-Raven, Philadephia 377-382
    • (1997) Brain Plasticity , pp. 377-382
    • Kawamata, T.1    Speliotes, E.K.2    Finklestein, S.P.3
  • 4
    • 0034213060 scopus 로고    scopus 로고
    • Recovery recapitulates ontogeny
    • Cramer S.C., and Chopp M. Recovery recapitulates ontogeny. Trends Neurosci 23 (2000) 265-271
    • (2000) Trends Neurosci , vol.23 , pp. 265-271
    • Cramer, S.C.1    Chopp, M.2
  • 5
    • 0037458918 scopus 로고    scopus 로고
    • Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat
    • Zhang R., Wang L., Zhang L., et al. Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat. Circ Res 92 (2003) 308-313
    • (2003) Circ Res , vol.92 , pp. 308-313
    • Zhang, R.1    Wang, L.2    Zhang, L.3
  • 6
    • 0036843061 scopus 로고    scopus 로고
    • Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats
    • Zhang R., Wang Y., Zhang L., et al. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 33 (2002) 2675-2680
    • (2002) Stroke , vol.33 , pp. 2675-2680
    • Zhang, R.1    Wang, Y.2    Zhang, L.3
  • 7
    • 0038443056 scopus 로고    scopus 로고
    • Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke
    • Chen J., Zhang Z.G., Li Y., et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 53 (2003) 743-751
    • (2003) Ann Neurol , vol.53 , pp. 743-751
    • Chen, J.1    Zhang, Z.G.2    Li, Y.3
  • 8
    • 0942290538 scopus 로고    scopus 로고
    • Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury
    • Lu D., Goussev A., Chen J., et al. Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury. J Neurotrauma 21 (2004) 21-32
    • (2004) J Neurotrauma , vol.21 , pp. 21-32
    • Lu, D.1    Goussev, A.2    Chen, J.3
  • 9
    • 4644339259 scopus 로고    scopus 로고
    • Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells
    • Shyu W.C., Lin S.Z., Yang H.I., et al. Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells. Circulation 110 (2004) 1847-1854
    • (2004) Circulation , vol.110 , pp. 1847-1854
    • Shyu, W.C.1    Lin, S.Z.2    Yang, H.I.3
  • 10
    • 3042688444 scopus 로고    scopus 로고
    • Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats
    • Wang L., Zhang Z., Wang Y., Zhang R., and Chopp M. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 35 (2004) 1732-1737
    • (2004) Stroke , vol.35 , pp. 1732-1737
    • Wang, L.1    Zhang, Z.2    Wang, Y.3    Zhang, R.4    Chopp, M.5
  • 11
    • 1842586163 scopus 로고    scopus 로고
    • Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat
    • Jin K., Sun Y., Xie L., Childs J., Mao X.O., and Greenberg D.A. Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 24 (2004) 399-408
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 399-408
    • Jin, K.1    Sun, Y.2    Xie, L.3    Childs, J.4    Mao, X.O.5    Greenberg, D.A.6
  • 12
    • 4043052443 scopus 로고    scopus 로고
    • Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model
    • Taguchi A., Soma T., Tanaka H., et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 114 (2004) 330-338
    • (2004) J Clin Invest , vol.114 , pp. 330-338
    • Taguchi, A.1    Soma, T.2    Tanaka, H.3
  • 13
    • 0041488864 scopus 로고    scopus 로고
    • Mobilized peripheral blood cells administered intravenously produce functional recovery in stroke
    • Willing A.E., Vendrame M., Mallery J., et al. Mobilized peripheral blood cells administered intravenously produce functional recovery in stroke. Cell Transplant 12 (2003) 449-454
    • (2003) Cell Transplant , vol.12 , pp. 449-454
    • Willing, A.E.1    Vendrame, M.2    Mallery, J.3
  • 14
    • 0013278301 scopus 로고    scopus 로고
    • Treatment of neural injury with marrow stromal cells
    • Chopp M., and Li Y. Treatment of neural injury with marrow stromal cells. Lancet Neurol 1 (2002) 92-100
    • (2002) Lancet Neurol , vol.1 , pp. 92-100
    • Chopp, M.1    Li, Y.2
  • 15
    • 0035167706 scopus 로고    scopus 로고
    • Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats
    • Chen J., Sanberg P.R., Li Y., et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32 (2001) 2682-2688
    • (2001) Stroke , vol.32 , pp. 2682-2688
    • Chen, J.1    Sanberg, P.R.2    Li, Y.3
  • 16
    • 27544488427 scopus 로고    scopus 로고
    • Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI
    • Jiang Q., Zhang Z.G., Ding G.L., et al. Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. Neuroimage 28 (2005) 698-707
    • (2005) Neuroimage , vol.28 , pp. 698-707
    • Jiang, Q.1    Zhang, Z.G.2    Ding, G.L.3
  • 17
    • 3142521479 scopus 로고    scopus 로고
    • Stem cell therapy for human neurodegenerative disorders-how to make it work
    • Lindvall O., Kokaia Z., and Martinez-Serrano A. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med 10 (2004) S42-S50
    • (2004) Nat Med , vol.10
    • Lindvall, O.1    Kokaia, Z.2    Martinez-Serrano, A.3
  • 18
    • 25144490621 scopus 로고    scopus 로고
    • Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy
    • Zhang R.L., Zhang Z.G., and Chopp M. Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy. Neuroscientist 11 (2005) 408-416
    • (2005) Neuroscientist , vol.11 , pp. 408-416
    • Zhang, R.L.1    Zhang, Z.G.2    Chopp, M.3
  • 19
    • 2342566505 scopus 로고    scopus 로고
    • Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats
    • Borlongan C.V., Lind J.G., Dillon-Carter O., et al. Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats. Brain Res 1010 (2004) 108-116
    • (2004) Brain Res , vol.1010 , pp. 108-116
    • Borlongan, C.V.1    Lind, J.G.2    Dillon-Carter, O.3
  • 20
    • 36249021493 scopus 로고    scopus 로고
    • Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views
    • Phinney D.G., and Prockop D.J. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 25 (2007) 2896-2902
    • (2007) Stem Cells , vol.25 , pp. 2896-2902
    • Phinney, D.G.1    Prockop, D.J.2
  • 21
    • 0034754052 scopus 로고    scopus 로고
    • A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats
    • Zhang R., Zhang L., Zhang Z., et al. A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats. Ann Neurol 50 (2001) 602-611
    • (2001) Ann Neurol , vol.50 , pp. 602-611
    • Zhang, R.1    Zhang, L.2    Zhang, Z.3
  • 22
    • 28844434260 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor as an arteriogenic factor in the treatment of ischaemic stroke
    • Hossmann K.A., and Buschmann I.R. Granulocyte-macrophage colony-stimulating factor as an arteriogenic factor in the treatment of ischaemic stroke. Expert Opin Biol Ther 5 (2005) 1547-1556
    • (2005) Expert Opin Biol Ther , vol.5 , pp. 1547-1556
