Resuscitating effect of melanocortin peptides after prolonged respiratory arrest

British Journal of Pharmacology

Volumn 121, Issue 7, 1997, Pages 1454-1460

  Guarini, Salvatore ^a   Bazzani, Carla ^a   Bertolini, Alfio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

MSH; ACTH; Hypoxia; Inotropic agents; Melanocortin peptides; Respiratory arrest; Resuscitation

Indexed keywords

ADRENALIN; ADRENERGIC NEURON BLOCKING AGENT; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA INTERMEDIN; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CARDIAC GLYCOSIDE; CATECHOLAMINE; CORTICOTROPIN; DOBUTAMINE; GLUTATHIONE; GUANETHIDINE; HYPOPHYSIS HORMONE; OUABAIN; PRAZOSIN;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS; BLOOD PH; EXPERIMENTAL MODEL; FEMALE; HEART OUTPUT; HEART RATE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PULSE PRESSURE; RAT; RESPIRATORY ARREST; RESUSCITATION;

ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; ANOXIA; ELECTROENCEPHALOGRAPHY; FEMALE; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; RESUSCITATION;

EID: 0030793624     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701264     Document Type: Article

References (39)

1. ADAN, R.A.H., CONE, R.D., BURBACH, J.P.H. & GISPEN, W.H. (1994). Differential effects of melanocortin peptides on neural melanocortin receptors. Mol. Pharmacol., 46, 1182-1190.
2. AMMON, H.P.T., MELIEN, M.C.M. & VERSPOHL, E.J. (1986). Pharmacokinetics of intravenously administered glutathione in the rat. J. Pharm. Pharmacol., 38, 721-725.
3. BAKER, C.C. (1986). Epidemiology of trauma: the civilian perspective. Ann. Emerg. Med., 15, 1389-1391.
4. BAZZANI, C., TAGLIAVINI, S., BERTOLINI, E., BERTOLINI, A. & GUARINI, S. (1992). Influence of ACTH-(1-24) on metabolic acidosis and hypoxemia induced by massive hemorrhage in rats. Resuscitation, 23, 113-120.
5. BELLAMY, R.F. (1984). The causes of death in conventional land warfare: implications for combat casualty care research. Mil. Med., 149, 55-62.
6. BELLAMY, R.F., MANINGAS, P.A. & VAYER, J.S. (1986). Epidemiology of trauma: military experience. Ann. Emerg. Med., 15, 1384-1388.
7. 7]α-MSH improves functional recovery in rats subjected to diencephalic hemisection. Eur. J. Pharmacol., 150, 211-219.
8. BENFEY, B.G. (1990). Function of myocardial α-adrenoceptors. Life Sci., 46, 743-757.
9. BERDEAUX, A., BOISSIER, J.R. & GIUDICELLI, J.F. (1977). Effects of atenolol on regional myocardial blood flow and ST segment elevation in the canine myocardium. Br. J. Pharmacol., 60, 433-440.
10. BERTOLINI, A. (1995). The opioid/anti-opioid balance in shock: a new target for therapy in resuscitation. Resuscitation, 30, 29-42.
11. BERTOLINI, A., FERRARI, W. & GUARINI, S. (1989). The adrenocorticotropic hormone (ACTH)-induced reversal of hemorrhagic shock. Resuscitation, 18, 253-267.
12. BERTOLINI, A., GUARINI, S. & FERRARI, W. (1986a). Adrenal-independent, anti-shock effect of ACTH-(1-24) in rats. Eur. J. Pharmacol., 122, 387-388.
13. BERTOLINI, A., GUARINI, S., FERRARI, W., NOERA, G., MASSINI, C. & DI TIZIO, S. (1987). ACTH-(1-24) restores blood pressure in acute hypovolaemia and haemorrhagic shock in humans. Eur. J. Clin. Pharmacol., 32, 537-538.
14. BERTOLINI, A., GUARINI, S., FERRARI, W. & ROMPIANESI, E. (1986b). Adrenocorticotropin reversal of experimental hemorrhagic shock is antagonized by morphine. Life Sci., 39, 1271-1280.
15. BERTOLINI, A., GUARINI, S., ROMPIANESI, E. & FERRARI, W. (1986c). α-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock. Eur. J. Pharmacol., 130, 19-26.
16. BJÖRKLUND, A., DUNNETT, S.B., STENEVI, U., LEWIS, M.E. & IVERSEN, S.D. (1980). Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res., 199, 307-333.
17. BREZENOFF, H.E. (1973). Centrally induced pressor responses to intravenous and intraventricular physostigmine evoked via different pathways. Eur. J. Pharmacol., 23, 290-292.
