Adrenocorticotropin normalizes the blood levels of nitric oxide in hemorrhage-shocked rats

European Journal of Pharmacology

Volumn 336, Issue 1, 1997, Pages 15-21

  Guarini, Salvatore ^a   Bini, Anna ^a   Bazzani, Carla ^a   Ricigliano, Guido Mattera ^a   Cainazzo, Maria Michela ^a   Tomasi, Aldo ^a   Alfio, Bertolini ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

ACTH (adrenocorticotropin); Electron spin resonance; Hemorrhagic shock; Nitric oxide (NO); Nitric oxide (NO) synthase, inducible

Indexed keywords

HEMOGLOBIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; S METHYLPSEUDOTHIOUREA; TETRACOSACTIDE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BREATHING RATE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HEART RATE; HEMORRHAGIC SHOCK; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PULSE PRESSURE; RAT;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BLOOD PRESSURE; FEMALE; HEART RATE; HEMOGLOBIN A, GLYCOSYLATED; MALE; NITRIC OXIDE; RATS; RATS, WISTAR; RESPIRATION; SHOCK, HEMORRHAGIC;

EID: 0030776975     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01210-7     Document Type: Article

References (46)

1. Bazzani C., Tagliavini S., Bertolini E., Bertolini A., Guarini S. Influence of ACTH-(1-24) on metabolic acidosis and hypoxemia induced by massive hemorrhage in rats. Resuscitation. 23:1992;113-120.
2. 1 receptors are involved in the ACTH-induced reversal of hemorrhagic shock. Eur. J. Pharmacol. 253:1994;303-306.
3. Bazzani, C., Bertolini, A., Guarini, S., 1997. Inhibition of nitric oxide synthases enhances the effect of ACTH in hemorrhagic shock. Life Sci., in press.
4. Bennet J., Ingram D.J.E., George P., Grifith J.S. Paramagnetic resonance absorption of ferrihaemoglobin and ferrimyoglobin derivatives. Nature (London). 176:1955;394.
5. Bertolini A. The opioid/anti-opioid balance in shock: A new target for therapy in resuscitation. Resuscitation. 30:1995;29-42.
6. Bertolini A., Guarini S., Ferrari W. Adrenal-independent, anti-shock effect of ACTH-(1-24) in rats. Eur. J. Pharmacol. 122:1986;387-388.
7. Bertolini A., Guarini S., Ferrari W., Rompianesi E. Adrenocorticotropin reversal of experimental hemorrhagic shock is antagonized by morphine. Life Sci. 39:1986;1271-1280.
8. Bertolini A., Guarini S., Rompianesi E., Ferrari W. α-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock. Eur. J. Pharmacol. 130:1986;19-26.
9. Bertolini A., Guarini S., Ferrari W., Noera G., Massini C., Di Tizio S. ACTH-(1-24) restores blood pressure in acute hypovolaemia and haemorrhagic shock in humans. Eur. J. Clin. Pharmacol. 32:1987;537-538.
10. Bertolini A., Ferrari W., Guarini S. The adrenocorticotropic hormone (ACTH)-induced reversal of hemorrhagic shock. Resuscitation. 18:1989;253-267.
11. Doyle M.P., Hoekstra J.W. Oxidation of nitrogen oxides by bound deoxygen in hemoproteins. J. Inorg. Biochem. 14:1981;351-358.
12. Ertel W., Morrison M., Ayala A., Chaudry I. Chloroquine attenuates hemorrhagic shock-induced suppression of Kuppffer cell antigen presentation and major histocompatibility complex class II antigen expression through blockade of tumor necrosis factor and prostaglandin release. Blood. 45:1991;1781-1788.
13. Guarini S., Rompianesi E., Ferrari W., Bertolini A. Influence of vagotomy and of atropine on the anti-shock effect of adrenocoticotropin. Neuropeptides. 8:1986;19-24.
14. Guarini S., Ferrari W., Mottillo G., Bertolini A. Anti-shock effect of ACTH: Haematological changes and influence of splenectomy. Arch. Int. Pharmacodyn. 289:1987;311-318.
15. Guarini S., Ferrari W., Bertolini A. Anti-shock effect of ACTH-(1-24): Influence of subtotal hepatectomy. Pharmacol. Res. Commun. 20:1988;395-403.
16. Guarini S., Ferrari W., Bertolini A. Involvement of the sympathetic nervous system in the cardiovascular effects of ACTH-(1-24) during hemorrhagic shock in rats. Naunyn-Schmiedeberg's. Arch. Pharmacol. 337:1988;556-560.
17. Guarini S., Tagliavini S., Bazzani C., Benelli A., Bertolini A., Ferrari W. Effect of ACTH-(1-24) on the volume of circulating blood and on regional blood flow in rats bled to hypovolemic shock. Resuscitation. 18:1989;133-134.
18. Guarini S., Tagliavini S., Bazzani C., Ferrante F., Bertolini A. Intracerebroventricular injection of hemicholinium-3 prevents the ACTH-induced, but not the physostigmine-induced, reversal of hemorrhagic shock in rats. Pharmacology. 40:1990;85-89.
19. Guarini S., Tagliavini S., Bazzani C., Ferrari W., Bertolini A. Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective. Crit. Care Med. 18:1990;862-865.
