Microextraction by packed sorbent for LC-MS/MS determination of drugs in whole blood samples

Bioanalysis

Volumn 2, Issue 2, 2010, Pages 197-205

  Said, Rana ^a   Kamel, Mohamed ^a   El Beqqali, Aziza ^a   Abdel Rehim, Mohamed ^b,c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KARLSTAD UNIVERSITY   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; LIDOCAINE; ROPIVACAINE; DRUG;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MONITORING; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROEXTRACTION BY PACKED SORBENT; ONLINE SYSTEM; QUALITY CONTROL; RELIABILITY; SOLID PHASE MICROEXTRACTION; ANALYSIS; BLOOD; BLOOD ANALYSIS; FRACTIONATION; ISOLATION AND PURIFICATION; METHODOLOGY; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

ANALYTIC SAMPLE PREPARATION METHODS; BLOOD CHEMICAL ANALYSIS; CALIBRATION; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; HUMANS; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 79952528837     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.09.187     Document Type: Article

References (24)

1. Johannessen WM, Tyssebotn IM, Aarbakke J. Antipyrine and acetaminophen kinetics in the rat: comparison of data based on blood samples from cut tail and a cannulated femoral artery. J. Pharm. Sci. 71, 1352-1356 (1982). (Pubitemid 13209457)
2. Durschlag M, Wurbel H, Stauffacher M. Repeated blood collection in the laboratory mouse by tail incision - modification of an old technique. Physiol. Behav. 60, 1565-1568 (1996). (Pubitemid 26418548)
3. Watanabe T, Schnulz D, Hammock B. High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleeding and LC/MS/MS analysis. Anal. Chem. Acta 559, 37-44 (2006). (Pubitemid 43184285)
4. Bateman KP, Castonguay G, Xu L, et al. Reduction of animal usage by serial bleeding of mice for pharmacokinetic studies: application of robotic sample preparation and fast liquid chromatography-mass spectrometry. J. Chromatogr. B 754, 245-251 (2001). (Pubitemid 32241089)
5. Said R, Abdel-Rehimc M, Sadeghia B, Al-Hashemia S, Hassana Z, Hassana M. Cyclophosphamide pharmacokinetics in mice: a comparison between retro orbital sampling versus serial tail vein bleeding. Open Pharmacol. J. 1, 30-35 (2007).
6. Abdel-Rehim M. New trend in sample preparation: online microextraction in packed syringe for liquid and gas chromatography applications: I. Determination of local anaesthetics in human plasma. J. Chromatogr. B 801, 317-321 (2004). (Pubitemid 38130082)
7. Abdel-Rehim M, Altun Z, Blomberg L. Microextraction in packed syringe (MEPS) for liquid and gas chromatographic applications: Part II - determination of ropivacaine and its metabolites in human plasma. J. Mass Spectr. 39, 1488-1493 (2004). (Pubitemid 39664935)
8. Altun Z, Abdel-Rehim M, Blomberg L. New trends in sample preparation: online microextraction in packed syringe (MEPS) for LC and GC applications. Part III: determination and validation of local anaesthetics in human plasma samples. J. Chromatogr. B 813, 129-135 (2004). (Pubitemid 39535438)
9. Vita M, Skansen P, Hassan M, Abdel-Rehim M. Development and validation of a liquid chromatography and tandem mass spectrometry method for determination of roscovitine in plasma and urine samples utilizing online sample preparation. J. Chromatogr. B 817, 303-307 (2005). (Pubitemid 40430996)
10. Abdel-Rehim M, Skansen P, Vita M, Hassan Z, Blomberg LG, Hassan M. Microextraction in packed syringe/liquid chromatography/electrospray tandem mass spectrometry for quantification of olomoucine in human plasma samples. Anal. Chim. Acta. 53, 35-39 (2005). (Pubitemid 40637521)
11. Altun Z, Blomberg L, Jagerdeo E, Abdel-Rehim M. Drug screening using microextraction in a packed syringe (MEPS)/mass spectrometry. Utilizing monolithic-, polymer-, and silica-based sorbents. J. Liq. Chromatogr. Relat. Technol. 29, 829-839 (2006).
