State of the science of cardioprotection: Challenges and opportunities-Proceedings of the 2010 NHLBI workshop on cardioprotection

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 16, Issue 3-4, 2011, Pages 223-232

  Kloner, Robert A ^a   Schwartz Longacre, Lisa ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

acute coronary syndromes; acute myocardial infarction; cardioactive agents; experimental cardiology; heart disease

Indexed keywords

4 [7 [[1 [(3 CHLORO 2 THIENYL)METHYL]PROPYL]AMINO] 3H IMIDAZO[4,5 B]PYRIDIN 3 YL] N ETHYL 2,3 DIHYDROXYCYCLOPENTANECARBOXAMIDE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYLSALICYLIC ACID; ADENOSINE; ADENOSINE RECEPTOR STIMULATING AGENT; ADIPONECTIN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIINFLAMMATORY AGENT; APELIN; ATRIAL NATRIURETIC FACTOR; BRADYKININ; CAPSAICIN; CARIPORIDE; CARVEDILOL; CHLORAMPHENICOL; CLOPIDOGREL; CYCLOSPORIN; DIAZOXIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPICATECHIN; HEPARIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEPTIN; PHENYLISOPROPYLADENOSINE; PLACEBO; PRASUGREL; PROPRANOLOL; RANOLAZINE; THROMBIN INHIBITOR; UNINDEXED DRUG;

BLOOD CLOT LYSIS; BLOOD PRESSURE CUFF; BRADYCARDIA; CLINICAL PRACTICE; CONFERENCE PAPER; CORONARY REPERFUSION; CORONARY STENT; DISEASE SEVERITY; DRUG HALF LIFE; DRUG MEGADOSE; EXPERIMENTAL MODEL; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HOSPITALIZATION; HUMAN; HYPOTENSION; INDUCED HYPOTHERMIA; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME; WORKSHOP;

ANIMALS; CARDIOLOGY; CARDIOTONIC AGENTS; CLINICAL TRIALS AS TOPIC; DRUG DISCOVERY; HUMANS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (U.S.); UNITED STATES;

EID: 80051539756     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248411402501     Document Type: Conference Paper

References (42)

