Development and validation of an HPLC-MS/MS method to determine clopidogrel in human plasma. Use of incurred samples to test back-conversion

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 30, 2010, Pages 3134-3142

  Silvestro, Luigi ^b   Gheorghe, Mihaela Cristina ^a   Tarcomnicu, Isabela ^b   Savu, Silviu ^b   Savu, Simona Rizea ^b   Iordachescu, Adriana ^a   Dulea, Constanta ^a  

^a Pharma Serv Int'l SRL   (Romania)

^b 3S Pharmacological Consultation and Research GmbH   (Germany)

Author keywords

Back conversion; Clopidogrel; Liquid chromatography; Pharmacokinetics; Platelet aggregation; Tandem mass spectrometry

Indexed keywords

ACCEPTANCE CRITERIA; ANALYTICAL METHOD; AUTOSAMPLERS; BACK-CONVERSION; CHROMATOGRAPHIC SEPARATIONS; CLOPIDOGREL; DEUTERATED ANALOGUE; EXTRACTION RECOVERY; HPLC-MS/MS; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS/MS; LOW TEMPERATURES; MATRIX EFFECTS; PHARMACOKINETIC STUDIES; PLATELET AGGREGATION; POSITIVE ELECTROSPRAY IONIZATION; QUANTITATIVE METHOD; REAL SAMPLES; REVERSED-PHASE COLUMNS; SAMPLE PREPARATION; STABILITY TESTS; SUPELCO; TANDEM MASS SPECTROMETRY;

AMIDES; CHROMATOGRAPHY; DEUTERIUM; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHARMACOKINETICS; PLASMA STABILITY; PLATELETS; STABILITY CRITERIA;

EXTRACTION;

CLOPIDOGREL; DEUTERIUM;

ACCURACY; ARTICLE; BLOOD STORAGE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; PLATELET AGGREGATION INHIBITORS; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TICLOPIDINE;

EID: 78049482865     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.09.022     Document Type: Article

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