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Volumn 21, Issue 1, 2010, Pages 263-276

Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer disease

Author keywords

Motor neurons; reactive oxygen species; spinal cord; Tg2576

Indexed keywords

AMYLOID BETA PROTEIN; CURCUMIN; AMYLOID PRECURSOR PROTEIN; CHOLINERGIC RECEPTOR STIMULATING AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; POTASSIUM CYANIDE;

EID: 77954978168     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-091528     Document Type: Article
Times cited : (46)

References (41)
  • 3
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG (2001) Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21, 372-381.
    • (2001) J Neurosci , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 4
    • 0037088956 scopus 로고    scopus 로고
    • Behavioral characterization of the Tg2576 transgenic model Alzheimer's disease through 19 months
    • King DL, Arendash GW (2002) Behavioral characterization of the Tg2576 transgenic model Alzheimer's disease through 19 months. Physiol Behavior 75, 627-642.
    • (2002) Physiol Behavior , vol.75 , pp. 627-642
    • King, D.L.1    Arendash, G.W.2
  • 5
    • 0020321767 scopus 로고
    • Novel proteinaceous infectious particles cause scrapie
    • Prusiner SB (1982) Novel proteinaceous infectious particles cause scrapie. Science 216, 136-144.
    • (1982) Science , vol.216 , pp. 136-144
    • Prusiner, S.B.1
  • 6
    • 0025910229 scopus 로고
    • Molecular biology of prion diseases
    • Prusiner SB (1991) Molecular biology of prion diseases. Science 252, 1515-1552.
    • (1991) Science , vol.252 , pp. 1515-1552
    • Prusiner, S.B.1
  • 7
    • 34347353311 scopus 로고    scopus 로고
    • Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1
    • Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS (2007) Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci 27, 7011-7020.
    • (2007) J Neurosci , vol.27 , pp. 7011-7020
    • Lazarov, O.1    Morfini, G.A.2    Pigino, G.3    Gadadhar, A.4    Chen, X.5    Robinson, J.6    Ho, H.7    Brady, S.T.8    Sisodia, S.S.9
  • 9
    • 34548553576 scopus 로고    scopus 로고
    • Age-dependent axonal degeneration in an Alzheimer mouse model
    • Wirths O, Weis J, Kayed R, Saido TC, Bayer TA (2007) Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging 28, 1689-1699.
    • (2007) Neurobiol Aging , vol.28 , pp. 1689-1699
    • Wirths, O.1    Weis, J.2    Kayed, R.3    Saido, T.C.4    Bayer, T.A.5
  • 10
    • 57249111794 scopus 로고    scopus 로고
    • Behavioral stress accelerates plaque pathogenesis in the brain of Tg2 576 mice via generation of metabolic oxidative stress
    • Lee KW, Kim JB, Seo JS, Kim TK, Im JY, Baek IS, Kim KS, Lee JK, Han PL (2009) Behavioral stress accelerates plaque pathogenesis in the brain of Tg2 576 mice via generation of metabolic oxidative stress. JNeurochem 108, 165-175.
    • (2009) JNeurochem , vol.108 , pp. 165-175
    • Lee, K.W.1    Kim, J.B.2    Seo, J.S.3    Kim, T.K.4    Im, J.Y.5    Baek, I.S.6    Kim, K.S.7    Lee, J.K.8    Han, P.L.9
  • 12
    • 33747348720 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent neuronal death proceeds via superoxide anion generation
    • Im JY, Kim D, Paik SG, Han PL (2006) Cyclooxygenase-2-dependent neuronal death proceeds via superoxide anion generation. Free Radic Biol Med 41, 960-972.
    • (2006) Free Radic Biol Med , vol.41 , pp. 960-972
    • Im, J.Y.1    Kim, D.2    Paik, S.G.3    Han, P.L.4
  • 15
    • 0037310446 scopus 로고    scopus 로고
    • Citrate syn-thase expression and enzyme activity after endurance training in cardiac and skeletal muscles
