-
1
-
-
48349136889
-
-
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van GA, Zelenika D, Franchimont D, Hugot JP, de VM, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M and Daly MJ. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-62.
-
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van GA, Zelenika D, Franchimont D, Hugot JP, de VM, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M and Daly MJ. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-62.
-
-
-
-
2
-
-
84969213492
-
000 cases of seven common diseases and 3,000 shared controls
-
Genome-wide association study of 14
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
3
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier RJ and Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448:427-34.
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
4
-
-
34247554965
-
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
-
Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ and Brant SR. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007; 39:596-604.
-
(2007)
Nat Genet
, vol.39
, pp. 596-604
-
-
Rioux, J.D.1
Xavier, R.J.2
Taylor, K.D.3
Silverberg, M.S.4
Goyette, P.5
Huett, A.6
Green, T.7
Kuballa, P.8
Barmada, M.M.9
Datta, L.W.10
Shugart, Y.Y.11
Griffiths, A.M.12
Targan, S.R.13
Ippoliti, A.F.14
Bernard, E.J.15
Mei, L.16
Nicolae, D.L.17
Regueiro, M.18
Schumm, L.P.19
Steinhart, A.H.20
Rotter, J.I.21
Duerr, R.H.22
Cho, J.H.23
Daly, M.J.24
Brant, S.R.25
more..
-
5
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De LV, Briggs J, Gunther S, Prescott NJ, Onnie CM, Hasler R, Sipos B, Folsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M and Schreiber S. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007; 39:207-11.
-
(2007)
Nat Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
Franke, A.2
Rosenstiel, P.3
Till, A.4
Teuber, M.5
Huse, K.6
Albrecht, M.7
Mayr, G.8
De, L.V.9
Briggs, J.10
Gunther, S.11
Prescott, N.J.12
Onnie, C.M.13
Hasler, R.14
Sipos, B.15
Folsch, U.R.16
Lengauer, T.17
Platzer, M.18
Mathew, C.G.19
Krawczak, M.20
Schreiber, S.21
more..
-
6
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS and Virgin HW. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-63.
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
Liu, J.Y.2
Brown, S.L.3
Miyoshi, H.4
Loh, J.5
Lennerz, J.K.6
Kishi, C.7
Kc, W.8
Carrero, J.A.9
Hunt, S.10
Stone, C.D.11
Brunt, E.M.12
Xavier, R.J.13
Sleckman, B.P.14
Li, E.15
Mizushima, N.16
Stappenbeck, T.S.17
Virgin, H.W.18
-
7
-
-
35348968286
-
The human microbiome project
-
Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R and Gordon JI. The human microbiome project. Nature 2007; 449:804-10.
-
(2007)
Nature
, vol.449
, pp. 804-810
-
-
Turnbaugh, P.J.1
Ley, R.E.2
Hamady, M.3
Fraser-Liggett, C.M.4
Knight, R.5
Gordon, J.I.6
-
8
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G and Flavell RA. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005; 307:731-4.
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
Chamaillard, M.2
Ogura, Y.3
Henegariu, O.4
Inohara, N.5
Nunez, G.6
Flavell, R.A.7
-
9
-
-
34548700796
-
Unveiling the roles of autophagy in innate and adaptive immunity
-
Levine B and Deretic V. Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol 2007; 7:767-77.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 767-777
-
-
Levine, B.1
Deretic, V.2
-
10
-
-
47849094901
-
Autophagic control of listeria through intracellular innate immune recognition in drosophila 1
-
Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T and Kurata S. Autophagic control of listeria through intracellular innate immune recognition in drosophila 1. Nat Immunol 2008; 9:908-16.
-
(2008)
Nat Immunol
, vol.9
, pp. 908-916
-
-
Yano, T.1
Mita, S.2
Ohmori, H.3
Oshima, Y.4
Fujimoto, Y.5
Ueda, R.6
Takada, H.7
Goldman, W.E.8
Fukase, K.9
Silverman, N.10
Yoshimori, T.11
Kurata, S.12
-
11
-
-
55249109400
-
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens
-
Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, Schmidt RE, Mizushima N, Deretic V, Sibley LD and Virgin HW. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 2008; 4:458-69.
