Recent advances in bioanalytical sample preparation for LC-MS analysis

Bioanalysis

Volumn 4, Issue 9, 2012, Pages 1123-1140

  Singleton, Christopher ^a  

^a Momenta Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ACEBUTOLOL; ALPRENOLOL; AMMONIUM ACETATE; ANTIDEPRESSANT AGENT; ASCOMYCIN; CARBAZOLE DERIVATIVE; CARBOPLATIN; CHLORPHENIRAMINE; DIACETOLOL; DOCETAXEL; DROSPIRENONE; ERLOTINIB; FLUOXETINE; HYDROCORTISONE; INDOLOCARBAZOLE DERIVATIVE; MIRTAZAPINE; MOLINDONE; N DESMETHYL ROSIGLITAZONE; NORFLUOXETINE; PACLITAXEL; PHOSPHOLIPID; RAPAMYCIN; RISPERIDONE; ROSIGLITAZONE; SIMVASTATIN; SULFONAMIDE; TIAPRIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIRCONIUM OXIDE;

AMBIENT IONIZATION MASS SPECTROMETRY; ANALYZER; CLINICAL ASSESSMENT TOOL; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; IONIZATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; LIQUID PHASE MICROEXTRACTION; MASS SPECTROMETRY; MICROEXTRACTION BY PACKED SOLVENT; NONHUMAN; ONLINE SYSTEM; PHOSPHOLIPID DEPLETION PLATE; PRECIPITATION; PROTEIN PRECIPITATION; REVIEW; SALT ASSISTED LIQUID LIQUID EXTRACTION; SOLID PHASE EXTRACTION; SOLID PHASE MICROEXTRACTION; SOLID SUPPORTED LIQUID EXTRACTION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LIQUID-LIQUID EXTRACTION; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; PLASMA; SALTS; SOLID PHASE MICROEXTRACTION;

EID: 84861368412     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.12.73     Document Type: Review

References (160)

1. King R, Bonfiglio R, Fernandez-Metzler C, Miller-Stein C, Olah T. Mechanistic investigation of ionization suppression in electrospray ionization. J. Amer. Soc. Mass Spectrom. 11(11), 942-950 (2000).
2. Little M, Wempe MF, Buchanan CM. Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma. J. Chromatogr. B (833), 219-230 (2006).
3. Fu I, Woolf EJ, Matuszewski BK. Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection. J. Pharm. Biomed. Anal. (18), 347-357 (1998).
4. Xia YQ, Jemal M. Phospholipids in liquid chromatography/mass spectrometry bioanalysis: Comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects. Rapid Commun. Mass Spectrom. 23(14), 2125-2138 (2009).
5. Weaver R, Riley RJ. Identification and reduction of ion suppression effects on pharmacokinetic parameters by polyethylene glycol 400. Rapid Commun. Mass Spectrom. 20, 2559-2564 (2006).
6. De Nardi C, Bonelli F. Moving from fast to ballistic gradient in liquid chromatography/ tandem mass spectrometry pharmaceutical bioanalysis: Matrix effect and chromatographic evaluations Rapid Commun. Mass Spectrom. 20, 2709-2716 (2006).
7. Xu X, Mei H, Wang S et al. A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays. Rapid Commun. Mass Spectrom. 19, 2643-2650 (2005).
8. Neville D. In silico prediction of retention times as a strategy to avoid matrix effects in LC-MS/MS bioanalysis. Chromatography Today 18-20 (2010).
9. Bonfiglio R, King RC, Olah TV, Merkle K. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun. Mass Spectrom. 13, 1175-1185 (1999).
10. Matuszewski BK, Constanzer ML, Chavez- Eng CM. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 75, 3019-3030 (2003).
11. Matuszewski BK. Standard line slopes as a measure of a relative matrix effect in quantitative HPLC-MS bioanalysis. J. Chromatogr. B 830, 293-300 (2006).
12. Bansal S, DeStefano A. Key elements of bioanalytical method validation for small molecules. AAPS J. 9(1), E109-E114 (2007).
13. US Department of Health and Human Services, FDA, Center for Drug Evaluation and Research, Center for Veterinary Medicine. Guidance for industry. Bioanalytical method validation (2001).
14. Viswanathan CT, Bansal S, Booth B et al. Workshop/conference report - quantitative bioanalytical methods validation and implementation: Best practices for chromatographic and ligand binding assays. AAPS J. 9(1), E30-E42 (2007).
15. Taylor PJ. Matrix effects: The Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin. Biochem. 38(4), 328-334 (2005).
16. Gosetti F, Mazzucco E, Zampieri D, Gennaro MC. Signal suppression/enhancement in high-performance liquid chromatography tandem mass spectrometry. J. Chromatogr. A 1217(25), 3929-3937 (2010).
17. Nerín C, Salafranca J, Aznar M, Batlle R. Critical review on recent developments in solventless techniques for extraction of analytes. Anal. Bioanal. Chem. 393(3), 809-833 (2009).