    • Siu PM, Donley DA, Bryner RW, Alway SE (2003) Citrate syn-thase expression and enzyme activity after endurance training in cardiac and skeletal muscles. J Appl Physiol 94, 555-560.
    • (2003) J Appl Physiol , vol.94 , pp. 555-560
    • Siu, P.M.1    Donley, D.A.2    Bryner, R.W.3    Alway, S.E.4
  • 17
    • 0038235339 scopus 로고    scopus 로고
    • Assessing disease onset and progression in the SOD1 mouse model of ALS
    • Weydt P, Hong SY, Kliot M, Moller T (2003) Assessing disease onset and progression in the SOD1 mouse model of ALS. Neuro Report 14, 1051-1054.
    • (2003) Neuro Report , vol.14 , pp. 1051-1054
    • Weydt, P.1    Hong, S.Y.2    Kliot, M.3    Moller, T.4
  • 19
    • 33645092125 scopus 로고    scopus 로고
    • Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein
    • Lee KW, Im JY, Song JS, Lee SH, Lee HJ, Ha HY, Koh JY, Gwag BJ, Yang SD, Paik SG, Han PL (2006) Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein. Neurobiol Dis 22, 10-24
    • (2006) Neurobiol Dis , vol.22 , pp. 10-24
    • Lee, K.W.1    Im, J.Y.2    Song, J.S.3    Lee, S.H.4    Lee, H.J.5    Ha, H.Y.6    Koh, J.Y.7    Gwag, B.J.8    Yang, S.D.9    Paik, S.G.10    Han, P.L.11
  • 20
    • 11144294809 scopus 로고    scopus 로고
    • Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene
    • Barnes P, Good M (2005) Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene. Behav Brain Res 157, 107-117.
    • (2005) Behav Brain Res , vol.157 , pp. 107-117
    • Barnes, P.1    Good, M.2
  • 21
    • 28844462038 scopus 로고    scopus 로고
    • A review of antioxidants and Alzheimer's disease
    • Frank B, Gupta S (2005) A review of antioxidants and Alzheimer's disease. Ann Clin Psychiatry 17, 269-286
    • (2005) Ann Clin Psychiatry , vol.17 , pp. 269-286
    • Frank, B.1    Gupta, S.2
  • 22
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21, 8370-8377.
    • (2001) J Neurosci , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 23
    • 34249733132 scopus 로고    scopus 로고
    • Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice
    • Gil-Bea FJ, Aisa B, Schliebs R, Ramirez MJ (2007) Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice. Behav Neurosci 121, 340-344.
    • (2007) Behav Neurosci , vol.121 , pp. 340-344
    • Gil-Bea, F.J.1    Aisa, B.2    Schliebs, R.3    Ramirez, M.J.4
  • 25
    • 0017841833 scopus 로고
    • Morphological investigations on axonal swellings and spheroids in various human diseases
    • Yagishita S (1978) Morphological investigations on axonal swellings and spheroids in various human diseases. Virchows Arch A Pathol AnatHistol 378, 181-197.
    • (1978) Virchows Arch A Pathol AnatHistol , vol.378 , pp. 181-197
    • Yagishita, S.1
  • 27
    • 14244261725 scopus 로고    scopus 로고
    • Axonal transport defects: A common theme in neurodegenerative diseases
    • Roy S, Zhang B, Lee VM, Trojanowski JQ (2005) Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol 109, 5-13.
    • (2005) Acta Neuropathol , vol.109 , pp. 5-13
    • Roy, S.1    Zhang, B.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 28
    • 0036905921 scopus 로고    scopus 로고
    • Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurode-generation in Alzheimer's disease brain
    • Butterfield DA (2002) Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurode-generation in Alzheimer's disease brain. A review. Free Radic Res 36, 1307-1313.
    • (2002) A Review. Free Radic Res , vol.36 , pp. 1307-1313
    • Butterfield, D.A.1
  • 29
    • 8744276616 scopus 로고    scopus 로고
