Adrenocorticotropin reverses vascular dysfunction and protects against splanchnic artery occlusion shock

British Journal of Pharmacology

Volumn 128, Issue 3, 1999, Pages 816-822

  Squadrito, Francesco ^a   Guarini, Salvatore ^b   Altavilla, Domenica ^a   Squadrito, Giovanni ^a   Campo, Giuseppe M ^a   Arlotta, Mariarita ^a   Quartarone, Cristina ^a   Saitta, Antonino ^a   Cucinotta, Domenico ^a   Bazzani, Carla ^b   Cainazzo, Maria M ^b   Mioni, Chiara ^b   Bertolini, Alfio ^b   Caputi, Achille P ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b NONE

Author keywords

ACTH(1 24); Splanchnic artery occlusion shock; TNF ; Vascular dysfunction

Indexed keywords

ACETYLCHOLINE; CORTICOTROPIN; INTERCELLULAR ADHESION MOLECULE 1; MYELOPEROXIDASE; PHENYLEPHRINE; TETRACOSACTIDE; TUMOR NECROSIS FACTOR ALPHA;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; HYPOTENSION; ILEUM; LEUKOPENIA; LYMPHOCYTIC INFILTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; SHOCK; SPLANCHNIC BLOOD FLOW; SURVIVAL RATE; VASCULAR DISEASE;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BLOOD PRESSURE; CONSTRICTION, PATHOLOGIC; ENDOTHELIUM, VASCULAR; IMMUNOHISTOCHEMISTRY; INTERCELLULAR ADHESION MOLECULE-1; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032698847     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702848     Document Type: Article

References (36)