12. Abdel-Rehim M, Andersson LI, Altun Z, Blomberg L. Microextraction in packed syringe online with liquid chromatography- tandem mass spectrometry: molecularly imprinted polymer as packing material for MEPS in selective extraction of ropivacaine from plasma. J. Liq. Chromatogr. Relat. Technol. 29, 1725-1736 (2006).
13. Abdel-Rehim M, Dahlgren M, Blomberg L. Quantification of ropivacaine and its major metabolites in human urine samples utilizing microextraction in a packed syringe automated with liquid chromatography-tandem mass spectrometry (MEPS-LC-MS/MS) J. Sep. Sci. 29, 1658-1661 (2006). (Pubitemid 44184065)
14. Abdel-Rehim M, Dahlgren M, Claude S, Tabacchi R, Blomberg L. Microextraction in packed syringe (MEPS) utilizing methylcyanopropyl-silarylene as coating polymer for extraction of drugs in biological samples. J. Liq. Chromatogr. Relat. Technol. 29, 2537-2544 (2006). (Pubitemid 44359359)
15. Abdel-Rehim M, Askemark M, Norsten- Höög C, Pettersson KJ, Halldin M. Quantification of 4-OH-2,6-xylidine and its conjugates in human urine samples utilising microextraction in packed syringe online with liquid chromatography and electrospray tandem mass spectrometry (MEPS-LC-MS/MS). J. Liq. Chromatogr. Relat. Technol. 29, 2413-2424 (2006). (Pubitemid 44221675)
16. El-Beqqali A, Kussak A, Blomberg L, Abdel-Rehim M. Microextraction in packed syringe/liquid chromatography/electrospray tandem mass spectrometry for quantification of acebutolol and metoprolol in human plasma and urine samples. J. Liq. Chromatogr. & Relat.Technol. 30, 575-586 (2007).
17. El-Beqqali A, Kussak A, Abdel-Rehim M. Determination of dopamine and serotonin in human urine samples utilizing microextraction online with liquid chromatography/electrospray tandem mass spectrometry. J. Sep. Sci. 30, 421-424 (2007). (Pubitemid 46359144)
18. El-Beqqali A, Abdel-Rehim M. Quantitative analysis of methadone in human urine samples by microextraction in packed syringe-gas chromatography-mass spectrometry (MEPS-GC-MS). J. Sep. Sci. 30, 2501-2505 (2007). (Pubitemid 350020050)
19. Abdel-Rehim M, Hassan Z, Skansen P, Hassan M. Simultaneous determination of busulphan in plasma samples by liquid chromatography-electrospray ionization mass spectrometry utilizing microextraction in packed syringe (MEPS) as online sample preparation method. J. Liq. Chromatogr. Relat. Technol. 30, 3029-3041 (2007). (Pubitemid 47537289)
20. Said R, Hassan Z, Hassan M, Abdel-Rehim M. Rapid and sensitive method for determination of cyclophosphamide in patients plasma samples utilizing microextraction by packed sorbent online with liquid chromatography- tandem mass spectrometry (MEPS-LC-MS/MS) J. Liq. Chromatogr. Relat. Technol. 31, 683-694 (2008). (Pubitemid 351171568)
21. Abdel-Rehim M, Andersson A, Breitholtz-Emanuelsson A, Sandberg-Ställ M, Brunfelter K, Norsten-Höög C. MEPS as a rapid sample preparation method to handle unstable compounds in a complex matrix: determination of AZD3409 in plasma samples utilizing MEPS-LC-MS- MS. J. Chromatogr. Sci. 46, 518-523 (2008). (Pubitemid 352006450)
22. Kamel M, Said R, Elbiqali A, Bassyouni F, Abdel-Rehim M. On-line determination of cyclophosphamide in blood samples utilizing microextraction by packed sorbent and liquid chromatography tandem mass spectrometry (MEPS-LC-MS/MS). Open Spec. J. 3, 26-30 (2009).
23. Jagerdeo E, Abdel-Rehim M. Screening of cocaine and its metabolites in human urine samples by direct analysis in real-time source coupled to time-of-flight mass spectrometry after online preconcentration utilizing microextraction by packed sorbent. J. Am. Soc. Mass Spectrom. 20, 891-899 (2009).
24. Srinivas NR. The emerging technique, microextraction in packed syringes in separation science - can it eliminate matrix effects and fit with LC/MS/MS strategy? J. Sep. Sci. 32, 165-166 (2009).