    • Amyloid ft-peptide (1-42) contributes to the oxidative stress and neurodegenera-tion found in Alzheimer's disease
    • Butterfield DA, Boyd-Kimball D (2004) Amyloid ft-peptide (1-42) contributes to the oxidative stress and neurodegenera-tion found in Alzheimer's disease. Brain Pathol 14, 426-432.
    • (2004) Brain Pathol , vol.14 , pp. 426-432
    • Butterfield, D.A.1    Boyd-Kimball, D.2
  • 30
    • 45249097300 scopus 로고    scopus 로고
    • Amyloid beta pep-tide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
    • Shelat PB, Chalimoniuk M, Wang JH, Strosznajder JB, Lee JC, Sun AY, Simonyi A, Sun GY (2008) Amyloid beta pep-tide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons. J Neurochem 106, 45-55.
    • (2008) J Neurochem , vol.106 , pp. 45-55
    • Shelat, P.B.1    Chalimoniuk, M.2    Wang, J.H.3    Strosznajder, J.B.4    Lee, J.C.5    Sun, A.Y.6    Simonyi, A.7    Sun, G.Y.8
  • 31
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: Presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL (2003) Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci USA 100, 10417-10422.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10417-10422
    • Gong, Y.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5    Finch, C.E.6    Krafft, G.A.7    Klein, W.L.8
  • 33
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neu-rodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
    • Haass C, Selkoe DJ (2007) Soluble protein oligomers in neu-rodegeneration: lessons from the Alzheimer's amyloid beta-peptide. NatRevMol Cell Biol 8, 101-112.
    • (2007) NatRevMol Cell Biol , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 34
    • 57649171115 scopus 로고    scopus 로고
    • Mitochondrial approaches for neuroprotection
    • Chaturvedi RK, Beal MF (2008) Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci 1147, 395-412.
    • (2008) Ann N y Acad Sci , vol.1147 , pp. 395-412
    • Chaturvedi, R.K.1    Beal, M.F.2
  • 35
    • 68149148549 scopus 로고    scopus 로고
    • Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells
    • Rhein V, Baysang G, Rao S, Meier F, Bonert A, Muller-Spahn F, Eckert A (2009) Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol 29, 1063-1071.
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 1063-1071
    • Rhein, V.1    Baysang, G.2    Rao, S.3    Meier, F.4    Bonert, A.5    Muller-Spahn, F.6    Eckert, A.7
  • 38
    • 0030450004 scopus 로고    scopus 로고
    • Cu/Zn superoxide dismu-tasegene mutations in amyotrophic lateral sclerosis: Correlation between genotype and clinical features
    • Radunovic A, Leigh PN (1996) Cu/Zn superoxide dismu-tasegene mutations in amyotrophic lateral sclerosis: correlation between genotype and clinical features. J Neurol Neuro-surg Psychiatry 61, 565-572.
    • (1996) J Neurol Neuro-surg Psychiatry , vol.61 , pp. 565-572
    • Radunovic, A.1    Leigh, P.N.2
  • 39
    • 33747605320 scopus 로고    scopus 로고
    • Molecular biology of amy-otrophic lateral sclerosis: Insights from genetics
    • Pasinelli P, and Brown RH (2006) Molecular biology of amy-otrophic lateral sclerosis: insights from genetics. Nat Rev Neu-rosci 7, 710-723.
    • (2006) Nat Rev Neu-rosci , vol.7 , pp. 710-723
    • Pasinelli, P.1    Brown, R.H.2
  • 41
    • 73549106551 scopus 로고    scopus 로고
    • Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway
    • Hamaguchi T, Ono K, Murase A, Yamada M. (2009) Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. Am J Pathol 175, 2557-2565.
    • (2009) Am J Pathol , vol.175 , pp. 2557-2565
    • Hamaguchi, T.1    Ono, K.2    Murase, A.3    Yamada, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.