1. ABOU-MOHAMED, G., PAPAPETROPOULOS, A., ULRICH, D., CATRAVAS, J.D., TUTTLE, R.R. & CALDWELL, R.W. (1995). HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro. J. Pharmacol. Exp. Ther., 275, 584-591.
2. ALTAVILLA, D., BERLINGHIERI, M.C., SEMINARA, S., IANNELLO, D., FOCA, A. & MASTROENI, P. (1989). Different effects of bacterial lipopolysaccharide on superoxide anion production by macrophages from normal and tumor bearing rats. Immunopharmacology, 17, 99-105.
3. ALTAVILLA, D., CAINAZZO, M.M., SQUADRITO, F., GUARINI, S., BERTOLINI, A. & BAZZANI, C. (1998). Tumour necrosis factor-α as a target of melanocortins in haemorrhagic shock, in the anaesthetized rats. Br. J. Pharmacol., 124, 1587-1590.
4. AOKI, N., SIEGFRIED, M. & LEFER, A.M. (1989). Anti-EDRF effect of tumor necrosis factor in isolated perfused cat carotid arteries. Am. J. Physiol, 256, H1509-H1512.
5. BAZZANI, C., BALUGANI, A., BERTOLINI, A. & GUARINI, S. (1993). Comparison of the effects of ACTH-(1-24), methylprednisolone, aprotinin, and norepinephrine in a model of hemorragic shock in rats. Resuscitation, 25, 219-226.
6. BAZZANI, C., BERTOLINI, A. & GUARINI, S. (1997). Inhibition of nitric oxide synthases enhances the effect of ACTH in hemorrhagic shock. Life Sci., 61, 1889-1897.
7. BERTOLINI, A. (1995). The opioid/anti-opioid balance in shock: a new target for therapy in resuscitation. Resuscitation, 30, 29-42.
8. BERTOLINI, A., GUARINI, S. & FERRARI, W. (1986a). Adrenal-independent, anti-shock effect of ACTH-(1-24) in rats. Eur. J. Pharmacol., 122, 387-388.
9. BERTOLINI, A., GUARINI, S., FERRARI, W., NOERA, G., MASSINI, C. & DI TIZIO, S. (1987). ACTH-(1-24) restores blood pressure in acute hypovolaemia and haemorrhagic shock in humans. Eur. J. Clin. Pharmacol., 32, 537-538.
10. BERTOLINI, A., GUARINI, S., FERRARI, W. & ROMPIANESI, E. (1986b). Adrenocorticotropin reversal of experimental hemorrhagic shock is antagonized by morphine. Life Sci., 39, 1271-1280.
11. BERTOLINI, A., GUARINI, S., ROMPIANESI, E. & FERRARI, W. (1986c). α-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock. Eur. J. Pharmacol., 130, 19-26.
12. BUSSE, R. & MULSCH, A. (1990). Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett., 275, 87-90.
13. EBERLE, A.N. (1988). The melanotropins, Chemistry, Physiology and Mechanisms of Action. Basel: Karger.
14. GENEDANI, S., BERNARDI, M., BALDINI, M.G. & BERTOLINI, A. (1990). ACTH-(1-24) stimulates the migration of human monocytes in vitro. Peptides, 11, 1305-1307.
15. GENEDANI, S., BERNARDI, M. & BERTOLINI, A. (1992). Neuropeptides of the stress response and monocyte motility. Ann. N.Y. Acad. Sci., 663, 494-496.
16. GUARINI, S., BINI, A., BAZZANI, C., MATTERA RICIGLIANO, G., CAINAZZO, M.M., TOMASI, A. & BERTOLINI, A. (1997). Adrenocorticotropin normalizes the blood levels of nitric oxide in hemorrhage-shocked rats. Eur. J. Pharmacol., 336, 15-21.
17. GUARINI, S., TAGLIAVINI, S., BAZZANI, C., FERRARI, W. & BERTOLINI, A. (1990). Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective. Crit. Care Med., 18, 862-865.
18. HSU, S.M., RAINE, I.. & FANGER, H. (1981). A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radio-immunoassay. Am J. Clin Path, 75, 734-737.
19. IOCULANO, M., SQUADRITO, F., ALTAVILLA, D., CANALE, P., CAMPO, G.M., SAITTA, A. & CAPUTI, A.P. (1994). Antibodies against intercellular adhesion molecule-1 protect against myocardial ischaemia-reperfusion injury in the rat. Eur. J. Pharmacol., 264, 143-149.
20. LUDBROOK, J. & VENTURA, S. (1995). ACTH-(1-24) blocks the decompensatory phase of the haemodynamic response to acute hypovolaemia in conscious rabbits. Eur. J. Pharmacol., 275, 267-275.
21. MAGGI, C.A. & MELI, A. (1986a). Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1: general considerations. Experientia, 42, 109-114.
22. MAGGI, C.A. & MELI, A. (1986b). Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: cardiovascular system. Experientia, 42, 292-297.
23. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
24. MULLANE, K.M., KRAEMER, M.R. & SMITH, B. (1985). Mycloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J. Pharmacol. Methods, 14, 156-157.
25. NOERA, G., ANGIELLO, L., BIAGI, B. & PENSA, P. (1991). Haemorrhagic shock in cardiac surgery. Pharmacological treatment with ACTH-(1-24). Resuscitation, 22, 123-127.
26. NOERA, G., PENSA, P., GUELFI, P., BIAGI, B., CURCIO, C. & BENTINI, B. (1989). ACTH-(1-24) and hemorrhagic shock: Preliminary clinical results. Resuscitation, 18, 145-147.
27. PINELLI, G., CHESI, G., DI DONATO, C., REVERZANI, A. & MARANI, L. (1989). Preliminary data on the use of ACTH-(1-24) in human shock conditions. Resuscitation, 18, 149-150.
28. RUFF, M.R. & GIFFORD, G.E. (1980). Purification and physicochemical characterization of rabbit tumor necrosis factor. J. Immunol., 125, 1671-1675.
29. SQUADRITO, F., ALTAVILLA, D., CANALE, P., IOCULANO, M., CAMPO, G.M., AMMENDOLIA, L., FERLITO, M., ZINGARELLI, B., SQUADRITO, G., SAITTA, A. & CAPUTI, A.P. (1994a). Participation of tumour necrosis factor and nitric oxide in the mediation of vascular dysfunction in splanchnic artery occlusion shock. Br. J. Pharmacol., 113, 1153-1158.
30. SQUADRITO, F., ALTAVILLA, D., CANALE, P., IOCULANO, M., CAMPO, G.M., AMMENDOLIA, L., SQUADRITO, G., SAITTA, A., CALAPAI, G. & CAPUTI, A.P. (1994b). Contribution of intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of splanchnic artery occlusion shock in the rat. Br. J. Pharmacol., 113, 912-916.
31. SQUADRITO, F., ALTAVILLA, D., IOCULANO, M., CALAPAI, G., ZINGARELLI, B., SAITTA, A., CAMPO, G.M., RIZZO, A. & CAPUTI, A.P. (1992). Passive immunisation with antibodies against tumor necrosis factor TNF-α protects from the lethality of splanchnic artery occlusion shock. Circ. Shock, 37, 236-244.
32. SQUADRITO, F., ALTAVILLA, D., SQUADRITO, G., CAMPO, G.M., IOCULANO, M., CANALE, P., ROSSI, F., SAITTA, A. & CAPUTI, A.P. (1996). Effects of S-ethylisothiourea, a potent inhibitor of nitric oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock. Br. J. Pharmacol., 119, 23-28.
33. STAR, R.A., RAJORA, N., HUANG, J., STOCK, R.C., CATANIA, A. & LIPTON, J.M. (1995). Evidence of autocrine modulation of macrophage nitric oxide synthase by α-melanocyte-stimulating hormone. Proc. Natl. Acad. Sci. U.S.A., 92, 8016-8020.
34. SZABÓ, C. & THIEMERMANN, C. (1994). Invited opinion: role of nitric oxide in hemorrhagic, traumatic and anaphylactic shock and thermal injury. Shock, 2, 145-155.
35. TAKAHASHI, K., ANDO, K., ANO, A., SHIMOSAWA, T., OGATA, E. & FUJITA, T. (1992). Tumor necrosis factor-α induces vascular hyporesponsiveness in Sprague-Dawley rats. Life. Sci., 50, 1437-1444.
36. THIEMERMANN, C., SZABO, C., MITCHELL, J.A. & VANE, J.R. (1993). Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc. Natl. Acad. Sci. U.S.A., 90, 267-271.