18. Kole PL, Venkatesh G, Kotecha J, Sheshala R. Recent advances in sample preparation techniques for effective bioanalytical methods. Biomed. Chromatogr. 25(1-2) 199-217 (2011).
19. Chambers E, Wagrowski-Diehl DM, Lu Z, Mazzeo JR. Systematic and comprehensive strategy for reducing matrix effects in LC/ MS/MS analyses. J. Chromatogr. B 852(1-2), 22-34 (2007).
20. Wu J, Lu J, Wilson C, Lin Y, Lu H. Effective liquid-liquid extraction method for analysis of pyrethroid and phenylpyrazole pesticides in emulsion-prone surface water samples. J. Chromatogr. A 1217(41), 6327-6333 (2010).
21. Lang Q, Wai CM. An extraction method for determination of ginkgolides and bilobalide in ginkgo leaf extracts. Anal. Chem. 71(14), 2929-2933 (1999).
22. Pan J, Jiang X, Chen Y-L. Automatic supported liquid extraction (SLE) coupled with hilic-ms/ms: An application to method development and validation of erlotinib in human plasma. Pharmaceutics 2(2), 105-118 (2010).
23. Li Y, Emm T, Yeleswaram S. Simultaneous determination of fluoxetine and its major active metabolite norfluoxetine in human plasms by LC-MS/MS using supported liquid extraction. Biomed. Chromatogr. 25(11), 1245-1251 (2011).
24. O'Maille G, Pai SM, Tao X, Douglas GT Jr, Jenkins RG. An improved LC-ESI-MS-MS method for simultaneous quantitation of rosiglitazone and N-desmethyl rosiglitazone in human plasma. J. Pharm. Biomed. Anal. 48(3), 934-939 (2008).
25. Wang AQ, Zeng W, Musson DG, Rogers JD, Fisher AL. A rapid and sensitive liquid chromatography/negative ion tandem mass spectrometry method for the determination of an indolocarbazole in human plasma using 96-well diatomaceous earth plates for solid-liquid extraction. Rapid Commun. Mass Spectrom. 16(10), 975-981 (2002).
26. Jiang H, Jiang X, Ji QC. Enantioselective determination of alprenolol in human plasma by liquid chromatography with tandem mass spectrometry using cellobiohydrolase chiral stationary phases. J. Chromatogr. B 872(1-2), 121-127 (2008).
27. Jiang H, Li Y, Pelzer M et al. Determination of molindone enantiomers in human plasma by high-performance liquid chromatography-tandem mass spectrometry using macrocyclic antibiotic chiral stationary phases. J. Chromatogr. A 1192(2), 230-238 (2008).
28. Jiang H, Randlett C, Junga H, Jiang X, Ji QC. Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma. J. Chromatogr. B 877(3), 173-180 (2009).
29. Ismaiel OA, Zhang T, Jenkins RG, Karnes HT. Investigation of endogenous blood plasma phospholipids, cholesterol and glycerides that contribute to matrix effects in bioanalysis by liquid chromatography/mass spectrometry. J. Chromatogr. B 878(31), 3303-3316 (2010
30. Wu S, Li W, Mujamdar T, Smith T, Bryant M, Tse FL. Supported liquid extraction in combination with LC-MS/MS for high-throughput quantitative analysis of hydrocortisone in mouse serum. Biomed. Chromatogr. 24(6), 632-638 (2009).
31. Fu X, Liao Y, Liu H. Sample preparation for pharmaceutical analysis. Anal. Bioanal. Chem. 381(1), 75-77 (2005).
32. Nguyen L, Zhong WZ, Painter CL, Zhang C, Rahavendran SV, Shen Z. Quantitative analysis of PD 0332991 in xenograft mouse tumor tissue by a 96-well supported liquid extraction format and liquid chromatography /mass spectrometry. J. Pharm. Biomed. Anal. 53(3), 228-234 (2010).
33. Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 24(20), 3011-3020 (2010).
34. Zhang J, Wu H, Kim E, El-Shourbagy TA. Salting-out assisted liquid-liquid extraction with acetonitrile: A new high throughput sample preparation technique for good laboratory practice bioanalysis using liquid chromatography-mass spectrometry. Biomed. Chromatogr. 23(4), 419-425 (2009).
35. Wang PG, Wei JS, Kim G, Chang M, El-Shourbagy T. Validation and application of a high-performance liquid chromatography-tandem mass spectrometric method for simultaneous quantification of lopinavir and ritonavir in human plasma using semi-automated 96-well liquid-liquid extraction. J. Chromatogr. A 1130(2), 302-307 (2006).
36. Yadav M, Rao R, Kurani H, Singhal P, Goswami S, Shrivastav PS. Application of a rapid and selective method for the simultaneous determination of protease inhibitors, lopinavir and ritonavir in human plasma by UPLC-ESI-MS/MS for bioequivalence study in Indian subjects. J. Pharm. Biomed. Anal. 49(4), 1115-1122 (2009).
