EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism

Anti-Cancer Drugs

Volumn 16, Issue 3, 2005, Pages 263-275

  Adams, Brian K ^a   Cai, Jiyang ^b,c   Armstrong, Jeff ^a   Herold, Marike ^a   Lu, Yang J ^a   Sun, Aiming ^a   Snyder, James P ^a   Liotta, Dennis C ^a   Jones, Dean P ^b   Shoji, Mamoru ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase; DNA fragmentation; EF24; G2 M cell cycle arrest; Glutathione; Mitochondrial membrane depolarization; Oxidized glutathione; Phosphatidylserine externalization; Reactive oxygen species; Reduction oxidation (redox)

Indexed keywords

CASPASE 3; CURCUMIN; DNA FRAGMENT; EF 24; GLUTATHIONE; GLUTATHIONE DISULFIDE; PHOSPHATIDYLSERINE; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; THIOREDOXIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL COUNT; CELL CYCLE; CELL CYCLE G2 PHASE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; WILD TYPE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASES; CELL CYCLE; COLONIC NEOPLASMS; CURCUMIN; FEMALE; HUMANS; MALE; OXIDATION-REDUCTION; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 20044389847     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200503000-00005     Document Type: Article

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