Antimicrobial properties of α-MSH and related synthetic melanocortins

TheScientificWorldJournal

Volumn 6, Issue , 2006, Pages 1241-1246

  Catania, A ^a   Colombo, G ^a   Rossi, C ^a   Carlin, A ^a   Sordi, A ^a   Lonati, C ^a   Turcatti, F ^a   Leonardi, P ^a   Grieco, P ^b   Gatti, S ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

melanocyte stimulating hormone; Candida albicans; Cyclic amp; Melanocortins; Natural antimicrobial peptides; Neuroimmunomodulation; Staphylococcus aureus

Indexed keywords

ADENYLATE CYCLASE; ALPHA INTERMEDIN; CYCLIC AMP; MELANOCORTIN; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; PEPTIDE FRAGMENT;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; CANDIDA ALBICANS; CELL CYCLE; CLINICAL TRIAL; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; NONHUMAN; PROTEIN BINDING; REVIEW; STAPHYLOCOCCUS AUREUS; YEAST; CHEMISTRY; COMPARATIVE STUDY; CYTOTOXICITY; DOSE RESPONSE; NEUTROPHIL; PHYSIOLOGY; SECOND MESSENGER; STRUCTURE ACTIVITY RELATION;

CANDIDA ALBICANS; MAMMALIA; STAPHYLOCOCCUS AUREUS;

ALPHA-MSH; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CYCLIC AMP; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; NEUTROPHILS; PEPTIDE FRAGMENTS; SECOND MESSENGER SYSTEMS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750630258     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2006.227     Document Type: Review

References (37)