    • Hossmann, K.A.1    Buschmann, I.R.2
  • 23
    • 33750317276 scopus 로고    scopus 로고
    • Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke
    • Zhang L., Zhang Z., Zhang R.L., et al. Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke. Brain Res 1118 (2006) 192-198
    • (2006) Brain Res , vol.1118 , pp. 192-198
    • Zhang, L.1    Zhang, Z.2    Zhang, R.L.3
  • 24
    • 34547738951 scopus 로고    scopus 로고
    • Niaspan increases angiogenesis and improves functional recovery after stroke
    • Chen J., Cui X., Zacharek A., et al. Niaspan increases angiogenesis and improves functional recovery after stroke. Ann Neurol 62 (2007) 49-58
    • (2007) Ann Neurol , vol.62 , pp. 49-58
    • Chen, J.1    Cui, X.2    Zacharek, A.3
  • 25
    • 34848876094 scopus 로고    scopus 로고
    • Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats
    • Zhao L.R., Berra H.H., Duan W.M., et al. Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats. Stroke 38 (2007) 2804-2811
    • (2007) Stroke , vol.38 , pp. 2804-2811
    • Zhao, L.R.1    Berra, H.H.2    Duan, W.M.3
  • 26
    • 0036470478 scopus 로고    scopus 로고
    • Neurogenesis in adult subventricular zone
    • Alvarez-Buylla A., and Garcia-Verdugo J.M. Neurogenesis in adult subventricular zone. J Neurosci 22 (2002) 629-634
    • (2002) J Neurosci , vol.22 , pp. 629-634
    • Alvarez-Buylla, A.1    Garcia-Verdugo, J.M.2
  • 27
    • 0030979469 scopus 로고    scopus 로고
    • Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain
    • Doetsch F., Garcia-Verdugo J.M., and Alvarez-Buylla A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci 17 (1997) 5046-5061
    • (1997) J Neurosci , vol.17 , pp. 5046-5061
    • Doetsch, F.1    Garcia-Verdugo, J.M.2    Alvarez-Buylla, A.3
  • 28
    • 0030436269 scopus 로고    scopus 로고
    • Neuronal progenitor cells derived from the anterior subventricular zone of the neonatal rat forebrain continue to proliferate in vitro and express a neuronal phenotype
    • Luskin M.B., Zigova T., Soteres B.J., and Stewart R.R. Neuronal progenitor cells derived from the anterior subventricular zone of the neonatal rat forebrain continue to proliferate in vitro and express a neuronal phenotype. Mol Cell Neurosci 8 (1997) 351-366
    • (1997) Mol Cell Neurosci , vol.8 , pp. 351-366
    • Luskin, M.B.1    Zigova, T.2    Soteres, B.J.3    Stewart, R.R.4
  • 29
    • 33847629581 scopus 로고    scopus 로고
    • Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension
    • Curtis M.A., Kam M., Nannmark U., et al. Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science 315 (2007) 1243-1249
    • (2007) Science , vol.315 , pp. 1243-1249
    • Curtis, M.A.1    Kam, M.2    Nannmark, U.3
  • 30
    • 29144483551 scopus 로고    scopus 로고
    • Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells
    • Quinones-Hinojosa A., Sanai N., Soriano-Navarro M., et al. Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells. J Comp Neurol 494 (2006) 415-434
    • (2006) J Comp Neurol , vol.494 , pp. 415-434
    • Quinones-Hinojosa, A.1    Sanai, N.2    Soriano-Navarro, M.3
  • 31
    • 1442354188 scopus 로고    scopus 로고
    • Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
    • Sanai N., Tramontin A.D., Quinones-Hinojosa A., et al. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 427 (2004) 740-744
    • (2004) Nature , vol.427 , pp. 740-744
    • Sanai, N.1    Tramontin, A.D.2    Quinones-Hinojosa, A.3
  • 32
    • 0035898233 scopus 로고    scopus 로고
    • Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia
    • Zhang R.L., Zhang Z.G., Zhang L., and Chopp M. Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience 105 (2001) 33-41
    • (2001) Neuroscience , vol.105 , pp. 33-41
    • Zhang, R.L.1    Zhang, Z.G.2    Zhang, L.3    Chopp, M.4
  • 33
    • 0035836656 scopus 로고    scopus 로고
    • Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat
    • Jin K., Minami M., Lan J.Q., et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci USA 98 (2001) 4710-4715
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4710-4715
    • Jin, K.1    Minami, M.2    Lan, J.Q.3
  • 34
    • 0036895463 scopus 로고    scopus 로고
    • Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
    • Parent J.M., Vexler Z.S., Gong C., Derugin N., and Ferriero D.M. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol 52 (2002) 802-813
    • (2002) Ann Neurol , vol.52 , pp. 802-813
    • Parent, J.M.1    Vexler, Z.S.2    Gong, C.3    Derugin, N.4    Ferriero, D.M.5
  • 35
    • 0036735672 scopus 로고    scopus 로고
    • Neuronal replacement from endogenous precursors in the adult brain after stroke
    • Arvidsson A., Collin T., Kirik D., Kokaia Z., and Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 8 (2002) 963-970
    • (2002) Nat Med , vol.8 , pp. 963-970
    • Arvidsson, A.1    Collin, T.2    Kirik, D.3    Kokaia, Z.4    Lindvall, O.5
  • 36
    • 1842586126 scopus 로고    scopus 로고
    • Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats
    • Zhang R., Zhang Z., Wang L., et al. Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats. J Cereb Blood Flow Metab 24 (2004) 441-448
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 441-448
    • Zhang, R.1    Zhang, Z.2    Wang, L.3
  • 37
    • 33745001464 scopus 로고    scopus 로고
    • Persistent production of neurons from adult brain stem cells during recovery after stroke
    • Thored P., Arvidsson A., Cacci E., et al. Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells 24 (2006) 739-747
    • (2006) Stem Cells , vol.24 , pp. 739-747
    • Thored, P.1    Arvidsson, A.2    Cacci, E.3
  • 38
    • 33748338787 scopus 로고    scopus 로고
    • Evidence for stroke-induced neurogenesis in the human brain
    • Jin K., Wang X., Xie L., et al. Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci USA 103 (2006) 13198-13202
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13198-13202
    • Jin, K.1    Wang, X.2    Xie, L.3
  • 39
    • 33845621647 scopus 로고    scopus 로고
    • Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain
    • Macas J., Nern C., Plate K.H., and Momma S. Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain. J Neurosci 26 (2006) 13114-13119
    • (2006) J Neurosci , vol.26 , pp. 13114-13119
    • Macas, J.1    Nern, C.2    Plate, K.H.3    Momma, S.4
  • 41
    • 22144432224 scopus 로고    scopus 로고
    • Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells
    • Abramova N., Charniga C., Goderie S.K., and Temple S. Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells. Dev Biol 283 (2005) 269-281