18. DESAULLES, P.A., BARTHE, P., SCHÄR, B. & STAEHELIN, M. (1966). The adrenocorticotrophic properties of α-melanophore-stimulating hormone. Acta Endocrinol., 51, 609-618.
19. 1-Adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiol. Rev., 73, 469 487.
20. GREGG, D.E. & FISHER, L.C. (1963). Blood supply to the heart. In Handbook of Physiology, Circulation Sect. 2, Vol II, pp. 1517-1584. Bethesda: American Physiological Society.
21. GUARINI, S., BAZZANI, C., MATTERA RICIGLIANO, G., BINI, A., TOMASI, A. & BERTOLINI, A. (1996). Influence of ACTH-(1-24) on free radical levels in the blood of haemorrhage-shocked rats: direct ex vivo detection by electron spin resonance spectrometry. Br. J. Pharmacol., 119, 29 34.
22. GUARINI, S., FERRARI, W., MOTTILLO, G. & BERTOLINI, A. (1987). Anti-shock effect of ACTH: haematological changes and influence of splenectomy. Arch. Int. Pharmacodyn., 289, 311-318.
23. GUARINI, S., TAGLIAVINI, S., BAZZANI, C., BENELLI, A., BERTOLINI, A. & FERRARI, W. (1989). Effect of ACTH-(1-24) in the volume of circulating blood and on regional blood flow in rats bled to hypovolemic shock. Resuscitation, 18, 133-134.
24. GUARINI, S., TAGLIAVINI, S., BAZZANI, C., FERRARI, W. & BERTOLINI, A. (1990). Early treatment with ACTH-(1 24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective. Crit. Care Med., 18, 862-865.
25. HOL, E.M., GISPEN, W.H. & BÄR, P.R. (1995). ACTH-related peptides: receptors and signal transduction systems involved in their neurotrophic and neuroprotective actions. Peptides, 16, 979-993.
26. LUDBROOK, J. & VENTURA, S. (1995). ACTH-(1 24) blocks the decompensatory phase of the haemodynamic response to acute hypovolaemia in conscious rabbit. Eur. J. Pharmacol., 275, 267-275.
27. MANDEL, W., SINGER, M.J., GUDMUNSON, H.R., MEISTER, L. & MODERN, F.W.S. (1951). Intravenous use of pituitary adrenocorticotropic hormone (ACTH). A report on its administration in twenty-five patients. J. Am. Med. Assoc., 146, 546-551.
28. MORRIS, R. (1984). Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods, 11, 47-60.
29. MURPHY, B.E.P. (1967). Some studies of the protein binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J. Clin. Endocrinol., 27, 973 990.
30. NOERA, G., ANGIELLO, L., BIAGI, B. & PENSA, P. (1991). Haemorrhagic shock in cardiac surgery. Pharmacological treatment with ACTH-(1 24). Resuscitation, 22, 123-127.
31. NOERA, G., PENSA, P., GUELFI, P., BIAGI, B., CURCIO, C. & BENTINI, B. (1989). ACTH-(1-24) and haemorrhagic shock: preliminary clinical results. Resuscitation, 18, 145-147.
32. PINELLI, G., CHESI, C., DI DONATO, C., REVERZERANI, A. & MARANI, L. (1989). Preliminary data on the use of ACTH-(1-24) in human shock conditions. Resuscitation, 18, 149-150.
33. RUSSEL, J.Q. & KLAASSEN, C.D. (1973). Biliary excretion of cardiac glycosides. J. Pharmacol. Exp. Ther., 186, 455 462.
34. SZABO, B., HEDLER, L. & STARKE, K. (1989). Facilitation of the release of noradrenaline: an extra-adrenal effect of adrenocorticotropic hormone. Resuscitation, 18, 229-242.
35. TRUNKEY, D.D. (1983). Trauma. Sci. Am., 249, 28 35.
36. VAN BERGEN, P., JANSSEN, P.M.L., HOOGERHOUT, P., DE WILDT, D.J. & VERSTEEG, D.H.G. (1995). Cardiovascular effects of γ-MSH/ACTH-like peptides: structure-activity relationship. Eur. J. Pharmacol., 294, 795 803.
37. VAN MEEL, J.C.A., DE JONGE, A., TIMMERMANS, P.B.M.W.M. & VAN ZWIETEN, P.A. (1981). Selectivity of some alpha adrenoceptor agonists for peripheral alpha-1 and alpha-2 adrenoceptors in the normotensive rat. J. Pharmacol. Exp. Ther., 219, 760-767.
38. VARAGIĆ, V. & VOJVODIĆ, N. (1962). Effect of guanethidine, hemicholinium and mebutamate on the hypertensive response to eserine and catechol amines. Br. J. Pharmacol., 19, 451-457.
39. WILLERSON, J.T., HUTTON, I., WATSON, J.T., PLATT, M.R. & TEMPLETON, G.H. (1976). Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs. Circulation, 53, 828-833.