High-throughput salting-out assisted liquid/liquid extraction with acetonitrile for the simultaneous determination of simvastatin and simvastatin acid in human plasma with liquid chromatography

Analytica Chimica Acta

Volumn 661, Issue 2, 2010, Pages 167-172

  Zhang, Jun ^a   Rodila, Ramona ^a   Gage, Eric ^a   Hautman, Mathew ^a   Fan, Leimin ^a   King, Linda L ^a   Wu, Huaiqin ^a   El Shourbagy, Tawakol A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

High throughput; Liquid chromatography; Salting out; Salting out assisted liquid liquid extraction; Simvastatin; Simvastatin acid

Indexed keywords

HIGH-THROUGHPUT; LIQUID/LIQUID EXTRACTION; SALTING-OUT; SIMVASTATIN; SIMVASTATIN ACID;

ACETONITRILE; ACIDS; CHROMATOGRAPHIC ANALYSIS; LIQUIDS; MASS SPECTROMETRY; PLASMA STABILITY; THROUGHPUT;

LIQUID CHROMATOGRAPHY;

ACETONITRILE; SIMVASTATIN; SIMVASTATIN ACID; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ACCURACY; ACIDITY; ANALYTIC METHOD; ARTICLE; BIOEQUIVALENCE; BLOOD ANALYSIS; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DILUTION; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSFORMATION; HIGH THROUGHPUT SCREENING; HUMAN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS DESIGN; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; ROOM TEMPERATURE; TANDEM MASS SPECTROMETRY; TEMPERATURE DEPENDENCE; VALIDATION PROCESS;

ACETONITRILES; ANALYTIC SAMPLE PREPARATION METHODS; BLOOD CHEMICAL ANALYSIS; CALIBRATION; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PHYSICOCHEMICAL PROCESSES; REPRODUCIBILITY OF RESULTS; SALTS; SIMVASTATIN; TEMPERATURE; THERAPEUTIC EQUIVALENCY; TIME FACTORS;

EID: 74549152916     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2009.12.023     Document Type: Article

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