Glutamine Increases Autophagy Under Basal and Stressed Conditions in Intestinal Epithelial Cells

Gastroenterology

Volumn 136, Issue 3, 2009, Pages

  Sakiyama, Toshio ^a   Musch, Mark W ^a   Ropeleski, Mark J ^b   Tsubouchi, Hirohito ^c   Chang, Eugene B ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b QUEEN S UNIVERSITY   (Canada)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLUTAMINE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOLIPID;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL STRAIN CACO 2; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEAT STRESS; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; NONHUMAN; OXIDATIVE STRESS; PHAGOSOME; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

EID: 60449083715     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.12.002     Document Type: Article

References (50)

1. Stein W.H., and Moore S. The free amino acids of human blood plasma. J Biol Chem 21 (1954) 915-926
2. Windmueller H.G., and Spaeth A.E. Respiratory fuels and nitrogen metabolism in vivo in small intestine of fed rats. Quantitative importance of glutamine, glutamate, and aspartate. J Biol Chem 255 (1980) 107-112
3. Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection?. J Nutr 131 (2001) 2515S-2522S
4. Askanazi J., Carpentier Y.A., Michelsen C.B., et al. Muscle and plasma amino acids following injury. Influence of intercurrent infection. Ann Surg 192 (1980) 78-85
5. Parry-Billings M., Evans J., Calder P.C., et al. Does glutamine contribute to immunosuppression after major burns?. Lancet 336 (1990) 523-525
6. Goeters C., Wenn A., Mertes N., et al. Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Crit Care Med 30 (2002) 2032-2037
7. Novak F., Heyland D.K., Avenell A., et al. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med 30 (2002) 2022-2029
8. Griffiths R.D., Allen K.D., Andrews F.J., et al. Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection. Nutrition 18 (2002) 546-552
9. Levine B., and Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6 (2004) 463-477
10. Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2 (2001) 211-216
11. Klionsky D.J., and Emr S.D. Autophagy as a regulated pathway of cellular degradation. Science 290 (2000) 1717-1721
12. Kabeya Y., Mizushima N., Ueno T., et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19 (2000) 5720-5728
13. Tanida I., Minematsu-Ikeguchi N., Ueno T., et al. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1 (2005) 84-91
14. Schworer C.M., Shiffer K.A., and Mortimore G.E. Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver. J Biol Chem 256 (1981) 7652-7658
15. Blommaart E.F.C., Luiken J.J., Blommaart P.J., et al. Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 270 (1995) 2320-2326
16. Patti M.-E., Brambilla E., Luzi L., et al. Bidirectional modulation of insulin action by amino acids. J Clin Invest 101 (1998) 1519-1529
17. Hara K., Yonezawa K., Weng Q.P., et al. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273 (1998) 14484-14494
18. 12 myotubes through a mammalian target of rapamycin-independent signaling pathway. J Biol Chem 275 (2000) 29900-29906
19. Kanazawa T., Taneike I., Akaishi R., et al. Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated hepatocytes. J Biol Chem 279 (2004) 8452-8459
20. Kadowaki M., Karim M.R., Carpi A., et al. Nutrient control of macroautophagy in mammalian cells. Mol Aspects Med 27 (2006) 426-443
21. Moore M.N., Allen J.I., and Somerfield P.J. Autophagy: role in surviving environmental stress. Mar Environ Res 62 (2006) S420-S425
22. Sartor R.B. Induction of mucosal immune responses by bacteria and bacterial components. Curr Opin Gastroenterol 17 (2001) 555-561
23. Ko T.C., Beauchamp R.D., Townsend Jr. C.M., et al. Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation. Surgery 114 (1993) 147-153
24. Scheppach W., Loges C., Bartram P., et al. Effect of free glutamine and alanyl-glutamine dipeptide on mucosal proliferation of the human ileum and colon. Gastroenterology 107 (1994) 429-434
25. Buchman A.L., Moukarzel A.A., Bhuta S., et al. Parenteral nutrition is associated with intestinal morphologic and functional changes in humans. JPEN J Parenter Enteral Nutr 19 (1995) 453-460
26. Van der Hulst R.R., van Kreel B.K., von Meyenfeldt M.F., et al. Glutamine and the preservation of gut integrity. Lancet 341 (1993) 1363-1365
27. Musch M.W., Ciancio M.J., Sarge K., et al. Induction of heat shock protein 70 protects intestinal epithelial IEC-18 cells from oxidant and thermal injury. Am J Physiol 270 (1996) C429-C436
28. Wischmeyer P.E., Musch M.W., Madonna M.B., et al. Glutamine protects intestinal epithelial cells: role of inducible HSP70. Am J Physiol 272 (1997) G879-G884
29. Wischmeyer P.E., Riehm J., Singleton K.D., et al. Glutamine attenuates tumor necrosis factor-α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition 19 (2003) 1-6
30. Coëffier M., Marion R., Ducrotté P., et al. Modulating effect of glutamine on IL-1β-induced cytokine production by human gut. Clin Nutr 22 (2003) 407-413
31. Singleton K.D., Beckey V.E., and Wischmeyer P.E. Glutamine prevents activation of NF-κB and stress kinase pathways, attenuates inflammatory cytokine release, and prevents acute respiratory distress syndrome (ARDS) following sepsis. Shock 24 (2005) 583-589
32. Harward T.R., Coe D., Souba W.W., et al. Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. J Surg Res 56 (1994) 351-355
33. Evans M.E., Jones D.P., and Ziegler T.R. Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway. Am J Physiol Gastrointest Liver Physiol 289 (2005) G388-G396
34. Paquette J.C., Guérin P.J., and Gauthier E.R. Rapid induction of the intrinsic apoptotic pathway by L-glutamine starvation. J Cell Physiol 202 (2005) 912-921
35. Fuchs B.C., and Bode B.P. Stressing out over survival: glutamine as an apoptotic modulator. J Surg Res 131 (2006) 26-40
36. Onodera J., and Ohsumi Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem 280 (2005) 31582-31586
37. Kuma A., Hatano M., Matsui M., et al. The role of autophagy during the early neonatal starvation period. Nature 432 (2004) 1032-1036
38. Periyasamy-Thandavan S., Jiang M., Wei Q., et al. Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney Int 74 (2008) 631-640
39. Ogawa M., Yoshimori T., Suzuki T., et al. Escape of intracellular Shigella from autophagy. Science 307 (2005) 727-731
40. Gutierrez M.G., Saka H.A., Chinen I., et al. Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae. Proc Natl Acad Sci U S A 104 (2007) 1829-1834
41. Hampe J., Franke A., Rosenstiel P., et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39 (2007) 207-211
42. Rioux J.D., Xavier R.J., Taylor K.D., et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39 (2007) 596-604
43. Parkes M., Barrett J.C., Prescott N.J., et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39 (2007) 830-832
44. Singh S.B., Davis A.S., Taylor G.A., et al. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313 (2006) 1438-1441
45. Codogno P., and Meijer A.J. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 12 Suppl 2 (2005) 1509-1518
46. Krause U., Bertrand L., Maisin L., et al. Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes. Eur J Biochem 269 (2002) 3742-3750
47. Nakajo T., Yamatsuji T., Ban H., et al. Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells. Biochem Biophys Res Commun 326 (2005) 174-180
48. 12 cells. Amino Acids 35 (2008) 147-155
49. Häussinger D., Schliess F., Dombrowski F., et al. Involvement of p38MAPK in the regulation of proteolysis by liver cell hydration. Gastroenterology 116 (1999) 921-935
50. Comes F., Matrone A., Lastella P., et al. A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells. Cell Death Differ 14 (2007) 693-702