Simultaneous determination of a hydrophobic drug candidate and its metabolite in human plasma with salting-out assisted liquid/liquid extraction using a mass spectrometry friendly salt

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 4, 2008, Pages 1243-1248

  Wu, Huaiqin ^a   Zhang, Jun ^a   Norem, Katherine ^a   El Shourbagy, Tawakol A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Acetonitrile; High throughput; Liquid liquid extraction; Mass spectrometry; SALLE; Salting out

Indexed keywords

1 [4 (3 AMINO 1H INDAZOL 4 YL)PHENYL] 3 (2 FLUORO 5 METHYLPHENYL)UREA; A 849529; ACETONITRILE; AMMONIUM ACETATE; DRUG METABOLITE; HEXANE; INORGANIC SALT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN TISSUE; HYDROPHILICITY; HYDROPHOBICITY; LIQUID LIQUID EXTRACTION; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SALTING OUT ASSISTED LIQUID LIQUID EXTRACTION; TANDEM MASS SPECTROMETRY;

ACETATES; ACETONITRILES; CALIBRATION; CHROMATOGRAPHY, LIQUID; DRUGS, INVESTIGATIONAL; HUMANS; HYDROPHOBICITY; INDAZOLES; MASS SPECTROMETRY; PHENYLUREA COMPOUNDS; QUALITY CONTROL; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY;

EID: 57849137291     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.09.002     Document Type: Article

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