    • (2005) Dev Biol , vol.283 , pp. 269-281
    • Abramova, N.1    Charniga, C.2    Goderie, S.K.3    Temple, S.4
  • 42
    • 33847219581 scopus 로고    scopus 로고
    • Stroke induces gene profile changes associated with neurogenesis and angiogenesis in adult subventricular zone progenitor cells
    • Liu X.S., Zhang Z.G., Zhang R.L., et al. Stroke induces gene profile changes associated with neurogenesis and angiogenesis in adult subventricular zone progenitor cells. J Cereb Blood Flow Metab 27 (2007) 564-574
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 564-574
    • Liu, X.S.1    Zhang, Z.G.2    Zhang, R.L.3
  • 43
    • 48849093105 scopus 로고    scopus 로고
    • Ischemic stroke and neurogenesis in the subventricular zone
    • Zhang R.L., Zhang Z.G., and Chopp M. Ischemic stroke and neurogenesis in the subventricular zone. Neuropharmacology 55 (2008) 345-352
    • (2008) Neuropharmacology , vol.55 , pp. 345-352
    • Zhang, R.L.1    Zhang, Z.G.2    Chopp, M.3
  • 44
    • 24344510750 scopus 로고    scopus 로고
    • The cell biology of neurogenesis
    • Gotz M., and Huttner W.B. The cell biology of neurogenesis. Nat Rev Mol Cell Biol 6 (2005) 777-788
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 777-788
    • Gotz, M.1    Huttner, W.B.2
  • 45
    • 22244492586 scopus 로고    scopus 로고
    • Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development
    • Calegari F., Haubensak W., Haffner C., and Huttner W.B. Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development. J Neurosci 25 (2005) 6533-6538
    • (2005) J Neurosci , vol.25 , pp. 6533-6538
    • Calegari, F.1    Haubensak, W.2    Haffner, C.3    Huttner, W.B.4
  • 46
    • 27544465968 scopus 로고    scopus 로고
    • Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system
    • Huttner W.B., and Kosodo Y. Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system. Curr Opin Cell Biol 17 (2005) 648-657
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 648-657
    • Huttner, W.B.1    Kosodo, Y.2
  • 47
    • 0029789473 scopus 로고    scopus 로고
    • The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis
    • Takahashi T., Nowakowski R.S., and Caviness V.S. The leaving or Q fraction of the murine cerebral proliferative epithelium: a general model of neocortical neuronogenesis. J Neurosci 16 (1996) 6183-6196
    • (1996) J Neurosci , vol.16 , pp. 6183-6196
    • Takahashi, T.1    Nowakowski, R.S.2    Caviness, V.S.3
  • 48
    • 0024369746 scopus 로고
    • Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population
    • Nowakowski R.S., Lewin S.B., and Miller M.W. Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J Neurocytol 18 (1989) 311-318
    • (1989) J Neurocytol , vol.18 , pp. 311-318
    • Nowakowski, R.S.1    Lewin, S.B.2    Miller, M.W.3
  • 49
    • 39749140225 scopus 로고    scopus 로고
    • Lengthening the G phase of neural progenitor cells is concurrent with an increase of symmetric neuron generating division after stroke
    • Zhang R.L., Zhang Z.G., Roberts C., et al. Lengthening the G phase of neural progenitor cells is concurrent with an increase of symmetric neuron generating division after stroke. J Cereb Blood Flow Metab 28 (2008) 602-611
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 602-611
    • Zhang, R.L.1    Zhang, Z.G.2    Roberts, C.3
  • 50
    • 33745776761 scopus 로고    scopus 로고
    • Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum
    • Yamashita T., Ninomiya M., Acosta P.H., et al. Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J Neurosci 26 (2006) 6627-6636
    • (2006) J Neurosci , vol.26 , pp. 6627-6636
    • Yamashita, T.1    Ninomiya, M.2    Acosta, P.H.3
  • 51
    • 54049128494 scopus 로고    scopus 로고
    • Functional integration of newly generated neurons into striatum after cerebral ischemia in the adult rat brain
    • Hou S.W., Wang Y.Q., Xu M., et al. Functional integration of newly generated neurons into striatum after cerebral ischemia in the adult rat brain. Stroke 39 (2008) 2837-2844
    • (2008) Stroke , vol.39 , pp. 2837-2844
    • Hou, S.W.1    Wang, Y.Q.2    Xu, M.3
  • 52
    • 0242267625 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase promotes adult subventricular neuroblast migration after stroke
    • Katakowski M., Zhang Z.G., Chen J., et al. Phosphoinositide 3-kinase promotes adult subventricular neuroblast migration after stroke. J Neurosci Res 74 (2003) 494-501
    • (2003) J Neurosci Res , vol.74 , pp. 494-501
    • Katakowski, M.1    Zhang, Z.G.2    Chen, J.3
  • 53
    • 0038383066 scopus 로고    scopus 로고
    • Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation
    • Vojtek A.B., Taylor J., DeRuiter S.L., et al. Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation. Mol Cell Biol 23 (2003) 4417-4427
    • (2003) Mol Cell Biol , vol.23 , pp. 4417-4427
    • Vojtek, A.B.1    Taylor, J.2    DeRuiter, S.L.3
  • 54
    • 4744355621 scopus 로고    scopus 로고
    • Akt-1 expression level regulates CNS precursors
    • Sinor A.D., and Lillien L. Akt-1 expression level regulates CNS precursors. J Neurosci 24 (2004) 8531-8541
    • (2004) J Neurosci , vol.24 , pp. 8531-8541
    • Sinor, A.D.1    Lillien, L.2
  • 55
    • 4043140217 scopus 로고    scopus 로고
    • Down-regulation of p27kip1 increases proliferation of progenitor cells in adult rats
    • Zhang R., Zhang Z., Tsang W., Wang L., and Chopp M. Down-regulation of p27kip1 increases proliferation of progenitor cells in adult rats. Neuroreport 15 (2004) 1797-1800
    • (2004) Neuroreport , vol.15 , pp. 1797-1800
    • Zhang, R.1    Zhang, Z.2    Tsang, W.3    Wang, L.4    Chopp, M.5
  • 56
    • 0035050958 scopus 로고    scopus 로고
    • The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells
    • Chaudhary L.R., and Hruska K.A. The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells. J Cell Biochem 81 (2001) 304-311
    • (2001) J Cell Biochem , vol.81 , pp. 304-311
    • Chaudhary, L.R.1    Hruska, K.A.2
  • 57
    • 0029804116 scopus 로고    scopus 로고
    • Mechanism of activation of protein kinase B by insulin and IGF-1
    • Alessi D.R., Andjelkovic M., Caudwell B., et al. Mechanism of activation of protein kinase B by insulin and IGF-1. Embo J 15 (1996) 6541-6551
    • (1996) Embo J , vol.15 , pp. 6541-6551
    • Alessi, D.R.1    Andjelkovic, M.2    Caudwell, B.3
  • 58
    • 24944455102 scopus 로고    scopus 로고
    • Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone
    • Wang L., Zhang Z.G., Zhang R.L., and Chopp M. Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone. J Cereb Blood Flow Metab 25 (2005) 1150-1158
