Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 4, 2008, Pages

  Bruder, Eric D ^a   Taylor, Jennifer K ^a   Kamer, Kimberli J ^a   Raff, Hershel ^a,b,c  

^a ST LUKE S MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c St Luke's Physician's Office Bldg   (United States)

Author keywords

Adrenal cortex; Body temperature; Ontogeny; Oxygen; Pituitary

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN PD2; PROTEIN PD8; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL TISSUE; ARTERIAL OXYGEN SATURATION; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; HEART RATE; HYPOXIA; MITOCHONDRION; NEWBORN; NONHUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANIMALS; ANIMALS, NEWBORN; ANOXIA; BODY TEMPERATURE; CORTICOSTERONE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART RATE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; NEUROPEPTIDE Y; OXYGEN; PHOSPHOPROTEINS; PITUITARY GLAND, ANTERIOR; PITUITARY-ADRENAL SYSTEM; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECEPTORS, GLUCOCORTICOID; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS;

EID: 57349083071     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90400.2008     Document Type: Article

References (71)

1. Almahbobi G, Williams LJ, Hall PF. Attachment of mitochondria to intermediate filaments in adrenal cells: relevance to the regulation of steroid synthesis. Exp Cell Res 200: 361-369, 1992.
2. Ariyoshi N, Kim YC, Artemenko I, Bhattacharyya KK, Jefcoate CR. Characterization of the rat Star gene that encodes the predominant 3.5-kilobase pair mRNA ACTH stimulation of adrenal steroids in vivo precedes elevation of Star mRNA and protein. J Biol Chem 273: 7610-7619, 1998.
3. Bodnar M, Sarrieau A, Deschepper CF, Walker CD. Adrenal vasoactive intestinal peptide participates in neonatal corticosteroid production in the rat. Am J Physiol Regul Integr Comp Physiol 273: R1163-R1172, 1997.
4. Boggaram V, Funkenstein B, Waterman MR, Simpson ER. Lipoproteins and the regulation of adrenal steroidogenesis. Endocr Res 10: 387-409, 1984.
5. Bruder ED, Henderson LM, Raff H. Adrenal lipid profiles of chemically sympathectomized normoxic and hypoxic neonatal rats. Horm Metab Res 38: 807-811, 2006.
6. Bruder ED, Hoof JV, Young JB, Raff H. Epidermal growth factor and parathyroid hormone-related peptide mRNA in the mammary gland and their concentrations in milk: effects of postpartum hypoxia in lactating rats. Horm Metab Res 40: 446-453, 2008.
7. Bruder ED, Lee JJ, Widmaier EP, Raff H. Microarray and real-time PCR analysis of adrenal gland gene expression in the 7-day-old rat: effects of hypoxia from birth. Physiol Genomics 29: 193-200, 2007.
8. Bruder ED, Lee PC, Raff H. Metabolomic analysis of adrenal lipids during hypoxia in the neonatal rat: implications in steroidogenesis. Am J Physiol Endocrinol Metab 286: E697-E703, 2004.
9. Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM. Pathogenesis of bronchopulmonary dysplasia. Semin Perinatol 30: 171-178, 2006.
10. Denenberg VH, Bell RW. Critical periods for the effects of infantile experience on adult learning. Science 131: 227-228, 1960.
11. Deruelle P, Houfflin-Debarge V, Magnenant E, Jaillard S, Riou Y, Puech F, Storme L. Effects of antenatal glucocorticoids on pulmonary vascular reactivity in the ovine fetus. Am J Obstet Gynecol 189: 208-215, 2003.
12. Dobrota MHR. Conditions for density gradient separations. In: Preparative Centrifugation - A Practical Approach, edited by Rickwood D. Oxford: Oxford University Press, 1992, p. 77-142.
13. Ehrhart-Bornstein M, Bornstein SR, Gonzalez-Hernandez J, Holst JJ, Waterman MR, Scherbaum WA. Sympathoadrenal regulation of adrenocortical steroidogenesis. Endocr Res 21: 13-24, 1995.
14. Ehrhart-Bornstein M, Haidan A, Alesci S, Bornstein SR. Neurotransmitters and neuropeptides in the differential regulation of steroidogenesis in adrenocortical-chromaffin co-cultures. Endocr Res 26: 833-842, 2000.
15. Ehrhart-Bornstein M, Hinson JP, Bornstein SR, Scherbaum WA, Vinson GP. Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocr Rev 19: 101-143, 1998.
16. Engeland WC. Functional innervation of the adrenal cortex by the splanchnic nerve. Horm Metab Res 30: 311-314, 1998.
17. Frankel L, Stevenson DK. Metabolic emergencies of the newborn: hypoxemia and hypoglycemia. Compr Ther 13: 14-19, 1987.