37. Zhang J, Rodila R, Gage E et al. High-throughput salting-out assisted liquid-liquid extraction with acetonitrile for the simultaneous determination of simvastatin and simvastatin acid in human plasma with liquid chromatography. Anal. Chim. Acta 661(2), 167-172 (2010).
38. Noche GG, Laespada ME, Pavón JL, Cordero BM, Lorenzo SM. In situ aqueous derivatization and determination of non-steroidal anti-inflammatory drugs by salting-out-assisted liquid-liquid extraction and gas chromatography-mass spectrometry. J. Chromatogr. A 1218(37), 6240-6247 (2011).
39. Tsai WH, Huang TC, Chen HH, Wu YW, Huang JJ, Chuang HY. Determination of sulfonamides in swine muscle after salting-out assisted liquid extraction with acetonitrile coupled with back-extraction by a water/ acetonitrile/ dichloromethane ternary component system prior to high-performance liquid chromatography. J. Chromatogr. A 1217(3), 250-255 (2010).
40. Liu J, Jiang M, Li G, Xu L, Xie M. Miniaturized salting-out liquid-liquid extraction of sulfonamides from different matrices. Anal. Chim. Acta 679(1-2), 74-80 (2010).
41. Zhang J, Myasein F, Rodila R, Wu H, El-Shourbagy TA. High-throughput salting-out assisted liquid-liquid extraction and ultrafast LC for same-day delivery of first-in-human bioanalytical data. Bioanalysis 1(4), 715-719 (2009).
42. Xue YJ, Akinsanya JB, Liu J, Unger SE. A simplified protein precipitation/mixed-mode cation-exchange solid-phase extraction, followed by high-speed liquid chromatography/mass spectrometry, for the determination of a basic drug in human plasma. Rapid Commun. Mass Spectrom. 20(18), 2660-2668 (2006).
43. Myasein F, Kim E, Zhang J, Wu H, El-Shourbagy TA. Rapid, simultaneous determination of lopinavir and ritonavir in human plasma by stacking protein precipitations and salting-out assisted liquid- liquid extraction, and ultrafast LC-MS/MS. Anal. Chim. Acta 651(1), 112-116 (2009).
44. Wang M, Cai Z, Xu L. Coupling of acetonitrile deproteinization and salting-out extraction with acetonitrile stacking in chiral capillary electrophoresis for the determination of warfarin enantiomers. J. Chromatogr. A 1218(26), 4045-4051 (2011).
45. Wu H, Zhang J, Norem K, El-Shourbagy TA. Simultaneous determination of a hydrophobic drug candidate and its metabolite in human plasma with salting-out assisted liquid-liquid extraction using a mass spectrometry friendly salt. J. Pharm. Biomed. Anal. 48(4), 1243-1248 (2008).
46. Liu G, Zhou N, Zhang M et al. Hydrophobic solvent induced phase transition extraction to extract drugs from plasma for high performance liquid chromatography-mass spectrometric analysis. J. Chromatogr. A 1217(3), 243-249 (2010).
47. Bermingham S, O'Connor R, Regan F, McMahon GP. Simultaneous determination of anthracyclines and taxanes in human serum using online sample extraction coupled to high performance liquid chromatography with UV detection. J. Sep. Sci. 33(11), 1571-1579 (2010).
48. Míguez-Framil M, Moreda-Piñeiro A, Bermejo-Barrera P, Alvarez-Freire I, Tabernero MJ, Bermejo AM. Matrix solid-phase dispersion on column clean-up/ pre-concentration as a novel approach for fast isolation of abuse drugs from human hair. J. Chromatogr. A 1217(41), 6342-6349 (2010).
49. Gutiérrez Valencia TM, García De Llasera MP. Determination of organophosphorus pesticides in bovine tissue by an on-line coupled matrix solid-phase dispersion-solid phase extraction-high performance liquid chromatography with diode array detection method. J. Chromatogr. A 1218(39), 6869-6877 (2011).
50. Chu B, Lou D, Yu P, Hu S, Shen S. Development of an on-column enrichment technique based on C18-functionalized magnetic silica nanoparticles for the determination of lidocaine in rat plasma by high performance liquid chromatography. J. Chromatogr. A 1218(41), 7248-7253 (2011).
51. Chassaing C, Robinson S. Turbulent flow. Chromatography: An evolving solution for bioanalysis. Chromatography Today 20-24 (2009).
52. Cunliffe JM, Shen JX, Wei X, Dreyer DP, Hayes RN, Clement RP. Implementation of high-temperature superficially porous technologies for rapid LC-MS/MS diastereomer bioanalysis. Bioanalysis 3(7), 735-743 (2011).
53. Xia YQ, Jemal M. Phospholipids in liquid chromatography/mass spectrometry bioanalysis: Comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects. Rapid Commun. Mass Spectrom. 23(14), 2125-2138 (2009).
54. Mano N, Nozawa M, Sato M et al. Identification and elimination of ion suppression in the quantitative analysis of sirolimus in human blood by LC/ESI-MS/ MS. J. Chromatogr. B 879(13-14), 968-974 (2011).
