Development of an on-column enrichment technique based on C18-functionalized magnetic silica nanoparticles for the determination of lidocaine in rat plasma by high performance liquid chromatography

Journal of Chromatography A

Volumn 1218, Issue 41, 2011, Pages 7248-7253

  Chu, Bin ^a   Lou, Dujuan ^b   Yu, Panfeng ^c   Hu, Shaonan ^a   Shen, Shun ^d  

^a FUDAN UNIVERSITY   (China)

^b PATENT EXAMINATION COOPERATION CENTER OF THE PATENT OFFICE   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d FUDAN UNIVERSITY   (China)

Author keywords

High performance liquid chromatography; Lidocaine; Magnetic silica nanoparticles; On column enrichment; Rat plasma

Indexed keywords

ACETONITRILE SOLUTIONS; COMPLEX PLASMA; DETECTION LIMITS; ENRICHMENT TECHNIQUES; EXTRACTION CONDITIONS; FUNCTIONALIZED; HYDROPHOBIC INTERACTIONS; LIDOCAINE; LINEAR RANGE; MAGNETIC SILICA NANOPARTICLES; METHOD VALIDATIONS; QUANTIFICATION LIMIT; RAT PLASMA; SAMPLE SOLUTION; SILICA NANOPARTICLES;

ACETONITRILE; BODY FLUIDS; COLUMN CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; LIQUIDS; NANOMAGNETICS; NANOPARTICLES; RATS; SILICA; SILICON COMPOUNDS;

MAGNETOPLASMA;

ACETONITRILE; CARBON; CARBON 18; LIDOCAINE; MAGNETIC NANOPARTICLE; MAGNETIC SILICA NANOPARTICLE; MAGNETITE; ROPIVACAINE; SILICON DIOXIDE; SOLVENT; UNCLASSIFIED DRUG;

ACCURACY; ADSORPTION; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; LINEAR SYSTEM; MAGNET; MALE; NONHUMAN; ON COLUMN ENRICHMENT TECHNIQUE; PRIORITY JOURNAL; RAT; SYNTHESIS; VALIDATION PROCESS;

ACETONITRILES; AMIDES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIDOCAINE; MAGNETITE NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SILICON DIOXIDE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

RATTUS;

EID: 80052941908     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.08.053     Document Type: Article

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