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1150-1158
    • Wang, L.1    Zhang, Z.G.2    Zhang, R.L.3    Chopp, M.4
  • 59
    • 12844260208 scopus 로고    scopus 로고
    • Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice
    • Chen J., Zhang C., Jiang H., et al. Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab 25 (2005) 281-290
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 281-290
    • Chen, J.1    Zhang, C.2    Jiang, H.3
  • 60
    • 19544386970 scopus 로고    scopus 로고
    • Roles of bHLH genes in neural stem cell differentiation
    • Kageyama R., Ohtsuka T., Hatakeyama J., and Ohsawa R. Roles of bHLH genes in neural stem cell differentiation. Exp Cell Res 306 (2005) 343-348
    • (2005) Exp Cell Res , vol.306 , pp. 343-348
    • Kageyama, R.1    Ohtsuka, T.2    Hatakeyama, J.3    Ohsawa, R.4
  • 61
    • 20844442104 scopus 로고    scopus 로고
    • Mash1 specifies neurons and oligodendrocytes in the postnatal brain
    • Parras C.M., Galli R., Britz O., et al. Mash1 specifies neurons and oligodendrocytes in the postnatal brain. Embo J 23 (2004) 4495-4505
    • (2004) Embo J , vol.23 , pp. 4495-4505
    • Parras, C.M.1    Galli, R.2    Britz, O.3
  • 62
    • 33646127443 scopus 로고    scopus 로고
    • Neurogenin 1 mediates erythropoietin enhanced differentiation of adult neural progenitor cells
    • Wang L., Zhang Z.G., Zhang R.L., et al. Neurogenin 1 mediates erythropoietin enhanced differentiation of adult neural progenitor cells. J Cereb Blood Flow Metab 26 (2006) 556-564
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 556-564
    • Wang, L.1    Zhang, Z.G.2    Zhang, R.L.3
  • 63
    • 36148988387 scopus 로고    scopus 로고
    • The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells
    • Wang L., Zhang Z.G., Gregg S.R., et al. The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells. J Biol Chem 282 (2007) 32462-32470
    • (2007) J Biol Chem , vol.282 , pp. 32462-32470
    • Wang, L.1    Zhang, Z.G.2    Gregg, S.R.3
  • 64
    • 2942538154 scopus 로고    scopus 로고
    • Erythropoietin up-regulates SOCS2 in neuronal progenitor cells derived from SVZ of adult rat
    • Wang L., Zhang Z., Zhang R., et al. Erythropoietin up-regulates SOCS2 in neuronal progenitor cells derived from SVZ of adult rat. Neuroreport 15 (2004) 1225-1229
    • (2004) Neuroreport , vol.15 , pp. 1225-1229
    • Wang, L.1    Zhang, Z.2    Zhang, R.3
  • 65
    • 34848848202 scopus 로고    scopus 로고
    • Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats
    • Iwai M., Cao G., Yin W., Stetler R.A., Liu J., and Chen J. Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats. Stroke 38 (2007) 2795-2803
    • (2007) Stroke , vol.38 , pp. 2795-2803
    • Iwai, M.1    Cao, G.2    Yin, W.3    Stetler, R.A.4    Liu, J.5    Chen, J.6
  • 66
    • 34548295610 scopus 로고    scopus 로고
    • Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke
    • Gonzalez F.F., McQuillen P., Mu D., et al. Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. Dev Neurosci 29 (2007) 321-330
    • (2007) Dev Neurosci , vol.29 , pp. 321-330
    • Gonzalez, F.F.1    McQuillen, P.2    Mu, D.3
  • 67
  • 68
    • 1442329310 scopus 로고    scopus 로고
    • Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits
    • Raber J., Fan Y., Matsumori Y., et al. Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits. Ann Neurol 55 (2004) 381-389
    • (2004) Ann Neurol , vol.55 , pp. 381-389
    • Raber, J.1    Fan, Y.2    Matsumori, Y.3
  • 69
    • 34347338708 scopus 로고    scopus 로고
    • One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke
    • Shen L.H., Li Y., Chen J., et al. One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke. Stroke 38 (2007) 2150-2156
    • (2007) Stroke , vol.38 , pp. 2150-2156
    • Shen, L.H.1    Li, Y.2    Chen, J.3
  • 70
    • 0032159430 scopus 로고    scopus 로고
    • Development and differentiation of endothelium
    • Risau W. Development and differentiation of endothelium. Kidney Int Suppl 67 (1998) S3-S6
    • (1998) Kidney Int Suppl , vol.67
    • Risau, W.1
  • 71
    • 0033797255 scopus 로고    scopus 로고
    • VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
    • Zhang Z.G., Zhang L., Jiang Q., et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 106 (2000) 829-838
    • (2000) J Clin Invest , vol.106 , pp. 829-838
    • Zhang, Z.G.1    Zhang, L.2    Jiang, Q.3
  • 72
    • 0027936452 scopus 로고
    • Role of angiogenesis in patients with cerebral ischemic stroke
    • Krupinski J., Kaluza J., Kumar P., Kumar S., and Wang J.M. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 25 (1994) 1794-1798
    • (1994) Stroke , vol.25 , pp. 1794-1798
    • Krupinski, J.1    Kaluza, J.2    Kumar, P.3    Kumar, S.4    Wang, J.M.5
  • 73
    • 0014989685 scopus 로고
    • Ultrastructure of the microvasculature in experimental cerebral infarction
    • Garcia J., Cox J., and Hudgins W. Ultrastructure of the microvasculature in experimental cerebral infarction. Acta Neuropathol 18 (1971) 273-285
    • (1971) Acta Neuropathol , vol.18 , pp. 273-285
    • Garcia, J.1    Cox, J.2    Hudgins, W.3
  • 74
    • 0036205888 scopus 로고    scopus 로고
    • Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia
    • Zhang Z.G., Zhang L., Tsang W., et al. Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab 22 (2002) 379-392
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 379-392
    • Zhang, Z.G.1    Zhang, L.2    Tsang, W.3
  • 75
    • 0032920232 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis in the brain
    • Plate K.H. Mechanisms of angiogenesis in the brain. J Neuropathol Exp Neurol 58 (1999) 313-320
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 313-320
    • Plate, K.H.1
  • 76
    • 33750332097 scopus 로고    scopus 로고
    • Ischemic cerebral tissue response to subventricular zone cell transplantation measured by iterative self-organizing data analysis technique algorithm
    • Li L., Jiang Q., Zhang L., et al. Ischemic cerebral tissue response to subventricular zone cell transplantation measured by iterative self-organizing data analysis technique algorithm. J Cereb Blood Flow Metab 26 (2006) 1366-1377
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1366-1377
    • Li, L.1    Jiang, Q.2    Zhang, L.3
  • 77
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 386 (1997) 671-674
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 78
    • 0033793881 scopus 로고    scopus 로고
    • VEGF gene therapy: stimulating angiogenesis or angioma-genesis?