55. Corona G, Elia C, Casetta B, Frustaci S, Toffoli G. High-throughput plasma docetaxel quantification by liquid chromatography-tandem mass spectrometry. Clin. Chim. Acta 412(3-4), 358-364 (2011
56. Jiang H, Zhang Y, Ida M, LaFayette A, Fast DM. Determination of carboplatin in human plasma using HybridSPE-precipitation along with liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 879(22), 2162-2170 (2011).
57. Silvestro L, Gheorghe MC, Tarcomnicu I, Savu S, Savu SR, Iordachescu A, Dulea C. Development and validation of an HPLC-MS/MS method to determine clopidogrel in human plasma. Use of incurred samples to test back-conversion. J. Chromatogr. B 878(30), 3134-3142 (2010).
58. Ismaiel OA, Zhang T, Jenkins RG, Karnes HT. Investigation of endogenous blood plasma phospholipids, cholesterol and glycerides that contribute to matrix effects in bioanalysis by liquid chromatography/mass spectrometry. J. Chromatogr. B 878(31), 3303-3316 (2010).
59. Lu X, Ye M. Enrichment of phospholipids in biological samples using HybridSPE-PPT. Reporter 28(3), 6-7 (2010).
60. Matheron L, Sachon E, Burlina F, Sagan S, Lequin O, Bolbach G. Sequence-dependent enrichment of a model phosphopeptide: A combined MALDI-TOF and NMRstudy. Anal. Chem. 83(8), 3003-3010 (2011).
61. Kanaujia PK, Pardasani D, Tak V, Purohit AK, Dubey DK. Selective enrichment of the degradation products of organophosphorus nerve agents by zirconia based solid-phase extraction. J. Chromatogr. A 1218(38), 6612-6620 (2011).
62. Abdel-Rehim M. New trend in sample preparation: on-line microextraction in packed syringe for liquid and gas chromatography applications: I. Determination of local anaesthetics in human plasma samples using gas chromatography- mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 801(2), 317-321 (2004).
63. Abdel-Rehim M. Microextraction in packed syringe (MEPS) for liquid and gas chromatographic applications. Part II - determination of ropivacaine and its metabolites in human plasma samples using MEPS with liquid chromatography/ tandem mass spectrometry. J. Mass Spectrom. 39(12), 1488-1493 (2004).
64. Altun Z, Abdel-Rehim M, Blomberg LG. New trends in sample preparation: on-line microextraction in packed syringe (MEPS) for LC and GC applications: Part III: Determination and validation of local anaesthetics in human plasma samples using a cation-exchange sorbent, and MEPS-LC-MS-MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 813(1-2), 129-135 (2004).
65. Altun Z, Abdel-Rehim M. Study of the factors affecting the performance of microextraction by packed sorbent (MEPS) using liquid scintillation counter and liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta 630(2), 116-123 (2008).
66. Abdel-Rehim M. Recent advances in microextraction by packed sorbent for bioanalysis. J. Chromatogr. A 1217(16), 2569-2580 (2010).
67. Chaves AR, Leandro FZ, Carris JA, Queiroz ME. Microextraction in packed sorbent for analysis of antidepressants in human plasma by liquid chromatography and spectrophotometric detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(23), 2123-2129 (2010).
68. Sauvage FL, Gaulier JM, Lachâtre G, Marquet P. A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum. Ther. Drug Monit. 28(1), 123-130 (2006).
69. Saracino MA, Tallarico K, Raggi MA. Liquid chromatographic analysis of oxcarbazepine and its metabolites in plasma and saliva after a novel microextraction by packed sorbent procedure. Anal. Chim. Acta 661(2), 222-228 (2010).
70. Bhatt M, Shah S, Shivprakash. Rapid ultraperformance liquid chromatography-tandem mass spectrometry method for quantification of oxcarbazepine and its metabolite in human plasma. Biomed. Chromatog. 25(7), 751-759 (2011).
71. Contin M, Mohamed S, Candela C, Albani F, Riva R, Baruzzi A. Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(3-4) 461-465 (2010).
72. Rani S, Malik AK, Singh B. Novel micro-extraction by packed sorbent procedure for the liquid chromatographic analysis of antiepileptic drugs in human plasma and urine. J. Sep. Sci. 35(3), 359-366 (2012).
73. Lafay F, Vulliet E, Flament-Waton MM. Contribution of microextraction in packed sorbent for the analysis of cotinine in human urine by GC-MS. Anal. Bioanal. Chem. 396(2), 937-941 (2010).
74. Vlčková H, Solichová D, Bláha M, Solich P, Nováková L. Microextraction by packed sorbent as sample preparation step for atorvastatin and its metabolites in biological samples - Critical evaluation. J. Pharm. Biomed. Anal. 55(2), 301-308 (2011).
75. Rani S, Kumar A, Mailk AK, Singh B. Quantification of tricyclic and nontricyclic antidepressants in spiked plasma and urine samples using microextraction in packed syringe and analysis by LC and GC-MS. Chromatographia 74, 235-242 (2011).
