메뉴 건너뛰기




Volumn 36, Issue 2, 2010, Pages 125-132

Review: Autophagy and neurodegeneration: Survival at a cost?

Author keywords

Autophagy; Beclin 1; Cell death; Neurite retraction; Neuroprotection; PTEN induced kinase 1

Indexed keywords

ALPHA SYNUCLEIN; BECLIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PRION PROTEIN; SUPEROXIDE DISMUTASE;

EID: 77949881747     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2009.01062.x     Document Type: Review
Times cited : (71)

References (49)
  • 1
    • 69349090907 scopus 로고    scopus 로고
    • The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases
    • Yue Z, Friedman L, Komatsu M, Tanaka K. The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases. Biochim Biophys Acta 2009 1793 : 1496 1507
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1496-1507
    • Yue, Z.1    Friedman, L.2    Komatsu, M.3    Tanaka, K.4
  • 2
    • 44149124887 scopus 로고    scopus 로고
    • Autophagy in neuroprotection and neurodegeneration: A question of balance
    • Cherra SJ, Chu CT. Autophagy in neuroprotection and neurodegeneration: a question of balance. Future Neurol 2008 3 : 309 323
    • (2008) Future Neurol , vol.3 , pp. 309-323
    • Cherra, S.J.1    Chu, C.T.2
  • 3
    • 33845407202 scopus 로고    scopus 로고
    • Atg22 recycles amino acids to link the degradative and recycling functions of autophagy
    • Yang Z, Huang J, Geng J, Nair U, Klionsky DJ. Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell 2006 17 : 5094 5104
    • (2006) Mol Biol Cell , vol.17 , pp. 5094-5104
    • Yang, Z.1    Huang, J.2    Geng, J.3    Nair, U.4    Klionsky, D.J.5
  • 4
    • 3042723794 scopus 로고    scopus 로고
    • Autophagy: Molecular mechanisms, physiological functions and relevance in human pathology
    • Marino G, Lopez-Otin C. Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci 2004 61 : 1439 1454
    • (2004) Cell Mol Life Sci , vol.61 , pp. 1439-1454
    • Marino, G.1    Lopez-Otin, C.2
  • 5
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007 9 : 1102 1109
    • (2007) Nat Cell Biol , vol.9 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 6
    • 33847048316 scopus 로고    scopus 로고
    • Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death
    • Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 2007 170 : 75 86
    • (2007) Am J Pathol , vol.170 , pp. 75-86
    • Zhu, J.H.1    Horbinski, C.2    Guo, F.3    Watkins, S.4    Uchiyama, Y.5    Chu, C.T.6
  • 7
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2007 282 : 5641 5652
    • (2007) J Biol Chem , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 8
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: Two ubiquitin-like systems
    • Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev 2001 2 : 211 216
    • (2001) Nat Rev , vol.2 , pp. 211-216
    • Ohsumi, Y.1
  • 10
    • 33745866310 scopus 로고    scopus 로고
    • Autophagic stress in neuronal injury and disease
    • Chu CT. Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol 2006 65 : 423 432
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 423-432
    • Chu, C.T.1
  • 16
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 2008 283 : 23542 23556
    • (2008) J Biol Chem , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3    Stefanis, L.4
  • 20
    • 61849102412 scopus 로고    scopus 로고
    • Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy
    • Heiseke A, Aguib Y, Riemer C, Baier M, Schatzl HM. Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy. J Neurochem 2009 109 : 25 34
    • (2009) J Neurochem , vol.109 , pp. 25-34
    • Heiseke, A.1    Aguib, Y.2    Riemer, C.3    Baier, M.4    Schatzl, H.M.5
  • 22
    • 58449101589 scopus 로고    scopus 로고
    • Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
    • Ling D, Song HJ, Garza D, Neufeld TP, Salvaterra PM. Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS ONE 2009 4 : e4201
    • (2009) PLoS ONE , vol.4 , pp. 4201
    • Ling, D.1    Song, H.J.2    Garza, D.3    Neufeld, T.P.4    Salvaterra, P.M.5
  • 23
    • 68449089023 scopus 로고    scopus 로고
    • Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein
    • Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. Am J Pathol 2009 175 : 736 747
    • (2009) Am J Pathol , vol.175 , pp. 736-747
    • Yu, W.H.1    Dorado, B.2    Figueroa, H.Y.3    Wang, L.4    Planel, E.5    Cookson, M.R.6    Clark, L.N.7    Duff, K.E.8
  • 25
    • 56349126024 scopus 로고    scopus 로고
    • Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury
    • Carloni S, Buonocore G, Balduini W. Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 2008 32 : 329 339
    • (2008) Neurobiol Dis , vol.32 , pp. 329-339
    • Carloni, S.1    Buonocore, G.2    Balduini, W.3
  • 26
    • 67649399288 scopus 로고    scopus 로고
    • Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
    • Dagda RK, Cherra SJ 3rd., Kulich SM, Tandon A, Park D, Chu CT. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 2009 284 : 13843 13855
    • (2009) J Biol Chem , vol.284 , pp. 13843-13855
    • Dagda, R.K.1    Cherra III, S.J.2    Kulich, S.M.3    Tandon, A.4    Park, D.5    Chu, C.T.6
  • 27
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008 183 : 795 803
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 29