1. Maroko PR, Kjekshus JK, Sobel BE, et al. Factors influencing infarct size following experimental coronary artery occlusions. Circulation. 1971 ; 43 (1). 67-82
2. Reimer KA, Lowe JE, Rasmussen MM, Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation. 1977 ; 56 (5). 787-794
3. Ellis SG, Henschke CI, Sandor T, Wynne J, Braunwald E, Kloner RA. Time course of functional and biochemical recovery of myocardium salvaged by reperfusion. J Am Coll Cardiol. 1983 ; 1 (4). 1047-1055 (Pubitemid 13107525)
4. Hale SL, Kloner RA. Effect of combined KATP channel activation and Na+/H+ exchange inhibition on infarct size in rabbits. Am J Physiol (Heart Circ Physiol). 2000 ; 279: H2674-H2677
5. Hale SL, Kloner RA. Myocardial temperature in acute myocardial infarction: protection with mild regional hypothermia. Am J Physiol (Heart Circ Physiol). 1997 ; 273 (1 pt 2). H220-H227
6. Hale SL, Kloner RA. Effect of ischemic preconditioning on regional myocardial flow in the rabbit heart. Coronary Artery Dis. 1992 ; 3: 133-140
7. Hale SL, Kloner RA. Combination therapy for maximal myocardial infarct size reduction. Heart Dis. 2001 ; 3 (6). 351-356 (Pubitemid 34003374)
8. Birnbaum Y, Hale SL, Kloner RA. "Ischemic preconditioning at a distance." Reduction of myocardial infarction size by partial reduction of blood supply combined with rapid stimulation of gastrocnemius muscle in the rabbit. Circulation. 1997 ; 96 (5). 1641-1646 (Pubitemid 27375364)
9. Hale SL, Bellows SD, Hammerman H, Kloner RA. An adenosine A1 receptor agonist, R (-)-N-(2-phenylisopropyl) adenosine (PIA), but not adenosine itself, acts as a therapeutic preconditioning-mimetic agent in rabbits. Cardiovasc Res. 1993 ; 27 (12). 2140-2145 (Pubitemid 24034726)
10. Hale SL, Leeka JA, Kloner RA. Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel. J Cardiovasc Pharmacol Therap. 2006 ; 318 (1). 418-423
11. Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker R. Regional ischemic "preconditioning" protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993 ; 87 (3). 893-899 (Pubitemid 23070821)
12. Schwartz LM, Reimer KA, Crago MS, Jennings RB. Pharmacological preconditioning with diazoxide slows energy metabolism during sustained ischemia. Exp Clin Cardiol. 2007 ; 12 (3). 139-147 (Pubitemid 47520916)
13. Kloner RA, Rezkalla SH. Cardiac protection during acute myocardial infarction: where do we stand in 2004?. J Am Coll Cardiol. 2004 ; 44 (2). 276-286 (Pubitemid 38950583)
14. Bolli R, Becker L, Gross G, Mentzer R, Balshaw D, Lathrop DA. Myocardial protection at a crossroads: The need for translation into clinical therapy. Circ Res. 2004 ; 95 (2). 125-134 (Pubitemid 38988678)
15. Baxter GF, Hale SL, Miki T, et al. Adenosine A1 Agonist at Reperfusion Trial (AART): results of a three-center, blinded, randomized, controlled experimental infarct study. Cardiovasc Drugs Therap. 2000 ; 14 (6). 606-614
16. Mahaffey KW, Puma JA, Barbagelata A, et al. Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction. Results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) Trial. J Am Coll Cardiol. 1999 ; 34 (6). 1711-1720
17. Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol. 2005 ; 45 (11). 1775-1780 (Pubitemid 40779856)
18. Kloner RA, Forman MB, Gibbons RJ, Ross AM, Alexander RW, Stone GW. Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the AMISTAD-2 trial. Eur Heart J. 2006 ; 27 (20). 2400-2405 (Pubitemid 44522145)
19. OâNeill WW. A prospective, randomized trial of mild hypothermia during PCI treatment of ST elevation MI. Presented at Transcatheter Cardiovascular Therapeutics ; 2003 Washington DC ; 2003.
20. OâNeill WW, Martin JL, Dixon SR, et al. Acute myocardial infarction with hyperoxemic therapy (AMIHOT): a prospective, randomized trial of intracoronary hyperoxemic reperfusion after percutaneous coronary intervention. J Am Coll Cardiol. 2007 ; 50 (5). 397-405 (Pubitemid 47088128)
21. Stone GW, Martin JL, de Boer M-J, et al. Effect of supersaturated oxygen delivery on infarct size after percutaneous coronary intervention in acute myocardial infarction. Circ Cardiovasc Interv. 2009 ; 2 (5). 366-375
22. Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart. Circulation. 2005 ; 112 (14). 2143-2148 (Pubitemid 41475808)
23. Piot C, Croisille P, Staat P, et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med. 2008 ; 359 (5). 473-481
24. Botker HE, Kharbanba R, Schmidt MR, et al. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage patients with acute myocardial infarction: a randomized trial. Lancet. 2010 ; 375 (9716). 729-734
25. Kitakaze M, Asakura M, Kim J, et al. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomized trials. Lancet. 2007 ; 370 (9795). 1483-1493 (Pubitemid 47625560)
26. Hale SL, Dave RH, Kloner RA. Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia. Basic Res Cardiol. 1997 ; 92 (5). 351-357 (Pubitemid 28014561)
27. Schwartz LM, Verbinski SG, Vander Heide RS, Reimer KA. Epicardial temperature is a major predictor of myocardial infarct size in dogs. J Mol Cell Cardiol. 1997 ; 29 (6). 1577-1583 (Pubitemid 27270228)
28. Dixon SR, Whitbourn RJ, Dae MW, et al. Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol. 2002 ; 40 (11). 1928-1934 (Pubitemid 35425362)
29. Grines CL. Intravascular cooling adjacent to percutaneous coronary interventions for acute myocardial infarction. Presented at the 16th Annual Transcatheter Cardiovascular Therapeutics ; 2004 Washington DC ; 2004.
30. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986 ; 74 (5). 1124-1136 (Pubitemid 17174962)
31. Kloner RA, Yellon D. Does ischemic preconditioning occur in patients?. J Am Coll Cardiol. 1994 ; 24 (4). 1133-1142 (Pubitemid 24306429)
32. Schwartz LM, Sebbag L, Jennings RB, Reimer KA. Duration and reinstatement of myocardial protection against infarction by ischemic preconditioning in open chest dogs. J Mol Cell Cardiol. 2001 ; 33 (9). 1561-1570 (Pubitemid 32844216)
33. Kloner RA, Shook T, Przyklenk K, et al. Previous angina alters in-hospital outcome in TIMI 4: A clinical correlate to preconditioning?. Circulation. 1995 ; 91 (1). 37-45
34. Kloner RA. Shook T, Antman EM, et al. A prospective temporal analysis of the onset of preinfarct angina versus outcome: a prospective ancillary study in TIMI 9B. Circulation. 1998 ; 97 (11). 1042-1045
35. Zhao Z-Q, Corvera JS, Halkos E, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol (Heart Circ Physiol). 2003 ; 285 (2). H579-H588
36. Yang X-M, Downey JM, Cohen MV. Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by activation of ERK and production of nitric oxide. Circulation. 2003 ; (suppl) 108: 158
37. Dow J, Kloner RA. Postconditioning does not reduce myocardial infarct size in an in-vivo regional ischemia model. J Cardiovasc Pharmacol Therap. 2007 ; 12 (2). 153-163 (Pubitemid 46836328)
38. Hale SL, Mehra A, Leeka J, Kloner RA. Postconditioning fails to improve no reflow or alter infarction size in an open-chest rabbit model of myocardial ischemia/reperfusion. Am J Physiol (Heart and Circ Physio). 2008 ; 294 (1). H421-H425
39. Kloner RA, Dow J, Bhandari A. Postconditioning markedly attenuates ventricular arrhythmias after ischemia-reperfusion. J Cardiovasc Pharmacol Therap. 2006 ; 11 (1). 55-56
40. Schwartz LM, Lagranha CJ. Ischemic postconditioning during reperfusion activates Akt and ERK without protecting against lethal myocardial ischemia-reperfusion injury in pigs. Am J Physiol (Heart Circ Physiol). 2006 ; 209 (3). H1011-H1018
41. Skyschally A, van Caster P, Boengler K, et al. Ischemic postconditioning in pigs: no causal role for RISK activation. Circ Res. 2009 ; 104 (1). 15-18
42. Laskey W, Yoon S, Calzada N, Ricciardi MJ. Concordant improvements in coronary flow reserve and ST-segment resolution during percutaneous coronary intervention for acute myocardial infarction: a benefit of postconditioning. Catheter Cardiovasc Interv. 2008 ; 72 (2). 212-220