76. Said R, Pohanka A, Andersson M, Beck O, Abdel-Rehim M. Determination of remifentanil in human plasma by liquid chromatography-tandem mass spectrometry utilizing micro extraction in packed syringe (MEPS) as sample preparation. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879(11-12), 815-818 (2011).
77. Said R, Kamel M, El-Beqqali A, Abdel- Rehim M. Microextraction by packed sorbent for LC-MS/MS determination of drugs in whole blood samples. Bioanalysis 2(2), 197-205 (2010).
78. De Andrés F, Zougagh M, Castañeda G, Sánchez-Rojas JL, Ríos A. Screening of non-polar heterocyclic amines in urine by microextraction in packed sorbent-fluorimetric detection and confirmation by capillary liquid chromatography. Talanta 83(5), 1562-1567 (2011).
79. Vlčková H, Rabatinová M, Mikšová A et al. Determination of pravastatin and pravastatin lactone in rat plasma and urine using UHPLC-MS/MS and microextraction by packed sorbent. Talanta 90, 22-29 (2012).
80. Kamel M, Said R, Elbeqqali A, Bassyouni F, Abdel-Rehim M. On-line determination of cyclophosphamide in blood samples utilizing microextraction by packed sorbent and liquid chromatography tandem mass spectrometry (MEPS-LC-MS/MS). Open Spec. J. 3, 26-30 (2009).
81. Abdel-Rehim M, Dahlgren M, Blomberg L. Quantification of ropivacaine and its major metabolites in human urine samples utilizing microextraction in a packed syringe automated with liquid chromatography-tandem mass spectrometry (MEPS-LC-MS/MS). J. Sep. Sci. 29(11), 1658-1661 (2006).
82. Moreno IED, da Fonseca DM, Magalhães AR et al. Rapid determination of piperazine-type stimulants in human urine by microextraction in packed sorbent after method optimization using a multivariate approach. J. Chromatogr. A 1222, 116-120 (2012).
83. Nielsen K, Lauritsen FR, Nissila T, Ketola RA. Rapid screening of drug compounds in urine using a combination of microextraction by packed sorbent and rotating micropillar array electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 26(3), 297-303 (2012
84. Anizan S, Bichon E, Monteau F, Cesbron N, Antignac J-P, Le Bizec B. A new reliable sample preparation for high throughput focused steroid profiling by gas chromatography-mass spectrometry. J. Chromatogr. A 1217 (43), 6652-6660 (2010).
85. Abdel-Rehim M. Microextraction by packed sorbent (MEPS): A tutorial. Anal. Chim. Acta 701(2), 119-128 (2011).
86. Abdel-Rehim M. Recent advances in microextraction by packed sorbent for bioanalysis. J. Chromatogr. A 1217(16) 2569-2580 (2010).
87. Abdel-Rehim M. Microextraction by packed sorbent in bioanalysis. Bioanalysis 1(4), 687-691 (2009).
88. Kataoka H. Recent advances in solid-phase microextraction and related techniques for pharmaceutical and biomedical analysis. Curr. Pharm. Anal. 1(1), 65-84 (2005).
89. Vuckovic D, Shirey R, Chen Y et al. In vitro evaluation of new biocompatible coatings for solid-phase microextraction: Implications for drug analysis and in vivo sampling applications. Anal. Chim. Acta 638(2), 175-185 (2009).
90. Aurand C, Shirey B, Stenerson K. SPME for Bioanalysis. Supelco Reporter 26(4), 16-17 (2008).
91. Risticevic S, Lord H, Górecki T, Arthur CL, Pawliszyn J. Protocol for solid-phase microextraction method development. Nat. Prot. 5(1), 122-139 (2010).
92. Vuckovic D. In vivo solid-phase microextraction sampling: A promising future. Bioanalysis 3(12), 1305-1308 (2011).
93. Zhou SN, Ouyang G, Pawliszyn J. Comparison of microdialysis with solid-phase microextraction for in vitro and in vivo studies. J. Chromatogr. A 1196-1197, 45-56 (2008).
94. Zhang X, Es-haghi A, Musteata FM, Ouyang G, Pawliszyn J. Quantitative in vivo microsampling for pharmacokinetic studies based on an integrated solid-phase microextraction system. Anal. Chem. 79(12), 4507-4513 (2007).
95. Vuckovic D, De Lannoy I, Gien B et al. In vivo solid-phase microextraction for single rodent pharmacokinetics studies of carbamazepine and carbamazepine-10,11- epoxide in mice. J. Chromatogr. A 1218(21), 3367-3375 (2011).
96. Hutchinson JP, Setkova L, Pawliszyn J. Automation of solid-phase microextraction on a 96-well plate format. J. Chromatogr. A 1149(2), 127-137 (2007).
97. Vuckovic D, Cudjoe E, Hein D, Pawliszyn J. Automation of solid-phase microextraction in high-throughput format and applications to drug analysis. Anal. Chem. 80(18), 6870-6880 (2008).