-
(2008)
Cell Host Microbe
, vol.4
, pp. 458-469
-
-
Zhao, Z.1
Fux, B.2
Goodwin, M.3
Dunay, I.R.4
Strong, D.5
Miller, B.C.6
Cadwell, K.7
Delgado, M.A.8
Ponpuak, M.9
Green, K.G.10
Schmidt, R.E.11
Mizushima, N.12
Deretic, V.13
Sibley, L.D.14
Virgin, H.W.15
-
13
-
-
0037417893
-
Molecular features of adult mouse small intestinal epithelial progenitors
-
Stappenbeck TS, Mills JC and Gordon JI. Molecular features of adult mouse small intestinal epithelial progenitors. Proc Natl Acad Sci USA 2003; 100:1004-9.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1004-1009
-
-
Stappenbeck, T.S.1
Mills, J.C.2
Gordon, J.I.3
-
14
-
-
0344739789
-
Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases
-
Barbier M, Vidal H, Desreumaux P, Dubuquoy L, Bourreille A, Colombel JF, Cherbut C and Galmiche JP. Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases. Gastroenterol Clin Biol 2003; 27:987-91.
-
(2003)
Gastroenterol Clin Biol
, vol.27
, pp. 987-991
-
-
Barbier, M.1
Vidal, H.2
Desreumaux, P.3
Dubuquoy, L.4
Bourreille, A.5
Colombel, J.F.6
Cherbut, C.7
Galmiche, J.P.8
-
15
-
-
21144434528
-
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease
-
Yamamoto K, Kiyohara T, Murayama Y, Kihara S, Okamoto Y, Funahashi T, Ito T, Nezu R, Tsutsui S, Miyagawa JI, Tamura S, Matsuzawa Y, Shimomura I and Shinomura Y. Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. Gut 2005; 54:789-96.
-
(2005)
Gut
, vol.54
, pp. 789-796
-
-
Yamamoto, K.1
Kiyohara, T.2
Murayama, Y.3
Kihara, S.4
Okamoto, Y.5
Funahashi, T.6
Ito, T.7
Nezu, R.8
Tsutsui, S.9
Miyagawa, J.I.10
Tamura, S.11
Matsuzawa, Y.12
Shimomura, I.13
Shinomura, Y.14
-
16
-
-
7244257312
-
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression
-
Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, Herrlinger KR, Stallmach A, Noack F, Fritz P, Schroder JM, Bevins CL, Fellermann K and Stange EF. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression. Gut 2004; 53:1658-64.
-
(2004)
Gut
, vol.53
, pp. 1658-1664
-
-
Wehkamp, J.1
Harder, J.2
Weichenthal, M.3
Schwab, M.4
Schaffeler, E.5
Schlee, M.6
Herrlinger, K.R.7
Stallmach, A.8
Noack, F.9
Fritz, P.10
Schroder, J.M.11
Bevins, C.L.12
Fellermann, K.13
Stange, E.F.14
-
17
-
-
29144483937
-
Reduced Paneth cell α-defensins in ileal Crohn's disease
-
Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H Jr, Fellermann K, Ganz T, Stange EF and Bevins CL. Reduced Paneth cell α-defensins in ileal Crohn's disease. Proc Natl Acad Sci USA 2005; 102:18129-34.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
Salzman, N.H.2
Porter, E.3
Nuding, S.4
Weichenthal, M.5
Petras, R.E.6
Shen, B.7
Schaeffeler, E.8
Schwab, M.9
Linzmeier, R.10
Feathers, R.W.11
Chu, H.12
Lima Jr, H.13
Fellermann, K.14
Ganz, T.15
Stange, E.F.16
Bevins, C.L.17
-
18
-
-
46349102893
-
Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease
-
Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV and Radford-Smith GL. Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut 2008; 57:903-10.
-
(2008)
Gut
, vol.57
, pp. 903-910
-
-
Simms, L.A.1
Doecke, J.D.2
Walsh, M.D.3
Huang, N.4
Fowler, E.V.5
Radford-Smith, G.L.6
-
19
-
-
33644849605
-
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2
-
Voss E, Wehkamp J, Wehkamp K, Stange EF, Schröder JM and Harder J. NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem 2006; 281:2005-11.
-
(2006)
J Biol Chem
, vol.281
, pp. 2005-2011
-
-
Voss, E.1
Wehkamp, J.2
Wehkamp, K.3
Stange, E.F.4
Schröder, J.M.5
Harder, J.6
-
20
-
-
0038109983
-
Crohn's disease and the NOD2 gene: A role for paneth cells
-
Lala S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S, Ogunbiyi O, Nunez G and Keshav S. Crohn's disease and the NOD2 gene: a role for paneth cells. Gastro 2003; 125:47-57.
