Validation and application of a high-performance liquid chromatography-tandem mass spectrometric method for simultaneous quantification of lopinavir and ritonavir in human plasma using semi-automated 96-well liquid-liquid extraction

Journal of Chromatography A

Volumn 1130, Issue 2 SPEC. ISS., 2006, Pages 302-307

  Wang, Perry G ^a   Wei, Jack S ^a   Kim, Grace ^a   Chang, Min ^a   El Shourbagy, Tawakol ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Atmospheric pressure chemical ionization; High performance liquid chromatography tandem mass spectrometry; Human immunodeficiency virus; Human plasma; Kaletra; Lopinavir; Ritonavir

Indexed keywords

BODY FLUIDS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; MASS SPECTROMETRY; VIRUSES;

ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN PLASMA; KALETRA; LOPINAVIR; RITONAVIR;

DRUG PRODUCTS;

ACETIC ACID ETHYL ESTER; ACETONITRILE; AMMONIUM ACETATE; HEXANE; LOPINAVIR; METHANOL; RITONAVIR; TETRAHYDROFURAN; WATER;

AQUEOUS SOLUTION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG MONITORING; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; LIQUID LIQUID EXTRACTION; PARTICLE SIZE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33748981087     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2006.07.071     Document Type: Article

References (7)

1. Hopfgarther G., and Bourgogne E. Mass Spectrom. Rev. 22 (2003) 95
2. Jemal M. Biomed. Chromatogr. 14 (2000) 422
3. Wang P.G., Wei J., Chang M., and El-Shourbagy T. Biomed. Chromatogr. 19 (2005) 663
4. Yang L., Wu N., Clement R., and Rudewicz P. J. Chromatogr. B 799 (2004) 271
5. Lee M., and Kerns E. Mass Spectrom. Rev. 18 (1999) 187
6. Vogel M., and Ermer J. Biomed. Chromatogr. 14 (2000) 373
7. Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM), Rockville, MD, May 2001.