98. Vatinno R, Vuckovic D, Zambonin CG, Pawliszyn J. Automated high-throughput method using solid-phase microextraction- liquid chromatography-tandem mass spectrometry for the determination of ochratoxin A in human urine. J. Chromatogr. A 1201(2), 215-221 (2008).
99. Vuckovic D, Zhang X, Cudjoe E, Pawliszyn J. Solid-phase microextraction in bioanalysis: new devices and directions. J. Chromatogr. A 1217(25), 4041-4060 (2010).
100. Mullet M, Martin P, Pawliszyn J. In-tube molecularly imprinted polymer solid-phase microextraction for the selective determination of propranolol. Anal. Chem. 73(11), 2383-2389 (2001).
101. Koster EHM, Crescenzi C, den Hoedt W, Ensing K, De Jong GJ. Fibers coated with molecularly imprinted polymers for solid-phase microextraction. Anal. Chem. 73(13), 3140-3145 (2001).
102. Hu X, Pan J, Hu Y, Huo Y, Li G. Preparation and evaluation of solid-phase microextraction fiber based on molecularly imprinted polymers for trace analysis of tetracyclines in complicated samples. J. Chromatogr. A 1188(2), 97-107 (2008).
103. Hu X, Pan J, Hu Y, Li G. Preparation and evaluation of propranolol molecularly imprinted solid-phase microextraction fiber for trace analysis of b-blockers in urine and plasma samples. J. Chromatogr. A 1216(2), 190-197 (2009).
104. Qiu L, Liu W, Huang M, Zhang L. Preparation and application of solid-phase microextraction fiber based on molecularly imprinted polymer for determination of anabolic steroids in complicated samples. J. Chromatogr. A 1217(48), 7461-7740 (2010).
105. Tan F, Zhao H, Li X et al. Preparation and evaluation of molecularly imprinted solid-phase microextraction fibers for selective extraction of bisphenol A in complex samples. J. Chromatogr. A 1216(30), 5647-5654 (2009).
106. Prasad BB, Tiwari K, Singh M, Sharma PS, Patel AK, Srivastava S. Molecularly imprinted polymer-based solid-phase microextraction fiber coupled with molecularly imprinted polymer-based sensor for ultratrace analysis of ascorbic acid. J. Chromatogr. A 1198-1199, 59-66 (2008).
107. Turiel E, Martín-Esteban A. Molecularly imprinted polymers for solid-phase microextraction. J. Sep. Sci. 32(19), 3278-3284 (2009).
108. Turiel E, Tadeo JL, Martin-Esteban A. Molecularly imprinted polymeric fibers for solid-phase microextraction. Anal. Chem. 79(8), 3099-3104 (2007).
109. Pedersen-Bjergaard S, Rasmussen KE. Liquid-liquid-liquid microextraction for sample preparation of biological fluids prior to capillary electrophoresis. Anal. Chem. 71(14), 2650-2656 (1999).
110. Al Azzam KM, Makahleah A, Saad B, Mansor SM. Hollow fiber liquid-phase microextraction for the determination of trace amounts of rosiglitazone (anti-diabetic drug) in biological fluids using capillary electrophoresis and high performance liquid chromatographic methods. J. Chromatogr. A 1217(23), 3654-3659 (2010).
111. Esrafili A, Yamini Y, Shariati S. Hollow fiber-based liquid phase microextraction combined with high-performance liquid chromatography for extraction and determination of some antidepressant drugs in biological fluids. Anal. Chim. Acta. 604(2), 127-133 (2007).
112. Tahmasebi E, Yamini Y, Saleh A. Extraction of trace amounts of pioglitazone as an anti-diabetic drug with hollow fiber liquid phase microextraction and determination by high-performance liquid chromatography-ultraviolet detection in biological fluids. J. Chromatogr. B 877(20-21), 1923-1929 (2009).
113. Yang Y, Chen J, Shi YP. Determination of aconitine, hypaconitine and mesaconitine in urine using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography. J. Chromatogr. B 878(28), 2811-2816 (2010).
114. Ramos Payán M, Bello López MÁ, Fernández- Torres R, González JA, Callejón Mochón M. Hollow fiber-based liquid phase microextraction (HF-LPME) as a new approach for the HPLC determination of fluoroquinolones in biological and environmental matrices. J. Pharm. Biomed. Anal. 55(2), 332-341 (2011).
115. Hadjmohammadi M, Ghambari H. Three-phase hollow fiber liquid phase microextraction of warfarin from human plasma and its determination by high-performance liquid chromatography. J. Pharm. Biomed. Anal. 61, 44-49 (2012).
116. Ghambarian M, Yamini Y, Esrafili A. Three-phase hollow fiber liquid-phase microextraction based on two immiscible organic solvents for determination of tramadol in urine and plasma samples. J. Pharm. Biomed. Anal. 56(5), 1041-1045 (2011
117. Saraji M, Bidgoli AA, Farajmand B. Hollow fiber-based liquid-liquid-liquid microextraction followed by flow injection analysis using column-less HPLC for the determination of phenazopyridine in plasma and urine. J. Sep. Sci. 34(14), 1708-1725 (2011).