20. Guarini S., Bazzani C., Tagliavini S., Bertolini A., Ferrari W. Capsaicin prevents the adrenocorticotropin-induced improvement of cardiovascular function and survival in hemorrhage-shocked rats. Neurosci. Lett. 143:1992;181-184.
21. 2+-channels in the ACTH-induced reversal of haemorrhagic shock. Br. J. Pharmacol. 109:1993;645-650.
22. Harbrecht B.G., Billiar T.R., Stadler J., Demetris A.J., Ochoa J., Curran R.D., Simmons R.L. Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J. Leukocyte Biol. 52:1992;390-394.
23. Henry Y., Lepoivre M., Drapier J.C., Ducrocq C., Boucher J.L., Guissani A. EPR characterization of molecular targets for NO in mammalian cells and organelles. FASEB J. 7:1993;1124-1134.
24. Kilbourn R., Griffith O. Overproduction of nitric oxide in cytokine-mediated and septic shock. J. Natl. Cancer Inst. 84:1992;827-831.
25. Kohno M., Masumizu T., Mori A. ESR demonstration of nitric oxide production from nitroglycerin and sodium nitrite in the blood of rats. Free Radic. Biol. Med. 18:1995;451-457.
26. Kozlov, A., Bini, A., Iannone, A., Zini, I., Tomasi, A., 1996. Electron paramagnetic resonance characterization of rat neuronal NO production ex vivo. In: Packer, L. (Ed.), Methods in Enzymology. Nitric Oxide; Sources and Detection of NO; NO Synthase (Part A). Academic Press, San Diego, CA, pp. 229-236.
27. Ludbrook J., Rutter P. Effect of naloxone on haemodynamic responses to acute blood loss in unanaesthetized rabbits. J. Physiol. (Lond.). 400:1988;1-14.
28. Ludbrook J., Ventura S. ACTH-(1-24) blocks the decompensatory phase of the haemodynamic response to acute hypovolaemia in conscious rabbits. Eur. J. Pharmacol. 275:1995;267-275.
29. Maggi C., Meli A. Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: Cardiovascular system. Experientia. 42:1986;292-297.
30. Murphy, M.E., Noack, E., 1994. Nitric oxide assay using hemoglobin method. In: Packer, L. (Ed.), Methods in Enzymology. Oxygen Radicals in Biological Systems, Part C. Academic Press, San Diego; CA, pp. 240-250.
31. Noera G., Pensa P., Guelfi P., Biagi B., Curcio C., Bentini B. ACTH-(1-24) and hemorrhagic shock: Preliminary clinical results. Resuscitation. 18:1989;145-147.
32. Noera G., Angiello L., Biagi B., Pensa P. Haemorrhagic shock in cardiac surgery. Pharmacological treatment with ACTH-(1-24). Resuscitation. 22:1991;123-127.
33. Pinelli G., Chesi G., Di Donato C., Reverzani A., Marani L. Preliminary data on the use of ACTH-(1-24) in human shock conditions. Resuscitation. 18:1989;149-150.
34. Rein H., Ristau O., Scheller W. On the influence of allosteric effectors on the electron paramagnetic spectrum of nitric oxide hemoglobin. FEBS Lett. 24:1972;24-26.
35. Sato S., Tominaga T., Ohnishi T., Ohnishi S.T. EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat. Biochim. Biophys. Acta. 1181:1993;195-197.
36. Schadt J.C. Sympathetic and hemodynamic adjustments to hemorrhage: A possible role for endogenous opioid peptides. Resuscitation. 18:1989;219-228.
37. Schadt J.C., Gaddis R.R. Cardiovascular responses to hemorrhage and naloxone in conscious barodenervated rabbits. Am. J. Physiol. 251:1986;R909-R915.
38. Southan G.J., Szabò C., Thiemermann C. Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br. J. Pharmacol. 114:1995;510-516.
39. Szabò C., Southan G.J., Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc. Natl. Acad. Sci. USA. 91:1994;12472-12476.
40. Thiemermann C. Inhibition of nitric oxide synthase activity in circulatory shock: Friend or foe. Med. Sci. 11:1995;1643-1651.
41. Thiemermann C., Szabò C., Mitchell J., Vane J. Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc. Natl. Acad. Sci. USA. 90:1993;267-271.
42. Vanin A.F., Osipov A.N., Kubrina L.N., Burbaev D.S., Nalbandyan R.M. On the origin of paramagnetic centres with g=2.03 in animal tissues and microorganism. Stud. Biophys. 49:1975;13-25.
43. Wennmalm A., Lanne B., Petersson A.-S. Detection of endothelial-derived relaxing factor in human plasma in the basal state and following ischemia using electron paramagnetic resonance spectroscopy. Anal. Biochem. 187:1990;359-363.
44. Westenberger U., Thanner S., Ruf H.H., Gersonde K., Sutter G., Trentz O. Formation of free radicals and nitric oxide derivative of hemoglobin in rats during shock syndrome. Free Radic. Res. Commun. 11:1990;167-178.
45. Zingarelli B., Squadrito F., Altavilla D., Calapai G., Campo G., Calò M., Saitta A., Caputi A.P. Evidence for a role of nitric oxide in hypovolemic hemorrhagic shock. J. Cardiovasc. Pharmacol. 19:1992;982-986.
46. Zingarelli B., Squadrito F., Altavilla D., Calapai G., Di Rosa M., Caputi A.P. Role of tumor necrosis factor-α in acute hypovolemic hemorrhagic shock in rats. Am. J. Physiol. 266:1994;H1512-H1515.