Green tea catechins as a BACE1 (β-secretase) inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 22, 2003, Pages 3905-3908

  Jeon, So Young ^a   Bae, KiHwan ^b   Seong, Yeon Hee ^c   Song, Kyung Sik ^a  

^a Kyungpook National University   (South Korea)

^b Chungnam National University   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SECRETASE; CATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN GALLATE; GALLOCATECHIN; GREEN TEA EXTRACT;

ARTICLE; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0242285619     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.09.018     Document Type: Article

References (17)

1. Sisodia S.S., Price D.L. FASEB J. 9:1995;366.
2. Glenner G.G., Wong C.W. Biochem. Biophys. Res. Commun. 120:1984;885.
3. Selkoe D. J. Physiol. Rev. 81:2001;741.
4. (a) Vassar R., Bennett B.D., Babu-Khan S., Khan S., Mendiaz A., Denis P. Science. 286:1999;735
5. (b) Sinha S., Anderson J.P., Barbour R., Basi G.S., Caccavello R., Davis D. Nature. 402:1999;533.
6. 6 at 400 and 100 MHz, respectively. Chemical shifts were given in δ ppm from TMS (tetramethylsilane). EIMS was recorded on VG QUATTRO II (UK).
7. Es-Safi N.E., Guerneve C.L., Cheynier V., Moutounet M. Tetrahedron Lett. 41:2000;1917.
8. (a) Nonaka G., Kawahara O., Nishioka I. Chem. Pharm. Bull. 31:1983;3906
9. (b) Saeki K., Hayakawa S., Isemura M., Miyase T. Phytochemistry. 53:2000;391
10. (c) Kim J.-H., Kim S.-I., Song K.-S. Arch. Pharm. Res. 24:2001;292.
11. 0 was the fluorescence of the tested samples at zero time. All data are the mean of duplicated experiments. To check the quenching effect of the samples, the sample solution was added to the reaction mixture C, and any reduction in fluorescence by the sample was then investigated. Catechins had only a negligible quenching effect.
12. Kim S.-I., Song K.-S. J. Korean Soc. Agric. Chem. Biotechnol. 43:2000;158.
13. Corilagin was isolated from Phyllanthus ussurensis. Isolation and identification procedure will be published in Arch. Pharm. Res., 2003.
14. Hom R.K., Fang L.Y., Mamo S., Tung J.S., Guinn A.C., Walker D.E., Davis D.L., Gailunas A.F., Thorsett E.D., Sinha S., Knops J.E., Jewett N.E., Anderson J.P., John V. J. Med. Chem. 46:2003;1799.
15. Qin L., Liu Y., Cooper C., Liu B., Wilson B., Hong J.-S. J. Neurochem. 83:2002;973.
16. (a) Mitscher L.A., Jung M., Shankel D., Dou J., Steele L., Pillai S.P. Med. Res. Rev. 17:1997;327
17. (b) Higdon J.V., Frei B. Critical Rev. Food Sci. Nut. 43:2003;89.