118. Saraji M, Khalili Boroujeni M, Hajialiakbari Bidgoli AA. Comparison of dispersive liquid-liquid microextraction and hollow fiber liquid-liquid-liquid microextraction for the determination of fentanyl, alfentanil, and sufentanil in water and biological fluids by high-performance liquid chromatography. Anal. Bioanal. Chem. 400(7), 2149-2158 (2011).
119. Meng L, Liu X, Wang B, Shen G, Wang Z, Guo M. Simultaneous derivatization and extraction of free cyanide in biological samples with home-made hollow fiber-protected headspace liquid-phase microextraction followed by capillary electrophoresis with UV detection. J. Chromatogr. B 877(29), 3645-3651 (2009).
120. Lee J, Lee HK, Rasmussen KE, Pedersen- Bjergaard S. Environmental and bioanalytical applications of hollow fiber membrane liquid-phase microextraction: A review. Anal. Chim. Acta 624(2), 253-268 (2008).
121. Pedersen-Bjergaard S, Rasmussen KE. Liquid-phase microextraction with porous hollow fibers, a miniaturized and highly flexible format for liquid-liquid extraction. J. Chromatogr. A 1184(1-2), 132-142 (2008).
122. Chen H, Gamez G, Zenobi R. What can we learn from ambient ionization techniques? J. Am. Soc. Mass Spectrom. 20(11), 1947-1963 (2009).
123. Li L, Schug KA. On- and off-line coupling of separation techniques to ambient ionization mass spectrometry. Curr. Trends Mass Spectrom. 8-11 (2011).
124. Takáts Z, Wiseman JM, Gologan B, Cooks RG. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 5695(3060), 471-473 (2004).
125. Cody RB, Laramée JA, Durst HD. Versatile new ion source for the analysis of materials in open air under ambient conditions. Anal. Chem. 77(8), 2297-2302 (2005).
126. Chen H, Venter A, Cooks RG. Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation. Chem. Commun. 19, 2042-2044 (2006).
127. Myung S, Wiseman JM, Valentine SJ, Takats Z, Cooks RG, Clemmer DE. Coupling desorption electrospray ionization with ion mobility/mass spectrometry for analysis of protein structure: Evidence for desorption of folded and denatured states. J. Phys. Chem. B 110(10), 5045-5051 (2006).
128. Kaur-Atwal G, Weston DJ, Green PS, Crosland S, Bonner PL, Creaser CS. Analysis of tryptic peptides using desorption electrospray ionization combined with ion mobility spectrometry/mass spectrometry. Rapid Commun. Mass Spectrom. 21(7), 1131-1138 (2007).
129. Wiseman JM, Puolitaival SM, Takáts Z, Cooks RG, Caprioli RM. Mass spectrometric profiling of intact biological tissue by using desorption electrospray ionization. Angew. Chem. Int. Ed. 44(43), 7094-7097 (2005).
130. Manicke NE, Kistler T, Ifa DR, Cooks RG, Ouyang Z. High-throughput quantitative analysis by desorption electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom. 20(2), 321-325 (2009).
131. Chen H, Talaty NN, Takáts Z, Cooks RG. Desorption electrospray ionization mass spectrometry for high-throughput analysis of pharmaceutical samples in the ambient environment. Anal. Chem. 77(21), 6915-6927 (2005).
132. Suni NM, Lindfors P, Laine O et al. Matrix effect in the analysis of drugs of abuse from urine with desorption atmospheric pressure photoionization-mass spectrometry (DAPPI-MS) and desorption electrospray ionization-mass spectrometry (DESI-MS). Anal. Chim. Acta 699(1), 73-80 (2011).
133. Kennedy JH, Aurand C, Shirey R, Laughlin BC, Wiseman JM. Coupling desorption electrospray ionization with solid-phase microextraction for screening and quantitative analysis of drugs in urine. Anal. Chem. 82(17), 7502-7508 (2010).
134. Chen H, Talaty NN, Takáts Z, Cooks RG. Desorption electrospray ionization mass spectrometry for high-throughput analysis of pharmaceutical samples in the ambient environment. Anal. Chem. 77(21), 6915-6927 (2005).
135. Waldon DJ, Zhao Z, Teffera Y. Desorption electrospray ionization tissue imaging using heated nebulizing gas and high-resolution accurate mass spectra. Rapid Commun. Mass Spectrom. 24(16), 2352-2356 (2010).
136. Girod M, Shi Y, Cheng JX, Cooks RG. Desorption electrospray ionization imaging mass spectrometry of lipids in rat spinal cord. J. Am. Soc. Mass Spectrom. 21(7), 1177-1189 (2010).
137. Petucci C, Diffendal J, Kaufman D, Mekonnen B, Terefenko G, Musselman B. Direct analysis in real time for reaction monitoring in drug discovery. Anal. Chem. 79(13), 5064-5070 (2007).