1. Ganz, T. (2003) Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 3, 710-720.
2. Zasloff, M. (2002) Antimicrobial peptides of multicellular organisms. Nature 415, 389-395.
3. Yang, D., Biragyn, A., Hoover, D.M., Lubkowski, J., and Oppenheim, J.J. (2004) Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu. Rev. Immunol. 22, 181-215.
4. Yang, D., Chen, Q., Hoover, D.M., Staley, P., Tucker, K.D., Lubkowski, J., and Oppenheim, J.J. (2003) Many chemokines including CCL20/MIP-3α display antimicrobial activity. J. Leukoc. Biol. 74, 448-455.
5. Chaly, Y.V., Paleolog, E.M., Kolesnikova, T.S., Tikhonov, I.I., Petratchenko, E.V., and Voitenok, N.N. (2000) Neutrophil α-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells. Eur. Cytokine Netw. 11, 257-266.
6. Cole, A.M., Ganz, T., Liese, A.M., Burdick, M.D., Liu, L., and Strieter, R.M. (2001) Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J. Immunol. 167, 623-627.
7. Tang, Y.Q., Yeaman, M.R., and Selsted, M.E. (2002) Antimicrobial peptides from human platelets. Infect. Immun. 70, 6524-6533.
8. Brogden, K.A., Guthmiller, J.M., Salzet, M., and Zasloff, M. (2005) The nervous system and innate immunity: the neuropeptide connection. Nat. Immunol. 6, 558-564.
9. Zasloff, M. (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. U. S. A. 84, 5449-5453.
10. Benson, B.J. and Hadley, M.E. (1969) In vitro characterization of adrenergic receptors controlling skin gland secretion in two anurans Rana pipiens and Xenopus laevis. Comp. Biochem. Physiol. 30, 857-864.
11. Stolzenberg, E.D., Anderson, G.M., Ackermann, M.R., Whitlock, R.H., and Zasloff, M. (1997) Epithelial antibiotic induced in states of disease. Proc. Natl. Acad. Sci. U. S. A. 94, 8686-8690.
12. Hao, H.N., Zhao, J., Lotoczky, G., Grever, W.E., and Lyman, W.D. (2001) Induction of human β-defensin-2 expression in human astrocytes by lipopolysaccharide and cytokines. J. Neurochem. 77, 1027-1035.
13. Nakayama, K., Okamura, N., Arai, H., Sekizawa, K., and Sasaki, H. (1999) Expression of human β-defensin-1 in the choroid plexus. Ann. Neurol. 45, 685.
14. Bergman, P., Termen, S., Johansson, L., Nystrom, L., Arenas, E., Jonsson, A.B., Hokfelt, T., Gudmundsson, G.H., and Agerberth, B. (2005) The antimicrobial peptide rCRAMP is present in the central nervous system of the rat. J. Neurochem. 93, 1132-1140.
15. Blalock, J.E. (1999) Proopiomelanocortin and the immune-neuroendocrine connection. Ann. N. Y. Acad. Sci. 885, 161-172.
16. Catania, A., Gatti, S., Colombo, G., and Lipton, J.M. (2004) Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol. Rev. 56, 1-29.
17. Catania, A., Airaghi, L., Colombo, G., and Lipton, J.M. (2000) α-Melanocyte-stimulating hormone in normal human physiology and disease states. Trends Endocrinol. Metab. 11, 304-308.
18. Shih, S.T., Khorram, O., Lipton, J.M., and McCann, S.M. (1986) Central administration of α-MSH antiserum augments fever in the rabbit. Am. J. Physiol. 250, R803-R806.
19. Delgado Hernandez, R., Demitri, M.T., Carlin, A., Meazza, C., Villa, P., Ghezzi, P., Lipton, J.M., and Catania, A. (1999) Inhibition of systemic inflammation by central action of the neuropeptide α-melanocyte- stimulating hormone. Neuroimmunomodulation 6, 187-192.
20. Delgado, R., Carlin, A., Airaghi, L., Demitri, M.T., Meda, L., Galimberti, D., Baron, P., Lipton, J.M., and Catania, A. (1998) Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia. J. Leukoc. Biol. 63, 740-745.
21. Catania, A. and Lipton, J.M. (1993) α-Melanocyte stimulating hormone in the modulation of host reactions. Endocr. Rev. 14, 564-576.
22. Lipton, J.M. and Catania, A. (1997) Anti-inflammatory actions of the neuroimmunomodulator α-MSH. Immunol. Today 18, 140-145.
23. Fox, J.A. and Kraicer, J. (1981) Immunoreactive α-melanocyte stimulating hormone, its distribution in the gastrointestinal tract of intact and hypophysectomized rats. Life Sci. 28, 2127-2132.
24. Thody, A.J., Ridley, K., Penny, R.J., Chalmers, R., Fisher, C., and Shuster, S. (1983) MSH peptides are present in mammalian skin. Peptides 4, 813-816.
25. Gatti, S., Colombo, G., Buffa, R., Turcatti, F., Garofalo, L., Carboni, N., Ferla, L., Fassati, L.R., Lipton, J.M., and Catania, A. (2002) α-Melanocyte-stimulating hormone protects the allograft in experimental heart transplantation. Transplantation 74, 1678-1684.
26. Samson, W.K., Lipton, J.M., Zimmer, J.A., and Glyn, J.R. (1981) The effect of fever on central α-MSH concentrations in the rabbit. Peptides 2, 419-423.
27. Cutuli, M., Cristiani, S., Lipton, J.M., and Catania, A. (2000) Antimicrobial effects of α-MSH peptides. J. Leukoc. Biol. 67, 233-239.
28. Harcus, D., Nantel, A., Marcil, A., Rigby, T., and Whiteway, M. (2004) Transcription profiling of cyclic AMP signaling in Candida albicans. Mol. Biol. Cell 15, 4490-4499.
29. Wikberg, J.E., Muceniece, R., Mandrika, I., Prusis, P., Lindblom, J., Post, C., and Skottner, A. (2000) New aspects on the melanocortins and their receptors. Pharmacol. Res. 42, 393-420.
30. Rago, J.V., Vath, G.M., Tripp, T.J., Bohach, G.A., Ohlendorf, D.H., and Schlievert, P.M. (2000) Staphylococcal exfoliative toxins cleave α- and β-melanocyte-stimulating hormones. Infect. Immun. 68, 2366-2368.
31. Grieco, P., Rossi, C., Colombo, G., Gatti, S., Novellino, E., Lipton, J.M., and Catania, A. (2003) Novel α-melanocyte stimulating hormone peptide analogues with high candidacidal activity. J. Med. Chem. 46, 850-855.
32. Holder, J.R. and Haskell-Luevano, C. (2004) Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies. Med. Res. Rev. 24, 325-356.
33. Schioth, H.B., Mutulis, F., Muceniece, R., Prusis, P., and Wikberg, J.E. (1998) Selective properties of C- and N-terminals and core residues of the melanocyte-stimulating hormone on binding to the human melanocortin receptor subtypes. Eur. J. Pharmacol. 349, 359-366.
34. Grieco, P., Rossi, C., Gatti, S., Colombo, G., Carlin, A., Novellino, E., Lama, T., Lipton, J.M., and Catania, A. (2005) Design and synthesis of melanocortin peptides with candidacidal and anti-TNF-α properties. J. Med. Chem. 48, 1384-1388.
35. 2. J. Pept. Res. 66, 19-26.
36. 2 on endotoxin-induced host reactions. J. Surg. Res. 131, 209-214.
37. Prabhu, N.V., Perkyns, J.S., and Pettitt, B.M. (1999) Modeling of α-MSH conformations with implicit solvent. J. Pept. Res. 54, 394-407.