Melanocortin MC4 receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia

European Journal of Pharmacology

Volumn 670, Issue 2-3, 2011, Pages 479-486

  Spaccapelo, Luca ^a   Bitto, Alessandra ^b   Galantucci, Maria ^a   Ottani, Alessandra ^a   Irrera, Natasha ^b   Minutoli, Letteria ^b   Altavilla, Domenica ^b   Novellino, Ettore ^c   Grieco, Paolo ^c   Zaffe, Davide ^a   Squadrito, Francesco ^b   Giuliani, Daniela ^a   Guarini, Salvatore ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Apoptosis; Cerebral ischemia; Inflammation; Learning and memory; Neuroprotection; Synaptic plasticity

Indexed keywords

AFAMELANOTIDE; CASPASE 3; HORMONE RECEPTOR BLOCKING AGENT; HS 024; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; RO 27 3225; SODIUM CHLORIDE; STRESS ACTIVATED PROTEIN KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENCEPHALITIS; GENE FUNCTION; GERBIL; HIPPOCAMPUS; HISTOPATHOLOGY; IMMEDIATE EARLY GENE; LEARNING DISORDER; MALE; MEMORY DISORDER; MORNING DOSAGE; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE FUNCTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSIENT ISCHEMIC ATTACK; TREATMENT DURATION; UPREGULATION; ZIF268 GENE;

EID: 80755132138     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.09.015     Document Type: Article

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