Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: Relevance for neuronal survival under stress and in aging

Journal of Neurochemistry

Volumn 116, Issue 5, 2011, Pages 747-755

  Sodero, Alejandro O ^a   Trovò, Laura ^a   Iannilli, Francesca ^a   Van Veldhoven, Paul ^a   Dotti, Carlos G ^a   Martin, Mauricio G ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

aging; cholesterol; Cyp46; hippocampus; reactive oxygen species; tyrosine kinase B

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450; CYTOCHROME P450 46; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

AGING; CELL STRESS; CELL SURVIVAL; CHOLESTEROL METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HIPPOCAMPUS; HUMAN; LOSS OF FUNCTION MUTATION; NERVE CELL; NERVE CELL LESION; NERVE STIMULATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION;

AGING; ANIMALS; CELL DEATH; CHOLESTEROL; HIPPOCAMPUS; HUMANS; MODELS, BIOLOGICAL; NEURONS; OXIDATIVE STRESS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STEROID HYDROXYLASES; STRESS, PHYSIOLOGICAL; UP-REGULATION;

EID: 79851470427     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.07079.x     Document Type: Review

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