18. Frappell P, Lanthier C, Baudinette RV, Mortola JP. Metabolism and ventilation in acute hypoxia: a comparative analysis in small mammalian species. Am J Physiol Regul Integr Comp Physiol 262: R1040-R1046, 1992.
19. Friedman AH, Fahey JT. The transition from fetal to neonatal circulation: normal responses and implications for infants with heart disease. Semin Perinatol 17: 106-121, 1993.
20. Goodfriend TL, Calhoun DA. Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. Hypertension 43: 518-524, 2004.
21. Grongnet JF. Metabolic consequences of induced hypoxia in newborn lambs. Ann Rech Vet 15: 17-28, 1984.
22. Hall PF. On the mechanism of action of ACTH: the role of actin. Endocr Res 10: 431-461, 1984.
23. Hall PF. The roles of microfilaments and intermediate filaments in the regulation of steroid synthesis. J Steroid Biochem Mol Biol 55: 601-605, 1995.
24. Hermansen CL, Lorah KN. Respiratory distress in the newborn. Am Fam Physician 76: 987-994, 2007.
25. Hofstetter J, Suckow MA, Hickman DL. Morphophysiology. In: The Laboratory Rat, edited by Suckow MA, Weisbroth SH, and Franklin CL. New York: Elsevier, 2006, p. 93-127.
26. Knight DB. The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials. Semin Neonatol 6: 63-73, 2001.
27. Levine S, Huchton DM, Wiener SG, Rosenfeld P. Time course of the effect of maternal deprivation on the hypothalamic-pituitary-adrenal axis in the infant rat. Dev Psychobiol 24: 547-558, 1991.
28. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408, 2001.
29. Low JA, Froese AB, Galbraith RS, Smith JT, Sauerbrei EE, Derrick EJ. The association between preterm newborn hypotension and hypoxemia and outcome during the first year. Acta Paediatr 82: 433-437, 1993.
30. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S, Munson ML. Births: final data for 2005. Natl Vital Stat Rep 56: 1-103, 2007.
31. Martin RJ, Miller MJ, Carlo WA. Pathogenesis of apnea in preterm infants. J Pediatr 109: 733-741, 1986.
32. Miller MJ, Martin RJ. Apnea of prematurity. Clin Perinatol 19: 789-808, 1992.
33. Morales P, Rastogi A, Bez ML, Akintorin SM, Pyati S, Andes SM, Pildes RS. Effect of dexamethasone therapy on the neonatal ductus arteriosus. Pediatr Cardiol 19: 225-229, 1998.
34. Mortola JP. How newborn mammals cope with hypoxia. Respir Physiol 116: 95-103, 1999.
35. Mortola JP. Implications of hypoxic hypometabolism during mammalian ontogenesis. Respir Physiol Neurobiol 141: 345-356, 2004.
36. Mortola JP, Morgan CA, Virgona V. Respiratory adaptation to chronic hypoxia in newborn rats. J Appl Physiol 61: 1329-1336, 1986.
37. Ness GC, Zhao Z, Lopez D. Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. Arch Biochem Biophys 325: 242-248, 1996.
38. Nurse CA, Buttigieg J, Thompson R, Zhang M, Cutz E. Oxygen sensing in neuroepithelial and adrenal chromaffin cells. Novartis Found Symp 272: 106-114, 2006.
39. Nye J. Postnatal corticosteroids in the treatment of chronic lung disease in the preterm infant: past, present, and future. Neonatal Netw 26: 293-299, 2007.
40. Papadopoulos V, Brown AS, Hall PF. Calcium-calmodulin-dependent phosphorylation of cytoskeletal proteins from adrenal cells. Mol Cell Endocrinol 74: 109-123, 1990.
41. Papadopoulos V, Widmaier EP, Hall PF. The role of calmodulin in the responses to adrenocorticotropin of plasma membranes from adrenal cells. Endocrinology 126: 2465-2473, 1990.
42. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Burlington, VT: Elsevier Academic, 2005.
43. Pocathikorn A, Taylor RR, James I, Mamotte CD. LDL-receptor mRNA expression in men is downregulated within an hour of an acute fat load and is influenced by genetic polymorphism. J Nutr 137: 2062-2067, 2007.
44. Raff H, Hong JJ, Oaks MK, Widmaier EP. Adrenocortical responses to ACTH in neonatal rats: effect of hypoxia from birth on corticosterone, StAR, and PBR. Am J Physiol Regul Integr Comp Physiol 284: R78-R85, 2003.
45. Raff H, Jacobson L. Glucocorticoid feedback control of corticotropin in the hypoxic neonatal rat. J Endocrinol 192: 453-458, 2007.
46. Raff H, Jacobson L, Cullinan WE. Elevated corticosterone and inhibition of ACTH responses to CRH and ether in the neonatal rat: effect of hypoxia from birth. Am J Physiol Regul Integr Comp Physiol 285: R1224-R1230, 2003.
47. Raff H, Jacobson L, Cullinan WE. Augmented hypothalamic corticotrophin-releasing hormone mRNA and corticosterone responses to stress in adult rats exposed to perinatal hypoxia. J Neuroendocrinol 19: 907-912, 2007.