    • Carmeliet P. VEGF gene therapy: stimulating angiogenesis or angioma-genesis?. Nat Med 6 (2000) 1102-1103
    • (2000) Nat Med , vol.6 , pp. 1102-1103
    • Carmeliet, P.1
  • 79
    • 0032577571 scopus 로고    scopus 로고
    • Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border
    • Yancopoulos G.D., Klagsbrun M., and Folkman J. Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. Cell 93 (1998) 661-664
    • (1998) Cell , vol.93 , pp. 661-664
    • Yancopoulos, G.D.1    Klagsbrun, M.2    Folkman, J.3
  • 80
    • 0037317807 scopus 로고    scopus 로고
    • Temporal profile of angiogenesis and expression of related genes in the brain after ischemia
    • Hayashi T., Noshita N., Sugawara T., and Chan P.H. Temporal profile of angiogenesis and expression of related genes in the brain after ischemia. J Cereb Blood Flow Metab 23 (2003) 166-180
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 166-180
    • Hayashi, T.1    Noshita, N.2    Sugawara, T.3    Chan, P.H.4
  • 81
    • 0036173275 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia
    • Zhang Z., and Chopp M. Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia. Trends Cardiovasc Med 12 (2002) 62-66
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 62-66
    • Zhang, Z.1    Chopp, M.2
  • 82
    • 0033855388 scopus 로고    scopus 로고
    • Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke
    • Slevin M., Krupinski J., Slowik A., Kumar P., Szczudlik A., and Gaffney J. Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke. Stroke 31 (2000) 1863-1870
    • (2000) Stroke , vol.31 , pp. 1863-1870
    • Slevin, M.1    Krupinski, J.2    Slowik, A.3    Kumar, P.4    Szczudlik, A.5    Gaffney, J.6
  • 83
    • 0033678506 scopus 로고    scopus 로고
    • Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat
    • Beck H., Acker T., Wiessner C., Allegrini P.R., and Plate K.H. Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat. Am J Pathol 157 (2000) 1473-1483
    • (2000) Am J Pathol , vol.157 , pp. 1473-1483
    • Beck, H.1    Acker, T.2    Wiessner, C.3    Allegrini, P.R.4    Plate, K.H.5
  • 84
    • 0033966614 scopus 로고    scopus 로고
    • Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion
    • Lin T.N., Wang C.K., Cheung W.M., and Hsu C.Y. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 20 (2000) 387-395
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 387-395
    • Lin, T.N.1    Wang, C.K.2    Cheung, W.M.3    Hsu, C.Y.4
  • 85
    • 0037015059 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
    • Jin K., Zhu Y., Sun Y., Mao X.O., Xie L., and Greenberg D.A. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA 99 (2002) 11946-11950
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11946-11950
    • Jin, K.1    Zhu, Y.2    Sun, Y.3    Mao, X.O.4    Xie, L.5    Greenberg, D.A.6
  • 86
    • 0037418936 scopus 로고    scopus 로고
    • Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats
    • Chen J., Zhang Z.G., Li Y., et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res 92 (2003) 692-699
    • (2003) Circ Res , vol.92 , pp. 692-699
    • Chen, J.1    Zhang, Z.G.2    Li, Y.3
  • 87
    • 1642319466 scopus 로고    scopus 로고
    • Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis
    • Chen J., Li Y., Zhang R., et al. Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis. Brain Res 1005 (2004) 21-28
    • (2004) Brain Res , vol.1005 , pp. 21-28
    • Chen, J.1    Li, Y.2    Zhang, R.3
  • 88
    • 34648839855 scopus 로고    scopus 로고
    • Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke
    • Zacharek A., Chen J., Cui X., et al. Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. J Cereb Blood Flow Metab 27 (2007) 1684-1691
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1684-1691
    • Zacharek, A.1    Chen, J.2    Cui, X.3
  • 89
    • 46049118038 scopus 로고    scopus 로고
    • Neural progenitor cells treated with EPO induce angiogenesis through the production of VEGF
    • Wang L., Chopp M., Gregg S.R., et al. Neural progenitor cells treated with EPO induce angiogenesis through the production of VEGF. J Cereb Blood Flow Metab 28 (2008) 1361-1368
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1361-1368
    • Wang, L.1    Chopp, M.2    Gregg, S.R.3
  • 90
    • 14644444482 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice
    • Chen J., Zacharek A., Zhang C., et al. Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J Neurosci 25 (2005) 2366-2375
    • (2005) J Neurosci , vol.25 , pp. 2366-2375
    • Chen, J.1    Zacharek, A.2    Zhang, C.3
  • 91
    • 0030981629 scopus 로고    scopus 로고
    • Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent
    • Reichenbach J.R., Venkatesan R., Schillinger D.J., Kido D.K., and Haacke E.M. Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology 204 (1997) 272-277
    • (1997) Radiology , vol.204 , pp. 272-277
    • Reichenbach, J.R.1    Venkatesan, R.2    Schillinger, D.J.3    Kido, D.K.4    Haacke, E.M.5
  • 92
    • 0033364292 scopus 로고    scopus 로고
    • Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds
    • Fazekas F., Kleinert R., Roob G., et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol 20 (1999) 637-642
    • (1999) AJNR Am J Neuroradiol , vol.20 , pp. 637-642
    • Fazekas, F.1    Kleinert, R.2    Roob, G.3
  • 93
    • 2942640440 scopus 로고    scopus 로고
    • Comparison of CT and three MR sequences for detecting and categorizing early (48 hours) hemorrhagic transformation in hyperacute ischemic stroke
    • Arnould M.C., Grandin C.B., Peeters A., Cosnard G., and Duprez T.P. Comparison of CT and three MR sequences for detecting and categorizing early (48 hours) hemorrhagic transformation in hyperacute ischemic stroke. AJNR Am J Neuroradiol 25 (2004) 939-944
    • (2004) AJNR Am J Neuroradiol , vol.25 , pp. 939-944
    • Arnould, M.C.1    Grandin, C.B.2    Peeters, A.3    Cosnard, G.4    Duprez, T.P.5
  • 94
    • 33846191628 scopus 로고    scopus 로고
    • Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke
    • Li L., Jiang Q., Zhang L., et al. Angiogenesis and improved cerebral blood flow in the ischemic boundary area detected by MRI after administration of sildenafil to rats with embolic stroke. Brain Res 1132 (2007) 185-192
    • (2007) Brain Res , vol.1132 , pp. 185-192
    • Li, L.1    Jiang, Q.2    Zhang, L.3
  • 95
    • 48749112427 scopus 로고    scopus 로고
    • Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats
    • Ding G., Jiang Q., Li L., et al. Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats. J Cereb Blood Flow Metab 28 (2008) 1440-1448
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1440-1448
    • Ding, G.1    Jiang, Q.2    Li, L.3
  • 96
    • 44449142547 scopus 로고    scopus 로고
    • Angiogenesis detected after embolic stroke in rat brain using magnetic resonance T2*WI
    • Ding G., Jiang Q., Li L., et al. Angiogenesis detected after embolic stroke in rat brain using magnetic resonance T2*WI. Stroke 39 (2008) 1563-1568
    • (2008) Stroke , vol.39 , pp. 1563-1568
    • Ding, G.1    Jiang, Q.2    Li, L.3
  • 97
    • 0027327080 scopus 로고
    • Prognostic value of blood vessel density in ischaemic stroke
    • Krupinski J., Kaluza J., Kumar P., Wang M., and Kumar S. Prognostic value of blood vessel density in ischaemic stroke. Lancet 342 (1993) 742
    • (1993) Lancet , vol.342 , pp. 742
    • Krupinski, J.1    Kaluza, J.2    Kumar, P.3    Wang, M.4    Kumar, S.5
  • 98
    • 0034623186 scopus 로고    scopus 로고
    • Measurement of cerebral microvessel diameters after embolic stroke in rat using quantitative laser scanning confocal microscopy
    • Morris D.C., Davies K., Zhang Z., and Chopp M. Measurement of cerebral microvessel diameters after embolic stroke in rat using quantitative laser scanning confocal microscopy. Brain Res 876 (2000) 31-36
    • (2000) Brain Res , vol.876 , pp. 31-36
    • Morris, D.C.1    Davies, K.2    Zhang, Z.3    Chopp, M.4
  • 99
    • 0035004385 scopus 로고    scopus 로고
    • Up-regulation of neuropilin-1 in neovasculature after focal cerebral ischemia in the adult rat
    • Zhang Z.G., Tsang W., Zhang L., Powers C., and Chopp M. Up-regulation of neuropilin-1 in neovasculature after focal cerebral ischemia in the adult rat. J Cereb Blood Flow Metab 21 (2001) 541-549
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 541-549
    • Zhang, Z.G.1    Tsang, W.2    Zhang, L.3    Powers, C.4    Chopp, M.5
  • 100
    • 33845656103 scopus 로고    scopus 로고
    • A neurovascular niche for neurogenesis after stroke
    • Ohab J.J., Fleming S., Blesch A., and Carmichael S.T. A neurovascular niche for neurogenesis after stroke. J Neurosci 26 (2006) 13007-13016
    • (2006) J Neurosci , vol.26 , pp. 13007-13016
    • Ohab, J.J.1    Fleming, S.2    Blesch, A.3    Carmichael, S.T.4
  • 101
    • 41149085575 scopus 로고    scopus 로고
    • Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke
    • Teng H., Zhang Z.G., Wang L., et al. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab 28 (2008) 764-771
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 764-771
    • Teng, H.1    Zhang, Z.G.2    Wang, L.3
  • 102
    • 35648934511 scopus 로고    scopus 로고
    • Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
    • Thored P., Wood J., Arvidsson A., Cammenga J., Kokaia Z., and Lindvall O. Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke. Stroke 38 (2007) 3032-3039
    • (2007) Stroke , vol.38 , pp. 3032-3039
    • Thored, P.1    Wood, J.2    Arvidsson, A.3    Cammenga, J.4    Kokaia, Z.5    Lindvall, O.6
  • 103
    • 0034597430 scopus 로고    scopus 로고
    • Vascular niche for adult hippocampal neurogenesis
    • Palmer T.D., Willhoite A.R., and Gage F.H. Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 425 (2000) 479-494
    • (2000) J Comp Neurol , vol.425 , pp. 479-494
    • Palmer, T.D.1    Willhoite, A.R.2    Gage, F.H.3
  • 104
    • 50849142558 scopus 로고    scopus 로고
    • Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions
    • Shen Q., Wang Y., Kokovay E., et al. Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3 (2008) 289-300
    • (2008) Cell Stem Cell , vol.3 , pp. 289-300
    • Shen, Q.1    Wang, Y.2    Kokovay, E.3
  • 105
    • 50849102656 scopus 로고    scopus 로고
    • A specialized vascular niche for adult neural stem cells
    • Tavazoie M., Van der Veken L., Silva-Vargas V., et al. A specialized vascular niche for adult neural stem cells. Cell Stem Cell 3 (2008) 279-288
    • (2008) Cell Stem Cell , vol.3 , pp. 279-288
    • Tavazoie, M.1    Van der Veken, L.2    Silva-Vargas, V.3
  • 106
    • 0032796824 scopus 로고    scopus 로고
    • Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma
    • Leventhal C., Rafii S., Rafii D., Shahar A., and Goldman S.A. Endothelial trophic support of neuronal production and recruitment from the adult mammalian subependyma. Mol Cell Neurosci 13 (1999) 450-464
    • (1999) Mol Cell Neurosci , vol.13 , pp. 450-464
    • Leventhal, C.1    Rafii, S.2    Rafii, D.3    Shahar, A.4    Goldman, S.A.5
  • 108
    • 29144536285 scopus 로고    scopus 로고
    • Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia
    • Robin A.M., Zhang Z.G., Wang L., et al. Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia. J Cereb Blood Flow Metab 26 (2006) 125-134
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 125-134
    • Robin, A.M.1    Zhang, Z.G.2    Wang, L.3
  • 109
    • 19944426191 scopus 로고    scopus 로고
    • Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
    • Imitola J., Raddassi K., Park K.I., et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci USA 101 (2004) 18117-18122
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 18117-18122
    • Imitola, J.1    Raddassi, K.2    Park, K.I.3
  • 110
    • 9144261661 scopus 로고    scopus 로고
    • SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury
    • Hill W.D., Hess D.C., Martin-Studdard A., et al. SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury. J Neuropathol Exp Neurol 63 (2004) 84-96
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 84-96
    • Hill, W.D.1    Hess, D.C.2    Martin-Studdard, A.3
