Cancer proliferation gene discovery through functional genomics

Science

Volumn 319, Issue 5863, 2008, Pages 620-624

  Schlabach, Michael R ^a   Luo, Ji ^a   Solimini, Nicole L ^a   Hu, Guang ^a   Xu, Qikai ^a   Li, Mamie Z ^a   Zhao, Zhenming ^a   Smogorzewska, Agata ^a,b   Sowa, Mathew E ^c   Ang, Xiaolu L ^c   Westbrook, Thomas F ^a   Liang, Anthony C ^a   Chang, Kenneth ^d   Hackett, Jennifer A ^a   Harper, J Wade ^c   Hannon, Gregory J ^d   Elledge, Stephen J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; RETROVIRUS VECTOR; SHORT HAIRPIN RNA;

CANCER; DECONVOLUTION; DISEASE TREATMENT; GENE; GENOMICS; IDENTIFICATION METHOD; MAMMAL; PROTEIN; RNA; SURVIVAL; VIABILITY;

ARTICLE; CANCER CELL; CELL CYCLE; CELL PROLIFERATION; CELL VIABILITY; FUNCTIONAL DISEASE; FUNCTIONAL GENOMICS; GENE DISCOVERY; GENETICS; HUMAN; HUMAN CELL; METHODOLOGY; MICROARRAY ANALYSIS; NEOPLASM; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL;

BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; GENE LIBRARY; GENES, NEOPLASM; GENETIC VECTORS; GENOME, HUMAN; GENOMICS; HUMANS; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RETROVIRIDAE; RNA, SMALL INTERFERING;

MAMMALIA;

EID: 38849098442     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1149200     Document Type: Article

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20. We thank A. L. Brass for the pMSCV-PM, pMSCV-PM-FF, and pMSCV-PM-mir30 vectors and for scientific advice; M. J. Solimini for help with data analysis; E. R. McDonald for scientific advice; T. Waldman and B. Vogelstein for the HCT116 and DLD-1 cell lines; and T. Moore from Open Biosystems for help with assembling library pools. G.H. is a fellow of the Helen Hay Whitney Foundation. X.L.A. is supported by a National Research Service Award fellowship, M.E.S. is supported by an American Cancer Society fellowship, and A.S. is supported by grant T32CA09216 to the MGH Pathology Department. T.F.W. is a fellow of the Susan G. Komen Foundation and is supported by grant PDF0403175. This work is supported by grants from NIH and the U.S. Department of Defense to G.J.H., J.W.H., and S.J.E. G.J.H. has a paid consulting relationship with Open Biosystems.