    • 0034307476 scopus 로고    scopus 로고
    • Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
    • Kegel KB, Kim M, Sapp E, McIntyre C, Castano JG, Aronin N, DiFiglia M. Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J Neurosci 2000 20 : 7268 7278
    • (2000) J Neurosci , vol.20 , pp. 7268-7278
    • Kegel, K.B.1    Kim, M.2    Sapp, E.3    McIntyre, C.4    Castano, J.G.5    Aronin, N.6    Difiglia, M.7
  • 30
    • 35848947235 scopus 로고    scopus 로고
    • Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: Implications for neurodegeneration and cell death
    • Chu CT, Zhu J, Dagda R. Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy 2007 3 : 663 666
    • (2007) Autophagy , vol.3 , pp. 663-666
    • Chu, C.T.1    Zhu, J.2    Dagda, R.3
  • 31
    • 47249094223 scopus 로고    scopus 로고
    • Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
    • Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R. Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ 2008 15 : 1318 1329
    • (2008) Cell Death Differ , vol.15 , pp. 1318-1329
    • Scarlatti, F.1    Maffei, R.2    Beau, I.3    Codogno, P.4    Ghidoni, R.5
  • 33
    • 50249168137 scopus 로고    scopus 로고
    • Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: Implications for Parkinson's disease
    • Dagda RK, Zhu J, Kulich SM, Chu CT. Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy 2008 4 : 770 782
    • (2008) Autophagy , vol.4 , pp. 770-782
    • Dagda, R.K.1    Zhu, J.2    Kulich, S.M.3    Chu, C.T.4
  • 34
    • 0034672063 scopus 로고    scopus 로고
    • Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells
    • Ogier-Denis E, Pattingre S, El Benna J, Codogno P. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J Biol Chem 2000 275 : 39090 39095
    • (2000) J Biol Chem , vol.275 , pp. 39090-39095
    • Ogier-Denis, E.1    Pattingre, S.2    El Benna, J.3    Codogno, P.4
  • 35
    • 0037332108 scopus 로고    scopus 로고
    • Role of reactive oxygen species in extracellular signal-regulated protein kinase phosphorylation and 6-hydroxydopamine cytotoxicity
    • Kulich SM, Chu CT. Role of reactive oxygen species in extracellular signal-regulated protein kinase phosphorylation and 6-hydroxydopamine cytotoxicity. J Biosci 2003 28 : 83 9
    • (2003) J Biosci , vol.28 , pp. 83-9
    • Kulich, S.M.1    Chu, C.T.2
  • 36
    • 33749419538 scopus 로고    scopus 로고
    • Activation of ERK1/2 pathway mediates oxidant-induced decreases in mitochondrial function in renal cells
    • Nowak G, Clifton GL, Godwin ML, Bakajsova D. Activation of ERK1/2 pathway mediates oxidant-induced decreases in mitochondrial function in renal cells. Am J Physiol 2006 291 : F840 F855
    • (2006) Am J Physiol , vol.291
    • Nowak, G.1    Clifton, G.L.2    Godwin, M.L.3    Bakajsova, D.4
  • 37
    • 69249153394 scopus 로고    scopus 로고
    • A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1
    • Wang J, Whiteman MW, Lian H, Wang G, Singh A, Huang D, Denmark T. A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1. J Biol Chem 2009 284 : 21412 21424
    • (2009) J Biol Chem , vol.284 , pp. 21412-21424
    • Wang, J.1    Whiteman, M.W.2    Lian, H.3    Wang, G.4    Singh, A.5    Huang, D.6    Denmark, T.7
  • 38
    • 39549117093 scopus 로고    scopus 로고
    • Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
    • Plowey ED, Cherra SJ, 3rd., Liu YJ, Chu CT. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem 2008 105 : 1048 1056
    • (2008) J Neurochem , vol.105 , pp. 1048-1056
    • Plowey, E.D.1    Cherra, S.J.2    Liu, Y.J.3    Chu, C.T.4
  • 44
    • 36148960499 scopus 로고    scopus 로고
    • Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons
    • Yang Y, Fukui K, Koike T, Zheng X. Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci 2007 26 : 2979 2988
    • (2007) Eur J Neurosci , vol.26 , pp. 2979-2988
    • Yang, Y.1    Fukui, K.2    Koike, T.3    Zheng, X.4
  • 45
    • 0035085211 scopus 로고    scopus 로고
    • Rescue from death but not from functional impairment: Caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals
    • von Coelln R, Kugler S, Bahr M, Weller M, Dichgans J, Schulz JB. Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals. J Neurochem 2001 77 : 263 273
    • (2001) J Neurochem , vol.77 , pp. 263-273
    • Von Coelln, R.1    Kugler, S.2    Bahr, M.3    Weller, M.4    Dichgans, J.5    Schulz, J.B.6
  • 46
    • 0036549215 scopus 로고    scopus 로고
    • Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons
    • Bilsland J, Roy S, Xanthoudakis S, Nicholson DW, Han Y, Grimm E, Hefti F, Harper SJ. Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons. J Neurosci 2002 22 : 2637 2649
    • (2002) J Neurosci , vol.22 , pp. 2637-2649
    • Bilsland, J.1    Roy, S.2    Xanthoudakis, S.3    Nicholson, D.W.4    Han, Y.5    Grimm, E.6    Hefti, F.7    Harper, S.J.8
  • 47
    • 32544432831 scopus 로고    scopus 로고
    • Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans
    • Rowland AM, Richmond JE, Olsen JG, Hall DH, Bamber BA. Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans. J Neurosci 2006 26 : 1711 1720
    • (2006) J Neurosci , vol.26 , pp. 1711-1720
    • Rowland, A.M.1    Richmond, J.E.2    Olsen, J.G.3    Hall, D.H.4    Bamber, B.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.