  • 111
    • 33845783926 scopus 로고    scopus 로고
    • Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke
    • Shen L.H., Li Y., Chen J., et al. Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab 27 (2007) 6-13
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 6-13
    • Shen, L.H.1    Li, Y.2    Chen, J.3
  • 112
    • 0041336932 scopus 로고    scopus 로고
    • Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat
    • Chen J., Li Y., Katakowski M., et al. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res 73 (2003) 778-786
    • (2003) J Neurosci Res , vol.73 , pp. 778-786
    • Chen, J.1    Li, Y.2    Katakowski, M.3
  • 113
    • 39149131038 scopus 로고    scopus 로고
    • SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model
    • Wang Y., Deng Y., and Zhou G.Q. SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model. Brain Res 1195 (2008) 104-112
    • (2008) Brain Res , vol.1195 , pp. 104-112
    • Wang, Y.1    Deng, Y.2    Zhou, G.Q.3
  • 114
    • 33745271531 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration
    • Wang L., Zhang Z.G., Zhang R.L., et al. Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J Neurosci 26 (2006) 5996-6003
    • (2006) J Neurosci , vol.26 , pp. 5996-6003
    • Wang, L.1    Zhang, Z.G.2    Zhang, R.L.3
  • 115
    • 33645453552 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke
    • Lee S.R., Kim H.Y., Rogowska J., et al. Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. J Neurosci 26 (2006) 3491-3495
    • (2006) J Neurosci , vol.26 , pp. 3491-3495
    • Lee, S.R.1    Kim, H.Y.2    Rogowska, J.3
  • 116
    • 0030750143 scopus 로고    scopus 로고
    • Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system
    • Carmeliet P., Moons L., Dewerchin M., et al. Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system. Ann N Y Acad Sci 811 (1997) 191-206
    • (1997) Ann N Y Acad Sci , vol.811 , pp. 191-206
    • Carmeliet, P.1    Moons, L.2    Dewerchin, M.3
  • 117
    • 50249110037 scopus 로고    scopus 로고
    • Neural stem/progenitor cells promote endothelial cell morphogenesis and protect endothelial cells against ischemia via HIF-1alpha-regulated VEGF signaling
    • Roitbak T., Li L., and Cunningham L.A. Neural stem/progenitor cells promote endothelial cell morphogenesis and protect endothelial cells against ischemia via HIF-1alpha-regulated VEGF signaling. J Cereb Blood Flow Metab 28 (2008) 1530-1542
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1530-1542
    • Roitbak, T.1    Li, L.2    Cunningham, L.A.3
  • 118
    • 33646337394 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of neural repair after stroke: making waves
    • Carmichael S.T. Cellular and molecular mechanisms of neural repair after stroke: making waves. Ann Neurol 59 (2006) 735-742
    • (2006) Ann Neurol , vol.59 , pp. 735-742
    • Carmichael, S.T.1
  • 119
    • 33746308062 scopus 로고    scopus 로고
    • Glial inhibition of CNS axon regeneration
    • Yiu G., and He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 7 (2006) 617-627
    • (2006) Nat Rev Neurosci , vol.7 , pp. 617-627
    • Yiu, G.1    He, Z.2
  • 120
    • 13544268736 scopus 로고    scopus 로고
    • Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells
    • Li Y., Chen J., Zhang C.L., et al. Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells. Glia 49 (2005) 407-417
    • (2005) Glia , vol.49 , pp. 407-417
    • Li, Y.1    Chen, J.2    Zhang, C.L.3
  • 121
    • 29744441582 scopus 로고    scopus 로고
    • Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke
    • Shen L.H., Li Y., Chen J., et al. Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience 137 (2006) 393-399
    • (2006) Neuroscience , vol.137 , pp. 393-399
    • Shen, L.H.1    Li, Y.2    Chen, J.3
  • 122
    • 62149098424 scopus 로고    scopus 로고
    • Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain
    • Shen L.H., Li Y., Gao Q., Savant-Bhonsale S., and Chopp M. Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain. Glia 56 (2008) 1747-1754
    • (2008) Glia , vol.56 , pp. 1747-1754
    • Shen, L.H.1    Li, Y.2    Gao, Q.3    Savant-Bhonsale, S.4    Chopp, M.5
  • 123
    • 34247539527 scopus 로고    scopus 로고
    • Axonal sprouting into the denervated spinal cord and synaptic and postsynaptic protein expression in the spinal cord after transplantation of bone marrow stromal cell in stroke rats
    • Liu Z., Li Y., Qu R., et al. Axonal sprouting into the denervated spinal cord and synaptic and postsynaptic protein expression in the spinal cord after transplantation of bone marrow stromal cell in stroke rats. Brain Res 1149 (2007) 172-180
    • (2007) Brain Res , vol.1149 , pp. 172-180
    • Liu, Z.1    Li, Y.2    Qu, R.3
  • 124
    • 0035019990 scopus 로고    scopus 로고
    • Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain
    • Gregersen R., Christensen T., Lehrmann E., Diemer N.H., and Finsen B. Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain. Exp Brain Res 138 (2001) 384-392
    • (2001) Exp Brain Res , vol.138 , pp. 384-392
    • Gregersen, R.1    Christensen, T.2    Lehrmann, E.3    Diemer, N.H.4    Finsen, B.5
  • 126
    • 0030861649 scopus 로고    scopus 로고
    • Endogenous progenitors remyelinate demyelinated axons in the adult CNS
    • Gensert J.M., and Goldman J.E. Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 19 (1997) 197-203
    • (1997) Neuron , vol.19 , pp. 197-203
    • Gensert, J.M.1    Goldman, J.E.2
  • 127
    • 0033571859 scopus 로고    scopus 로고
    • Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter
    • Roy N.S., Wang S., Harrison-Restelli C., et al. Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter. J Neurosci 19 (1999) 9986-9995
    • (1999) J Neurosci , vol.19 , pp. 9986-9995
    • Roy, N.S.1    Wang, S.2    Harrison-Restelli, C.3
  • 128
    • 33747806913 scopus 로고    scopus 로고
    • MRI detects white matter reorganization after neural progenitor cell treatment of stroke
    • Jiang Q., Zhang Z.G., Ding G.L., et al. MRI detects white matter reorganization after neural progenitor cell treatment of stroke. Neuroimage 32 (2006) 1080-1089
