Direct analysis of DBS: Emerging and desirable technologies

Bioanalysis

Volumn 3, Issue 15, 2011, Pages 1675-1678

  Abu Rabie, Paul ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

automation; direct analysis; direct desorption; dried blood spot; dried matrix spot; drug development; hematocrit; internal standard; regulated bioanalysis

Indexed keywords

AUTOMATION; BIOTECHNOLOGY; BLOOD; BLOOD ANALYSIS; DESORPTION; DRIED BLOOD SPOT; EDITORIAL; ELECTROSPRAY; ELUTION; HEMATOCRIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SENSITIVITY ANALYSIS;

EID: 80051683422     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.11.159     Document Type: Editorial

References (12)

1. Barfeld M, Spooner N, Lad R, Parry S, Fowles S. Application of dried blood spots combined with HPLC-MS/MS for the quantifcation of acetaminophen in toxicokinetic studies. J. Chromatogr. B. 870, 32-37 (2008).
2. Barfeld M, Wheller R. Use of dried plasma spots in the determination of pharmacokinetics in clinical studies: validation of a quantitative bioanalytical method. Anal. Chem. 83, 118-124 (2011).
3. Spooner N, Lad R, Barfeld M. Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method. Anal. Chem. 81, 1557-1563 (2009).
4. Edelbroek PM, Van der Heijden J, Stolk LML. Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls. Ther. Drug Monit. 31, 327-336 (2009).
5. Abu-Rabie P, Spooner N. Direct quantitative bioana lysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface. Anal. Chem. 81, 10275-10284 (2009).
6. th ASMS Conference on Mass Spectrometry and Allied Topics. SLC, UT, USA, 23-27 May 2010.
7. Kertesz V, Van Berkel GJ. Fully automated liquid extraction-based surface sampling and ionisation using a chip-based robotic nanoelectrospray platform. J. Mass Spectrom. 45, 252-260 (2010).
8. Van Berkel GJ, Pasilis SP, Ovchinnikova O. Established and emerging atmospheric pressure surface sampling/ionization techniques for mass spectrometry. J. Mass Spectrom. 43, 1161-1180 (2008).
9. Harris GA, Galhena AS, Fernandez FM. Ambient sampling/ionization mass spectrometry: applications and current trends. Anal. Chem. (2011) (In press).
10. Wiseman JM, Evans CA, Bowen CL, Kennedy JH. Direct ana lysis of dried blood spots utilizing desorption electrospray ionization (DESI) mass spectrometry. Analyst 135, 720-725 (2010).
11. Manicke NE,Yang Q, Wang H, Oradua S, Ouyang Z, Cooks RG. Assessment of paper spray ionization for quantitation of pharmaceuticals in blood spots. Intl J. Mass Spect. 300, 123-129 (2011).
12. Denniff P, Spooner N. The effect of hematocrit on assay bias when using DBS samples for the quantitiative bioana lysis of drugs. Bioana lysis 8, 1385-1395 (2010).