Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 833, Issue 2, 2006, Pages 219-230

  Little, James L ^a   Wempe, Michael F ^a   Buchanan, Charles M ^a  

^a EASTMAN CHEMICAL COMPANY   (United States)

Author keywords

Drug discovery; Electrospray mass spectrometry; Glycerophosphocholines; LC MS MS; Lecithin; Matrix effects; Matrix suppression; Pharmaceutical analysis; Phospholipids; Plasma

Indexed keywords

IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHOSPHOLIPIDS; PLASMAS;

DRUG DISCOVERY; ELECTROSPRAY MASS SPECTROMETRY; GLYCEROPHOSPHOCHOLINES; LC-MS/MS; LECITHIN; MATRIX EFFECTS; MATRIX SUPPRESSION; PHARMACEUTICAL ANALYSIS;

DRUG PRODUCTS;

4 HYDROXYTAMOXIFEN; DIPHENHYDRAMINE; GLYCEROPHOSPHATE; GLYCEROPHOSPHOETHANOLAMINE; GLYCEROPHOSPHORYLCHOLINE; HYDROXYITRACONAZOLE; ITRACONAZOLE; NORTAMOXIFEN; TAMOXIFEN;

ARTICLE; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; FRAGMENTATION REACTION; IONIZATION; LIPID ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHROMATOGRAPHY, LIQUID; DOGS; HUMANS; MASS SPECTROMETRY; MICE; PHOSPHOLIPIDS; RABBITS; RATS; TAMOXIFEN;

EID: 33645224920     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.02.011     Document Type: Article

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