138. Zhao Y, Lam M, Wu D, Mak R. Quantification of small molecules in plasma with direct analysis in real time tandem mass spectrometry, without sample preparation and liquid chromatographic separation. Rapid Commun. Mass Spectrom. 22(20), 3217-3224 (2008).
139. Manicke NE, Kistler T, Ifa DR, Cooks RG, Ouyang Z. High-throughput quantitative analysis by desorption electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom. 20(2), 321-325 (2009).
140. Abu-Rabie P. Direct analysis of DBS: Emerging and desirable technologies. Bioanalysis 3(15), 1675-1678 (2011).
141. Wong P, Pham R, Bruenner BA, James CA. Increasing efficiency for dried blood spot analysis: Prospects for automation and simplified sample analysis. Bioanalysis 2(11), 1787-1789 (2010).
142. Yu S, Crawford E, Tice J, Musselman B, Wu JT. Bioanalysis without sample cleanup or chromatography: The evaluation and initial implementation of direct analysis in real time ionization mass spectrometry for the quantification of drugs in biological matrixes. Anal. Chem. 81(1), 193-202 (2009).
143. Crawford E, Gordon J, Wu JT, Musselman B, Liu R, Yu S. Direct analysis in real time coupled with dried spot sampling for bioanalysis in a drug-discovery setting. Bioanalysis 3(11), 1217-1226 (2011).
144. Abu-Rabie P. Direct analysis of DBS: Emerging and desirable technologies. Bioanalysis 3(15), 1675-1678 (2011).
145. Jagerdeo E, Abdel-Rehim M. Screening of cocaine and its metabolites in human urine samples by direct analysis in real-time source coupled to time-of-flight mass spectrometry after online preconcentration utilizing microextraction by packed sorbent. J. Am. Soc. Mass Spectrom. 20(5), 891-899 (2009).
146. Zhao Y, Lam M, Wu D, Mak R. Quantification of small molecules in plasma with direct analysis in real time tandem mass spectrometry, without sample preparation and liquid chromatographic separation. Rapid Commun. Mass Spectrom. 22(20), 3217-3224, (2008).
147. Morlock G, Ueda Y. New coupling of planar chromatography with direct analysis in real time mass spectrometry. J. Chromatogr. A 1143(1-2), 243-251 (2007).
148. Van Berkel GJ, Tomkins BA, Kertesz V. Thin-layer chromatography/ desorption electrospray ionization mass spectrometry: Investigation of goldenseal alkaloids. Anal. Chem. 79(7), 2778-2789 (2007
149. Pasilis SP, Kertesz V, Van Berkel GJ, Schulz M, Schorcht S. Using HPTLC/DESI-MS for peptide identification in 1D separations of tryptic protein digests. Anal. Bioanal. Chem. 391(1), 317-324 (2008).
150. Takats Z, Wiseman JM, Ifa DR, Cooks RG. Desorption electrospray ionization (DESI) analysis of tryptic digests/peptides. CSH Protoc. prot4993 (2008).
151. Paglia G, Ifa DR, Wu C, Corso G, Cooks RG. Desorption electrospray ionization mass spectrometry analysis of lipids after two-dimensional high-performance thin-layer chromatography partial separation. Anal. Chem. 82(5), 1744-1750 (2010).
152. Lin Z, Zhang S, Zhao M, Yang C, Chen D, Zhang X. Rapid screening of clenbuterol in urine samples by desorption electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 22(12), 1882-1888 (2008).
153. Chen H, Yang S, Wortmann A, Zenobi R. Neutral desorption sampling of living objects for rapid analysis by extractive electrospray ionization mass spectrometry. Angew. Chem. Int. Ed. 46(40), 7591-7594 (2007).
154. Berchtold C, Meier L, Zenobi R. Evaluation of extractive electrospray ionization and atmospheric pressure chemical ionization for the detection of narcotics in breath. Int. J. Mass Spectrom. (299), 145-150 (2011).
155. Martínez-Lozano P, Fernández De la Mora J. Electrospray ionization of volatiles in breath. Int. J. Mass Spectrom. 265(1), 68-72 (2007).
156. Gu H, Chen H, Pan Z et al. Monitoring diet effects via biofluids and their implications for metabolomics studies. Anal. Chem. 79(1), 89-97 (2007).
157. Weston DJ. Ambient ionization mass spectrometry: Current understanding of mechanistic theory; analytical performance and application areas. Analyst 135(4), 661-668 (2010).
158. Ifa DR, Wu C, Ouyang Z, Cooks RG. Desorption electrospray ionization and other ambient ionization methods: Current progress and preview. Analyst 135(4) 669-681 (2010).
159. Huang MZ, Cheng SC, Cho YT, Shiea J. Ambient ionization mass spectrometry: A tutorial. Anal. Chim. Acta 702(1), 1-15 (2011).
160. Harris GA, Galhena AS, Fernández FM. Ambient sampling/ionization mass spectrometry: Applications and current trends. Anal. Chem. 831(12) 4508-4538 (2011