-
(2003)
Gastro
, vol.125
, pp. 47-57
-
-
Lala, S.1
Ogura, Y.2
Osborne, C.3
Hor, S.Y.4
Bromfield, A.5
Davies, S.6
Ogunbiyi, O.7
Nunez, G.8
Keshav, S.9
-
21
-
-
10744222688
-
Expression of NOD2 in Paneth cells: A possible link to Crohn's ileitis
-
Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M, Cho JH, Hart J, Greenson JK, Keshav S and Nunez G. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 2003; 52:1591-7.
-
(2003)
Gut
, vol.52
, pp. 1591-1597
-
-
Ogura, Y.1
Lala, S.2
Xin, W.3
Smith, E.4
Dowds, T.A.5
Chen, F.F.6
Zimmermann, E.7
Tretiakova, M.8
Cho, J.H.9
Hart, J.10
Greenson, J.K.11
Keshav, S.12
Nunez, G.13
-
22
-
-
54849421128
-
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
-
Kuballa P, Huett A, Rioux JD, Daly MJ and Xavier RJ. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE 2008; 3:3391.
-
(2008)
PLoS ONE
, vol.3
, pp. 3391
-
-
Kuballa, P.1
Huett, A.2
Rioux, J.D.3
Daly, M.J.4
Xavier, R.J.5
-
23
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H and Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885-9.
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
Yamamoto, A.4
Nakahara, Y.5
Suzuki-Migishima, R.6
Yokoyama, M.7
Mishima, K.8
Saito, I.9
Okano, H.10
Mizushima, N.11
-
24
-
-
0037031856
-
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
-
Madison BB, Dunbar L, Qiao XT, Braunstein K, Braunstein E and Gumucio DL. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem 2002; 277:33275-83.
-
(2002)
J Biol Chem
, vol.277
, pp. 33275-33283
-
-
Madison, B.B.1
Dunbar, L.2
Qiao, X.T.3
Braunstein, K.4
Braunstein, E.5
Gumucio, D.L.6
-
25
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH and Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008; 134:743-56.
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.H.2
Franke, A.3
Glickman, J.N.4
Zeissig, S.5
Tilg, H.6
Nieuwenhuis, E.E.7
Higgins, D.E.8
Schreiber, S.9
Glimcher, L.H.10
Blumberg, R.S.11
-
26
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
-
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T and Akira S. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 2008; 456:264-8.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
Tanaka, K.11
Kawai, T.12
Tsujimura, T.13
Takeuchi, O.14
Yoshimori, T.15
Akira, S.16
-
27
-
-
35348921764
-
The Atg5 Atg12 conjugate associates with innate antiviral immune responses
-
Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki K and Okuda K. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc Natl Acad Sci USA 2007; 104:14050-5.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14050-14055
-
-
Jounai, N.1
Takeshita, F.2
Kobiyama, K.3
Sawano, A.4
Miyawaki, A.5
Xin, K.Q.6
Ishii, K.J.7
Kawai, T.8
Akira, S.9
Suzuki, K.10
Okuda, K.11
-
28
-
-
20144381544
-
Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death
-
Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Oshumi Y and Jung YK. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005; 280:20722-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 20722-20729
-
-
Pyo, J.O.1
Jang, M.H.2
Kwon, Y.K.3
Lee, H.J.4
Jun, J.I.5
Woo, H.N.6
Cho, D.H.7
Choi, B.8
Lee, H.9
Kim, J.H.10
Mizushima, N.11
Oshumi, Y.12
Jung, Y.K.13
-
29
-
-
33749162486
-
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
-
Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, Brunner T and Simon HU. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 2006; 8:1124-32.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1124-1132
-
-
Yousefi, S.1
Perozzo, R.2
Schmid, I.3
Ziemiecki, A.4
Schaffner, T.5
Scapozza, L.6
Brunner, T.7
Simon, H.U.8
-
30
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K and Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005; 169:425-34.
-
(2005)
J Cell Biol
, vol.169
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
Ezaki, J.7
Mizushima, N.8
Ohsumi, Y.9
Uchiyama, Y.10
Kominami, E.11
Tanaka, K.12
Chiba, T.13
|