Oxidative DNA damage in the aging mouse brain

Movement Disorders

Volumn 14, Issue 6, 1999, Pages 972-980

  Cardozo Pelaez, Fernando ^a   Song, Shijie ^a   Parthasarathy, Anand ^a   Hazzi, Christopher ^a   Naidu, Kamatham ^a   Sanchez Ramos, Juan ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

8 Hydroxy 2'deoxyguanosine; Aging; DNA damage; Dopamine; Locomotor activity

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; COPPER ZINC SUPEROXIDE DISMUTASE; DOPAMINE; GLUTATHIONE PEROXIDASE; MANGANESE SUPEROXIDE DISMUTASE; OXYGEN RADICAL;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; CAUDATE NUCLEUS; CELL LOSS; CELL POPULATION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DNA DAMAGE; ENZYME ACTIVITY; HIPPOCAMPUS; LOCOMOTION; MALE; MEDULLA OBLONGATA; MESENCEPHALON; MOTOR COORDINATION; MOUSE; NERVE CELL LESION; NEUROCHEMISTRY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATION; PONS; PRIORITY JOURNAL; PUTAMEN;

AGE FACTORS; ANIMALS; ANTIOXIDANTS; BRAIN; BRAIN MAPPING; CORPUS STRIATUM; DNA DAMAGE; DOPAMINE; FREE RADICALS; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; OXIDATIVE STRESS; PARKINSONIAN DISORDERS; REACTIVE OXYGEN SPECIES; SUBSTANTIA NIGRA;

EID: 0032751079     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8257(199911)14:6<972::AID-MDS1010>3.0.CO;2-0     Document Type: Article

References (30)

1. Reiderer P, Wuketic S. Time course of nigrostriatal degeneration in Parkinson's disease. J Neural Transm 1976;3:277-301.
2. Hornykiewicz O. Brain Neurotransmitter Changes in Parkinson's Disease. Boston, MA: Butterworth, 1982.
3. Robinson DS. Changes in monoamine oxidase and monoamines with human development and aging. Federation Proceedings 1975;34:103-107.
4. Cote LJ, Krezner LT. Biochemical changes in normal aging in human brain. Adv Neurol 1983;38:19-30.
5. Graham DG, Tiffany SM, Bell WR, Gutknecht WF. Autooxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine and related compounds toward C1300 neuroblastoma cells. Mol Pharmacol 1978;14:644-653.
6. Graham DG. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol Pharmacol 1978;14: 633-643.
7. Levay G, Ye Q, Bodell WJ. Formation of DNA adducts and oxidative base damage by copper mediated oxidation of dopamine and 6-hydroxydopamine. Exp Neurol 1997;146:570-574.
8. Dexter DT, Carter CJ, Wells FR, et al. Basal lipid peroxidation in s. nigra is increased in Parkinson's disease. J Neurochem 1989;52: 381-389.
9. Alam ZI, Jenner A, Daniel SE, et al. Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 1997;69:1196-1203.
10. Sanchez-Ramos J, Overvik E, Ames BN. A marker of oxyradical-mediated DNA damage (8-hydroxy-2′deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain. Neurodegeneration 1994;3:197-204.
11. Dizdaroglu M. Chemical determination of free radical-induced damage to DNA. Free Radic Biol Med 1991;10:225-242.
12. Adelman R, Saul RL, Ames BN. Oxidative damage to DNA: relation to species metabolic rate and life span. Proc Natl Acad Sci USA 1988;85:2706-2708.
13. Agarwal S, Sohal RS. DNA oxidative damage and life expectancy in houseflies. Proc Natl Acad Sci USA 1994;91:12332-12335.
14. Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN. Oxidative damage to DNA during aging: 8-hydroxy2′deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 1990;87:4533-4537.
15. Mecocci P, MacGarvey U, Kaufman AE, et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 1993;34:609-616.
16. Cardozo-Pelaez F, Song S, Parthasarathy A, Epstein CJ, Sanchez-Ramos J. Attenuation of age-dependent oxidative damage to DNA and protein in brainstem of Tg Cu/Zn SOD mice. Neurobiol Aging 1998;19:311-316.
17. Laws GM, Adams SP. Measurement of 8-OHdG in DNA by HPLC/ECD: the importance of DNA purity. Biotechniques 1995; 20:36-38.
18. Shigenaga MK, Park JW, Cundy K, Gimenco CJ, Ames BN. In vivo oxidative DNA damage: measurement of 8-hydroxy2′deoxyguanosine in DNA and urine by high performance liquid chromatography with electrochemical detection. Methods Enzymol 1990;186:521-530.
19. Elstner EF, Heupel A. Inhibition of nitrite formation from hydroxyammonium-chloride: a simple assay for superoxide dismutase. Anal Biochem 1976;70:616-620.
20. Wendel A. Glutathione peroxidase. Methods Enzymol 1981;77: 325-333.
21. Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H. Formation of 8-OH-deoxyguanosine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 1986;7:1849-1851.
22. Kuchino Y, Mori F, Kasai H, et al. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature 1987;327:77-79.
23. Wood ML, Dizdaroglu M, Gajewski E, Essigmann JM. Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry 1990; 29:7024-7032.
24. Cleaver J, Kraemer KH. Xeroderma pigmentosum and Cockayne syndrome. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Basis of Inherited Disease. New York, NY: McGraw-Hill, 1995:4393-4419.
25. Cristiano F, de Haan JB, Iannello RC, Kola I. Changes in the levels of enzymes which modulate the antioxidant balance occur during aging and correlate with cellular damage. Mech Ageing Dev 1995; 80:93-105.
26. Hussain S, Slikker W, Ali SF. Age-related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain. Int J Dev Neurosci 1995;13:811-817.
27. Orr WC, Sohal RS. Extension of life-span by overexpression of superoxide dismutase and catalase in drosophila melanogaster. Science 1994;263:1128-1130.
28. Benkovic S, Connor JR. Ferritin, transferrin and iron in selected regions of the adult and aged rat brain. J Comp Neurol 1993;338: 97-113.
29. Iacopino AM, Christakos S. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. Proc Natl Acad Sci USA 1990;87: 4078-4082.
30. Gulyaeva NV, Stephanichev MY, Onufried MV, et al. Cardiac arrest indices decrease nitric oxide synthase activity and increase free radical generation in rat brain regions. Neurosci Lett 1996; 220:147-150.