    • (2006) Neuroimage , vol.32 , pp. 1080-1089
    • Jiang, Q.1    Zhang, Z.G.2    Ding, G.L.3
  • 129
    • 48749112427 scopus 로고    scopus 로고
    • Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats
    • Ding G., Jiang Q., Li L., et al. Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats. J Cereb Blood Flow Metab 28 (2008) 1440-1448
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1440-1448
    • Ding, G.1    Jiang, Q.2    Li, L.3
  • 130
    • 0036868692 scopus 로고    scopus 로고
    • The basis of anisotropic water diffusion in the nervous system-a technical review
    • Beaulieu C. The basis of anisotropic water diffusion in the nervous system-a technical review. NMR Biomed 15 (2002) 435-455
    • (2002) NMR Biomed , vol.15 , pp. 435-455
    • Beaulieu, C.1
  • 131
    • 0036868662 scopus 로고    scopus 로고
    • Fiber tracking: principles and strategies-technical review
    • Mori S., and van Zijl P.C. Fiber tracking: principles and strategies-technical review. NMR Biomed 15 (2002) 468-480
    • (2002) NMR Biomed , vol.15 , pp. 468-480
    • Mori, S.1    van Zijl, P.C.2
  • 132
    • 0034859413 scopus 로고    scopus 로고
    • Three-dimensional anisotropy contrast magnetic resonance axonography to predict the prognosis for motor function in patients suffering from stroke
    • Watanabe T., Honda Y., Fujii Y., Koyama M., Matsuzawa H., and Tanaka R. Three-dimensional anisotropy contrast magnetic resonance axonography to predict the prognosis for motor function in patients suffering from stroke. J Neurosurg 94 (2001) 955-960
    • (2001) J Neurosurg , vol.94 , pp. 955-960
    • Watanabe, T.1    Honda, Y.2    Fujii, Y.3    Koyama, M.4    Matsuzawa, H.5    Tanaka, R.6
  • 133
    • 62449146929 scopus 로고    scopus 로고
    • MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia
    • Li L., Jiang Q., Ding G., et al. MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia. Stroke 40 (2009) 936-941
    • (2009) Stroke , vol.40 , pp. 936-941
    • Li, L.1    Jiang, Q.2    Ding, G.3
  • 134
    • 19544376511 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke: two decades of success and failure
    • Cheng Y.D., Al-Khoury L., and Zivin J.A. Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx 1 (2004) 36-45
    • (2004) NeuroRx , vol.1 , pp. 36-45
    • Cheng, Y.D.1    Al-Khoury, L.2    Zivin, J.A.3
  • 135
    • 41849103827 scopus 로고    scopus 로고
    • Repairing the human brain after stroke-I-mechanisms of spontaneous recovery
    • Cramer S.C. Repairing the human brain after stroke-I-mechanisms of spontaneous recovery. Ann Neurol 63 (2008) 272-287
    • (2008) Ann Neurol , vol.63 , pp. 272-287
    • Cramer, S.C.1
  • 136
    • 44849123458 scopus 로고    scopus 로고
    • Repairing the human brain after stroke-II-restorative therapies
    • Cramer S.C. Repairing the human brain after stroke-II-restorative therapies. Ann Neurol 63 (2008) 549-560
    • (2008) Ann Neurol , vol.63 , pp. 549-560
    • Cramer, S.C.1
  • 137
    • 34247869881 scopus 로고    scopus 로고
    • The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agents
    • Cramer S.C., Koroshetz W.J., and Finklestein S.P. The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agents. Stroke 38 (2007) 1393-1395
    • (2007) Stroke , vol.38 , pp. 1393-1395
    • Cramer, S.C.1    Koroshetz, W.J.2    Finklestein, S.P.3
  • 138
    • 60549090781 scopus 로고    scopus 로고
    • Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke
    • Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke 40 (2009) 510-515
    • (2009) Stroke , vol.40 , pp. 510-515
  • 139
    • 33750532312 scopus 로고    scopus 로고
    • Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial
    • Wolf S.L., Winstein C.J., Miller J.P., et al. Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. JAMA 296 (2006) 2095-2104
    • (2006) JAMA , vol.296 , pp. 2095-2104
    • Wolf, S.L.1    Winstein, C.J.2    Miller, J.P.3
  • 140
    • 37049038230 scopus 로고    scopus 로고
    • Retention of upper limb function in stroke survivors who have received constraint-induced movement therapy: the EXCITE randomised trial
    • Wolf S.L., Winstein C.J., Miller J.P., et al. Retention of upper limb function in stroke survivors who have received constraint-induced movement therapy: the EXCITE randomised trial. Lancet Neurol 7 (2008) 33-40
    • (2008) Lancet Neurol , vol.7 , pp. 33-40
    • Wolf, S.L.1    Winstein, C.J.2    Miller, J.P.3
  • 141
    • 0033845975 scopus 로고    scopus 로고
    • Transplantation of cultured human neuronal cells for patients with stroke
    • Kondziolka D., Wechsler L., Goldstein S., et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55 (2000) 565-569
    • (2000) Neurology , vol.55 , pp. 565-569
    • Kondziolka, D.1    Wechsler, L.2    Goldstein, S.3
  • 142
    • 24944466539 scopus 로고    scopus 로고
    • Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial
    • Kondziolka D., Steinberg G.K., Wechsler L., et al. Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg 103 (2005) 38-45
    • (2005) J Neurosurg , vol.103 , pp. 38-45
    • Kondziolka, D.1    Steinberg, G.K.2    Wechsler, L.3
  • 143
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang O.Y., Lee J.S., Lee P.H., and Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57 (2005) 874-882
    • (2005) Ann Neurol , vol.57 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3    Lee, G.4
  • 144
    • 33845480805 scopus 로고    scopus 로고
    • Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem cell Trial of recovery EnhanceMent after Stroke (STEMS) pilot randomized, controlled trial (ISRCTN 16784092)
    • Sprigg N., Bath P.M., Zhao L., et al. Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem cell Trial of recovery EnhanceMent after Stroke (STEMS) pilot randomized, controlled trial (ISRCTN 16784092). Stroke 37 (2006) 2979-2983
    • (2006) Stroke , vol.37 , pp. 2979-2983
    • Sprigg, N.1    Bath, P.M.2    Zhao, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.