48. Raff H, Jankowski BM, Bruder ED, Engeland WC, Oaks MK. The effect of hypoxia from birth on the regulation of aldosterone in the 7-day-old rat: plasma hormones, steroidogenesis in vitro, and steroidogenic enzyme messenger ribonucleic acid. Endocrinology 140: 3147-3153, 1999.
49. Raff H, Jankowski BM, Goodfriend TL, Baker JE, Papanek PE. Effect of exposure to hypoxia from birth on aldosterone in rabbits: role of unesterified fatty acids. Am J Physiol Regul Integr Comp Physiol 272: R1084-R1087, 1997.
50. Raff H, Lee JJ, Widmaier EP, Oaks MK, Engeland WC. Basal and adrenocorticotropin-stimulated corticosterone in the neonatal rat exposed to hypoxia from birth: modulation by chemical sympathectomy. Endocrinology 145: 79-86, 2004.
51. Reyes ZC, Claure N, Tauscher MK, D'Ugard C, Vanbuskirk S, Bancalari E. Randomized, controlled trial comparing synchronized intermittent mandatory ventilation and synchronized intermittent mandatory ventilation plus pressure support in preterm infants. Pediatrics 118: 1409-1417, 2006.
52. Schinner S, Bornstein SR. Cortical-chromaffin cell interactions in the adrenal gland. Endocr Pathol 16: 91-98, 2005.
53. Seidler FJ, Slotkin TA. Adrenomedullary function in the neonatal rat: responses to acute hypoxia. J Physiol 358: 1-16, 1985.
54. Smith MA, Kim SY, van Oers HJ, Levine S. Maternal deprivation and stress induce immediate early genes in the infant rat brain. Endocrinology 138: 4622-4628, 1997.
55. Strack AM, Bradbury MJ, Dallman MF. Corticosterone decreases nonshivering thermogenesis and increases lipid storage in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 268: R183-R191, 1995.
56. Strack AM, Horsley CJ, Sebastian RJ, Akana SF, Dallman MF. Glucocorticoids and insulin: complex interaction on brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 268: R1209-R1216, 1995.
57. Thompson RJ, Jackson A, Nurse CA. Developmental loss of hypoxic chemosensitivity in rat adrenomedullary chromaffin cells. J Physiol 498: 503-510, 1997.
58. Tin W. Optimal oxygen saturation for preterm babies. Do we really know? Biol Neonate 85: 319-325, 2004.
59. Tin W, Wiswell TE. Adjunctive therapies in chronic lung disease: examining the evidence. Semin Fetal Neonatal Med 13: 44-52, 2008.
60. Walker CD. Chemical sympathectomy and maternal separation affect neonatal stress responses and adrenal sensitivity to ACTH. Am J Physiol Regul Integr Comp Physiol 268: R1281-R1288, 1995.
61. Walker CD, Aubert ML. Effects of early undernutrition and handling on the adrenocortical activity of neonatal rats. Life Sci 43: 1983-1990, 1988.
62. Walker CD, Perrin M, Vale W, Rivier C. Ontogeny of the stress response in the rat: role of the pituitary and the hypothalamus. Endocrinology 118: 1445-1451, 1986.
63. Walker CD, Sapolsky RM, Meaney MJ, Vale WW, Rivier CL. Increased pituitary sensitivity to glucocorticoid feedback during the stress nonresponsive period in the neonatal rat. Endocrinology 119: 1816-1821, 1986.
64. Walker CD, Scribner KA, Cascio CS, Dallman MF. The pituitary-adrenocortical system of neonatal rats is responsive to stress throughout development in a time-dependent and stressor-specific fashion. Endocrinology 128: 1385-1395, 1991.
65. Walker CD, Sizonenko PC, Aubert ML. Modulation of the neonatal pituitary and adrenocortical responses to stress by thyroid hormones in the rat: effects of hypothyroidism and hyperthyroidism. Neuroendocrinology 50: 265-273, 1989.
66. Watterberg KL, Gerdes JS, Cook KL. Impaired glucocorticoid synthesis in premature infants developing chronic lung disease. Pediatr Res 50: 190-195, 2001.
67. Watterberg KL, Gerdes JS, Gifford KL, Lin HM. Prophylaxis against early adrenal insufficiency to prevent chronic lung disease in premature infants. Pediatrics 104: 1258-1263, 1999.
68. Watterberg KL, Scott SM, Backstrom C, Gifford KL, Cook KL. Links between early adrenal function and respiratory outcome in preterm infants: airway inflammation and patent ductus arteriosus. Pediatrics 105: 320-324, 2000.
69. Watts AG, Tanimura S, Sanchez-Watts G. Corticotropin-releasing hormone and arginine vasopressin gene transcription in the hypothalamic paraventricular nucleus of unstressed rats: daily rhythms and their interactions with corticosterone. Endocrinology 145: 529-540, 2004.
70. Zhang L. Prenatal hypoxia and cardiac programming. J Soc Gynecol Investig 12: 2-13, 2005.
71. Zilz A, Li H, Castello R, Papadopoulos V, Widmaier EP. Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands. Endocrinology 140: 859-864, 1999.